Condition

Chronic Kidney Disease (CKD)

Chronic kidney disease means the kidneys slowly lose their ability to filter waste and extra fluid from the blood, which raises heart risk. Coenzyme Q10 and black seed have moderate evidence, and small trials found blood glucose improved with the first and the inflammation marker CRP went down with the second. Those trials measured blood markers rather than kidney function itself, so the picture is still early.

Sources: PMID 35958521; PMID 37036558

Supplements studied: 21
Graded outcomes: 18
Trials: 15
People studied: 13,448

Evidence by supplement

Strong
Moderate
Limited
Very limited

21 supplements

Resveratrol

Resveratrol: outcomes studied for Chronic Kidney Disease (CKD)
Grade	Outcome	Effect	Size	Studies	People
	Blood glucose Small Improvement	Improves (the measure goes down)	Small effect	7 studies	216 people
Studies that measured blood glucose Effect of resveratrol on glucose control and insulin sensitivity: a meta-analysis of 11 randomized controlled trials.Am J Clin Nutr · PMID 24695890 Resveratrol supplementation and type 2 diabetes: a systematic review and meta-analysisCrit Rev Food Sci Nutr · PMID 33480264 Influence of Age and Dose on the Effect of Resveratrol for Glycemic Control in Type 2 Diabetes Mellitus: Systematic Review and Meta-Analysis.Molecules · PMID 36014469 and 4 more on the Resveratrol page
	C-Reactive Protein (CRP)	Improves (the measure goes down)		3 studies	70 people
Studies that measured c-reactive protein (crp) Evidence-based nutritional and pharmacological interventions targeting chronic low-grade inflammation in middle-age and older adults: A systematic review and meta-analysis.Ageing Res Rev · PMID 29803716 Can resveratrol supplement change inflammatory mediators? A systematic review and meta-analysis on randomized clinical trials.Eur J Clin Nutr · PMID 30013206 The effects of resveratrol supplementation on biomarkers of inflammation and oxidative stress among patients with metabolic syndrome and related disorders: a systematic review and meta-analysis of randomized controlled trials.Food Funct · PMID 30426122
	Kidney Function	Improves (the measure goes up)		2 studies	135 people
Studies that measured kidney function Resveratrol may mildly improve renal function in the general adult population: A systematic review and meta-analysis of randomized controlled clinical trials.Nutr Res · PMID 36996691 Effects of resveratrol supplementation on renal function in adults: a systematic review and dose-response meta-analysis.Naunyn Schmiedebergs Arch Pharmacol · PMID 40580309
	Liver Enzymes	Changes; see studies		2 studies	216 people
Studies that measured liver enzymes Effects of resveratrol supplementation on liver enzymes: A systematic review and meta-analysis of randomised controlled trials.Int J Clin Pract · PMID 32869460 Efficacy of resveratrol supplementation on liver enzymes in patients with non-alcoholic fatty liver disease: A systematic review and meta-analysisComplement Ther Med · PMID 33271299
	Total cholesterol	Improves (the measure goes down)		2 studies	190 people
Studies that measured total cholesterol The effects of resveratrol on glycemic control and cardiometabolic parameters in patients with T2DM: A systematic review and meta-analysis.Med Clin · PMID 34666902 Effect of Resveratrol on Blood Lipid Levels in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis.Obesity · PMID 30569644
	Blood Pressure	Improves (the measure goes down)		1 study	156 people
	Triglycerides	Improves (the measure goes down)		1 study	216 people
	Blood Urea Nitrogen	Improves (the measure goes up)			1,311 people
	Blood Urea Nitrogen (BUN)	Improves (the measure goes up)			894 people
	Body Mass Index (BMI)	Improves (the measure goes down)			266 people
	Creatinine	Improves (the measure goes up)			1,617 people
	Insulin Resistance	Improves (the measure goes down)			156 people
	Serum Albumin	Improves (the measure goes up)			516 people
	TNF-Alpha	Improves (the measure goes down)			156 people
	Uric Acid	Improves (the measure goes down)			353 people

