Supplement
Coenzyme Q10 is a compound your cells use in their mitochondria to make energy, and it also acts as an antioxidant. People mostly look at it for heart health, and small trials in coronary artery disease found antioxidant enzyme activity went up, though the evidence is limited. Trials in heart failure and after a heart attack found no clear difference in exercise tolerance or HDL cholesterol, and they were very small.
Sources: PMID 21996047; PMID 12841346; PMID 21462215
- Updated
- How we grade
- 71 studies cited
- Best evidence
- Grade B
- Conditions studied
- 43
- Outcomes
- 268
- Graded outcomes
- 02239
Evidence by condition
- Strong
- Moderate
- Limited
- Very limited
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Depression Symptoms Moderate Improvement | Improves (the measure goes down) | Moderate effect | 2 studies | 137 people | ||
Studies that measured depression symptoms | ||||||
| Fatigue Symptoms | Improves (the measure goes down) | 3 studies | 48 people | |||
Studies that measured fatigue symptoms
| ||||||
Rheumatoid Arthritis (RA)
- Blood Pressure: improves
- Low-density lipoprotein (LDL): improves
- C-Reactive Protein (CRP): improves
Polycystic Ovary Syndrome (PCOS)
- Blood glucose: improves
- Low-density lipoprotein (LDL): improves
- Follicle-Stimulating Hormone: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Blood glucose Small Improvement | Improves (the measure goes down) | Small effect | 3 studies | 86 people | ||
Studies that measured blood glucose
| ||||||
| Low-density lipoprotein (LDL) | Improves (the measure goes down) | 4 studies | 353 people | |||
Studies that measured low-density lipoprotein (ldl)
| ||||||
| Follicle-Stimulating Hormone | Improves (the measure goes up) | 2 studies | 140 people | |||
| Total cholesterol | Improves (the measure goes down) | 2 studies | 353 people | |||
Studies that measured total cholesterol | ||||||
| High-density lipoprotein (HDL) | Improves (the measure goes up) | 1 study | 353 people | |||
Studies that measured high-density lipoprotein (hdl) | ||||||
| Estrogen | Changes; see studies | 394 people | ||||
| Glycemic Control | Improves (the measure goes up) | 86 people | ||||
| Insulin | Changes; see studies | 86 people | ||||
| Insulin Resistance | Improves (the measure goes down) | 414 people | ||||
| Luteinizing Hormone | Improves (the measure goes up) | 224 people | ||||
| Progesterone | Improves (the measure goes up) | 519 people | ||||
| Sex Hormone Binding Globulin | Improves (the measure goes up) | 86 people | ||||
| Testosterone | Improves (the measure goes up) | 529 people | ||||
| Triglycerides | Improves (the measure goes down) | 353 people | ||||
Type 1 Diabetes
- Blood glucose: improves
- Blood Pressure: improves
- Low-density lipoprotein (LDL): improves
End-Stage Renal Disease
- Blood glucose: improves
- Low-density lipoprotein (LDL): improves
- HbA1c: improves
General Cardiovascular Health
- Anti-Oxidant Enzyme Profile: improves
- Oxidative Stress Biomarkers: improves
- Blood Pressure: improves
Fibromyalgia
- Anti-Oxidant Enzyme Profile: improves
- Oxidative Stress Biomarkers: improves
- Fatigue Symptoms: improves
Infertility
- Anti-Oxidant Enzyme Profile: improves
- Oxidative Stress Biomarkers: improves
- Follicle-Stimulating Hormone: improves
Coronary Artery Disease (CAD)
- Anti-Oxidant Enzyme Profile: improves
- Oxidative Stress Biomarkers: improves
- Low-density lipoprotein (LDL): improves
Heart Failure
- Blood Flow: improves
- Exercise Tolerance: improves
- Left Ventricular Ejection Fraction: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Blood Flow Small Increase | Improves (the measure goes up) | Small effect | 2 studies | 23 people | ||
| Exercise Tolerance | Improves (the measure goes up) | 2 studies | 89 people | |||
| Left Ventricular Ejection Fraction | Improves (the measure goes up) | 1 study | 41 people | |||
Studies that measured left ventricular ejection fraction | ||||||
| Heart Size | Changes; see studies | 41 people | ||||
| Oxygen Uptake | Improves (the measure goes up) | 23 people | ||||
| Quality of Life | Improves (the measure goes up) | 41 people | ||||
Multiple Sclerosis (MS)
- Depression Symptoms: improves
- Fatigue Symptoms: improves
- Interleukin 6: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Depression Symptoms Moderate Improvement | Improves (the measure goes down) | Moderate effect | 2 studies | 48 people | ||
Studies that measured depression symptoms | ||||||
| Fatigue Symptoms | Improves (the measure goes down) | 3 studies | 48 people | |||
Studies that measured fatigue symptoms
| ||||||
| Interleukin 6 | Improves (the measure goes down) | 2 studies | 48 people | |||
Studies that measured interleukin 6
| ||||||
| Matrix metallopeptidase 9 | Improves (the measure goes up) | 1 study | 48 people | |||
Studies that measured matrix metallopeptidase 9 | ||||||
| Interleukin 4 | Improves (the measure goes up) | 48 people | ||||
