Resveratrol

Resveratrol is a bioactive molecule found in plant sources such as grapes, peanuts, blueberries, and, famously, red wine. Resveratrol has anti-inflammatory and antioxidant properties that benefit cardiovascular function, glycemic control, and lipid metabolism. Although it’s promoted for lifespan extension, there’s no evidence for this in humans and limited evidence in animals.

Quick Answer

What it is

Resveratrol is a bioactive molecule found in plant sources such as grapes, peanuts, blueberries, and, famously, red wine. Resveratrol has anti-inflammatory and antioxidant properties that benefit cardiovascular function, glycemic control, and lipid metabolism.

Key findings

  • Grade B: Blood Pressure
  • Grade B: Blood Urea Nitrogen (BUN) (Osteoarthritis (OA))
  • Grade B: Body Mass Index (BMI) (Body Composition)

Safety

No specific caution or interaction language was detected in the current summary/outcome notes.

ℹ️ Quick Facts: Resveratrol

Quick Facts: Resveratrol

  • Best Evidence:Grade B
  • Conditions Studied:41
  • Research Outcomes:318
  • Grade B Findings:17
  • Key Effect:Type 2 Diabetes
Outcomes by grade:
A0
B17
C8
D10
41 conditions Β· 318 outcomes

Detailed Outcomes

Grade:
Effect:
Size:
Sort:
|
B
Blood Pressure
Small Improvement
small↓Improves
?
Vascular Function
↑Improves
?
Exercise Adaptations
↑Improves
?
Exercise-Induced Oxidation
1 study
↑Worsens
B
Blood Urea Nitrogen (BUN)
Small Decrease
17 studies
small↓Improves
?
Serum Albumin
10 studies
↑Improves
?
Uric Acid
4 studies
↓Improves
?
Kidney Function
↑Improves
?
Osteoarthritis Symptoms
1 study
↓Improves
?
Pain
↓Improves
B
Blood Urea Nitrogen (BUN)
Small Decrease
17 studies
small↓Improves
?
Serum Albumin
10 studies
↑Improves
?
Uric Acid
4 studies
↓Improves
?
Kidney Function
↑Improves
B
Blood Urea Nitrogen (BUN)
Small Decrease
17 studies
small↓Improves
?
Serum Albumin
10 studies
↑Improves
?
Uric Acid
4 studies
↓Improves
?
Kidney Function
↑Improves
B
Blood Urea Nitrogen (BUN)
Small Decrease
17 studies
small↓Improves
?
Serum Albumin
10 studies
↑Improves
?
Uric Acid
4 studies
↓Improves
?
Kidney Function
↑Improves
B
Blood Urea Nitrogen (BUN)
Small Decrease
17 studies
small↓Improves
?
Serum Albumin
10 studies
↑Improves
?
Uric Acid
4 studies
↓Improves
?
Kidney Function
↑Improves
B
Body Mass Index (BMI)
Small Decrease
10 studies
small↓Improves
?
Weight
↓Improves
?
Waist circumference
5 studies
↓Improves
?
Hip Circumference
3 studies
↓Improves
?
Waist-Hip Ratio
3 studies
↑Improves
B
Blood glucose
Small Improvement
small↓Improves
C
Adiponectin
Small Increase
1 study
small↑Improves
?
Body Mass Index (BMI)
25 studies
↓Improves
?
Weight
↓Improves
?
Blood Urea Nitrogen (BUN)
17 studies
↑Improves
?
Triglycerides
↓Improves
?
High-density lipoprotein (HDL)
14 studies
↑Improves
?
TNF-Alpha
12 studies
↓Improves
?
Blood Pressure
↓Improves
?
Vascular Function
↑Improves
?
Serum Albumin
10 studies
↑Improves
?
Body Fat
8 studies
↓Improves
?
Insulin Resistance
7 studies
↓Improves
?
HbA1c
6 studies
↓Improves
?
Insulin
6 studies
↑Worsens
?
Low-density lipoprotein (LDL)
6 studies
↓Improves
?
Liver Enzymes
↑Worsens
?
Total cholesterol
↓Improves
?
Waist circumference
5 studies
↓Improves
?
Uric Acid
4 studies
↓Improves
?
C-Reactive Protein (CRP)
↓Improves
?
Kidney Function
↑Improves
?
Superoxide Dismutase Activity
