Muscle Size & Strength

This page on muscle size and strength covers strategies to maximize muscle gain and strength gain. There is notable overlap in nutrition and supplementation strategies to facilitate these two goals, but there is some divergence in the best type of exercise. A larger muscle tends to be a stronger muscle.

Quick Answer

What it is

This page on muscle size and strength covers strategies to maximize muscle gain and strength gain. There is notable overlap in nutrition and supplementation strategies to facilitate these two goals, but there is some divergence in the best type of exercise.

Key findings

  • Grade B: Muscle Mass (Soy Protein)
  • Grade B: Muscle Protein Synthesis (Calcium Caseinate)
  • Grade B: Lean Mass Gains (Beef Protein)

Safety

No specific caution or interaction language was detected in the current summary/outcome notes.

ℹ️ Quick Facts

Quick Facts: Muscle Size & Strength

  • Supplements Studied:45
  • Research Trials:153
  • Total Participants:25,809
  • Top Supplement:Creatine (B)
153 trials
25,809 ppts
45 supps · 334 outcomes

Evidence-Based Protocol

Supplement stack ranked by research quality

Strong Evidence

Primary Stack (Tier 1)

3-5g daily (loading phase optional: 20g/day for 5-7 days)

Increases phosphocreatine stores for ATP regeneration, enhances training capacity, and promotes cell volumization

100 studies | 8,000 participants
1.6-2.2g/kg body weight daily (20-40g per meal)

Provides essential amino acids (especially leucine) to maximize muscle protein synthesis and support recovery

50 studies | 4,000 participants

Supporting Stack (Tier 2)

Leucine metabolite that reduces muscle protein breakdown and supports lean mass gains

25 studies | 1,500 participants
3-6g daily (split doses to minimize tingling)

Increases muscle carnosine to buffer acid during high-intensity sets, allowing more training volume

30 studies | 1,200 participants
300-600mg standardized extract daily

Adaptogen that reduces cortisol, improves recovery, and enhances strength and muscle gains

8 studies | 500 participants
2000-5000 IU daily (target 40-60 ng/mL)

Vitamin D receptors in muscle tissue regulate protein synthesis; deficiency impairs muscle function

15 studies | 1,000 participants

How It Works

Building muscle requires progressive resistance training plus adequate nutrition and recovery. While training provides the stimulus, supplements can enhance the muscle-building response and accelerate results. This protocol includes the most evidence-based supplements for muscle hypertrophy and strength.

Creatine Monohydrate is the single most effective and well-researched supplement for increasing muscle mass and strength. It works by increasing your muscles' stores of phosphocreatine, which regenerates ATP (cellular energy) during intense exercise. This allows you to perform more reps, lift heavier weights, and recover faster between sets—all of which drive greater muscle growth. Studies consistently show 5-10% greater strength gains and 1-2 kg more lean mass over 8-12 weeks. It also promotes cell volumization (water drawn into muscle cells), which may directly stimulate protein synthesis.
Protein is essential for muscle growth—you can't build muscle without adequate amino acids. The leucine content of protein is particularly important as it directly activates mTOR, the master regulator of muscle protein synthesis. Research shows 1.6-2.2g/kg body weight is optimal for muscle building, with 20-40g of high-quality protein per meal. Whey protein is rapidly absorbed (ideal post-workout), while casein provides sustained amino acid release.
HMB is a metabolite of leucine that primarily works by reducing muscle protein breakdown. It's most effective for beginners, during caloric deficits, or when training volume is very high. It can help preserve muscle and support modest gains in lean mass.
Beta-Alanine increases carnosine levels in muscles, which buffers the acid produced during high-rep sets. This allows you to push through more reps in the 8-15 range—exactly the rep range most important for hypertrophy. The famous tingling (paresthesia) is harmless.
Ashwagandha is an adaptogen that reduces cortisol (a catabolic hormone) and improves recovery. Studies in resistance-trained individuals show significantly greater increases in strength and muscle size compared to placebo.
Vitamin D deficiency impairs muscle function and is surprisingly common. Adequate vitamin D supports muscle protein synthesis and strength. If you're deficient, correcting it can meaningfully improve your training results.

Expected timeline: Creatine loading saturates muscles in 5-7 days; maintenance provides ongoing benefit. Protein effects are continuous with training. Beta-alanine requires 2-4 weeks to build carnosine stores. Ashwagandha benefits appear over 8-12 weeks.

