Prediabetes

Prediabetes is the intermediate stage between healthy blood glucose levels and diabetes. It is associated with an increased risk of cardiovascular disease and type 2 diabetes. Weight loss induced by lifestyle intervention is the primary treatment and is very effective.

Quick Answer

What it is

Prediabetes is the intermediate stage between healthy blood glucose levels and diabetes. It is associated with an increased risk of cardiovascular disease and type 2 diabetes.

Key findings

  • Grade B: Blood glucose (Inulin)
  • Grade B: Beta-cell function (Carnosine)
  • Grade C: Blood Pressure (Thiamine (Vitamin B1))

Safety

  • It is associated with an increased risk of cardiovascular disease and type 2 diabetes.
â„šī¸ Quick Facts

Quick Facts: Prediabetes

  • Supplements Studied:21
  • Research Trials:16
  • Total Participants:59,118
  • Top Supplement:Vitamin D (B)
16 trials
59,118 ppts
21 supps ¡ 144 outcomes

Evidence-Based Protocol

Supplement stack ranked by research quality

Moderate Evidence

Primary Stack (Tier 1)

900-2000mg daily

AMPK-activating alkaloid with metabolic regulatory effects; evidence for prediabetes

288 studies | 26,048 participants
2000mg - 35g

Supports prediabetes through multiple biochemical pathways

106 studies | 34,932 participants
See product label

Supports prediabetes through multiple biochemical pathways

106 studies | 34,932 participants
15mg - 20g

Supports prediabetes through multiple biochemical pathways

94 studies | 9,690 participants

Supporting Stack (Tier 2)

See product label

Supports prediabetes through multiple biochemical pathways

46 studies | 5,940 participants

Supports prediabetes through multiple biochemical pathways

120 studies | 4,544 participants

Supports prediabetes through multiple biochemical pathways

120 studies | 4,544 participants
See product label

Supports prediabetes through multiple biochemical pathways

178 studies | 4,032 participants

How It Works

This combination of Berberine, L-Carnitine, and l-carnitine provides comprehensive support for prediabetes. Think of it as giving your body the specific tools it needs to function better.

Generated from peer-reviewed researchSchema v1.0.0

Supplements for Prediabetes

Sorted by strength of evidence

BVitamin D
2
Beta-cell function↑Glycemic ControlImproves↑InsulinWorsens
BSaffron
1
↓Blood glucoseImproves↑Blood Urea Nitrogen (BUN)Improves↑Kidney FunctionImproves
BCarnosine
1
↑Beta-cell functionImproves↓Blood glucoseImproves↑High-density lipoprotein (HDL)Improves
BInulin
1
↓Blood glucoseImproves↑InsulinWorsens↓Insulin ResistanceImproves
BAloe Vera
1
↓Blood glucoseImproves↑HbA1cWorsens↑Total cholesterolWorsens
BBerberine
1
↓Blood glucoseImproves↓TriglyceridesImproves↓Total cholesterolImproves
BL-Carnitine
1
↓Blood glucoseImproves↓TriglyceridesImproves↓Low-density lipoprotein (LDL)Improves
BPanax Ginseng (Korean Ginseng)
1
↓Blood glucoseImproves↓Blood PressureImproves↓Total cholesterolImproves
BResistant Starch
1
↓Blood glucoseImproves↑InsulinWorsens↓HbA1cImproves
CZinc
1
↓Blood glucoseImproves↓HbA1cImproves↑InsulinWorsens
CThiamine (Vitamin B1)
1
↓Blood PressureImproves↓C-Reactive Protein (CRP)Improves↑High-density lipoprotein (HDL)Improves
CMagnesium
1
↓Blood glucoseImproves↓Blood PressureImproves↓C-Reactive Protein (CRP)Improves
CBanana Flower
1
↓Body Weight/BMIImproves
CCurcumin
1
↓Blood glucoseImproves↓C-Reactive Protein (CRP)Improves↑FructosamineWorsens
DFlaxseed
1
Adiponectin↓Blood glucoseImproves↑InsulinWorsens
DProbiotics
1
Beta-cell function↓HbA1cImproves↓Blood glucoseImproves
DGreen Tea Extract
1
Blood glucose↑InsulinWorsens↓HbA1cImproves
DChromium
1
Blood Flow↓Blood glucoseImproves↓Blood PressureImproves