3 studies
↑Improves
?
Glycemic Control
↑Improves
?
Interleukin 6
2 studies
↓Improves
?
Oxidative Stress Biomarkers
↓Improves
?
Intercellular Adhesion Molecule 1
1 study
↑Worsens
?
Plasminogen Inhibitor-1
1 study
↑Improves
B
Blood glucose
Small Improvement
small↓Improves
?
Blood Urea Nitrogen (BUN)
17 studies
↑Improves
?
TNF-Alpha
15 studies
↓Improves
?
Serum Albumin
10 studies
↑Improves
?
Insulin Resistance
7 studies
↓Improves
?
Body Mass Index (BMI)
6 studies
↓Improves
?
HbA1c
6 studies
↓Improves
?
Insulin
6 studies
↑Worsens
?
Liver Enzymes
↑Worsens
?
Triglycerides
↓Improves
?
Blood Pressure
↓Improves
?
Total cholesterol
↓Improves
?
Uric Acid
4 studies
↓Improves
?
C-Reactive Protein (CRP)
↓Improves
?
Kidney Function
↑Improves
?
Interleukin 6
2 studies
↓Improves
?
Intercellular Adhesion Molecule 1
1 study
↑Worsens
?
Plasminogen Inhibitor-1
1 study
↑Improves
?
Vascular Function
↑Improves
B
Blood glucose
Small Improvement
small↓Improves
?
Body Mass Index (BMI)
25 studies
↓Improves
?
Weight
↓Improves
?
Waist circumference
11 studies
↓Improves
?
Body Fat
8 studies
↓Improves
?
Insulin Resistance
7 studies
↓Improves
?
HbA1c
6 studies
↓Improves
?
Insulin
6 studies
↑Worsens
?
Intercellular Adhesion Molecule 1
1 study
↑Worsens
?
Plasminogen Inhibitor-1
1 study
↑Improves
?
Vascular Function
↑Improves
B
Adiponectin
Small Increase
6 studies
small↑Improves
?
Body Mass Index (BMI)
25 studies
↓Improves
?
C-Reactive Protein (CRP)
↓Improves
?
Blood Urea Nitrogen (BUN)
17 studies
↑Improves
?
Total cholesterol
↓Improves
?
High-density lipoprotein (HDL)
15 studies
↑Improves
?
Low-density lipoprotein (LDL)
15 studies
↓Improves
?
Weight
↓Improves
?
Interleukin 6
13 studies
↓Improves
?
Glycemic Control
↑Improves
?
TNF-Alpha
12 studies
↓Improves
?
Vascular Function
↑Improves
?
HbA1c
10 studies
↓Improves
?
Serum Albumin
10 studies
↑Improves
?
Body Fat
8 studies
↓Improves
?
Leptin
8 studies
↑Improves
?
Waist circumference
7 studies
↓Improves
?
Blood glucose
↓Improves
?
Liver Enzymes
↑Worsens
?
Triglycerides
↓Improves
?
Blood Pressure
↓Improves
?
Insulin Resistance
4 studies
↓Improves
?
Uric Acid
4 studies
↓Improves
?
Kidney Function
↑Improves
?
Superoxide Dismutase Activity
3 studies
↑Improves
?
Insulin
1 study
↑Worsens
B
Adiponectin
Small Increase
6 studies
small↑Improves
?
Blood Pressure
↓Improves
?
Body Mass Index (BMI)
25 studies
↓Improves
?
C-Reactive Protein (CRP)
↓Improves
?
Blood Urea Nitrogen (BUN)
17 studies
↑Improves
?
Total cholesterol
↓Improves
?
High-density lipoprotein (HDL)
15 studies
↑Improves
?
Low-density lipoprotein (LDL)
15 studies
↓Improves
?
Weight
↓Improves
?
Interleukin 6
13 studies
↓Improves
?
Glycemic Control
↑Improves
?
TNF-Alpha
12 studies
↓Improves
?
Serum Albumin
10 studies
↑Improves
?
Blood glucose
↓Improves
?
Body Fat
8 studies
↓Improves
?
Leptin
8 studies
↑Improves
?
Insulin Resistance
7 studies
↓Improves
?
Waist circumference
7 studies
↓Improves
?
HbA1c
6 studies
↓Improves
?
Insulin
6 studies
↑Worsens
?
Uric Acid
4 studies
↓Improves
?
Vascular Function
↑Improves
?
Kidney Function
↑Improves
?
Superoxide Dismutase Activity
3 studies
↑Improves
?
Intercellular Adhesion Molecule 1
1 study
↑Worsens
?
Liver Enzymes
↑Worsens
?
Plasminogen Inhibitor-1
1 study
↑Improves
B
Adiponectin
Small Increase
6 studies
small↑Improves
?
Total cholesterol
↓Improves