| Multiple Sclerosis Symptoms | Improves (the measure goes down) | 48 people | ||||
| TNF-Alpha | Improves (the measure goes down) | 48 people | ||||
Bipolar Disorder
- Anti-Oxidant Enzyme Profile: improves
- Oxidative Stress Biomarkers: improves
- Depression Symptoms: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Anti-Oxidant Enzyme Profile Small Increase | Improves (the measure goes up) | Small effect | 2 studies | 89 people | ||
| Oxidative Stress Biomarkers | Improves (the measure goes down) | 9 studies | 89 people | |||
| Depression Symptoms | Improves (the measure goes down) | 2 studies | 89 people | |||
| Interleukin 6 | Improves (the measure goes down) | 2 studies | 89 people | |||
| Interleukin 10 | Improves (the measure goes up) | 89 people | ||||
| TNF-Alpha | Improves (the measure goes down) | 89 people |
Autism Spectrum Disorder (ASD)
- Anti-Oxidant Enzyme Profile: improves
- Oxidative Stress Biomarkers: improves
- Autism Symptoms: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Anti-Oxidant Enzyme Profile Small Increase | Improves (the measure goes up) | Small effect | 2 studies | 78 people | ||
| Oxidative Stress Biomarkers | Improves (the measure goes down) | 9 studies | 78 people | |||
| Autism Symptoms | Improves (the measure goes down) | 78 people |
Low Testosterone
- Follicle-Stimulating Hormone: worsens
- Seminal Motility: improves
- Luteinizing Hormone: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Follicle-Stimulating Hormone Small Decrease | Worsens (the measure goes down) | Small effect | 2 studies | 212 people | ||
| Seminal Motility | Improves (the measure goes up) | 2 studies | 212 people | |||
| Luteinizing Hormone | Improves (the measure goes up) | 212 people | ||||
| Sperm Quality | Improves (the measure goes up) | 212 people | ||||
| Testosterone | Improves (the measure goes up) | 212 people |
Myalgic Encephalomyelitis (Chronic Fatigue Syndrome)
- Depression Symptoms: improves
- Fatigue Symptoms: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Depression Symptoms Moderate Improvement | Improves (the measure goes down) | Moderate effect | 2 studies | 48 people | ||
| Fatigue Symptoms | Improves (the measure goes down) | 3 studies | 48 people |
Obesity
- Blood Flow: improves
- Oxidative Stress Biomarkers: improves
- Fatigue Symptoms: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Blood Flow Small Increase | Improves (the measure goes up) | Small effect | 2 studies | 51 people | ||
| Oxidative Stress Biomarkers | Improves (the measure goes down) | 9 studies | 51 people | |||
| Fatigue Symptoms | Improves (the measure goes down) | 3 studies | 51 people | |||
| C-Reactive Protein (CRP) | Improves (the measure goes down) | 2 studies | 51 people | |||
| Inflammation | Improves (the measure goes down) | 2 studies | 51 people | |||
| Total cholesterol | Improves (the measure goes down) | 2 studies | 51 people | |||
| Vascular Function | Improves (the measure goes up) | 2 studies | 51 people | |||
| Quality of Life | Improves (the measure goes up) | 51 people |
Dyslipidemia
- Blood Flow: improves
- Oxidative Stress Biomarkers: improves
- Blood Pressure: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Blood Flow Small Increase | Improves (the measure goes up) | Small effect | 2 studies | 40 people | ||
| Oxidative Stress Biomarkers | Improves (the measure goes down) | 9 studies | 40 people | |||
| Blood Pressure | Improves (the measure goes down) | 4 studies | 40 people | |||
| HbA1c | Improves (the measure goes down) | 2 studies | 40 people |
Idiopathic Asthenozoospermia
- Seminal Motility: improves
- Sperm Quality: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Seminal Motility Small Improvement | Improves (the measure goes up) | Small effect | 2 studies | 22 people | ||
| Sperm Quality | Improves (the measure goes up) | 22 people |
Ischemic Heart Disease
- Blood Flow: improves
- Oxygen Uptake: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Blood Flow Small Increase | Improves (the measure goes up) | Small effect | 2 studies | 33 people | ||
| Oxygen Uptake | Improves (the measure goes up) | 33 people |
Overweight
- Anti-Oxidant Enzyme Profile: improves
- Oxidative Stress Biomarkers: improves
- Interleukin 6: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Anti-Oxidant Enzyme Profile Small Increase | Improves (the measure goes up) | Small effect | 2 studies | 60 people | ||
| Oxidative Stress Biomarkers | Improves (the measure goes down) | 9 studies | 60 people | |||
| Interleukin 6 | Improves (the measure goes down) | 2 studies | 60 people | |||
| Endogenous Advanced Glycation End Products | Improves (the measure goes up) | 60 people | ||||
| Lipoprotein(a) | Improves (the measure goes up) | 60 people |
Muscle Recovery
- Exercise-Induced Oxidation: improves
- Muscle Damage: changes; see studies
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Exercise-Induced Oxidation Small Decrease | Improves (the measure goes down) | Small effect | 1 study | 33 people | ||
