Alpha-Lipoic Acid
Alpha-lipoic acid (ALA) is an endogenous antioxidant involved in mitochondrial energy metabolism. Notable: Most evidence is C-grade or D-grade despite popularity. Best evidence is for diabetic neuropathy (IV administration - prescription in Germany), blood flow improvement, and inflammation reduction in RA. Often combined with L-carnitine. R-ALA is the biologically active form; supplements often contain racemic (R+S) mixture. Effects are short-lived due to rapid metabolism. May cause mild hypoglycemia.
Quick Answer
What it is
Alpha-lipoic acid (ALA) is an endogenous antioxidant involved in mitochondrial energy metabolism. Notable: Most evidence is C-grade or D-grade despite popularity.
Key findings
- Grade C: Blood glucose (Type 2 Diabetes)
- Grade C: Blood Flow
- Grade C: Inflammation (Rheumatoid Arthritis (RA))
Safety
No specific caution or interaction language was detected in the current summary/outcome notes.
ℹ️ Quick Facts: Alpha-Lipoic Acid
Quick Facts: Alpha-Lipoic Acid
- Best Evidence:Grade C
- Conditions Studied:20
- Research Outcomes:40
- Key Effect:Sickle Cell Disease
Detailed Outcomes
Evidence by Condition
Best grade per condition (each condition may have multiple outcomes)
Research Citations (25)
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