Coenzyme Q10

Coenzyme Q10: outcomes studied for Chronic Kidney Disease (CKD)
Grade	Outcome	Effect	Size	Studies	People
	Blood glucose Small Improvement	Improves (the measure goes down)	Small effect	3 studies	86 people
Studies that measured blood glucose Coenzyme Q10 administration has no effect on sICAM-1 and metabolic parameters of pediatrics with type 1 diabetes mellitusInt J Vitam Nutr Res · PMID 31942840 Clinical trial of the effects of coenzyme Q10 supplementation on glycemic control and markers of lipid profiles in diabetic hemodialysis patientsInt Urol Nephrol · PMID 30251010 Effects of coenzyme Q10 supplementation on glycemic control: A GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials.EClinicalMedicine · PMID 35958521
	Oxidative Stress Biomarkers	Improves (the measure goes down)		9 studies	384 people
Studies that measured oxidative stress biomarkers Oxidative stress correlates with headache symptoms in fibromyalgia: coenzyme Q₁₀ effect on clinical improvementPLoS One · PMID 22532869 Coenzyme Q10 supplementation alleviates pain in pregabalin-treated fibromyalgia patients via reducing brain activity and mitochondrial dysfunctionFree Radic Res · PMID 31387429 Reversal of mitochondrial dysfunction by coenzyme Q10 supplement improves endothelial function in patients with ischaemic left ventricular systolic dysfunction: a randomized controlled trialAtherosclerosis · PMID 21388622 and 6 more on the Coenzyme Q10 page
	Low-density lipoprotein (LDL)	Improves (the measure goes down)		4 studies	112 people
Studies that measured low-density lipoprotein (ldl) Effects of Coenzyme Q10 Supplementation on Metabolic Indicators in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis.Clin Ther · PMID 39904656 Effectiveness of Coenzyme Q10 Supplementation for Type 2 Diabetes Mellitus: A Systematic Review and Meta-AnalysisInt J Endocrinol · PMID 30305810 Treatment of coenzyme Q10 for 24 weeks improves lipid and glycemic profile in dyslipidemic individualsJ Clin Lipidol · PMID 29454678 and 1 more on the Coenzyme Q10 page
	C-Reactive Protein (CRP)	Improves (the measure goes down)		2 studies	384 people
Studies that measured c-reactive protein (crp) Effects of coenzyme Q10 on arterial stiffness, metabolic parameters, and fatigue in obese subjects: a double-blind randomized controlled studyJ Med Food · PMID 21370966 Efficacy and Optimal Dose of Coenzyme Q10 Supplementation on Inflammation-Related Biomarkers: A GRADE-Assessed Systematic Review and Updated Meta-Analysis of Randomized Controlled Trials.Mol Nutr Food Res · PMID 37118903
	Total cholesterol	Improves (the measure goes down)		2 studies	284 people
Studies that measured total cholesterol Effects of Coenzyme Q10 Supplementation on Lipid Profiles in Adults: A Meta-analysis of Randomized Controlled Trials.J Clin Endocrinol Metab · PMID 36337001 The Effects of Coenzyme Q10 Supplementation on Metabolic Profiles of Patients with Chronic Kidney Disease: A Systematic Review and Meta-analysis of Randomized Controlled Trials.Curr Pharm Des · PMID 30417782
	High-density lipoprotein (HDL)	Improves (the measure goes up)		1 study	284 people
	Insulin	Changes; see studies			384 people
	Insulin Resistance	Improves (the measure goes down)			384 people
	Kidney Function	Improves (the measure goes up)			324 people
	Triglycerides	Improves (the measure goes down)			284 people

Black seed

C-Reactive Protein (CRP): improves
Interleukin 6: changes; see studies
Oxidative Stress Biomarkers: changes; see studies

Black seed: outcomes studied for Chronic Kidney Disease (CKD)
Grade	Outcome	Effect	Size	Studies	People
	C-Reactive Protein (CRP) Small Decrease	Improves (the measure goes down)	Small effect	1 study	727 people
Studies that measured c-reactive protein (crp) The effect of Nigella sativa (black seed) on biomarkers of inflammation and oxidative stress: an updated systematic review and meta-analysis of randomized controlled trials.Inflammopharmacology · PMID 37036558
	Interleukin 6	Changes; see studies			156 people
	Oxidative Stress Biomarkers	Changes; see studies			591 people
	Superoxide Dismutase Activity	Improves (the measure goes up)			364 people
	TNF-Alpha	Changes; see studies			307 people
	Total Antioxidant Capacity (TAC)	Improves (the measure goes up)			480 people