?
High-density lipoprotein (HDL)
15 studies
↑Improves
?
Low-density lipoprotein (LDL)
15 studies
↓Improves
?
Weight
↓Improves
?
Glycemic Control
↑Improves
?
HbA1c
10 studies
↓Improves
?
Leptin
8 studies
↑Improves
?
Waist circumference
7 studies
↓Improves
?
Body Fat
1 study
↓Improves
B
Blood glucose
Small Improvement
small↓Improves
?
Creatinine
23 studies
↑Improves
?
Blood Urea Nitrogen (BUN)
17 studies
↑Improves
?
Blood Urea Nitrogen
16 studies
↑Improves
?
Serum Albumin
10 studies
↑Improves
?
Body Mass Index (BMI)
6 studies
↓Improves
?
Liver Enzymes
↑Worsens
?
Triglycerides
↓Improves
?
Blood Pressure
↓Improves
?
Insulin Resistance
4 studies
↓Improves
?
TNF-Alpha
4 studies
↓Improves
?
Total cholesterol
↓Improves
?
Uric Acid
4 studies
↓Improves
?
Kidney Function
↑Improves
?
C-Reactive Protein (CRP)
↓Improves
B
C-Reactive Protein (CRP)
Small Decrease
small↓Improves
?
Interleukin 6
2 studies
↓Improves
B
Inflammatory Bowel Disease Symptoms
Small Improvement
small↓Improves
?
Quality of Life
2 studies
↑Improves
?
Ulcerative Colitis Symptoms
2 studies
↓Improves
B
Inflammatory Bowel Disease Symptoms
Small Improvement
small↓Improves
?
Quality of Life
2 studies
↑Improves
?
Ulcerative Colitis Symptoms
2 studies
↓Improves
C
Blood Flow
Small Increase
small↑Improves
?
TNF-Alpha
15 studies
↓Improves
?
C-Reactive Protein (CRP)
↓Improves
?
Interleukin 6
2 studies
↓Improves
?
Low-density lipoprotein (LDL)
2 studies
↓Improves
?
Total cholesterol
↓Improves
?
Blood glucose
↓Improves
?
Blood Pressure
↓Improves
?
High-density lipoprotein (HDL)
1 study
↑Improves
?
Insulin
1 study
↑Worsens
?
Insulin Resistance
1 study
↓Improves
?
Intercellular Adhesion Molecule 1
1 study
↑Worsens
?
Left Ventricular Ejection Fraction
1 study
↑Improves
?
Plasminogen Inhibitor-1
1 study
↑Improves
?
Vascular Function
↑Improves
C
Blood glucose
Small Improvement
small↓Improves
?
Blood Pressure
↓Improves
?
Blood Urea Nitrogen (BUN)
17 studies
↑Improves
?
C-Reactive Protein (CRP)
↓Improves
?
Interleukin 6
15 studies
↓Improves
?
TNF-Alpha
15 studies
↓Improves
?
Vascular Function
↑Improves
?
Serum Albumin
10 studies
↑Improves
?
Uric Acid
4 studies
↓Improves
?
Kidney Function
↑Improves
?
Insulin
1 study
↑Worsens
?
Insulin Resistance
1 study
↓Improves
?
Intercellular Adhesion Molecule 1
1 study
↑Worsens
?
Low-density lipoprotein (LDL)
1 study
↓Improves
?
Plasminogen Inhibitor-1
1 study
↑Improves
?
Total cholesterol
↓Improves
C
Acne Symptoms
Moderate Improvement
moderate↓Improves
?
Body Mass Index (BMI)
25 studies
↓Improves
?
Weight
↓Improves
?
Blood Urea Nitrogen (BUN)
17 studies
↑Improves
?
Waist circumference
11 studies
↓Improves
?
Serum Albumin
10 studies
↑Improves
?
Body Fat
8 studies
↓Improves
?
Uric Acid
4 studies
↓Improves
?
C-Reactive Protein (CRP)
↓Improves
?
Follicle-Stimulating Hormone
3 studies
↑Improves
?
Kidney Function
↑Improves
?
Luteinizing Hormone
3 studies
↑Improves
?
Testosterone
↑Improves
?
DHEAS
2 studies
↑Improves
?
Prolactin
2 studies
↑Improves
?
Sex Hormone Binding Globulin
2 studies
↑Improves
?
Thyroid-Stimulating Hormone
2 studies
↑Improves
?
Total cholesterol
↓Improves
?
Excessive Hair Growth
1 study
↑Improves
?
Fertility
1 study
↑Improves
?
High-density lipoprotein (HDL)
1 study
↑Improves
?
Intercellular Adhesion Molecule 1
1 study
↑Worsens
?
Low-density lipoprotein (LDL)
1 study
