Condition
Inflammatory Bowel Disease (IBD)
Inflammatory bowel disease, which includes Crohn's disease and ulcerative colitis, is a long-term condition in which the immune system attacks the gut lining, causing inflammation, diarrhea, belly pain and fatigue. Among supplements, resveratrol has the best-supported findings, and symptoms improved in a small study. Curcumin showed no clear difference for Crohn's symptoms, and the resveratrol evidence is only moderate.
Sources: PMID 33960587
- Supplements studied
- 3
- Medicines and peptides
- 1
- Graded outcomes
- 3
- Trials
- 7
- People studied
- 2,766
Evidence by supplement
- Strong
- Moderate
- Limited
- Very limited
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Inflammatory Bowel Disease Symptoms Small Improvement | Improves (the measure goes down) | Small effect | 1 study | 105 people | ||
Studies that measured inflammatory bowel disease symptoms | ||||||
| Quality of Life | Improves (the measure goes up) | 105 people | ||||
| Ulcerative Colitis Symptoms | Improves (the measure goes down) | 105 people | ||||
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Crohn's Disease Symptoms No effect | NoneNo effect | 92 people | ||||
| Ulcerative Colitis Symptoms | Improves (the measure goes down) | 2 studies | 367 people | |||
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Inflammatory Bowel Disease Symptoms | Improves (the measure goes down) | 1 study | 1 person | |||
Studies that measured inflammatory bowel disease symptoms | ||||||
Prescription medicines and peptides studied, for context
Vasoactive Intestinal Peptide (VIP/Aviptadil)
- Inflammatory Bowel Disease: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Inflammatory Bowel Disease Preclinical: VIP levels downregulated during intestinal inflammation. Animal models show potent anti-inflammatory effects. Nanomedicine delivery systems (SSM) allow lower effective doses. No completed human RCTs for IBD. | Improves (the measure goes down) | Moderate effect | 3 studies |
Key findings
- Inflammatory Bowel Disease SymptomsImproves (the measure goes down)
- Crohn's Disease Symptoms
The Inflammatory Bowel Disease (IBD) Adjunctive Support protocol
2 primary supplements · 7 supporting supplements
- Curcumin1–3 g daily with piperine or as bioavailable formulation
- ProbioticsVSL#3: 450–3,600 billion CFU daily; or other high-potency multi-strain formulas
Shop the evidence-backed picks
Support alongside medical care. These supplements are not a treatment for Inflammatory Bowel Disease (IBD). If you are being treated for it, talk to your clinician before adding one: supplements can interact with medicines.
The collection holds the supplements we grade A or B for its theme, in third-party tested products where the catalog has them. It opens in our Fullscript store. You can look through it without signing in; Fullscript asks for a free account to order.
Or shop one supplement
The supplement graded A or B for Inflammatory Bowel Disease (IBD). Each opens third-party tested products for that supplement.
- Grade B
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Studies cited
5 studies from PubMed
- Effects of Low FODMAP Diet on Symptoms, Fecal Microbiome, and Markers of Inflammation in Patients With Quiescent Inflammatory Bowel Disease in a Randomized Trial
- A randomized, 6-wk trial of a low FODMAP diet in patients with inflammatory bowel disease
- Efficacy of the Autoimmune Protocol Diet for Inflammatory Bowel Disease
- An Autoimmune Protocol Diet Improves Patient-Reported Quality of Life in Inflammatory Bowel Disease
- Efficacy and safety of medical therapy for low bone mineral density in patients with inflammatory bowel disease: a meta-analysis and systematic review.