Fish Oil

Inflammation: improves
Weight: improves

Fish Oil: outcomes studied for Chronic Kidney Disease (CKD)
Grade	Outcome	Effect	Size	Studies	People
	Inflammation Small Decrease	Improves (the measure goes down)	Small effect	4 studies	31 people
Studies that measured inflammation Effects of marine omega-3 fatty acids on serum systemic and vascular inflammation markers and oxidative stress in hemodialysis patientsAnn Nutr Metab · PMID 21757893 Influence of very long-chain n-3 fatty acids on plasma markers of inflammation in middle-aged menProstaglandins Leukot Essent Fatty Acids · PMID 18403189 Effects of omega-3 fatty acids on postprandial triglycerides and monocyte activationAtherosclerosis · PMID 23017356 and 1 more on the Fish Oil page
	Weight	Improves (the measure goes down)		7 studies	31 people
Studies that measured weight The influence of n-3 polyunsaturated fatty acids and very low calorie diet during a short-term weight reducing regimen on weight loss and serum fatty acid composition in severely obese womenPhysiol Res · PMID 15857162 Dietary supplementation with n-3 PUFA does not promote weight loss when combined with a very-low-energy dietBr J Nutr · PMID 22214842 Moderate consumption of fatty fish reduces diastolic blood pressure in overweight and obese European young adults during energy restrictionNutrition · PMID 19487105 and 4 more on the Fish Oil page

Charcoal

Uremic Toxins: changes; see studies

Charcoal: outcomes studied for Chronic Kidney Disease (CKD)
Grade	Outcome	Effect	Size	Studies	People	Studies list
	Uremic Toxins Small studies suggest activated charcoal (AST-120/Kremezin) may reduce uremic toxins like indoxyl sulfate in CKD. Mixed results on clinical outcomes.	Changes; see studies	Small effect		200 people

Creatine

Kidney Function
Muscle Creatine Content: improves

Creatine: outcomes studied for Chronic Kidney Disease (CKD)
Grade	Outcome	Effect	Size	Studies	People
	Kidney Function No effect		NoneNo effect	5 studies	20 people
Studies that measured kidney function Creatine supplementation does not impair kidney function in type 2 diabetic patients: a randomized, double-blind, placebo-controlled, clinical trialEur J Appl Physiol · PMID 20976468 Effects of creatine supplementation on renal function: a randomized, double-blind, placebo-controlled clinical trialEur J Appl Physiol · PMID 18188581 Effect of short-term high-dose creatine supplementation on measured GFR in a young man with a single kidneyAm J Kidney Dis · PMID 20060630 and 2 more on the Creatine page
	Muscle Creatine Content	Improves (the measure goes up)		11 studies	20 people
Studies that measured muscle creatine content Effect of oral creatine supplementation on human muscle GLUT4 protein content after immobilizationDiabetes · 2001 · PMID 11147785 Role of submaximal exercise in promoting creatine and glycogen accumulation in human skeletal muscle1999 · PMID 10444618 Effect of creatine monohydrate in improving cellular energetics and muscle strength in ambulatory Duchenne muscular dystrophy patients: a randomized, placebo-controlled 31P MRS studyMagn Reson Imaging · PMID 20395096 and 8 more on the Creatine page

L-Carnitine

Aerobic Exercise Metrics
High-density lipoprotein (HDL): improves
Total cholesterol: improves