↓Improves
?
Plasminogen Inhibitor-1
1 study
↑Improves
?
Triglycerides
↓Improves
?
Vascular Function
↑Improves
C
Blood Flow
Small Increase
small↑Improves
?
C-Reactive Protein (CRP)
↓Improves
?
High-density lipoprotein (HDL)
1 study
↑Improves
?
Low-density lipoprotein (LDL)
1 study
↓Improves
?
Total cholesterol
↓Improves
C
Cerebral Blood Flow
Small Increase
1 study
small↑Improves
?
Cognition
1 study
↑Improves
?
Fatigue Symptoms
1 study
↓Improves
C
Intercellular Adhesion Molecule 1
Small Decrease
1 study
small↓Improves
?
Plasminogen Inhibitor-1
1 study
↑Improves
?
Vascular Function
↑Improves
C
Blood glucose
Small Improvement
small↓Improves
?
Blood Pressure
↓Improves
?
Insulin
1 study
↑Worsens
?
Insulin Resistance
1 study
↓Improves
?
Low-density lipoprotein (LDL)
1 study
↓Improves
?
Total cholesterol
↓Improves
D
Body Fat
No effect
8 studies
none
?
Body Mass Index (BMI)
25 studies
↓Improves
?
Weight
↓Improves
?
Waist circumference
11 studies
↓Improves
D
Body Fat
No effect
8 studies
none
?
Body Mass Index (BMI)
25 studies
↓Improves
?
Weight
↓Improves
?
Waist circumference
11 studies
↓Improves
D
Body Fat
No effect
8 studies
none
?
Body Mass Index (BMI)
25 studies
↑Worsens
?
Weight
↑Worsens
?
Waist circumference
11 studies
↑Worsens
D
Bilirubin
No effect
5 studies
none
?
Blood Pressure
↓Improves
?
Body Mass Index (BMI)
25 studies
↓Improves
?
Weight
↓Improves
?
C-Reactive Protein (CRP)
↓Improves
?
Blood Urea Nitrogen (BUN)
17 studies
↑Improves
?
Liver Enzymes
↑Worsens
?
Interleukin 6
13 studies
↓Improves
?
TNF-Alpha
12 studies
↓Improves
?
Vascular Function
↑Improves
?
Waist circumference
11 studies
↓Improves
?
Serum Albumin
10 studies
↑Improves
?
Blood glucose
↓Improves
?
Body Fat
8 studies
↓Improves
?
Insulin Resistance
7 studies
↓Improves
?
HbA1c
6 studies
↓Improves
?
Insulin
6 studies
↑Worsens
?
Uric Acid
4 studies
↓Improves
?
Kidney Function
↑Improves
?
Superoxide Dismutase Activity
3 studies
↑Improves
?
Glycemic Control
↑Improves
?
Intercellular Adhesion Molecule 1
1 study
↑Worsens
?
Metabolic Rate
1 study
↑Improves
?
Plasminogen Inhibitor-1
1 study
↑Improves
?
Triglycerides
↓Improves
D
Bilirubin
No effect
5 studies
none
?
Liver Enzymes
↑Worsens
D
Bilirubin
No effect
5 studies
none
?
Liver Enzymes
↑Worsens
D
Bilirubin
No effect
5 studies
none
?
Liver Enzymes
↑Worsens
D
Upper Respiratory Tract Infection Risk
No effect
none
?
Upper Respiratory Tract Infection Symptoms
1 study
↓Improves
D
Upper Respiratory Tract Infection Risk
No effect
none
?
Upper Respiratory Tract Infection Symptoms
1 study
↓Improves
D
Upper Respiratory Tract Infection Risk
No effect
none
?
Upper Respiratory Tract Infection Symptoms
1 study
↓Improves
?
Aerobic Exercise Metrics
↑Improves
?
Acne Symptoms
↓Improves
?
Glycemic Control
↑Improves
?
Anaerobic Capacity
Small Detriment
1 study
small
?
Fat Oxidation
↑Improves
?
Glycogen
1 study
↑Improves
?
Oxygen Uptake
1 study
↑Improves
?
Power Output
1 study
↑Improves
?
DNA methylation
↑Worsens
?
Anaerobic Capacity
Small Detriment
1 study
small
?
Fat Oxidation
↑Improves
?
Glycogen
1 study
↑Improves
?
Oxygen Uptake
1 study
↑Improves
?
Glycemic Control
↑Improves
?
Acne Symptoms
↓Improves
?
Anaerobic Capacity
Small Detriment
1 study
small
?
Fat Oxidation
↑Improves
?
Glycogen
1 study
↑Improves
?
Oxygen Uptake
1 study
↑Improves
?
Power Output
1 study
↑Improves

