B
Body Mass Index (BMI)
Small Decrease
641 participants
small↓Improves
?
Weight
6 studies446 participants
↓Improves
?
Waist circumference
5 studies328 participants
↓Improves
?
Waist-Hip Ratio
3 studies316 participants
↑Improves
Berberine
Berberine is a plant alkaloid with a long history of use in Ayurvedic and traditional Chinese medicine for the management of various health conditions. Its seemingly potent ability to reduce blood sugar rivals that of some anti-diabetic drugs.
Quick Answer
What it is
Berberine is a plant alkaloid with a long history of use in Ayurvedic and traditional Chinese medicine for the management of various health conditions. Its seemingly potent ability to reduce blood sugar rivals that of some anti-diabetic drugs.
Key findings
- Grade B: Blood glucose (Type 2 Diabetes)
- Grade B: Body Mass Index (BMI) (Body Composition)
- Grade B: Apolipoprotein B (Type 2 Diabetes)
Safety
No specific caution or interaction language was detected in the current summary/outcome notes.
ℹ️ Quick Facts: Berberine
Quick Facts: Berberine
- Best Evidence:Grade B
- Conditions Studied:19
- Research Outcomes:148
- Grade B Findings:9
- Key Effect:Atherosclerosis
Outcomes by grade:
A0
B9
C8
D2
19 conditions · 148 outcomes
Detailed Outcomes
Grade:
Effect:
Size:
Sort:
|
B
Blood glucose
Large Improvement
11 studies912 participants
large↓Improves
B
Apolipoprotein B
Small Improvement
2 studies127 participants
small↓Improves
?
Triglycerides
2291 participants
↓Improves
?
Total cholesterol
2227 participants
↓Improves
?
Blood Pressure
20 studies1426 participants
↓Improves
?
Low-density lipoprotein (LDL)
20 studies1860 participants
↓Improves
?
High-density lipoprotein (HDL)
1729 participants
↑Improves
?
Insulin
16 studies1138 participants
↑Worsens
?
Insulin Resistance
15 studies1347 participants
↓Improves
?
C-Reactive Protein (CRP)
10 studies870 participants
↓Improves
?
HbA1c
786 participants
↓Improves
?
Interleukin 6
6 studies536 participants
↓Improves
?
TNF-Alpha
5 studies466 participants
↓Improves
?
Glycemic Control
116 participants
↑Improves
B
Blood glucose
Large Improvement
11 studies912 participants
large↓Improves
?
Triglycerides
2291 participants
↓Improves
?
Total cholesterol
2227 participants
↓Improves
?
Low-density lipoprotein (LDL)
20 studies1860 participants
↓Improves
?
High-density lipoprotein (HDL)
1729 participants
↑Improves
?
Insulin Resistance
15 studies1347 participants
↓Improves
?
C-Reactive Protein (CRP)
10 studies870 participants
↓Improves
?
HbA1c
786 participants
↓Improves
?
Interleukin 6
6 studies536 participants
↓Improves
?
TNF-Alpha
5 studies466 participants
↓Improves
B
Apolipoprotein B
Small Improvement
2 studies127 participants
small↓Improves
?
Triglycerides
3004 participants
↓Improves
?
Low-density lipoprotein (LDL)
35 studies2824 participants
↓Improves
?
High-density lipoprotein (HDL)
2784 participants
↑Improves
?
Total cholesterol
2804 participants
↓Improves
?
HbA1c
1156 participants
↓Improves
?
Blood Pressure
20 studies1426 participants
↓Improves
?
Insulin
16 studies1138 participants
↑Worsens
?
Insulin Resistance
14 studies1119 participants
↓Improves
?
Luteinizing Hormone
8 studies577 participants
↑Improves
?
Testosterone
8 studies577 participants
↑Improves
?
Body Mass Index (BMI)
487 participants
↓Improves
?
Follicle-Stimulating Hormone
7 studies497 participants
↑Improves
?
Waist-Hip Ratio
5 studies402 participants
↑Improves
?
Sex Hormone Binding Globulin
3 studies228 participants
↑Improves
?
Blood glucose
2 studies4257 participants
↓Improves
?
Fertility
2 studies501 participants
↑Improves
B
Apolipoprotein B
Small Improvement
2 studies127 participants
small↓Improves
?
Triglycerides
3004 participants
↓Improves
?
Low-density lipoprotein (LDL)
35 studies2824 participants
↓Improves
?
High-density lipoprotein (HDL)
2784 participants
↑Improves
?
Total cholesterol
2804 participants
↓Improves
?
HbA1c
1156 participants
↓Improves
?
Blood Pressure
20 studies1426 participants
↓Improves
?
Insulin
16 studies1138 participants
↑Worsens
?
Insulin Resistance
14 studies1119 participants
↓Improves
?
Blood glucose
1 study2713 participants
↓Improves
B
Blood glucose
Large Improvement
2 studies2897 participants
large↓Improves
?
Triglycerides
3004 participants
↓Improves
?
Low-density lipoprotein (LDL)
35 studies2824 participants
↓Improves
?
High-density lipoprotein (HDL)
2784 participants
↑Improves
?
Total cholesterol
2804 participants
↓Improves
?
HbA1c
1156 participants
↓Improves
?
Blood Pressure
20 studies1426 participants
↓Improves
?
Insulin
16 studies1138 participants
↑Worsens
?
Insulin Resistance
14 studies1119 participants
↓Improves
?
Glycemic Control
184 participants
↑Improves
?
Liver Enzymes
1 study184 participants
↑Worsens
?