Detailed Outcomes

Grade:
Effect:
Size:
Sort:
|
B
Blood glucose
Small Improvement
33 studies
small↓Improves
?
Insulin
26 studies
↑Worsens
?
Insulin Resistance
18 studies
↓Improves
?
HbA1c
12 studies
↓Improves
B
Blood glucose
Small Improvement
17 studies
small↓Improves
?
Triglycerides
17 studies
↓Improves
?
Low-density lipoprotein (LDL)
16 studies
↓Improves
?
HbA1c
15 studies
↓Improves
?
Body Mass Index (BMI)
14 studies
↓Improves
?
Insulin Resistance
8 studies
↓Improves
?
C-Reactive Protein (CRP)
4 studies
↓Improves
?
Body Fat
3 studies
↓Improves
?
Leptin
3 studies
↑Improves
?
TNF-Alpha
3 studies
↓Improves
?
Insulin
2 studies
↑Worsens
?
Total cholesterol
2 studies
↓Improves
?
High-density lipoprotein (HDL)
1 study
↑Improves
?
Liver Enzymes
1 study
↑Worsens
B
Blood glucose
Small Improvement
16 studies
small↓Improves
?
Insulin
15 studies
↑Worsens
?
HbA1c
4 studies
↓Improves
?
Insulin Resistance
3 studies
↓Improves
B
Blood glucose
Small Improvement
12 studies
small↓Improves
?
Blood Urea Nitrogen (BUN)
7 studies
↑Improves
?
Kidney Function
7 studies
↑Improves
?
Liver Enzymes
7 studies
↑Worsens
?
Blood Pressure
5 studies
↓Improves
?
Creatinine
1 study
↑Improves
?
HbA1c
1 study
↓Improves
?
High-density lipoprotein (HDL)
1 study
↑Improves
?
Low-density lipoprotein (LDL)
1 study
↓Improves
?
Sperm Count
1 study
↑Improves
?
Sperm Quality
1 study
↑Improves
?
Total cholesterol
1 study
↓Improves
?
Triglycerides
1 study
↓Improves
?
Urea
1 study
↑Improves
B
Blood glucose
Large Improvement
11 studies
large↓Improves
?
Triglycerides
25 studies
↓Improves
?
Total cholesterol
24 studies
↓Improves
?
Low-density lipoprotein (LDL)
20 studies
↓Improves
?
High-density lipoprotein (HDL)
18 studies
↑Improves
?
Insulin Resistance
15 studies
↓Improves
?
C-Reactive Protein (CRP)
10 studies
↓Improves
?
HbA1c
10 studies
↓Improves
?
Interleukin 6
6 studies
↓Improves
?
TNF-Alpha
5 studies
↓Improves
B
Blood glucose
Small improvement in fasting blood glucose
5 studies
small↓Improves
?
HbA1c
6 studies
↑Worsens
?
Total cholesterol
4 studies
↑Worsens
?
Triglycerides
4 studies
↑Worsens
?
High-density lipoprotein (HDL)
3 studies
↑Improves
?
Low-density lipoprotein (LDL)
3 studies
↑Worsens
?
Insulin
2 studies
↑Worsens
B
Blood glucose
Small Improvement
5 studies
small↓Improves
?
Blood Pressure
29 studies
↓Improves
?
Total cholesterol
18 studies
↓Improves
?
Triglycerides
17 studies
↓Improves
?
High-density lipoprotein (HDL)
16 studies
↑Improves
?
Low-density lipoprotein (LDL)
15 studies
↓Improves
?
HbA1c
12 studies
↓Improves
?
Body Fat
4 studies
↓Improves
?
Insulin
4 studies
↑Worsens
B
Beta-cell function
Small Increase
3 studies
small↑Improves
?
Blood glucose
7 studies
↓Improves
?
High-density lipoprotein (HDL)
6 studies
↑Improves
?
Total cholesterol
6 studies
↓Improves
?
Insulin
4 studies
↑Worsens
?
Low-density lipoprotein (LDL)
4 studies
↓Improves
?
Insulin Resistance
3 studies
↓Improves
?
Body Fat
1 study
↓Improves
?
Bone Mineral Density
1 study
↑Improves
?
Muscle Strength
1 study
↑Improves
C
Blood glucose
Small Improvement
1 study
small↓Improves
?
HbA1c
1 study
↓Improves
?
Insulin
1 study
↑Worsens
?
Insulin Resistance
1 study
↓Improves
C
Blood Pressure
Small Improvement
1 study
small↓Improves
?
C-Reactive Protein (CRP)
1 study
↓Improves
?
High-density lipoprotein (HDL)
1 study
↑Improves
?
Low-density lipoprotein (LDL)
1 study
↓Improves
?
Total cholesterol
1 study
↓Improves
?
Triglycerides
1 study
↓Improves
C
Blood glucose
Small Improvement
1 study
small↓Improves
?
Blood Pressure
1 study
↓Improves
?
C-Reactive Protein (CRP)
1 study
↓Improves
?
HbA1c
1 study
↓Improves
?
High-density lipoprotein (HDL)
1 study
↑Improves
?
Insulin
1 study
↑Worsens
?
Insulin Resistance
1 study
↓Improves
?
Low-density lipoprotein (LDL)
1 study
↓Improves
?
Total cholesterol
1 study
↓Improves
?
Triglycerides
1 study
↓Improves
?
Uric Acid
1 study
↓Improves
C
Body Weight/BMI
Double-blind RCT (PMID: 30887937): Green banana biomass significantly reduced body weight and BMI in prediabetic adults
1 study
moderate↓Improves
C
Blood glucose
Small Improvement
1 study
small↓Improves
?
C-Reactive Protein (CRP)
1 study
↓Improves
?
Fructosamine
1 study
↑Worsens
?
HbA1c
1 study
↓Improves
?
High-density lipoprotein (HDL)
1 study
↑Improves
?
Lymphocyte Count
1 study
↑Improves
?
Monocyte Count
1 study
↑Improves
?
Neutrophil Count
1 study
↑Improves
?
Total cholesterol
1 study
↓Improves
?
White Blood Cell Count
1 study
↑Improves
D
Blood glucose
No effect
17 studies
none
?
Insulin
13 studies
↑Worsens
?
HbA1c
7 studies
↓Improves
?
Insulin Resistance
5 studies
↓Improves
?
Glycemic Control
3 studies
↑Improves
D
Adiponectin
No effect
8 studies
none
?
Blood glucose
24 studies
↓Improves
?
Insulin
18 studies
↑Worsens
?
Insulin Resistance
13 studies
↓Improves
?
HbA1c
11 studies
↓Improves
?
Leptin
11 studies
↑Improves
D
Beta-cell function
No effect
2 studies
none
?
HbA1c
8 studies
↓Improves
?
Blood glucose
7 studies
↓Improves
?
Insulin
7 studies
↑Worsens
?
Insulin Resistance
6 studies
↓Improves
?
Blood Pressure
4 studies
↓Improves
?
High-density lipoprotein (HDL)
4 studies
↑Improves
?
Low-density lipoprotein (LDL)
4 studies
↓Improves
?
Triglycerides
4 studies
↓Improves
?
Total cholesterol
3 studies
↓Improves
D
Blood Flow
No effect
1 study
none
?
Blood glucose
1 study
↓Improves
?
Blood Pressure
1 study
↓Improves
?
Glycemic Control
1 study
↑Improves
?
High-density lipoprotein (HDL)
1 study
↑Improves
?
Kidney Function
1 study
↑Improves
?
Low-density lipoprotein (LDL)
1 study
↓Improves
?
Proteinuria
1 study
↑Improves
?
Total cholesterol
1 study
↓Improves
?
Triglycerides
1 study
↓Improves
?
Weight
1 study
↓Improves
D
Beta-cell function
No effect
1 study
none
?
Glycemic Control
2 studies
↑Improves
?
Insulin
1 study
↑Worsens
?
Insulin Resistance
1 study
↓Improves
?
Type 2 Diabetes Incidence
1 study
↑Worsens
?
Glycemic Control
1 study
↑Improves
?
Insulin Resistance
1 study
↓Improves
?
Glycemic Control
1 study
↑Improves

