Dr. Grey AI

Coenzyme Q10

Coenzyme Q10 is a molecule found in mitochondria that has a critical role in producing energy for the body. It also plays an important role in the endogenous antioxidant system.

Quick Answer

What it is

Coenzyme Q10 is a molecule found in mitochondria that has a critical role in producing energy for the body. It also plays an important role in the endogenous antioxidant system.

Key findings

  • Grade B: Depression Symptoms (Depression)
  • Grade B: Blood glucose (Chronic Kidney Disease (CKD))
  • Grade C: Anti-Oxidant Enzyme Profile (Coronary Artery Disease (CAD))

Safety

No specific caution or interaction language was detected in the current summary/outcome notes.

ℹ️ Quick Facts: Coenzyme Q10

Quick Facts: Coenzyme Q10

  • Best Evidence:Grade B
  • Conditions Studied:41
  • Research Outcomes:268
  • Grade B Findings:2
  • Key Effect:Fibromyalgia
Outcomes by grade:
A0
B2
C23
D9
41 conditions · 268 outcomes

Detailed Outcomes

Grade:
Effect:
Size:
Sort:
|
B
Depression Symptoms
Moderate Improvement
moderate↓Improves
?
Fatigue Symptoms
↓Improves
B
Blood glucose
Small Improvement
small↓Improves
?
Kidney Function
5 studies
↑Improves
?
High-density lipoprotein (HDL)
↑Improves
?
Total cholesterol
↓Improves
?
Triglycerides
4 studies
↓Improves
?
Low-density lipoprotein (LDL)
↓Improves
?
C-Reactive Protein (CRP)
↓Improves
?
Insulin
1 study
↑Worsens
?
Insulin Resistance
1 study
↓Improves
?
Oxidative Stress Biomarkers
↓Improves
C
Anti-Oxidant Enzyme Profile
Small Increase
small↑Improves
?
Oxidative Stress Biomarkers
↓Improves
?
Cardiovascular Disease Mortality
1 study
↓Improves
?
Endogenous Advanced Glycation End Products
1 study
↑Improves
?
High-density lipoprotein (HDL)
↑Improves
?
Interleukin 6
↓Improves
?
Lipoprotein(a)
1 study
↑Improves
?
Low-density lipoprotein (LDL)
↓Improves
?
Plasma Vitamin C
1 study
↑Improves
?
Plasma Vitamin E
1 study
↑Improves
?
Stroke Risk
1 study
↑Worsens
?
Total cholesterol
↓Improves
?
Triglycerides
1 study
↓Improves
C
Blood glucose
Small Improvement
small↓Improves
?
High-density lipoprotein (HDL)
↑Improves
?
Low-density lipoprotein (LDL)
↓Improves
?
Total cholesterol
↓Improves
?
Triglycerides
2 studies
↓Improves
?
Blood Pressure
↓Improves
?
Cramps
1 study
↓Improves
?
Creatine Kinase
1 study
↑Worsens
?
Fatigue Symptoms
↓Improves
?
Glycemic Control
1 study
↑Improves
?
HbA1c
↓Improves
?
Insulin
1 study
↑Worsens
?
Kidney Function
1 study
↑Improves
?
Liver Enzymes
1 study
↑Worsens
?
Urea
1 study
↑Improves
?
vLDL-C
1 study
↓Improves
C
Exercise-Induced Oxidation
Small Decrease
small↓Improves
?
Muscle Damage
↑Worsens
C
Calcitonin Gene-related Peptide
Small Decrease
1 study
small↓Improves
?
Migraine Duration