L-Carnitine: outcomes studied for Chronic Kidney Disease (CKD)
Grade	Outcome	Effect	Size	Studies	People
	Aerobic Exercise Metrics No effect		NoneNo effect	4 studies	12 people
Studies that measured aerobic exercise metrics Effect of glycine propionyl-L-carnitine on aerobic and anaerobic exercise performanceInt J Sport Nutr Exerc Metab · PMID 18272931 L -Carnitine and the recovery from exhaustive endurance exercise: a randomised, double-blind, placebo-controlled trialEur J Appl Physiol · PMID 16193341 Effects of carnitine coingested caffeine on carnitine metabolism and endurance capacity in athletesJ Nutr Sci Vitaminol · PMID 11922111 and 1 more on the L-Carnitine page
	High-density lipoprotein (HDL)	Improves (the measure goes up)		12 studies	229 people
Studies that measured high-density lipoprotein (hdl) Comparative study to evaluate the effect of l-carnitine plus glimepiride versus glimepiride alone on insulin resistance in type 2 diabetic patientsDiabetes Metab Syndr · PMID 30641691 Effects of simvastatin and carnitine versus simvastatin on lipoprotein(a) and apoprotein(a) in type 2 diabetes mellitusExpert Opin Pharmacother · PMID 19618992 Comparison between orlistat plus l-carnitine and orlistat alone on inflammation parameters in obese diabetic patientsFundam Clin Pharmacol · PMID 21077943 and 9 more on the L-Carnitine page
	Total cholesterol	Improves (the measure goes down)		6 studies	229 people
Studies that measured total cholesterol Effect of oral L-carnitine administration on insulin sensitivity and lipid profile in type 2 diabetes mellitus patientsAnn Nutr Metab · PMID 18714152 Effects of carnitine on glucose and lipid metabolic profiles and fertility outcomes in women with polycystic ovary syndrome: A systematic review and meta-analysis.Clin Endocrinol · PMID 36746677 Oral carnitine supplementation reduces body weight and insulin resistance in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trialClin Endocrinol · PMID 26666519 and 3 more on the L-Carnitine page
	Blood glucose	Improves (the measure goes down)		5 studies	229 people
Studies that measured blood glucose L-Carnitine's Effect on the Biomarkers of Metabolic Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled TrialsNutrients · PMID 32932644 Ameliorating hypertension and insulin resistance in subjects at increased cardiovascular risk: effects of acetyl-L-carnitine therapyHypertension · PMID 19620516 Effects of exercise intensity and altered substrate availability on cardiovascular and metabolic responses to exercise after oral carnitine supplementation in athletesInt J Sport Nutr Exerc Metab · PMID 21813919 and 2 more on the L-Carnitine page
	Triglycerides	Improves (the measure goes down)		4 studies	229 people
Studies that measured triglycerides The effects of L-carnitine supplementation on cardiovascular risk factors in participants with impaired glucose tolerance and diabetes: a systematic review and dose-response meta-analysis.Diabetol Metab Syndr · PMID 39085907 Effects of combined treatment with simvastatin and L-carnitine on triglyceride levels in diabetic patients with hyperlipidaemiaClin Drug Investig · PMID 23315432 Effects of L-carnitine supplementation on lipid profiles in patients with coronary artery diseaseLipids Health Dis · PMID 27317162 and 1 more on the L-Carnitine page
	Insulin	Changes; see studies		3 studies	229 people
	Exercise-Induced Oxidation	Changes; see studies		2 studies	12 people
	Blood Pressure	Improves (the measure goes down)		1 study	229 people
	HbA1c	Improves (the measure goes down)		1 study	229 people
	Weight	Improves (the measure goes down)		1 study	229 people
	Anti-Oxidant Enzyme Profile	Improves (the measure goes up)			12 people
	Glycemic Control	Improves (the measure goes up)			229 people
	Kidney Function	Improves (the measure goes up)			229 people
	Lipoprotein(a)	Improves (the measure goes up)			229 people
	Low-density lipoprotein (LDL)	Improves (the measure goes down)			229 people

Vitamin E

Free Testosterone
Luteinizing Hormone: improves
Prolactin: improves

Vitamin E: outcomes studied for Chronic Kidney Disease (CKD)
Grade	Outcome	Effect	Size	Studies	People
	Free Testosterone No effect		NoneNo effect	1 study	36 people
Studies that measured free testosterone Effect of vitamin E therapy on sexual functions of uremic patients in hemodialysisInt J Artif Organs · PMID 1490755
	Luteinizing Hormone	Improves (the measure goes up)			36 people
	Prolactin	Improves (the measure goes up)			36 people

Yarrow

Plasma Nitrate

Yarrow: outcomes studied for Chronic Kidney Disease (CKD)
Grade	Outcome	Effect	Size	Studies	People	Studies list
	Plasma Nitrate No effect		NoneNo effect	1 study	31 people
Studies that measured plasma nitrate Effect of herbal medicine achillea millefolium on plasma nitrite and nitrate levels in patients with chronic kidney disease: a preliminary study.Iran J Kidney Dis · PMID 22976260

