Infertility
Infertility is usually defined as the inability to have a pregnancy that does not result in stillbirth or miscarriage after trying for at least one year.
Quick Answer
What it is
Infertility is usually defined as the inability to have a pregnancy that does not result in stillbirth or miscarriage after trying for at least one year.
Key findings
- Grade A: LH Surge Prevention (Cetrorelix (Cetrotide))
- Grade A: Clinical Pregnancy Rate (Cetrorelix (Cetrotide))
- Grade A: OHSS Prevention (Cetrorelix (Cetrotide))
Safety
- Phase 2 clinical trial showed kisspeptin-54 effectively triggered oocyte maturation in 95% of women at high risk of OHSS, with embryo formation in 90%.
- Only 7% of kisspeptin-treated women developed mild OHSS, with no moderate, severe, or critical cases - a significant improvement over standard hCG triggers in high-risk patients.
- Studies have high heterogeneity and risk of bias.
ℹ️ Quick Facts
Quick Facts: Infertility
- Supplements Studied:26
- Research Trials:34
- Total Participants:12,966
- Top Supplement:Maca (B)
Evidence-Based Protocol
Supplement stack ranked by research quality
Primary Stack (Tier 1)
Supports mitochondrial function in sperm and eggs, improving motility and oocyte quality
Transports fatty acids for energy production in sperm; improves sperm motility and morphology
Supporting Stack (Tier 2)
Essential for DNA synthesis in rapidly dividing cells; supports sperm production and early embryonic development
Critical for testosterone synthesis, sperm production, and maintaining sperm membrane integrity
How It Works
Infertility affects about 15% of couples and can have male, female, or combined factors. For men, sperm quality (count, motility, morphology) is key. For women, egg quality and ovarian function matter most. Both sperm and eggs are highly dependent on mitochondrial energy production, which declines with age and oxidative stress.
Expected timeline: Sperm production takes about 74 days, so improvements in male parameters take 2-3 months. Women should supplement for at least 3 months before conception attempts or IVF cycles.
Supplements for Infertility
Sorted by strength of evidence
Detailed Outcomes
Research Citations (1)
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