6 studies
↓Improves
?
Migraine Frequency
↓Improves
?
Migraine Severity
6 studies
↓Improves
?
Nausea Symptoms
↓Improves
?
Interleukin 10
1 study
↑Improves
?
Interleukin 6
↓Improves
?
TNF-Alpha
1 study
↓Improves
C
Anti-Oxidant Enzyme Profile
Small Increase
small↑Improves
?
Total cholesterol
↓Improves
?
Low-density lipoprotein (LDL)
↓Improves
?
Triglycerides
42 studies
↓Improves
?
High-density lipoprotein (HDL)
↑Improves
?
Blood Pressure
↓Improves
?
Vascular Function
↑Improves
?
Blood Flow
↑Improves
?
Blood glucose
↓Improves
?
C-Reactive Protein (CRP)
↓Improves
?
Exercise Tolerance
↑Improves
?
HbA1c
↓Improves
?
Oxidative Stress Biomarkers
↓Improves
?
Oxygen Uptake
1 study
↑Improves
C
Anti-Oxidant Enzyme Profile
Small Increase
small↑Improves
?
Fibromyalgia Symptoms
↓Improves
?
Anxiety Symptoms
2 studies
↓Improves
?
Oxidative Stress Biomarkers
↓Improves
?
Pain
2 studies
↓Improves
?
Fatigue Symptoms
↓Improves
?
Inflammation
↓Improves
?
Sleep Quality
1 study
↑Improves
?
Subjective Well-Being
1 study
↑Improves
?
Total cholesterol
↓Improves
C
Anti-Oxidant Enzyme Profile
Small Increase
small↑Improves
?
Sperm Quality
4 studies
↑Improves
?
Oxidative Stress Biomarkers
↓Improves
?
Seminal Motility
0
↑Improves
?
Sperm Count
2 studies0
↑Improves
?
Follicle-Stimulating Hormone
↑Improves
?
Luteinizing Hormone
1 study
↑Improves
?
Testosterone
1 study
↑Improves
C
Blood Flow
Small Increase
small↑Improves
?
Exercise Tolerance
↑Improves
?
Heart Size
1 study
↑Worsens
?
Left Ventricular Ejection Fraction
↑Improves
?
Oxygen Uptake
1 study
↑Improves
?
Quality of Life
1 study
↑Improves
C
Apolipoprotein A
Small Increase
1 study
small↑Improves
?
High-density lipoprotein (HDL)
↑Improves
?
Low-density lipoprotein (LDL)
↓Improves
?
Total cholesterol
↓Improves
?
Triglycerides
2 studies
↓Improves
?
Apolipoprotein B
1 study
↓Improves
?
Blood glucose
↓Improves
?
Blood Pressure
↓Improves
?
Glycemic Control
1 study
↑Improves
?
Insulin
1 study
↑Worsens
?
Intercellular Adhesion Molecule 1
1 study
↑Worsens
?
Interleukin 6
↓Improves
?
Weight
1 study
↓Improves
C
Depression Symptoms
Moderate Improvement
moderate↓Improves
?
Fatigue Symptoms
↓Improves
?
Interleukin 4
1 study
↑Improves
?
Interleukin 6
↓Improves
?
Matrix metallopeptidase 9
↑Improves
?
Multiple Sclerosis Symptoms
1 study
↓Improves
?
TNF-Alpha
1 study
↓Improves
C
Blood glucose
Small Improvement
small↓Improves
?
Testosterone
5 studies
↑Improves
?
Progesterone
4 studies
↑Improves
?
Insulin Resistance
3 studies
↓Improves
?
Luteinizing Hormone
3 studies
↑Improves
?
Estrogen
2 studies
↑Worsens
?
Follicle-Stimulating Hormone
↑Improves
?
High-density lipoprotein (HDL)
↑Improves
?
Low-density lipoprotein (LDL)
↓Improves
?
Total cholesterol