| Muscle Damage | Changes; see studies | 1 study | 18 people |
Migraine Headache
- Calcitonin Gene-related Peptide: improves
- Interleukin 6: improves
- Migraine Frequency: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Calcitonin Gene-related Peptide Small Decrease | Improves (the measure goes down) | Small effect | 45 people | |||
| Interleukin 6 | Improves (the measure goes down) | 2 studies | 45 people | |||
| Migraine Frequency | Improves (the measure goes down) | 2 studies | 324 people | |||
| Nausea Symptoms | Improves (the measure goes down) | 2 studies | 122 people | |||
| Interleukin 10 | Improves (the measure goes up) | 45 people | ||||
| Migraine Duration | Improves (the measure goes down) | 324 people | ||||
| Migraine Severity | Improves (the measure goes down) | 324 people | ||||
| TNF-Alpha | Improves (the measure goes down) | 45 people |
High Cholesterol
- Apolipoprotein A: improves
- Blood Pressure: improves
- Low-density lipoprotein (LDL): improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Apolipoprotein A Small Increase | Improves (the measure goes up) | Small effect | 101 people | |||
| Blood Pressure | Improves (the measure goes down) | 4 studies | 101 people | |||
| Low-density lipoprotein (LDL) | Improves (the measure goes down) | 4 studies | 153 people | |||
| Blood glucose | Improves (the measure goes down) | 3 studies | 101 people | |||
| Interleukin 6 | Improves (the measure goes down) | 2 studies | 52 people | |||
| Total cholesterol | Improves (the measure goes down) | 2 studies | 153 people | |||
| High-density lipoprotein (HDL) | Improves (the measure goes up) | 1 study | 153 people | |||
| Apolipoprotein B | Improves (the measure goes down) | 101 people | ||||
| Glycemic Control | Improves (the measure goes up) | 101 people | ||||
| Insulin | Changes; see studies | 101 people | ||||
| Intercellular Adhesion Molecule 1 | Changes; see studies | 52 people | ||||
| Triglycerides | Improves (the measure goes down) | 153 people | ||||
| Weight | Improves (the measure goes down) | 101 people |
Peyronie's Disease
- Erections: improves
- Peyronie's Disease Symptoms: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Erections Small Increase | Improves (the measure goes up) | Small effect | 186 people | |||
| Peyronie's Disease Symptoms | Improves (the measure goes down) | 1 study | 186 people |
Cardiomyopathy
- Exercise Tolerance
- Left Ventricular Ejection Fraction: improves
- Heart Size: changes; see studies
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Exercise Tolerance No effect | NoneNo effect | 2 studies | 41 people | |||
| Left Ventricular Ejection Fraction | Improves (the measure goes up) | 1 study | 41 people | |||
| Heart Size | Changes; see studies | 41 people | ||||
| Quality of Life | Improves (the measure goes up) | 41 people |
Mitochondrial Cytopathy
- Exercise Tolerance
- Quality of Life: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Exercise Tolerance No effect | NoneNo effect | 2 studies | 30 people | |||
| Quality of Life | Improves (the measure goes up) | 30 people |
Skin Health
- Skin Dryness
- UV Skin Damage: changes; see studies
- Skin Elasticity: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Skin Dryness No effect | NoneNo effect | 1 study | 33 people | |||
| UV Skin Damage | Changes; see studies | 1 study | 41 people | |||
| Skin Elasticity | Improves (the measure goes up) | 33 people | ||||
| Wrinkles | Improves (the measure goes up) | 33 people |
Cardiovascular Disease
- High-density lipoprotein (HDL)
- Low-density lipoprotein (LDL): improves
- Interleukin 6: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| High-density lipoprotein (HDL) No effect | NoneNo effect | 1 study | 52 people | |||
| Low-density lipoprotein (LDL) | Improves (the measure goes down) | 4 studies | 52 people | |||
| Interleukin 6 | Improves (the measure goes down) | 2 studies | 52 people | |||
| Total cholesterol | Improves (the measure goes down) | 2 studies | 52 people | |||
| Intercellular Adhesion Molecule 1 | Changes; see studies | 52 people | ||||
| Triglycerides | Improves (the measure goes down) | 52 people |
Metabolic Health
- Adiponectin
- Anaerobic Capacity
- Oxidative Stress Biomarkers: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Adiponectin No effect | NoneNo effect | 14 people | ||||
| Anaerobic Capacity No effect | NoneNo effect | 18 people | ||||
| Oxidative Stress Biomarkers | Improves (the measure goes down) | 9 studies | 1,501 people | |||
| Blood Pressure | Improves (the measure goes down) | 4 studies | 1,831 people | |||
| Low-density lipoprotein (LDL) | Improves (the measure goes down) | 4 studies | 2,387 people | |||
| Blood glucose | Improves (the measure goes down) | 3 studies | 2,157 people | |||
| Anti-Oxidant Enzyme Profile | Improves (the measure goes up) | 2 studies | 60 people | |||