Related Conditions

Type 2 Diabetes

18 shared supplements ¡ 868 outcomes

Type 2 diabetes (T2D) is a disease in which blood glucose levels are too high. It is characterized by insulin resistance in muscle, fat, and pancreas cells and an inability of the pancreas to manufacture enough insulin to control blood glucose levels. T2D is strongly associated with excess body fat, and weight loss induced by lifestyle changes is extremely effective for treating T2D.

Metabolic Syndrome

14 shared supplements ¡ 391 outcomes

Metabolic syndrome refers to a group of cardiometabolic risk factors: abdominal obesity, high blood pressure, high fasting blood sugar, high blood triglycerides, and low HDL-C. If a person has at least three of these, they have metabolic syndrome.

Metabolic Health

14 shared supplements ¡ 975 outcomes

Research on metabolism, blood glucose regulation, insulin sensitivity, and metabolic syndrome.

14 shared supplements ¡ outcomes

Overweight

13 shared supplements ¡ 379 outcomes

Overweight is characterized as having a body mass index (BMI) of 25 to 29.9. Having overweight is associated with increased risk of conditions such as cardiovascular disease. However, this may not be the case in people with increased lean mass (e.g., athletes or weight lifters).

Obesity

11 shared supplements ¡ 525 outcomes

Obesity is a condition of excessive body fat that increases the risk for other conditions such as diabetes and heart disease. Fat is how the body stores extra calories that were eaten but not used. Obesity treatment usually involves restricting the calories eaten or creating a negative calorie balance.

Nonalcoholic Fatty Liver Disease (NAFLD)

10 shared supplements ¡ 221 outcomes

Non-alcoholic fatty liver disease (NAFLD) is a condition in which excessive fat (more than 5% of liver weight) accumulates in the liver due to causes unrelated to alcohol.

High Blood Pressure

10 shared supplements ¡ 393 outcomes

High blood pressure is when the force of your blood pushing against the walls of the arteries is consistently too high. High blood pressure is often caused by an unhealthy lifestyle, although it can result from other medical conditions as well.