↓Improves
?
Triglycerides
2 studies
↓Improves
?
Glycemic Control
1 study
↑Improves
?
Insulin
1 study
↑Worsens
?
Sex Hormone Binding Globulin
1 study
↑Improves
C
Anti-Oxidant Enzyme Profile
Small Increase
small↑Improves
?
Depression Symptoms
↓Improves
?
Interleukin 10
1 study
↑Improves
?
Interleukin 6
↓Improves
?
Oxidative Stress Biomarkers
↓Improves
?
TNF-Alpha
1 study
↓Improves
C
Anti-Oxidant Enzyme Profile
Small Increase
small↑Improves
?
Autism Symptoms
1 study
↓Improves
?
Oxidative Stress Biomarkers
↓Improves
C
Follicle-Stimulating Hormone
Small Decrease
small↓Worsens
?
Luteinizing Hormone
1 study
↑Improves
?
Seminal Motility
↑Improves
?
Sperm Quality
1 study
↑Improves
?
Testosterone
1 study
↑Improves
C
Depression Symptoms
Moderate Improvement
moderate↓Improves
?
Fatigue Symptoms
↓Improves
C
Blood Flow
Small Increase
small↑Improves
?
C-Reactive Protein (CRP)
↓Improves
?
Fatigue Symptoms
↓Improves
?
Inflammation
↓Improves
?
Oxidative Stress Biomarkers
↓Improves
?
Quality of Life
1 study
↑Improves
?
Total cholesterol
↓Improves
?
Vascular Function
↑Improves
C
Blood Pressure
Small Improvement
small↓Improves
?
C-Reactive Protein (CRP)
↓Improves
?
High-density lipoprotein (HDL)
↑Improves
?
Low-density lipoprotein (LDL)
↓Improves
?
Total cholesterol
↓Improves
?
Weight
1 study
↓Improves
C
Blood Flow
Small Increase
small↑Improves
?
Blood Pressure
↓Improves
?
HbA1c
↓Improves
?
Oxidative Stress Biomarkers
↓Improves
C
Blood glucose
Small Improvement
small↓Improves
?
Glycemic Control
1 study
↑Improves
?
HbA1c
↓Improves
?
High-density lipoprotein (HDL)
↑Improves
?
Insulin
1 study
↑Worsens
?
Low-density lipoprotein (LDL)
↓Improves
?
Total cholesterol
↓Improves
?
Triglycerides
1 study
↓Improves
?
vLDL-C
1 study
↓Improves
C
Seminal Motility
Small Improvement
small↑Improves
?
Sperm Quality
1 study
↑Improves
C
Blood Flow
Small Increase
small↑Improves
?
Oxygen Uptake
1 study
↑Improves
C
Anti-Oxidant Enzyme Profile
Small Increase
small↑Improves
?
Endogenous Advanced Glycation End Products
1 study
↑Improves
?
Interleukin 6
↓Improves
?
Lipoprotein(a)
1 study
↑Improves
?
Oxidative Stress Biomarkers
↓Improves
C
Erections
Small Increase
1 study
small↑Improves
?
Peyronie's Disease Symptoms
↓Improves
D
Adiponectin
No effect
2 studies
none
?
HbA1c
↓Improves
?
High-density lipoprotein (HDL)
↑Improves
?
Low-density lipoprotein (LDL)
↓Improves
?
Total cholesterol
↓Improves
?
Blood glucose
↓Improves
?
Blood Pressure
↓Improves
?
Triglycerides
10 studies
↓Improves
?
Insulin
4 studies
↑Worsens
?
Insulin Resistance
4 studies
↓Improves
?
Oxidative Stress Biomarkers
↓Improves
?
Glycemic Control
2 studies
↑Improves
?
Anti-Oxidant Enzyme Profile
↑Improves
?
Blood Flow
↑Improves
?
