Condition
Periodontitis
Periodontitis is a serious gum infection in which bacteria and the body's own inflammatory response damage the soft tissue and bone that hold teeth in place, and it can lead to tooth loss. Among supplements, vitamin D and coenzyme Q10 have the strongest support, with the evidence rated moderate in hundreds of participants. Resveratrol trials found blood glucose improved, but that is a different outcome from gum health, and the evidence there is limited.
Sources: PMID 24695890; PMID 33480264
- Supplements studied
- 2
- Graded outcomes
- 1
- People studied
- 1,822
Evidence by supplement
- Strong
- Moderate
- Limited
- Very limited
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Blood glucose Small Improvement | Improves (the measure goes down) | Small effect | 7 studies | 871 people | ||
Studies that measured blood glucose
| ||||||
| Total cholesterol | Improves (the measure goes down) | 2 studies | 871 people | |||
| Blood Pressure | Improves (the measure goes down) | 1 study | 871 people | |||
Studies that measured blood pressure | ||||||
| Insulin | Changes; see studies | 871 people | ||||
| Insulin Resistance | Improves (the measure goes down) | 871 people | ||||
| Low-density lipoprotein (LDL) | Improves (the measure goes down) | 871 people | ||||
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Dental Health Metrics | Improves (the measure goes up) | 1 study | 951 people | |||
Studies that measured dental health metrics | ||||||
Key findings
- Blood glucoseImproves (the measure goes down)
The Periodontitis Support protocol
2 primary supplements · 3 supporting supplements
- Vitamin D2,000–4,000 IU daily
- Coenzyme Q10100–200 mg daily
Studies cited
100 studies from PubMed
- The effects of probiotic supplementation on cardiometabolic health in patients with prediabetes: a systematic review, meta-analysis, and GRADE assessment.
- Lactococcus lactis strain Plasma activates plasmacytoid dendritic cells and mitigates common cold-like symptoms in healthy adults: a meta-analysis of individual participant data.
- Probiotics and Immune Health: Current Knowledge and Future Perspectives
- Probiotics for Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis
- Resveratrol: A Potential Therapeutic Natural Polyphenol for Neurodegenerative Diseases Associated with Mitochondrial Dysfunction
- Resveratrol: An Overview of Clinical Trials in Human Cancer Prevention and Treatment
- Probiotics for Prevention and Treatment of Diarrhea: A Systematic Review and Meta-Analysis
- Probiotics for the Prevention and Treatment of Depression: A Systematic Review and Meta-Analysis
- Effects of Probiotics on Metabolic Syndrome: A Systematic Review of Randomized Clinical Trials
- Probiotics and Weight Loss: A Systematic Review and Meta-Analysis
- The Gut Microbiome, Probiotics, and Their Impact on Skin Health: A Review
- Resveratrol and Its Analogs: Potent Agents to Reverse Epithelial-to-Mesenchymal Transition in Tumors
- Resveratrol and Sirtuins: A Story of Living Long Healthy Life
- Therapeutic Potential of Resveratrol in Alzheimer's Disease: A Review of the Evidence
- Resveratrol as a Chemopreventive Agent: A Promising Molecule for Fighting Cancer
- Health Benefits of Probiotics: A Review
- Probiotics: Comprehensive Review of Growth Promotion Mechanisms and Action in Food Products
- Probiotics: Classification, Mode of Action and Role in Human Nutrition
- Resveratrol and Health - A Comprehensive Review of Human Clinical Trials
- Resveratrol: A Double-Edged Sword in Health Benefits
- Resveratrol and Caloric Restriction: The Role of Sirtuins in Aging and Age-Related Diseases
- The Multitarget Activity of Natural Bioactive Compounds in Parkinson's Disease: Role of Resveratrol
- Resveratrol: A New Treatment for Diseases Associated with Oxidative Stress
- Safety of Probiotics: A Comprehensive Review
- Probiotics, Prebiotics and Inflammation: A Review of the Science
- Probiotics and Healthy Ageing: A Systematic Review and Meta-Analysis
- Resveratrol-Based Compounds and Neurodegeneration: Recent Insight in Multitarget Neuroprotection
- An Overview of the Anticancer Properties of Resveratrol
- An Update on Resveratrol and Diabetes: From Metabolism to Clinical Trial Results
- World Gastroenterology Organisation Global Guidelines: Probiotics and Prebiotics
- Probiotics for Human Use: Current Advances and Future Perspectives
- Resveratrol Blunts the Positive Effects of Exercise Training on Cardiovascular Health in Aged Men
- Probiotics for people with cystic fibrosis.