Generated from peer-reviewed researchSchema v2.0

Supplements for Muscle Size & Strength

Sorted by strength of evidence

BCreatine
2
Anaerobic CapacityImprovesAerobic Exercise MetricsJump HeightImproves
BChromium
1
Body FatImprovesMuscle MassImprovesWeightWorsens
BAshwagandha
1
Aerobic Exercise MetricsImprovesStrengthImprovesPower OutputImproves
BSoy Protein
1
Muscle MassImprovesStrengthImproves
BCalcium Caseinate
1
Muscle Protein SynthesisImproves
BNitrate
1
Jump HeightImprovesPeak power output (PPO)ImprovesStrengthImproves
BBeef Protein
1
Lean Mass GainsImprovesLower-Limb StrengthImproves
CAlpha-GPC
1
Growth HormoneImprovesPower OutputImproves
CArachidonic Acid
1
Anaerobic CapacityImprovesBody FatWorsensCortisolWorsens
CVitamin D
1
Interleukin 5ImprovesPower OutputImproves
CFenugreek
1
Body FatImprovesFree TestosteroneImprovesStrengthImproves
CCaffeine
1
Blood Lactate (Exercise)WorsensPower OutputImprovesCortisolWorsens
CSpirulina
1
Muscle SorenessPower OutputImproves
CWhey Protein
1
Anti-Oxidant Enzyme ProfileImprovesMuscle MassImprovesStrengthImproves
CD-Ribose
1
Creatine KinaseImprovesLactate DehydrogenaseImprovesMuscle SorenessWorsens
CArginine
1
Blood FlowImprovesHeart RateWorsensBlood PressureWorsens
CSodium Bicarbonate
1
Anaerobic CapacityImprovesMuscular EnduranceImprovesMaximal voluntary isometric contraction (MVIC)Improves
DEphedrine
1
Power OutputSubjective Well-BeingImproves
DFish Oil
1
Anaerobic CapacityStrengthImprovesMuscle MassImproves
DCalcium
1
Free TestosteroneTestosteroneImproves

