Nicotinamide Mononucleotide

Nicotinamide mononucleotide (NMN) is a form of vitamin B3 taken to boost levels of NAD+ and for its purported anti-aging effects. Although NMN was formerly available as a supplement, classification of NMN in the U.S. as an investigational drug has reduced its availability to consumers in the U.S.[2]

Quick Answer

What it is

Nicotinamide mononucleotide (NMN) is a form of vitamin B3 taken to boost levels of NAD+ and for its purported anti-aging effects. Although NMN was formerly available as a supplement, classification of NMN in the U.S.

Key findings

  • Grade D: Blood glucose
  • Grade D: Muscle Mass (Sarcopenia)
  • Grade D: Insulin Resistance (Healthy Muscle Aging)

Safety

No specific caution or interaction language was detected in the current summary/outcome notes.

ℹ️ Quick Facts: Nicotinamide Mononucleotide

Quick Facts: Nicotinamide Mononucleotide

  • Best Evidence:Grade D
  • Conditions Studied:7
  • Research Outcomes:35
  • Key Effect:Healthy Muscle Aging
Outcomes by grade:
A0
B0
C0
D8
7 conditions Β· 35 outcomes

Detailed Outcomes

Grade:
Effect:
Sort:
|
D
Blood glucose
No effect
7 studies
none
?
Triglycerides
9 studies
↓Improves
?
Low-density lipoprotein (LDL)
8 studies
↓Improves
?
High-density lipoprotein (HDL)
7 studies
↑Improves
?
Serum NAD+ Levels
↑Improves
?
Total cholesterol
6 studies
↓Improves
?
Weight
6 studies
↓Improves
?
HbA1c
5 studies
↓Improves
?
Insulin
4 studies
↑Worsens
?
Insulin Resistance
↓Improves
D
Blood glucose
No effect
7 studies
none
?
Triglycerides
9 studies
↓Improves
?
Low-density lipoprotein (LDL)
8 studies
↓Improves
?
High-density lipoprotein (HDL)
7 studies
↑Improves
?
Serum NAD+ Levels
↑Improves
?
Total cholesterol
6 studies
↓Improves
?
Weight
6 studies
↓Improves
?
HbA1c
5 studies
↓Improves
?
Insulin
4 studies
↑Worsens
?
Insulin Resistance
↓Improves
D
Muscle Mass
No effect
none
?
Strength
5 studies
↑Improves
?
Walking Ability
↑Improves
D
Muscle Mass
No effect
none
?
Strength
5 studies
↑Improves
?
Walking Ability
↑Improves
D
Muscle Mass
No effect
none
?
Strength
5 studies
↑Improves
?
Walking Ability
↑Improves
D
Insulin Resistance
No effect
none
D
Walking Ability
No effect
none
D
Endogenous Advanced Glycation End Products
No effect
1 study
none
?
Pulse Wave Velocity
↓Improves
?
Anaerobic Capacity
↑Improves
?
Insulin Resistance
↓Improves

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