| C-Reactive Protein (CRP) | Improves (the measure goes down) | 2 studies | 1,145 people | |||
| HbA1c | Improves (the measure goes down) | 2 studies | 1,505 people | |||
| Inflammation | Improves (the measure goes down) | 2 studies | 14 people | |||
| Interleukin 6 | Improves (the measure goes down) | 2 studies | 880 people | |||
| Total cholesterol | Improves (the measure goes down) | 2 studies | 2,616 people | |||
| Exercise Capacity | Improves (the measure goes up) | 1 study | 23 people | |||
| Exercise-Induced Oxidation | Changes; see studies | 1 study | 41 people | |||
| High-density lipoprotein (HDL) | Improves (the measure goes up) | 1 study | 2,409 people | |||
| Insulin | Changes; see studies | 1,234 people | ||||
| Insulin Resistance | Improves (the measure goes down) | 988 people | ||||
| Oxygen Uptake | Improves (the measure goes up) | 23 people | ||||
| Sperm Count | Improves (the measure goes up) | 60 people | ||||
| Sperm Quality | Improves (the measure goes up) | 60 people | ||||
| Superoxide Dismutase Activity | Improves (the measure goes up) | 694 people | ||||
| TNF-Alpha | Improves (the measure goes down) | 721 people | ||||
| Total Antioxidant Capacity (TAC) | Improves (the measure goes up) | 835 people | ||||
| Triglycerides | Improves (the measure goes down) | 2,443 people |
Type 2 Diabetes
- Adiponectin
- Oxidative Stress Biomarkers: improves
- Blood Pressure: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Adiponectin No effect | NoneNo effect | 108 people | ||||
| Oxidative Stress Biomarkers | Improves (the measure goes down) | 9 studies | 174 people | |||
| Blood Pressure | Improves (the measure goes down) | 4 studies | 16 people | |||
| Low-density lipoprotein (LDL) | Improves (the measure goes down) | 4 studies | 16 people | |||
| Blood glucose | Improves (the measure goes down) | 3 studies | 619 people | |||
| Anti-Oxidant Enzyme Profile | Improves (the measure goes up) | 2 studies | 60 people | |||
| Blood Flow | Improves (the measure goes up) | 2 studies | 40 people | |||
| HbA1c | Improves (the measure goes down) | 2 studies | 765 people | |||
| Interleukin 6 | Improves (the measure goes down) | 2 studies | 60 people | |||
| Total cholesterol | Improves (the measure goes down) | 2 studies | 16 people | |||
| Vascular Function | Improves (the measure goes up) | 2 studies | 23 people | |||
| High-density lipoprotein (HDL) | Improves (the measure goes up) | 1 study | 16 people | |||
| Leptin | Improves (the measure goes up) | 1 study | 74 people | |||
| Endogenous Advanced Glycation End Products | Improves (the measure goes up) | 60 people | ||||
| Glycemic Control | Improves (the measure goes up) | 134 people | ||||
| Insulin | Changes; see studies | 228 people | ||||
| Insulin Resistance | Improves (the measure goes down) | 228 people | ||||
| Lipoprotein(a) | Improves (the measure goes up) | 60 people | ||||
| Triglycerides | Improves (the measure goes down) | 16 people | ||||
| vLDL-C | Improves (the measure goes down) | 60 people |
General Athletic Performance
- Aerobic Exercise Metrics
- Oxidative Stress Biomarkers: improves
- Fatigue Symptoms: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Aerobic Exercise Metrics No effect | NoneNo effect | 15 people | ||||
| Oxidative Stress Biomarkers | Improves (the measure goes down) | 9 studies | 33 people | |||
| Fatigue Symptoms | Improves (the measure goes down) | 3 studies | 32 people | |||
| Exercise Tolerance | Improves (the measure goes up) | 2 studies | 30 people | |||
| Total cholesterol | Improves (the measure goes down) | 2 studies | 15 people | |||
| Exercise Capacity | Improves (the measure goes up) | 1 study | 23 people | |||
| Exercise-Induced Oxidation | Changes; see studies | 1 study | 56 people | |||
| Power Output | Improves (the measure goes up) | 1 study | 15 people | |||
| Anaerobic Capacity | Improves (the measure goes up) | 33 people | ||||
| Heart Rate | Improves (the measure goes down) | 15 people | ||||
| Lactate Threshold | Improves (the measure goes up) | 15 people | ||||
| Oxygen Uptake | Improves (the measure goes up) | 23 people | ||||
| Quality of Life | Improves (the measure goes up) | 30 people | ||||
| Rating of Perceived Exertion | Improves (the measure goes up) | 32 people |
Aerobic Exercise Performance
- Aerobic Exercise Metrics
- Oxidative Stress Biomarkers: improves
- Power Output: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Aerobic Exercise Metrics No effect | NoneNo effect | 15 people | ||||
| Oxidative Stress Biomarkers | Improves (the measure goes down) | 9 studies | 15 people | |||
| Power Output | Improves (the measure goes up) | 1 study | 15 people | |||
| Anaerobic Capacity | Improves (the measure goes up) | 15 people | ||||
| Heart Rate | Improves (the measure goes down) | 15 people | ||||
| Lactate Threshold | Improves (the measure goes up) | 15 people | ||||
| Rating of Perceived Exertion | Improves (the measure goes up) | 15 people |
High Blood Pressure
