Astaxanthin

Astaxanthin is the red-pink carotenoid pigment giving salmon, krill, and algae their color. One of the most potent natural antioxidants (10x stronger than beta-carotene for singlet oxygen quenching). C-grade evidence for antioxidant enzyme profile improvement. D-grade for arterial stiffness (no effect). Mixed evidence for metabolic, skin, and eye health. Often marketed for exercise performance and aging but evidence is inconsistent. Derived from Haematococcus pluvialis algae or synthetic (algae preferred).

Quick Answer

What it is

Astaxanthin is the red-pink carotenoid pigment giving salmon, krill, and algae their color. One of the most potent natural antioxidants (10x stronger than beta-carotene for singlet oxygen quenching).

Key findings

  • Grade B: Anti-Oxidant Enzyme Profile (Overweight)
  • Grade C: Aerobic Exercise Metrics (Aerobic Exercise Performance)
  • Grade C: B Cell Count (Immune Health)

Safety

No specific caution or interaction language was detected in the current summary/outcome notes.

ℹ️ Quick Facts: Astaxanthin

Quick Facts: Astaxanthin

  • Best Evidence:Grade B
  • Conditions Studied:24
  • Research Outcomes:202
  • Grade B Findings:1
  • Key Effect:Overweight
Outcomes by grade:
A0
B1
C12
D13
24 conditions Β· 202 outcomes