- Probiotics for the prevention of gestational diabetes mellitus: A meta-analysis of randomized controlled trials.
- The effects of probiotics supplements on metabolic indices and clinical signs in patients with diabetic retinopathy, a randomized double blind clinical trial.
- Effect of applying Lactiplantibacillus plantarum subsp. plantarum N793 to the scalps of men and women with thinning hair: a randomized, double-blind, placebo-controlled, parallel-group study.
- Randomized Clinical Trial to Evaluate the Effect of Probiotic Intake on Androgenic Alopecia.
- Impact of probiotics on sleep quality and mood states in patients with insomnia: a systematic review and meta-analysis.
- Gaba-producing lactobacilli boost cognitive reactivity to negative mood without improving cognitive performance: A human Double-Blind Placebo-Controlled Cross-Over study.
- The effect of probiotic consumption on lipid profile, glycemic index, inflammatory markers, and liver function in NAFLD patients: A systematic review and meta-analysis of randomized controlled trials.
- Efficacy of probiotics in the treatment of oral mucositis in head and neck cancer patients: A systematic review and meta-analysis.
- The effect of probiotics on severe oral mucositis in cancer patients undergoing chemotherapy and/or radiotherapy: A meta-analysis.
- Oral probiotic supplementation to alleviate diarrhea induced by fluoropyrimidines or irinotecan-based chemotherapy: A systematic review and meta-analysis.
- The impact of probiotics on core autism symptoms - A systematic review and meta-analysis of randomized clinical trials.
- Efficacy and safety of Bacteroides fragilis BF839 for pediatric autism spectrum disorder: a randomized clinical trial.
- Probiotics for autism spectrum disorder: An updated systematic review and meta-analysis of effects on symptoms.
- The efficacy and safety of probiotics in the adjuvant treatment of psoriasis: a systematic review and meta-analysis of randomized controlled trials.
- Effects of probiotic supplementation on testosterone levels in healthy ageing men: A 12-week double-blind, placebo-controlled randomized clinical trial.
- A 12-Week, Single-Centre, Randomised, Double-Blind, Placebo-Controlled, Parallel-Design Clinical Trial for the Evaluation of the Efficacy and Safety of Lactiplantibacillus plantarum SKO-001 in Reducing Body Fat.
- Effects of oral supplementation of probiotics on body weight and visceral fat in obese patients: a meta-analysis and systematic review.
- The effects of probiotics administration during pregnancy on preeclampsia and associated maternal, fetal, and newborn outcomes: a systematic review and meta-analysis.
- Effects of probiotics supplementation on glycemic profile in adults with type 2 diabetes mellitus: A grade-assessed systematic review and dose-response meta-analysis of randomized controlled trials.
- The Effect of Probiotics on Obesity with Comorbid Depression: A Systematic Review and Meta-Analysis.
- A network meta-analysis of probiotics in the treatment of childhood asthma.
- Efficacy of probiotics as adjuvant therapy in bronchial asthma: a systematic review and meta-analysis.
- Efficacy and safety of Saccharomyces boulardii as an adjuvant therapy for the eradication of Helicobacter pylori: a meta-analysis.
- Efficacy of probiotics regimens for Helicobacter pylori eradication: A systematic review, pairwise, and network meta-analysis of randomized controlled trials.
- Effect of probiotics on C-reactive protein levels in schizophrenia: Evidence from a systematic review and meta-analysis.
- Probiotics Supplementation for Improving Glucolipid Parameters in Individuals with Prediabetes: A Systematic Review and Meta-Analysis of Randomized Trials.
- Systematic review and meta-analysis on probiotics as treatment for food allergies among pediatric patients: A 2024 update.
- Efficacy of Oral Probiotic Supplementation in Preventing Vulvovaginal Infections During Pregnancy: A Randomized and Placebo-Controlled Clinical Trial.
- Clinical effects of probiotics on the treatment of gingivitis and periodontitis: a systematic review and meta-analysis.
- Evaluation of the efficacy of probiotics in the chemoradiotherapy of colorectal cancer: a meta-analysis of Randomized Controlled Trials.