Detailed Outcomes

Grade:
Effect:
Size:
Sort:
|
B
Muscle Mass
Small Improvement
18 studies
smallImproves
?
Strength
5 studies
Improves
B
Muscle Protein Synthesis
Casein stimulates MPS comparably to whey over 24h despite lower acute peak. With resistance training, muscle gains are similar to whey protein.
8 studies
moderateImproves
B
Lean Mass Gains
Meta-analysis (PMID: 31261854): no difference from whey (SMD -0.01, p=0.970); BP vs no protein: SMD 0.34, p=0.049
7 studies
moderateImproves
B
Lower-Limb Strength
Meta-analysis: BP vs no protein significantly increased lower-limb strength (SMD 0.40, p=0.014)
7 studies
moderateImproves
B
Aerobic Exercise Metrics
Moderate Improvement
7 studies
moderateImproves
?
Strength
7 studies
Improves
?
Power Output
4 studies
Improves
?
Body Fat
3 studies
Worsens
?
High-density lipoprotein (HDL)
2 studies
Improves
?
Liver Enzymes
2 studies
Worsens
?
Low-density lipoprotein (LDL)
2 studies
Worsens
?
Muscle Mass
2 studies
Improves
?
Red Blood Cell Count
2 studies
Improves
?
Total cholesterol
2 studies
Worsens
?
Triglycerides
2 studies
Worsens
?
Weight
2 studies
Worsens
?
White Blood Cell Count
2 studies
Improves
?
Anaerobic Capacity
1 study
Improves
?
Blood Pressure
1 study
Worsens
?
Exercise Capacity
1 study
Improves
?
Hematocrit
1 study
Improves
?
Hemoglobin
1 study
Improves
?
Kidney Function
1 study
Improves
?
Muscle Damage
1 study
Worsens
?
Muscle Soreness
1 study
Worsens
?
Oxygen Uptake
1 study
Improves
?
Rating of Perceived Exertion
1 study
Improves
?
Serum Albumin
1 study
Improves
?
Serum Platelets
1 study
Improves
?
Subjective Well-Being
1 study
Improves
?
Testosterone
1 study
Improves
?
Urea
1 study
Improves
?
vLDL-C
1 study
Worsens
B
Jump Height
Small Increase
6 studies
smallImproves
?
Peak power output (PPO)
19 studies
Improves
?
Strength
6 studies
Improves
?
Sprint Performance Metrics
5 studies
Improves
?
Power Output
1 study
Improves
B
Body Fat
Small Decrease
5 studies
smallImproves
?
Muscle Mass
5 studies
Improves
?
Weight
5 studies
Worsens
?
Power Output
3 studies
Improves
?
Insulin
1 study
Worsens
?
Muscular Endurance
1 study
Improves
B
Anaerobic Capacity
Small Improvement
3 studies
smallImproves
D
Aerobic Exercise Metrics
No effect
1 study
none
?
Jump Height
23 studies
Improves
?
Peak power output (PPO)
12 studies
Improves
?
Muscle Damage
11 studies
Worsens
?
Muscle Mass
10 studies
Improves
?
Body Fat
9 studies
Worsens
?
Muscle Creatine Content
8 studies
Improves
?
Strength
7 studies
Improves
?
Muscle Soreness
6 studies
Worsens
?
Exercise-Induced Oxidation
5 studies
Worsens
?
Inflammation
5 studies
Worsens
?
Power Output
5 studies
Improves
?
IGF-1
4 studies
Improves
?
Weight
4 studies
Worsens
?
Fatigue Resistance
3 studies
Worsens
?
Hydration (Total Body Water)
2 studies
Improves
?
Muscular Endurance
2 studies
Improves
?
Testosterone
2 studies
Improves
?
Blood Flow
1 study
Improves
?
Blood Pressure
1 study
Worsens
?
Glycogen
1 study
Improves
?
Growth Hormone
1 study
Improves
?
Kidney Function
1 study
Improves
?
Metabolic Rate
1 study
Improves
?
Myonuclei Proliferation
1 study
Improves
?
Myostatin
1 study
Improves
?
Proteinuria
1 study
Improves
?
Range of Motion
1 study
Improves
?
Satellite Cell Recruitment
1 study
Improves
?
Skeletal Muscle Atrophy
1 study
Improves
C
Anti-Oxidant Enzyme Profile
Small Increase
1 study
smallImproves
?
Muscle Mass
11 studies
Improves
?
Strength
7 studies
Improves
?
Body Fat
3 studies
Worsens
?
Heart Rate
3 studies
Worsens
?
Peak power output (PPO)
3 studies
Improves
?
Power Output
3 studies
Improves
?
Rating of Perceived Exertion
3 studies
Improves
?
Muscle protein synthesis (MPS)
2 studies
Improves
?
Respiratory Exchange Ratio
2 studies
Improves
?
Weight
2 studies
Worsens
?
Blood Pressure
1 study
Worsens
?
Bone Mineral Density
1 study
Improves
?
High-density lipoprotein (HDL)
1 study
Improves
?
IGF-1
1 study
Improves
?
Insulin
1 study
Worsens
C
Blood Lactate (Exercise)
Small Increase
1 study
smallWorsens
?
Power Output
5 studies
Improves
?
Cortisol
2 studies
Worsens
?
Heart Rate
2 studies
Worsens
?
Testosterone
2 studies
Improves
?
Training Volume
2 studies
Improves
?
Blood Pressure
1 study
Worsens
?
Metabolic Rate