Vitamin C

High-density lipoprotein (HDL)
Triglycerides: improves
Inflammation: improves

Vitamin C: outcomes studied for Chronic Kidney Disease (CKD)
Grade	Outcome	Effect	Size	Studies	People
	High-density lipoprotein (HDL) No effect		NoneNo effect		112 people
	Triglycerides	Improves (the measure goes down)		5 studies	112 people
Studies that measured triglycerides Effect of vitamin C on inflammation and metabolic markers in hypertensive and/or diabetic obese adults: a randomized controlled trialDrug Des Devel Ther · PMID 26170625 Does short-term vitamin C reduce cardiovascular risk in type 2 diabetes?Endocr Pract · PMID 23757614 Effects of atorvastatin and vitamin C on forearm hyperaemic blood flow, asymmentrical dimethylarginine levels and the inflammatory process in patients with type 2 diabetes mellitusHeart · PMID 16914485 and 2 more on the Vitamin C page
	Inflammation	Improves (the measure goes down)		2 studies	941 people
Studies that measured inflammation Prolonged vitamin C supplementation and recovery from eccentric exerciseEur J Appl Physiol · PMID 15024666 Effect of ascorbic acid on inflammatory markers after cardiothoracic surgeryAm J Health Syst Pharm · PMID 21856809
	Total cholesterol	Improves (the measure goes down)		2 studies	112 people
Studies that measured total cholesterol Influence of quercetin supplementation on disease risk factors in community-dwelling adultsJ Am Diet Assoc · PMID 21443986 Oral vitamin C supplementation decreased low-density lipoprotein in adults on hemodialysis: A systematic review and meta-analysis.Nutr Res · PMID 40532258
	Low-density lipoprotein (LDL)	Improves (the measure goes down)			112 people

Selenium

Body Mass Index (BMI)
Triglycerides: improves
C-Reactive Protein (CRP): improves

Selenium: outcomes studied for Chronic Kidney Disease (CKD)
Grade	Outcome	Effect	Size	Studies	People
	Body Mass Index (BMI) No effect		NoneNo effect		2,080 people
	Triglycerides	Improves (the measure goes down)		1 study	2,080 people
Studies that measured triglycerides Effect of selenium supplementation on hemodialysis patients: a meta-analysis.Int Urol Nephrol · PMID 39900786
	C-Reactive Protein (CRP)	Improves (the measure goes down)			2,080 people
	Ferritin	Improves (the measure goes up)			2,080 people
	Hemoglobin	Improves (the measure goes up)			2,080 people
	High-density lipoprotein (HDL)	Improves (the measure goes up)			2,080 people
	Low-density lipoprotein (LDL)	Improves (the measure goes down)			2,080 people
	Total cholesterol	Improves (the measure goes down)			2,080 people

Fiber

C-Reactive Protein (CRP)
Blood Urea Nitrogen
Interleukin 6: improves

Fiber: outcomes studied for Chronic Kidney Disease (CKD)
Grade	Outcome	Effect	Size	Studies	People
	C-Reactive Protein (CRP) No effect		NoneNo effect		157 people
	Blood Urea Nitrogen		Small effect	1 study	498 people
Studies that measured blood urea nitrogen Effects of Dietary Fiber Supplementation on Modulating Uremic Toxins and Inflammation in Chronic Kidney Disease Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Toxins · PMID 39998074
	Interleukin 6	Improves (the measure goes down)			265 people
	p-cresyl sulfate (PCS)	Improves (the measure goes up)			398 people
	Serum Indoxyl Sulfate (IS)	Improves (the measure goes up)			398 people
	TMAO	Improves (the measure goes up)			135 people
	TNF-Alpha	Improves (the measure goes down)			157 people
	Uric Acid	Improves (the measure goes down)			118 people

Vitamin K

Calcium Score
Osteocalcin: improves
Pulse Wave Velocity: improves

Vitamin K: outcomes studied for Chronic Kidney Disease (CKD)
Outcome	Effect	Size	Studies	People
Calcium Score No effect		NoneNo effect		733 people
Osteocalcin	Improves (the measure goes up)		1 study	733 people
Pulse Wave Velocity	Improves (the measure goes down)			733 people

Soy Protein

Blood Urea Nitrogen
Serum Albumin: improves
C-Reactive Protein (CRP): improves

Soy Protein: outcomes studied for Chronic Kidney Disease (CKD)
Outcome	Effect	Size	Studies	People
Blood Urea Nitrogen No effect		NoneNo effect		522 people
Serum Albumin	Improves (the measure goes up)		1 study	522 people
C-Reactive Protein (CRP)	Improves (the measure goes down)			522 people
High-density lipoprotein (HDL)	Improves (the measure goes up)			522 people
Low-density lipoprotein (LDL)	Improves (the measure goes down)			522 people
Proteinuria	Improves (the measure goes up)			522 people
Serum Calcium	Improves (the measure goes up)			522 people
Serum Phosphorus	Changes; see studies			522 people
Total cholesterol	Improves (the measure goes down)			522 people
Triglycerides	Improves (the measure goes down)			522 people