- Clinical efficacy of probiotic supplementation in the treatment of knee osteoarthritis: a meta-analysis.
- The effect of probiotics on select cognitive domains in mild cognitive impairment and Alzheimer's disease: A systematic review and meta-analysis.
- Efficacy of probiotic supplementation in influencing cognitive function in Alzheimer's disease: A systematic review and meta-analysis.
- Effectiveness of probiotic supplements on cognitive function in mild cognitive impairment and Alzheimer's disease: A meta-analysis of randomized controlled trials.
- Probiotics are a good choice for the treatment of bacterial vaginosis: a meta-analysis of randomized controlled trial
- Efficacy and safety of Saccharomyces boulardii CNCM I-745 for the treatment of pediatric acute diarrhea in China: a systematic review and meta-analysis.
- Efficacy of probiotics in reducing the duration and severity of acute gastroenteritis in children: A meta-analysis of randomized controlled trials.
- Investigating the effects of probiotics during the menopause transition: A systematic review & meta-analysis.
- Effects of probiotic supplements on bone mineral density and bone turnover markers in postmenopausal women: A systematic review.
- Impact of probiotic supplementation on serum levels of brain-derived neurotrophic factor: GRADE-based dose-response meta-analysis.
- Probiotic Supplementation and Inflammatory Status in Coronary Artery Disease: A Systematic Review and Meta-Analysis.
- Cardioprotection by resveratrol: A human clinical trial in patients with stable coronary artery disease
- The effects of resveratrol on glycemic control and cardiometabolic parameters in patients with T2DM: A systematic review and meta-analysis.
- Evidence-based nutritional and pharmacological interventions targeting chronic low-grade inflammation in middle-age and older adults: A systematic review and meta-analysis.
- Can resveratrol supplement change inflammatory mediators? A systematic review and meta-analysis on randomized clinical trials.
- Resveratrol supplementation efficiently improves endothelial health: A systematic review and meta-analysis of randomized controlled trials.
- Trans-resveratrol alters mammary promoter hypermethylation in women at increased risk for breast cancer
- Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: a double-blind, placebo-controlled, crossover investigation
- Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients
- The efficacy of resveratrol supplementation on inflammation and oxidative stress in type-2 diabetes mellitus patients: randomized double-blind placebo meta-analysis.
- Pilot Study of Resveratrol in Older Adults With Impaired Glucose Tolerance
- Effect of resveratrol on glucose control and insulin sensitivity: a meta-analysis of 11 randomized controlled trials.
- Resveratrol supplementation and type 2 diabetes: a systematic review and meta-analysis
- Influence of Age and Dose on the Effect of Resveratrol for Glycemic Control in Type 2 Diabetes Mellitus: Systematic Review and Meta-Analysis.
- Resveratrol treatment as an adjunct to pharmacological management in type 2 diabetes mellitus--systematic review and meta-analysis.
- Effects of Resveratrol on Metabolic Indicators in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis.
- Efficacy of resveratrol supplementation in patients with nonalcoholic fatty liver disease: A systematic review and meta-analysis of clinical trials
- The effects of resveratrol supplementation in patients with type 2 diabetes, metabolic syndrome, and nonalcoholic fatty liver disease: an umbrella review of meta-analyses of randomized controlled trials
- Effect of Resveratrol on Blood Lipid Levels in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis.
- Fine wine or sour grapes? A systematic review and meta-analysis of the impact of red wine polyphenols on vascular health
- The effects of resveratrol supplementation on biomarkers of inflammation and oxidative stress among patients with metabolic syndrome and related disorders: a systematic review and meta-analysis of randomized controlled trials.
- Resveratrol supplementation significantly influences obesity measures: a systematic review and dose-response meta-analysis of randomized controlled trials.
- Resveratrol may mildly improve renal function in the general adult population: A systematic review and meta-analysis of randomized controlled clinical trials.
- Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans
- Effects of resveratrol supplementation on liver enzymes: A systematic review and meta-analysis of randomised controlled trials.
- The Effects of Resveratrol Supplementation on Endothelial Function and Blood Pressures Among Patients with Metabolic Syndrome and Related Disorders: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
- Resveratrol supplementation does not augment performance adaptations or fibre-type-specific responses to high-intensity interval training in humans