- Blood Pressure: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Blood Pressure | Improves (the measure goes down) | 4 studies | 113 people |
Metabolic Syndrome
- Blood Pressure: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Blood Pressure | Improves (the measure goes down) | 4 studies | 30 people |
Fatigue
- Fatigue Symptoms: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Fatigue Symptoms | Improves (the measure goes down) | 3 studies | 602 people |
Parkinson's Disease
- Parkinson's Disease Symptoms: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Parkinson's Disease Symptoms | Improves (the measure goes down) | 2 studies | 809 people |
Immune Health
- Inflammation: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Inflammation | Improves (the measure goes down) | 2 studies | 20 people |
Menopause
- Ovarian Reserve: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Ovarian Reserve | Improves (the measure goes up) | 1 study | 44 people |
Prader-Willi Syndrome (PWS)
- Prader-Willi Syndrome Symptoms: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Prader-Willi Syndrome Symptoms | Improves (the measure goes down) | 1 study | 26 people |
Preeclampsia
- Pre-Eclampsia Risk: changes; see studies
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Pre-Eclampsia Risk | Changes; see studies | 1 study | 197 people |
Hysterectomy
- Ovarian Reserve: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Ovarian Reserve | Improves (the measure goes up) | 1 study | 44 people |
What the published studies found
5 automated readings
LDL cholesterol
The studies disagree. A Cochrane review (2014, 6 studies, 218 people) did not settle it for LDL cholesterol, while 5 of the 8 studies read found no clear difference. The evidence is very weak.
8 studies counted of 9 read: 8 reviews.
- Meta-analysis, 2014; 6 studies, 218 people; healthy adults or high CVD risk without diagnosis: unclear: evidence too weak to tell (the review the verdict rests on).
unable to determine if there was any significant difference
Co-enzyme Q10 supplementation for the primary prevention of cardiovascular disease - Meta-analysis, 2025; 16 studies; patients with Type 2 Diabetes: no clear difference.
but did not change lipid profile
Effects of Coenzyme Q10 Supplementation on Metabolic Indicators in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis - Meta-analysis, 2023; 6 studies: no clear difference.
overall non-significant decrease in the lipid profiles
Effects of coenzyme Q10 supplementation on lipid profiles and liver enzymes of nonalcoholic fatty liver disease (NAFLD) patients: A systematic review and meta-analysis of randomized controlled trials - Meta-analysis, 2022; 50 studies, 2,794 people: improves. Effects of Coenzyme Q10 Supplementation on Lipid Profiles in Adults: A Meta-analysis of Randomized Controlled Trials
- Systematic review, 2022; 12 studies; patients with chronic kidney disease: no clear difference.
had no effects on total cholesterol, or LDL-cholesterol
A systematic review for the efficacy of coenzyme Q10 in patients with chronic kidney disease - Meta-analysis, 2018; 21 studies, 1,039 people; patients with metabolic diseases: no clear difference.
increased LDL- (SMD 0.04; 95% CI, -0.27, 0.36)
The Effects of Coenzyme Q10 Supplementation on Lipid Profiles Among Patients with Metabolic Diseases: A Systematic Review and Meta-analysis of Randomized Controlled Trials - Meta-analysis, 2018; 8 studies, 526 people; patients with coronary artery disease: no clear difference.
no significant effects of CoQ10 supplementation on LDL-cholesterol
The effects of coenzyme Q10 supplementation on lipid profiles among patients with coronary artery disease: a systematic review and meta-analysis of randomized controlled trials - Meta-analysis, 2018; 7 studies; patients diagnosed with Chronic Kidney Disease: improves.
LDL-cholesterol (SMD=-0.47; 95% CI, -0.78, -0.17; P=0.003
The Effects of Coenzyme Q10 Supplementation on Metabolic Profiles of Patients with Chronic Kidney Disease: A Systematic Review and Meta-analysis of Randomized Controlled Trials
- Meta-analysis, 2014; 6 studies, 218 people; healthy adults or high CVD risk without diagnosis: unclear: evidence too weak to tell (the review the verdict rests on).
Fatigue
The studies disagree. The best available review (2025, 24 studies) did not settle it for fatigue, while 4 of the 7 studies read found an improvement. The evidence is very weak.
7 studies counted of 9 read: 5 reviews and 2 trials (62 people in the trials).
- Meta-analysis, 2025; 24 studies; healthy adults: unclear: evidence too weak to tell (the review the verdict rests on).
Evidence for reduced subjective fatigue was suggestive
Coenzyme Q10 supplementation increases blood concentrations but shows limited and inconsistent effects on exercise performance: a systematic review and meta-analysis - Meta-analysis, 2025; 5 studies, 474 people; patients with depression: unclear: evidence too weak to tell.