Sodium Bicarbonate

Blood Pressure
Serum Bicarbonate: improves
Kidney Function: improves

Sodium Bicarbonate: outcomes studied for Chronic Kidney Disease (CKD)
Outcome	Effect	Size	Studies	People
Blood Pressure No effect		NoneNo effect		1,380 people
Serum Bicarbonate	Improves (the measure goes up)		26 studies	1,380 people
Kidney Function	Improves (the measure goes up)		1 study	1,380 people
Net Acid Excretion	Improves (the measure goes up)		1 study	108 people
Heart Failure Risk	Changes; see studies			1,380 people
Leg Edema	Changes; see studies			1,380 people
Plasma Total Carbon Dioxide	Improves (the measure goes up)			108 people

Resistant Starch

Blood Urea Nitrogen (BUN)
C-Reactive Protein (CRP)
Serum Phosphorus: changes; see studies

Resistant Starch: outcomes studied for Chronic Kidney Disease (CKD)
Outcome	Effect	Size	Studies	People
Blood Urea Nitrogen (BUN) No effect		NoneNo effect		203 people
C-Reactive Protein (CRP) No effect		NoneNo effect		167 people
Serum Phosphorus	Changes; see studies		2 studies	205 people
TNF-Alpha	Improves (the measure goes down)		1 study	116 people
High-density lipoprotein (HDL)	Improves (the measure goes up)			158 people
Interleukin 6	Improves (the measure goes down)			213 people
Kidney Function	Improves (the measure goes up)			197 people
Serum Albumin	Improves (the measure goes up)			284 people
Total cholesterol	Improves (the measure goes down)			158 people
Triglycerides	Improves (the measure goes down)			158 people
Uric Acid	Improves (the measure goes down)			168 people

Nicotinamide

Serum Calcium
Serum Phosphorus: changes; see studies

Nicotinamide: outcomes studied for Chronic Kidney Disease (CKD)
Grade	Outcome	Effect	Size	Studies	People	Studies list
	Serum Calcium No effect		NoneNo effect		219 people
	Serum Phosphorus	Changes; see studies		1 study	98 people

Chia seeds

Itching: improves

Chia seeds: outcomes studied for Chronic Kidney Disease (CKD)
Grade	Outcome	Effect	Size	Studies	People	Studies list
	Itching	Improves (the measure goes up)		1 study	5 people

Melatonin

Cerebral Blood Flow: improves

Melatonin: outcomes studied for Chronic Kidney Disease (CKD)
Grade	Outcome	Effect	Size	Studies	People	Studies list
	Cerebral Blood Flow	Improves (the measure goes up)		1 study	10 people

Curcumin

Vascular Function: improves

Curcumin: outcomes studied for Chronic Kidney Disease (CKD)
Grade	Outcome	Effect	Size	Studies	People	Studies list
	Vascular Function	Improves (the measure goes up)		1 study	88 people

Cocoa Extract

Kidney Oxygenation: improves

Cocoa Extract: outcomes studied for Chronic Kidney Disease (CKD)
Grade	Outcome	Effect	Size	Studies	People	Studies list
	Kidney Oxygenation	Improves (the measure goes up)		1 study	10 people

Key findings

Blood glucoseResveratrolImproves (the measure goes down)
C-Reactive Protein (CRP)Black seedImproves (the measure goes down)
InflammationFish OilImproves (the measure goes down)

The Chronic Kidney Disease (CKD) Supportive Care protocol

2 primary supplements · 2 supporting supplements

Omega-3 Fatty Acids2–4 g EPA/DHA daily
Coenzyme Q10100–300 mg daily

See the full protocol

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Support alongside medical care. These supplements are not a treatment for Chronic Kidney Disease (CKD). If you are being treated for it, talk to your clinician before adding one: supplements can interact with medicines.

The supplements graded A or B for Chronic Kidney Disease (CKD). Each opens third-party tested products for that supplement.

Grade B
Grade B
Grade B

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Studies cited

4 studies from PubMed

Mediterranean diet improves dyslipidemia and biomarkers in chronic renal failure patientsFood Funct · PMID 21776461
Safety and impact of the Mediterranean diet in patients with chronic kidney disease: a pilot randomized crossover trial.Front Nutr · PMID 39296514
Efficacy and safety of ketoanalogue supplementation combined with protein-restricted diets in advanced chronic kidney disease: a systematic review and meta-analysis.J Nephrol · PMID 39340710
Concentrated red grape juice exerts antioxidant, hypolipidemic, and antiinflammatory effects in both hemodialysis patients and healthy subjectsAm J Clin Nutr · PMID 16825703

Evidence by supplement

Key findings

The Chronic Kidney Disease (CKD) Supportive Care protocol

Shop the evidence-backed picks

Studies cited

Related conditions

Supplement stack for Chronic Kidney Disease (CKD)