1 study
Improves
?
Subjective Well-Being
1 study
Improves
C
Anaerobic Capacity
Small Improvement
1 study
smallImproves
?
Muscular Endurance
13 studies
Improves
?
Maximal voluntary isometric contraction (MVIC)
11 studies
Improves
?
Blood Acidity
3 studies
Worsens
?
Blood Lactate (Exercise)
3 studies
Worsens
?
Serum Bicarbonate
3 studies
Improves
?
Training Volume
2 studies
Improves
?
Power Output
1 study
Improves
C
Blood Flow
Small Increase
1 study
smallImproves
?
Heart Rate
2 studies
Worsens
?
Blood Pressure
1 study
Worsens
?
Power Output
1 study
Improves
?
Vascular Function
1 study
Improves
C
Body Fat
Small Decrease
1 study
smallImproves
?
Free Testosterone
5 studies
Improves
?
Strength
5 studies
Improves
?
Testosterone
5 studies
Improves
?
Estrogen
3 studies
Worsens
?
Muscle Mass
3 studies
Improves
?
DHT
1 study
Improves
C
Interleukin 5
Small Increase
1 study
smallImproves
?
Power Output
1 study
Improves
C
Growth Hormone
Small Increase
1 study
smallImproves
?
Power Output
1 study
Improves
C
Anaerobic Capacity
Small Improvement
1 study
smallImproves
?
Body Fat
1 study
Worsens
?
Cortisol
1 study
Worsens
?
Muscle Mass
1 study
Improves
?
Power Output
1 study
Improves
?
Testosterone
1 study
Improves
C
Creatine Kinase
Small Decrease
1 study
smallImproves
?
Lactate Dehydrogenase
1 study
Improves
?
Muscle Soreness
1 study
Worsens
?
Muscle Strength
1 study
Improves
?
Myoglobin
1 study
Improves
?
Oxidative Stress Biomarkers
1 study
Worsens
C
Muscle Soreness
Mixed effect
1 study
?
Power Output
1 study
Improves
D
Muscle Mass
No effect
3 studies
none
?
Strength
5 studies
Improves
?
Walking Ability
4 studies
Improves
D
Body Fat
No effect
2 studies
none
?
Muscle Mass
4 studies
Improves
?
Testosterone
4 studies
Improves
?
Estrogen
3 studies
Worsens
?
Serum DHEA
3 studies
Improves
?
Power Output
2 studies
Improves
?
Cortisol
1 study
Worsens
?
Follicle-Stimulating Hormone
1 study
Improves
?
Functionality in Elderly or Injured
1 study
Improves
?
Libido
1 study
Improves
?
Liver Enzymes
1 study
Worsens
?
Luteinizing Hormone
1 study
Improves
?
Prostate-Specific Antigen
1 study
Improves
?
Sex Hormone Binding Globulin
1 study
Improves
?
Sleep Quality
1 study
Improves
?
Subjective Well-Being
1 study
Improves
?
Total cholesterol
1 study
Worsens
?
Weight
1 study
Worsens
D
Body Fat
No effect
2 studies
none
?
Muscle Mass
2 studies
Improves
?
Power Output
2 studies
Improves
?
Fatigue Symptoms
1 study
Worsens
?
Testosterone
1 study
Improves
D
Anaerobic Capacity
No effect
1 study
none
?
Power Output
12 studies
Improves
?
Muscular Endurance
6 studies
Improves
?
Blood Lactate (Exercise)
5 studies
Worsens
?
Blood Pressure
2 studies
Worsens
?
Fatigue Symptoms
2 studies
Worsens
?
Heart Rate
2 studies
Worsens
?
Muscle Soreness
2 studies
Worsens
?
Urea
2 studies
Improves
?
Bilirubin
1 study
Worsens
?
Body Fat
1 study
Worsens
?
Hemoglobin
1 study
Improves
?
Hydration (Total Body Water)
1 study
Improves
?
Kidney Function
1 study
Improves
?
Liver Enzymes
1 study
Worsens
?
Muscle Mass
1 study
Improves
?
Muscle Oxygenation
1 study
Improves
?
Rating of Perceived Exertion
1 study
Improves
?
Red Blood Cell Count
1 study
Improves
?
Serum Albumin
1 study
Improves
?
Strength
1 study
Improves
?
Training Volume
1 study
Improves
?
Weight
1 study
Worsens
?
White Blood Cell Count
1 study
Improves
D
Anaerobic Capacity
No effect
1 study
none
?
Muscle Mass
13 studies
Improves
?
Strength
12 studies
Improves
?
Body Fat
8 studies
Worsens
?
Power Output
6 studies
Improves
?
Weight
6 studies
Worsens
?
Food Intake
4 studies
Worsens
?
Muscle Damage
3 studies
Worsens
?
Bone Mineral Density
2 studies
Improves
?
Fatigue Symptoms
2 studies
Worsens
?
Liver Enzymes
2 studies
Worsens
?
Training Volume
2 studies
Improves
?
Cortisol
1 study
Worsens
?
High-density lipoprotein (HDL)
1 study
Improves
?
Low-density lipoprotein (LDL)
1 study
Worsens
?
Muscle Soreness
1 study
Worsens
?
Testosterone
1 study
Improves
?
Total cholesterol
1 study
Worsens
D
Anaerobic Capacity
No effect
1 study
none
?
Power Output
4 studies
Improves
?
Blood Lactate (Exercise)
2 studies
Worsens
?
Fatigue Symptoms
2 studies
Worsens
?
Muscular Endurance
2 studies
Improves
?
Rating of Perceived Exertion