No significant benefit was observed for fatigue
Effects of Coenzyme Q10 Supplementation on Depressive Symptoms and Fatigue: A Systematic Review and Meta-Analysis of Randomized Controlled Trials - Systematic review, 2024; 20 studies, 483 people; patients with rheumatic diseases including fibromyalgia, rheumatoid arthritis, and antiphospholipid syndrome: improves.
patients observed improvements in pain, fatigue, sleep
Coenzyme Q10 supplementation in rheumatic diseases: A systematic review - Systematic review, 2022; 13 studies, 1,126 people: improves.
statistically significant reduction in fatigue scores
Effectiveness of Coenzyme Q10 Supplementation for Reducing Fatigue: A Systematic Review and Meta-Analysis of Randomized Controlled Trials - Systematic review, 2019; 16 studies; adolescents and adults with various conditions: improves.
showed significant beneficial effects (p < 0.05) of CoQ10 supplementation on fatigue status
Effect of coenzyme Q10 supplementation on fatigue: A systematic review of interventional studies - Randomised trial, 2016; 47 people; patients with multiple sclerosis: improves.
significant decrease of FSS and BDI in CoQ10 group
Coenzyme Q10 as a treatment for fatigue and depression in multiple sclerosis patients: A double blind randomized clinical trial - Crossover trial, 2010; 15 people; healthy sedentary men: no clear difference.
decreases did not differ from that seen with placebo
The effects of coenzyme Q10 supplementation on performance during repeated bouts of supramaximal exercise in sedentary men
- Meta-analysis, 2025; 24 studies; healthy adults: unclear: evidence too weak to tell (the review the verdict rests on).
Migraine frequency
The studies disagree. The best available review (2019, 2 studies, 97 people) did not settle it for migraine frequency, while 6 of the 8 studies read found an improvement. The evidence is very weak.
8 studies counted of 10 read: 6 reviews and 2 trials (87 people in the trials).
- Meta-analysis, 2019; 2 studies, 97 people; adults with migraine: unclear: evidence too weak to tell (the review the verdict rests on).
coenzyme Q10 did not significantly decrease migraine frequency
Vitamins and Minerals for Migraine Prophylaxis: A Systematic Review and Meta-analysis - Meta-analysis, 2025; 22 studies; adults with migraine: improves.
CoQ10 decreased the frequency (MD = -1.73)
Effects of selected dietary supplements on migraine prophylaxis: A systematic review and dose-response meta-analysis of randomized controlled trials - Meta-analysis, 2021; 6 studies, 371 people; adult patients with migraine: improves. Coenzyme Q10 supplementation for prophylaxis in adult patients with migraine-a meta-analysis
- Meta-analysis, 2020; 4 studies, 221 people: improves. Effect of coenzyme Q10 supplementation on clinical features of migraine: a systematic review and dose-response meta-analysis of randomized controlled trials
- Meta-analysis, 2019; 5 studies, 346 people: no clear difference.
comparable with placebo with respect to migraine attacks/month
Efficacy of CoQ10 as supplementation for migraine: A meta-analysis - Systematic review, 2010; patients with frequent or insufficiently controlled migraine attacks: improves. Non-pharmacological approach to migraine prophylaxis: part II
- Randomised trial, 2019; 45 people; non-menopausal women with episodic migraine: improves.
significant improvement was found in frequency
Oral coenzyme Q10 supplementation in patients with migraine: Effects on clinical features and inflammatory markers - Randomised trial, 2005; 42 people: improves.
CoQ10 was superior to placebo for attack-frequency, headache-days and days-with-nausea in the third treatment month
Efficacy of coenzyme Q10 in migraine prophylaxis: a randomized controlled trial
- Meta-analysis, 2019; 2 studies, 97 people; adults with migraine: unclear: evidence too weak to tell (the review the verdict rests on).
Sleep quality
Mixed or unclear: two readings of the studies disagreed. One reading found evidence too weak to tell for sleep quality, the other an improvement. The question is open.
1 study counted of 7 read: 1 trial (50 people in the trials).
- Randomised trial, 2025; 50 people; patients with tinnitus due to presbycusis: improves.
sleep disorder (-7.60 ± 1.38) and (-1.0 ± 8.55)
The Effect of Coenzyme Q10 on Tinnitus Severity and Sleep Quality in Patients with Presbycusis
- Randomised trial, 2025; 50 people; patients with tinnitus due to presbycusis: improves.
Stress
The best available review (2026, 14 studies, 433 people) found a small improvement in stress. 5 of the 6 studies read agree; 1 found mixed results. The evidence is moderate.
6 studies counted of 10 read: 5 reviews and 1 trial (69 people in the trials).
- Meta-analysis, 2026; 14 studies, 433 people: improves (the review the verdict rests on).
reduced blood malondialdehyde concentration (standardized mean difference: -0.289
Effects of coenzyme Q10 analogs on oxidative stress, muscle, and metabolism after exercise: A meta-analysis and systematic review - Systematic review, 2023: improves. Alleviating effects of coenzyme Q10 supplements on biomarkers of inflammation and oxidative stress: results from an umbrella meta-analysis
- Systematic review, 2022; 21 studies: mixed results.
increased the levels of antioxidant enzymes
Discovering the Potential Value of Coenzyme Q10 in Oxidative Stress: Enlightenment From a Synthesis of Clinical Evidence Based on Various Population - Meta-analysis, 2021; 17 studies, 972 people: improves.
decreased malondialdehyde (SMD -1.02 mmol/L, 95% CI -1.60 to -0.44
Diabetes, Age, and Duration of Supplementation Subgroup Analysis for the Effect of Coenzyme Q10 on Oxidative Stress: A Systematic Review and Meta-Analysis - Meta-analysis, 2020; 19 studies: improves.