Liver Fat
1 study184 participants
↓Improves
B
Blood glucose
Large Improvement
2 studies2737 participants
large↓Improves
?
Triglycerides
3004 participants
↓Improves
?
Low-density lipoprotein (LDL)
35 studies2824 participants
↓Improves
?
High-density lipoprotein (HDL)
2784 participants
↑Improves
?
Total cholesterol
2804 participants
↓Improves
?
HbA1c
1156 participants
↓Improves
?
Blood Pressure
20 studies1426 participants
↓Improves
?
Insulin
16 studies1138 participants
↑Worsens
?
Insulin Resistance
14 studies1119 participants
↓Improves
?
Glycemic Control
24 participants
↑Improves
B
Apolipoprotein B
Small Improvement
2 studies127 participants
small↓Improves
?
Total cholesterol
1397 participants
↓Improves
?
High-density lipoprotein (HDL)
1248 participants
↑Improves
?
Low-density lipoprotein (LDL)
12 studies1224 participants
↓Improves
?
Triglycerides
1224 participants
↓Improves
C
Blood glucose
Large Improvement
1 study2713 participants
large↓Improves
?
Triglycerides
3004 participants
↓Improves
?
Low-density lipoprotein (LDL)
35 studies2824 participants
↓Improves
?
High-density lipoprotein (HDL)
2784 participants
↑Improves
?
Total cholesterol
2804 participants
↓Improves
?
HbA1c
1156 participants
↓Improves
?
Blood Pressure
20 studies1426 participants
↓Improves
?
Insulin
16 studies1138 participants
↑Worsens
?
Insulin Resistance
14 studies1119 participants
↓Improves
C
Blood glucose
Large Improvement
1 study116 participants
large↓Improves
?
Total cholesterol
13692 participants
↓Improves
?
Triglycerides
13692 participants
↓Improves
?
Glycemic Control
116 participants
↑Improves
?
HbA1c
116 participants
↓Improves
?
High-density lipoprotein (HDL)
13576 participants
↑Improves
?
Insulin
1 study116 participants
↑Worsens
?
Low-density lipoprotein (LDL)
1 study13576 participants
↓Improves
C
C-Reactive Protein (CRP)
Small Decrease
1 study120 participants
small↓Improves
?
Total cholesterol
689 participants
↓Improves
?
Triglycerides
689 participants
↓Improves
?
High-density lipoprotein (HDL)
589 participants
↑Improves
?
Interleukin 6
2 studies240 participants
↓Improves
?
TNF-Alpha
2 studies240 participants
↓Improves
?
Low-density lipoprotein (LDL)
1 study689 participants
↓Improves
C
C-Reactive Protein (CRP)
Small Decrease
1 study120 participants
small↓Improves
?
Total cholesterol
689 participants
↓Improves
?
Triglycerides
689 participants
↓Improves
?
High-density lipoprotein (HDL)
589 participants
↑Improves
?
Interleukin 6
2 studies240 participants
↓Improves
?
TNF-Alpha
2 studies240 participants
↓Improves
?
Low-density lipoprotein (LDL)
1 study689 participants
↓Improves
C
Blood glucose
Large Improvement
1 study1544 participants
large↓Improves
?
Luteinizing Hormone
8 studies577 participants
↑Improves
?
Testosterone
8 studies577 participants
↑Improves
?
Body Mass Index (BMI)
487 participants
↓Improves
?
Follicle-Stimulating Hormone
7 studies497 participants
↑Improves
?
Total cholesterol
457 participants
↓Improves
?
Waist-Hip Ratio
5 studies402 participants
↑Improves
?
Sex Hormone Binding Globulin
3 studies228 participants
↑Improves
?
Fertility
2 studies501 participants
↑Improves
C
C-Reactive Protein (CRP)
Small Decrease
1 study120 participants
small↓Improves
?
Total cholesterol
689 participants
↓Improves
?
Triglycerides
689 participants
↓Improves
?
High-density lipoprotein (HDL)
589 participants
↑Improves
?
Interleukin 6
2 studies240 participants
↓Improves
?
TNF-Alpha
2 studies240 participants
↓Improves
?
Low-density lipoprotein (LDL)
1 study689 participants
↓Improves
C
C-Reactive Protein (CRP)
Small Decrease
1 study120 participants
small↓Improves
?
Total cholesterol
689 participants
↓Improves
?
Triglycerides
689 participants
↓Improves
?
High-density lipoprotein (HDL)
589 participants
↑Improves
?
Interleukin 6
2 studies240 participants
↓Improves
?
TNF-Alpha
2 studies240 participants
↓Improves
?
Low-density lipoprotein (LDL)
1 study689 participants
↓Improves
C
Blood glucose
Large Improvement
1 study1449 participants
large↓Improves
?
Total cholesterol
1297 participants
↓Improves
?
Triglycerides
1231 participants
↓Improves
?
Low-density lipoprotein (LDL)
14 studies1233 participants
↓Improves
?
High-density lipoprotein (HDL)
1133 participants
↑Improves
?
Insulin Resistance
5 studies471 participants
↓Improves
D
Exercise Tolerance
No effect
156 participants
none
?
Quality of Life
1 study156 participants
↑Improves
D
Exercise Tolerance
No effect
156 participants
none
?
Quality of Life
1 study156 participants
↑Improves
?
Colorectal Polyp Incidence
1076 participants
↑Worsens
?
Canker Sores Symptoms
84 participants
↓Improves
Evidence by Condition
Best grade per condition (each condition may have multiple outcomes)
Research Citations (28)
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