2 studies
Improves
?
Body Fat
1 study
Worsens
?
Cortisol
1 study
Worsens
?
Growth Hormone
1 study
Improves
?
Heart Rate
1 study
Worsens
?
IGF-1
1 study
Improves
?
Insulin
1 study
Worsens
?
Muscle Creatine Content
1 study
Improves
?
Muscle Mass
1 study
Improves
?
Muscle Oxygenation
1 study
Improves
?
Muscle Soreness
1 study
Worsens
?
Nitric Oxide
1 study
Improves
?
Oxidative Stress Biomarkers
1 study
Worsens
?
Training Volume
1 study
Improves
?
Weight
1 study
Worsens
D
Cortisol
No effect
1 study
none
?
Fatigue Symptoms
1 study
Worsens
?
Growth Hormone
1 study
Improves
?
Muscular Endurance
1 study
Improves
?
Power Output
1 study
Improves
?
Testosterone
1 study
Improves
D
Anaerobic Capacity
No effect
1 study
none
?
Strength
11 studies
Improves
?
Muscle Mass
9 studies
Improves
?
Sprint Performance Metrics
1 study
Improves
D
Bilirubin
No effect
1 study
none
?
Blood Urea Nitrogen
1 study
Improves
?
Creatinine
1 study
Improves
?
Gamma-Glutamyltransferase
1 study
Improves
?
Kidney Function
1 study
Improves
?
Liver Enzymes
1 study
Worsens
?
Power Output
1 study
Improves
?
Strength
1 study
Improves
?
Urea
1 study
Improves
?
Uric Acid
1 study
Worsens
?
Urinary Albumin
1 study
Improves
D
Blood Pressure
No effect
1 study
none
?
Heart Rate
1 study
Worsens
?
Muscle Damage
1 study
Worsens
?
Muscle Soreness
1 study
Worsens
?
Power Output
1 study
Improves
D
Body Fat
No effect
1 study
none
?
Free Testosterone
1 study
Improves
?
Muscle Mass
1 study
Improves
?
Strength
1 study
Improves
?
Testosterone
1 study
Improves
D
Free Testosterone
No effect
1 study
none
?
Testosterone
1 study
Improves
D
Body Fat
No effect
1 study
none
?
Muscle Mass
1 study
Improves
?
Weight
1 study
Worsens
D
Body Fat
No effect
1 study
none
?
Estrogen
1 study
Worsens
?
Muscle Mass
1 study
Improves
?
Power Output
1 study
Improves
?
Testosterone
1 study
Improves
?
Weight
1 study
Worsens
D
Cortisol
No effect
1 study
none
?
Liver Enzymes
1 study
Worsens
?
Muscle Mass
1 study
Improves
?
Power Output
1 study
Improves
?
Testosterone
1 study
Improves
?
Total cholesterol
1 study
Worsens
?
Triglycerides
1 study
Worsens
D
Power Output
No effect
1 study
none
?
Subjective Well-Being
1 study
Improves
D
Cortisol
No effect
1 study
none
?
Estrogen
1 study
Worsens
?
Growth Hormone
1 study
Improves
?
High-density lipoprotein (HDL)
1 study
Improves
?
Insulin
1 study
Worsens
?
Plasma Endorphins
1 study
Improves
?
Power Output
1 study
Improves
?
Testosterone
1 study
Improves
?
Total cholesterol
1 study
Worsens
?
Triglycerides
1 study
Worsens
D
Body Fat
No effect
1 study
none
?
Muscle Mass
1 study
Improves
?
Power Output
1 study
Improves
D
Adrenocorticotropic Hormone
No effect
1 study
none
?
Aerobic Exercise Metrics
1 study
Improves
?
Blood Lactate (Exercise)
1 study
Worsens
?
Cortisol
1 study
Worsens
?
Fatigue Symptoms
1 study
Worsens
?
Muscular Endurance
1 study
Improves
?
Strength
1 study
Improves
?
Subjective Well-Being
1 study
Improves
D
Anaerobic Capacity
No effect
1 study
none
?
Body Fat
1 study
Worsens
?
Bone Mineral Density
1 study
Improves
?
Muscle Mass
1 study
Improves
?
Muscle Soreness
1 study
Worsens
?
Power Output
1 study
Improves
?
Weight
1 study
Worsens
D
Body Fat
No effect
1 study
none
?
Liver Enzymes
1 study
Worsens
?
Muscle Mass
1 study
Improves
?
Power Output
1 study
Improves
?
Rating of Perceived Exertion
1 study
Improves
D
Anaerobic Capacity
No effect
1 study
none
?
Power Output
1 study
Improves
D
Body Fat
No effect
1 study
none
?
IGF-1
1 study
Improves
?
Insulin
1 study
Worsens
?
Irisin
1 study
Improves
?
Muscle Mass
1 study
Improves
?
Power Output
1 study
Improves
D
Aerobic Exercise Metrics
No effect
1 study
none
?
Erythropoietin
1 study
Improves
?
IGF-1
1 study
Improves
?
Muscle Mass
1 study
Improves
?
Power Output
1 study
Improves
?
Red Blood Cell Count
1 study
Improves
?
Testosterone
1 study
Improves
?
Carbohydrate Oxidation
1 study
Improves
?
Aerobic Exercise Metrics
Small Detriment
1 study
small
?
Blood Flow
1 study
Improves
?
Blood Pressure
1 study
Worsens
?
Heart Rate
1 study
Worsens
?
Power Output
1 study
Improves
?
Muscular Endurance
1 study
Improves
?
Strength
1 study
Improves

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