CoQ10 increased the levels of TAC
The effect of coenzyme Q10 supplementation on oxidative stress: A systematic review and meta-analysis of randomized controlled clinical trials - Randomised trial, 2024; 69 people; patients with moderate and severe depression: improves.
serum levels of nitric oxide and total thiol groups significantly decreased and increased
Discovering the Potential Value of Coenzyme Q10 as an Adjuvant Treatment in Patients With Depression
- Meta-analysis, 2026; 14 studies, 433 people: improves (the review the verdict rests on).
Key findings
- Blood glucoseImproves (the measure goes down)
- Depression SymptomsImproves (the measure goes down)
- Blood PressureImproves (the measure goes down)
Shop the evidence-backed picks
Third-party tested Coenzyme Q10 products, in the forms the graded studies used where we can match them.
- Grade B
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Studies cited
71 studies from PubMed
- Effects of Coenzyme Q10 Supplementation on Depressive Symptoms and Fatigue: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
- Oral coenzyme Q10 supplementation in patients with migraine: Effects on clinical features and inflammatory markers
- Efficacy of coenzyme Q10 in migraine prophylaxis: a randomized controlled trial
- Effectiveness of coenzyme Q10 in prophylactic treatment of migraine headache: an open-label, add-on, controlled trial
- A randomized, double-blinded, placebo-controlled, crossover, add-on study of CoEnzyme Q10 in the prevention of pediatric and adolescent migraine
- The synergistic effects of nano-curcumin and coenzyme Q10 supplementation in migraine prophylaxis: a randomized, placebo-controlled, double-blind trial
- Oxidative stress correlates with headache symptoms in fibromyalgia: coenzyme Q₁₀ effect on clinical improvement
- Coenzyme Q10 supplementation alleviates pain in pregabalin-treated fibromyalgia patients via reducing brain activity and mitochondrial dysfunction
- Increased oxidative stress and coenzyme Q10 deficiency in juvenile fibromyalgia: amelioration of hypercholesterolemia and fatigue by ubiquinol-10 supplementation
- Coenzyme q10 regulates serotonin levels and depressive symptoms in fibromyalgia patients: results of a small clinical trial
- Can coenzyme q10 improve clinical and molecular parameters in fibromyalgia?
- Reversal of mitochondrial dysfunction by coenzyme Q10 supplement improves endothelial function in patients with ischaemic left ventricular systolic dysfunction: a randomized controlled trial
- Dose-Response Effect of Coenzyme Q10 Supplementation on Blood Pressure among Patients with Cardiometabolic Disorders: A Grading of Recommendations Assessment, Development, and Evaluation (GRADE)-Assessed Systematic Review and Meta-Analysis of Randomized Controlled Trials.
- Electrocardiographic and hemodynamic effects of coenzyme Q10 in healthy individuals: a double-blind, randomized controlled trial
- Effects of coenzyme Q10 on vascular endothelial function in humans: A meta-analysis of randomized controlled trials
- Coenzyme Q10 and exercise training in chronic heart failure
- Effects of Coenzyme Q10 Supplementation on Lipid Profiles in Adults: A Meta-analysis of Randomized Controlled Trials.
- Mediterranean Diet Supplemented With Coenzyme Q10 Modifies the Expression of Proinflammatory and Endoplasmic Reticulum Stress-Related Genes in Elderly Men and Women
- Efficacy of coenzyme Q10 on semen parameters, sperm function and reproductive hormones in infertile men
- Coenzyme Q(10) supplementation in infertile men with idiopathic asthenozoospermia: an open, uncontrolled pilot study
- Effect of Coenzyme Q10 supplementation on antioxidant enzymes activity and oxidative stress of seminal plasma: a double-blind randomised clinical trial
- Coenzyme Q10 improves seminal oxidative defense but does not affect on semen parameters in idiopathic oligoasthenoteratozoospermia: a randomized double-blind, placebo controlled trial
- Coenzyme Q10 administration has no effect on sICAM-1 and metabolic parameters of pediatrics with type 1 diabetes mellitus
- Clinical trial of the effects of coenzyme Q10 supplementation on glycemic control and markers of lipid profiles in diabetic hemodialysis patients
- Effects of coenzyme Q10 supplementation on serum values of adiponectin, leptin, 8-isoprostane and malondialdehyde in women with type 2 diabetes
- Effects of Coenzyme Q10 Supplementation on Metabolic Indicators in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis.