Evidence by Condition

Best grade per condition (each condition may have multiple outcomes)

BType 2 Diabetes
2
↓Blood glucoseImproves↑AdiponectinImproves↓Body Mass Index (BMI)Improves
BAlcoholic Hepatitis
2
Bilirubin↑Liver EnzymesWorsens
BNonalcoholic Fatty Liver Disease (NAFLD)
1
↑AdiponectinImproves↓Body Mass Index (BMI)Improves↓C-Reactive Protein (CRP)Improves
BMetabolic Syndrome
1
↑AdiponectinImproves↓Blood PressureImproves↓Body Mass Index (BMI)Improves
BCardiovascular Disease
1
↓Blood glucoseImproves↑Blood Urea Nitrogen (BUN)Improves↓TNF-AlphaImproves
BOverweight
1
↓Blood glucoseImproves↓Body Mass Index (BMI)Improves↓WeightImproves
BChronic Kidney Disease (CKD)
1
↓Blood glucoseImproves↑CreatinineImproves↑Blood Urea Nitrogen (BUN)Improves
BOsteoarthritis (OA)
1
↓Blood Urea Nitrogen (BUN)Improves↑Serum AlbuminImproves↓Uric AcidImproves
BChronic Obstructive Pulmonary Disease (COPD)
1
↓Blood Urea Nitrogen (BUN)Improves↑Serum AlbuminImproves↓Uric AcidImproves
BBody Composition
1
↓Body Mass Index (BMI)Improves↓WeightImproves↓Waist circumferenceImproves
BDyslipidemia
1
↑AdiponectinImproves↓Total cholesterolImproves↑High-density lipoprotein (HDL)Improves
BHeart Failure
1
↓Blood Urea Nitrogen (BUN)Improves↑Serum AlbuminImproves↓Uric AcidImproves
BHepatic Encephalopathy
1
↓Blood Urea Nitrogen (BUN)Improves↑Serum AlbuminImproves↓Uric AcidImproves
BInflammatory Bowel Disease (IBD)
1
↓Inflammatory Bowel Disease SymptomsImproves↑Quality of LifeImproves↓Ulcerative Colitis SymptomsImproves
BKidney Health
1
↓Blood Urea Nitrogen (BUN)Improves↑Serum AlbuminImproves↓Uric AcidImproves
BStable Angina
1
↓C-Reactive Protein (CRP)Improves↓Interleukin 6Improves
BUlcerative Colitis
1
↓Inflammatory Bowel Disease SymptomsImproves↑Quality of LifeImproves↓Ulcerative Colitis SymptomsImproves
CCoronary Artery Disease (CAD)
1
↑Blood FlowImproves↓TNF-AlphaImproves↓C-Reactive Protein (CRP)Improves
CHigh Blood Pressure
1
↓Blood glucoseImproves↓Blood PressureImproves↑Blood Urea Nitrogen (BUN)Improves
CPolycystic Ovary Syndrome (PCOS)
1
↓Acne SymptomsImproves↓Body Mass Index (BMI)Improves↓WeightImproves

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