Endogenous Advanced Glycation End Products
1 study
↑Improves
?
Interleukin 6
↓Improves
?
Leptin
↑Improves
?
Lipoprotein(a)
1 study
↑Improves
?
Vascular Function
↑Improves
?
vLDL-C
1 study
↓Improves
D
Adiponectin
No effect
1 study
none
D
Anaerobic Capacity
No effect
1 study
none
?
Total cholesterol
↓Improves
?
Low-density lipoprotein (LDL)
↓Improves
?
Triglycerides
42 studies
↓Improves
?
High-density lipoprotein (HDL)
↑Improves
?
Blood glucose
↓Improves
?
HbA1c
↓Improves
?
Blood Pressure
↓Improves
?
Oxidative Stress Biomarkers
↓Improves
?
C-Reactive Protein (CRP)
↓Improves
?
Insulin
21 studies
↑Worsens
?
Interleukin 6
↓Improves
?
TNF-Alpha
17 studies
↓Improves
?
Insulin Resistance
16 studies
↓Improves
?
Superoxide Dismutase Activity
16 studies
↑Improves
?
Total Antioxidant Capacity (TAC)
14 studies
↑Improves
?
Exercise-Induced Oxidation
↑Worsens
?
Anti-Oxidant Enzyme Profile
↑Improves
?
Exercise Capacity
↑Improves
?
Inflammation
↓Improves
?
Oxygen Uptake
1 study
↑Improves
?
Sperm Count
1 study
↑Improves
?
Sperm Quality
1 study
↑Improves
D
Aerobic Exercise Metrics
No effect
1 study
none
?
Exercise-Induced Oxidation
↑Worsens
?
Anaerobic Capacity
2 studies
↑Improves
?
Fatigue Symptoms
↓Improves
?
Oxidative Stress Biomarkers
↓Improves
?
Rating of Perceived Exertion
2 studies
↑Improves
?
Exercise Capacity
↑Improves
?
Exercise Tolerance
↑Improves
?
Heart Rate
1 study
↓Improves
?
Lactate Threshold
1 study
↑Improves
?
Oxygen Uptake
1 study
↑Improves
?
Power Output
↑Improves
?
Quality of Life
1 study
↑Improves
?
Total cholesterol
↓Improves
D
Skin Dryness
No effect
none
?
UV Skin Damage
↑Worsens
?
Skin Elasticity
1 study
↑Improves
?
Wrinkles
1 study
↑Improves
D
Aerobic Exercise Metrics
No effect
1 study
none
?
Anaerobic Capacity
1 study
↑Improves
?
Heart Rate
1 study
↓Improves
?
Lactate Threshold
1 study
↑Improves
?
Oxidative Stress Biomarkers
↓Improves
?
Power Output
↑Improves
?
Rating of Perceived Exertion
1 study
↑Improves
D
Exercise Tolerance
No effect
none
?
Heart Size
1 study
↑Worsens
?
Left Ventricular Ejection Fraction
↑Improves
?
Quality of Life
1 study
↑Improves
D
High-density lipoprotein (HDL)
No effect
none
?
Intercellular Adhesion Molecule 1
1 study
↑Worsens
?
Interleukin 6
↓Improves
?
Low-density lipoprotein (LDL)
↓Improves
?
Total cholesterol
↓Improves
?
Triglycerides
1 study
↓Improves
D
Exercise Tolerance
No effect
none
?
Quality of Life
1 study
↑Improves
?
Fatigue Symptoms
↓Improves
?
Fatigue Symptoms
↓Improves
?
Parkinson's Disease Symptoms
↓Improves
?
Blood Pressure
↓Improves
?
Ovarian Reserve
↑Improves
?
Inflammation
↓Improves
?
Blood Pressure
↓Improves
?
Prader-Willi Syndrome Symptoms
↓Improves
?
Pre-Eclampsia Risk
↑Worsens
?
Ovarian Reserve
↑Improves