- Effectiveness of Coenzyme Q10 Supplementation for Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis
- Coenzyme Q(10) improves endothelial dysfunction of the brachial artery in Type II diabetes mellitus
- Coenzyme Q10 improves blood pressure and glycaemic control: a controlled trial in subjects with type 2 diabetes
- Coenzyme Q10 improves endothelial dysfunction in statin-treated type 2 diabetic patients
- The effects of coenzyme Q10 supplementation on cardiometabolic markers in overweight type 2 diabetic patients with stable myocardial infarction: A randomized, double-blind, placebo-controlled trial
- Influence of adjuvant Coenzyme Q10 on inflammatory and oxidative stress biomarkers in patients with bipolar disorders during the depressive episode
- Evaluating the Effect of Coenzyme Q10 Augmentation on Treatment of Bipolar Depression: A Double-Blind Controlled Clinical Trial
- Coenzyme Q10 (CoQ10) in isolated diastolic heart failure in hypertrophic cardiomyopathy (HCM)
- Coenzyme Q10 terclatrate and creatine in chronic heart failure: a randomized, placebo-controlled, double-blind study
- Effects of coenzyme Q10 on arterial stiffness, metabolic parameters, and fatigue in obese subjects: a double-blind randomized controlled study
- Coenzyme Q10 supplementation and exercise-induced oxidative stress in humans
- Effects of Coenzyme Q10 Supplementation on Biomarkers of Oxidative Stress in Adults: A GRADE-Assessed Systematic Review and Updated Meta-Analysis of Randomized Controlled Trials.
- Postprandial antioxidant effect of the Mediterranean diet supplemented with coenzyme Q10 in elderly men and women
- Effects of coenzyme Q10 supplementation on liver mitochondrial function and aerobic capacity in adolescent athletes
- Effects of coenzyme Q10 supplementation on plasma adiponectin, interleukin-6, and tumor necrosis factor-alpha levels in men
- Efficacy and Optimal Dose of Coenzyme Q10 Supplementation on Inflammation-Related Biomarkers: A GRADE-Assessed Systematic Review and Updated Meta-Analysis of Randomized Controlled Trials.
- Effects of coenzyme Q10 supplementation on glycemic control: A GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials.
- Impact of oral ubiquinol on blood oxidative stress and exercise performance
- The effects of coenzyme Q10 supplementation on performance during repeated bouts of supramaximal exercise in sedentary men
- Antifatigue effects of coenzyme Q10 during physical fatigue
- Oxidative stress and antioxidant defense in plasma after repeated bouts of supramaximal exercise: the effect of coenzyme Q10
- A randomized trial of coenzyme Q10 in mitochondrial disorders
- Randomized, double-blind, placebo-controlled trial of coenzyme Q10 in isolated systolic hypertension
- A randomized, double-blind, placebo-controlled crossover study of coenzyme Q10 therapy in hypertensive patients with the metabolic syndrome
- Effect of coenzyme Q10 administration on endothelial function and extracellular superoxide dismutase in patients with ischaemic heart disease: a double-blind, randomized controlled study
- Efficacy and Safety of Coenzyme Q10 Supplementation in the Treatment of Polycystic Ovary Syndrome: a Systematic Review and Meta-analysis
- Hormonal and Metabolic Effects of Coenzyme Q10 and/or Vitamin E in Patients With Polycystic Ovary Syndrome
- Treatment of coenzyme Q10 for 24 weeks improves lipid and glycemic profile in dyslipidemic individuals
- Beneficial Effects of Coenzyme Q10 Supplementation on Lipid Profile and Intereukin-6 and Intercellular Adhesion Molecule-1 Reduction, Preliminary Results of a Double-blind Trial in Acute Myocardial Infarction
- Developmental profiles in young children with Prader-Labhart-Willi syndrome: effects of weight and therapy with growth hormone or coenzyme Q10
- Effect of coenzyme Q10 on risk of atherosclerosis in patients with recent myocardial infarction
- Coenzyme Q10 supplementation reduces oxidative stress and increase antioxidant enzyme activity in patients with coronary artery disease
- Coenzyme Q10 as a treatment for fatigue and depression in multiple sclerosis patients: A double blind randomized clinical trial
- Coenzyme Q10 supplementation ameliorates inflammatory markers in patients with multiple sclerosis: a double blind, placebo, controlled randomized clinical trial
- Safety and efficacy of coenzyme Q10 supplementation in early chronic Peyronie's disease: a double-blind, placebo-controlled randomized study
- Coenzyme Q10 supplementation reduces oxidative stress and decreases antioxidant enzyme activity in children with autism spectrum disorders
- The effect of dietary intake of coenzyme Q10 on skin parameters and condition: Results of a randomised, placebo-controlled, double-blind study
- Aging skin is functionally anaerobic: importance of coenzyme Q10 for anti aging skin care
- Reducing exercise-induced muscular injury in kendo athletes with supplementation of coenzyme Q10
- Coenzyme Q10 supplementation during pregnancy reduces the risk of pre-eclampsia
- The efficacy and safety of coenzyme Q10 in Parkinson's disease: a meta-analysis of randomized controlled trials.
- Coenzyme Q10 supplementation provides mild symptomatic benefit in patients with Parkinson's disease
- The Effects of Coenzyme Q10 Supplementation on Metabolic Profiles of Patients with Chronic Kidney Disease: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
- Effectiveness of Coenzyme Q10 Supplementation for Reducing Fatigue: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
- The effect of coenzyme Q10 pretreatment on ovarian reserve in women undergoing hysterectomy with bilateral salpingectomy: a randomised, double-blind, placebo-controlled trial.