Evidence by Condition

Best grade per condition (each condition may have multiple outcomes)

BFibromyalgia
2
↑Anti-Oxidant Enzyme ProfileImproves↓Fibromyalgia SymptomsImproves↓Anxiety SymptomsImproves
BDepression
1
↓Depression SymptomsImproves↓Fatigue SymptomsImproves
BChronic Kidney Disease (CKD)
1
↓Blood glucoseImproves↑Kidney FunctionImproves↑High-density lipoprotein (HDL)Improves
CMitochondrial Cytopathy
2
Exercise Tolerance↑Quality of LifeImproves
CMigraine Headache
1
↓Calcitonin Gene-related PeptideImproves↓Migraine DurationImproves↓Migraine FrequencyImproves
CInfertility
1
↑Anti-Oxidant Enzyme ProfileImproves↑Sperm QualityImproves↓Oxidative Stress BiomarkersImproves
CCoronary Artery Disease (CAD)
1
↑Anti-Oxidant Enzyme ProfileImproves↓Oxidative Stress BiomarkersImproves↓Cardiovascular Disease MortalityImproves
CHeart Failure
1
↑Blood FlowImproves↑Exercise ToleranceImproves↑Heart SizeWorsens
CHigh Cholesterol
1
↑Apolipoprotein AImproves↑High-density lipoprotein (HDL)Improves↓Low-density lipoprotein (LDL)Improves
CMultiple Sclerosis (MS)
1
↓Depression SymptomsImproves↓Fatigue SymptomsImproves↑Interleukin 4Improves
CPolycystic Ovary Syndrome (PCOS)
1
↓Blood glucoseImproves↑TestosteroneImproves↑ProgesteroneImproves
CType 1 Diabetes
1
↓Blood glucoseImproves↑High-density lipoprotein (HDL)Improves↓Low-density lipoprotein (LDL)Improves
CBipolar Disorder
1
↑Anti-Oxidant Enzyme ProfileImproves↓Depression SymptomsImproves↑Interleukin 10Improves
CMuscle Recovery
1
↓Exercise-Induced OxidationImproves↑Muscle DamageWorsens
CAutism Spectrum Disorder (ASD)
1
↑Anti-Oxidant Enzyme ProfileImproves↓Autism SymptomsImproves↓Oxidative Stress BiomarkersImproves
CLow Testosterone
1
↓Follicle-Stimulating HormoneWorsens↑Luteinizing HormoneImproves↑Seminal MotilityImproves
CMyalgic Encephalomyelitis (Chronic Fatigue Syndrome)
1
↓Depression SymptomsImproves↓Fatigue SymptomsImproves
CObesity
1
↑Blood FlowImproves↓C-Reactive Protein (CRP)Improves↓Fatigue SymptomsImproves
CRheumatoid Arthritis (RA)
1
↓Blood PressureImproves↓C-Reactive Protein (CRP)Improves↑High-density lipoprotein (HDL)Improves
CDyslipidemia
1
↑Blood FlowImproves↓Blood PressureImproves↓HbA1cImproves

Research Citations (71)

Effects of Coenzyme Q10 Supplementation on Depressive Symptoms and Fatigue: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
(2026)
PMID: 41294251
Oral coenzyme Q10 supplementation in patients with migraine: Effects on clinical features and inflammatory markers
PMID: 29298622
Efficacy of coenzyme Q10 in migraine prophylaxis: a randomized controlled trial
PMID: 15728298
Effectiveness of coenzyme Q10 in prophylactic treatment of migraine headache: an open-label, add-on, controlled trial
PMID: 27670440
A randomized, double-blinded, placebo-controlled, crossover, add-on study of CoEnzyme Q10 in the prevention of pediatric and adolescent migraine
PMID: 21586650
The synergistic effects of nano-curcumin and coenzyme Q10 supplementation in migraine prophylaxis: a randomized, placebo-controlled, double-blind trial
PMID: 31241007
Oxidative stress correlates with headache symptoms in fibromyalgia: coenzyme Q₁₀ effect on clinical improvement
PMID: 22532869
Coenzyme Q10 supplementation alleviates pain in pregabalin-treated fibromyalgia patients via reducing brain activity and mitochondrial dysfunction
PMID: 31387429
Increased oxidative stress and coenzyme Q10 deficiency in juvenile fibromyalgia: amelioration of hypercholesterolemia and fatigue by ubiquinol-10 supplementation
PMID: 23394493
Coenzyme q10 regulates serotonin levels and depressive symptoms in fibromyalgia patients: results of a small clinical trial
PMID: 24525646

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