Detailed Outcomes

Grade:
Effect:
Size:
Sort:
|
B
Anti-Oxidant Enzyme Profile
Moderate Increase
2 studies
moderate↑Improves
?
Oxidative Stress Biomarkers
↑Worsens
?
Apolipoprotein A
1 study
↑Improves
?
Apolipoprotein B
1 study
↑Worsens
?
High-density lipoprotein (HDL)
↑Improves
?
Low-density lipoprotein (LDL)
1 study
↑Worsens
?
Total cholesterol
↑Worsens
?
Triglycerides
↑Worsens
?
Weight
↑Worsens
C
Aerobic Exercise Metrics
Small Improvement
2 studies
small↑Improves
?
Blood Lactate (Exercise)
↑Worsens
?
Blood glucose
↑Worsens
?
Fat Oxidation
1 study
↑Improves
?
Fatigue Resistance
1 study
↑Worsens
?
Free Fatty Acids
1 study
↑Improves
?
Heart Rate
1 study
↑Worsens
?
Insulin
1 study
↑Worsens
?
Oxygen Cost of Exercise
1 study
↑Improves
?
Power Output
1 study
↑Improves
?
Rating of Perceived Exertion
↑Improves
?
Respiratory Exchange Ratio
1 study
↑Improves
C
Anti-Oxidant Enzyme Profile
Moderate Increase
1 study
moderate↑Improves
D
Arterial Stiffness
No effect
1 study
none
C
B Cell Count
Small Decrease
1 study
small↓Worsens
?
Liver Enzymes
↑Worsens
?
C-Reactive Protein (CRP)
↑Worsens
?
DNA Damage
2 studies
↑Worsens
?
High-density lipoprotein (HDL)
↑Improves
?
Low-density lipoprotein (LDL)
2 studies
↑Worsens
?
Lymphocyte Count
↑Improves
?
Neutrophil Count
2 studies
↑Improves
?
Total Antioxidant Capacity (TAC)
2 studies
↑Improves
?
Triglycerides
↑Worsens
?
White Blood Cell Count
2 studies
↑Improves
?
Basophil Count
1 study
↑Improves
?
Bilirubin
1 study
↑Worsens
?
Blood glucose
↑Worsens
?
Eosinophil count
↑Worsens
?
Estrogen
1 study
↑Worsens
?
Fibrinogen
1 study
↑Improves
?
Hematocrit
1 study
↑Improves
?
Hemoglobin
1 study
↑Improves
?
Inflammation
↑Worsens
?
Interferon Gamma
1 study
↑Improves
?
Interleukin 2
1 study
↑Improves
?
Interleukin 6
1 study
↑Worsens
?
Monocyte Count
1 study
↑Improves
?
Muscle Damage
1 study
↑Worsens
?
Natural Killer Cell Activity
1 study
↑Improves
?
Natural Killer Cell Content
1 study
↑Improves
?
Oxidative Stress Biomarkers
↑Worsens
?
Red Blood Cell Count
1 study
↑Improves
?
Serum Albumin
1 study
↑Improves
?
Serum Platelets
1 study
↑Improves
?
T Cell Count
1 study
↑Improves
?
TNF-Alpha
1 study
↑Worsens
?
Uric Acid
1 study
↑Worsens
C
High-density lipoprotein (HDL)
Small Improvement
small↑Improves
D
Carpal Tunnel Symptoms
No effect
1 study
none
?
Low-density lipoprotein (LDL)
1 study
↑Worsens
?
Total cholesterol
↑Worsens
C
Adiponectin
Small Increase
1 study
small↑Improves
?
Blood glucose
↑Worsens
?
Blood Pressure
1 study
↑Worsens
?
Fructosamine
1 study
↑Worsens
?
High-density lipoprotein (HDL)
↑Improves
?
Low-density lipoprotein (LDL)
1 study
↑Worsens
?
Total cholesterol
↑Worsens
?
Triglycerides
↑Worsens
?
vLDL-C
1 study
↑Worsens
C
Adiponectin
Small Increase
1 study
small↑Improves
?
Blood glucose
↑Worsens
?
Blood Pressure
1 study
↑Worsens
?
High-density lipoprotein (HDL)
↑Improves
?
Low-density lipoprotein (LDL)
1 study
↑Worsens
?
Total cholesterol
↑Worsens
?
Triglycerides
↑Worsens
?
vLDL-C
1 study
↑Worsens
C
Adiponectin
Small Increase
1 study
small↑Improves
?
Blood glucose
↑Worsens
?
Blood Pressure
1 study
↑Worsens
?
High-density lipoprotein (HDL)
↑Improves
?
Low-density lipoprotein (LDL)
1 study
↑Worsens
?
Total cholesterol
↑Worsens
?
Triglycerides
↑Worsens
?
Weight
↑Worsens
C
Aerobic Exercise Metrics
Small Improvement
1 study
small↑Improves
?
Blood glucose
↑Worsens
?
Blood Lactate (Exercise)
↑Worsens
?
Free Fatty Acids
1 study
↑Improves
?
Heart Rate
1 study
↑Worsens
?
Insulin
1 study
↑Worsens
?
Oxygen Cost of Exercise
1 study
↑Improves
?
Rating of Perceived Exertion
↑Improves
?
Respiratory Exchange Ratio
1 study
↑Improves
C
DNA Damage
Moderate Improvement
1 study
moderate↓Improves
?
Gamma-Glutamyltransferase
6 studies
↑Improves
?
Liver Enzymes
↑Worsens
?
Estrogen
1 study
↑Worsens
?
Fibrinogen
1 study
↑Improves
?
High-density lipoprotein (HDL)
↑Improves
?
Kidney Function
1 study
↑Improves
?
Low-density lipoprotein (LDL)
1 study
↑Worsens
?
Lymphocyte Count
↑Improves
?
Neutrophil Count
1 study
↑Improves
?
Total Antioxidant Capacity (TAC)
1 study
↑Improves
?
Triglycerides
↑Worsens
?
White Blood Cell Count
1 study
↑Improves
C
GERD Symptoms
Mixed effect
C
Adiponectin
Small Increase
1 study
small↑Improves
?
Blood glucose
↑Worsens
?
Blood Pressure
1 study
↑Worsens
?
High-density lipoprotein (HDL)
↑Improves
?
Low-density lipoprotein (LDL)
1 study
↑Worsens
?
Total cholesterol
↑Worsens
?
Triglycerides
↑Worsens
?
Weight
↑Worsens
C
Oxidative Stress Biomarkers
Small Decrease
small↓Improves
?
Total Antioxidant Capacity (TAC)
1 study
↑Improves
?
Uric Acid
1 study
↑Worsens
D
Blood glucose
No effect
none
?
High-density lipoprotein (HDL)
↑Improves
?
Low-density lipoprotein (LDL)
8 studies
↑Worsens
?
Total cholesterol
↑Worsens
?
Triglycerides
↑Worsens
?
Blood Pressure
5 studies
↑Worsens
?
Insulin
2 studies
↑Worsens
D
Fat Oxidation
No effect
4 studies
none
?
Processing Accuracy
15 studies
↑Improves
?
Reaction Time
13 studies
↑Improves
?
Motor Control
↑Improves
D
Fat Oxidation
No effect
4 studies
none
?
Processing Accuracy
15 studies
↑Improves
?
Reaction Time
13 studies
↑Improves
?
Motor Control
↑Improves
D
Blood glucose
No effect
none
?
High-density lipoprotein (HDL)
↑Improves
?
Low-density lipoprotein (LDL)
7 studies
↑Worsens
?
Total cholesterol
↑Worsens
?
Triglycerides
↑Worsens
?
Blood Pressure
4 studies
↑Worsens
?
Body Mass Index (BMI)
↑Worsens
D
Arterial Stiffness
No effect
1 study
none
D
Inflammation
No effect
none
D
Bilirubin
No effect
1 study
none
?
Skin Dryness
↑Improves
?
Skin Elasticity
↑Improves
?
Skin Quality
2 studies
↑Improves
?
Blood glucose
↑Worsens
?
HbA1c
1 study
↑Worsens
?
High-density lipoprotein (HDL)
↑Improves
?
Interleukin 1-alpha
1 study
↑Improves
?
Kidney Function
1 study
↑Improves
?
Low-density lipoprotein (LDL)
1 study
↑Worsens
?
Triglycerides
↑Worsens
?
Uric Acid
1 study
↑Worsens
?
UV Skin Damage
1 study
↑Worsens
?
Wrinkles
1 study
↑Improves
D
Blood Pressure
No effect
1 study
none
?
DNA Damage
1 study
↑Worsens
?
Estrogen
1 study
↑Worsens
?
Fibrinogen
1 study
↑Improves
?
Follicle-Stimulating Hormone
1 study
↑Improves
?
High-density lipoprotein (HDL)
↑Improves
?
Kidney Function
1 study
↑Improves
?
Liver Enzymes
↑Worsens
?
Low-density lipoprotein (LDL)
1 study
↑Worsens
?
Neutrophil Count
1 study
↑Improves
?
Total Antioxidant Capacity (TAC)
1 study
↑Improves
?
Triglycerides
↑Worsens
?
White Blood Cell Count
1 study
↑Improves
D
Bilirubin
No effect
1 study
none
?
Blood glucose
↑Worsens
?
HbA1c
1 study
↑Worsens
?
Hematocrit
1 study
↑Improves
?
High-density lipoprotein (HDL)
↑Improves
?
Intraocular Pressure
1 study
↑Improves
?
Kidney Function
1 study
↑Improves
?
Ocular Blood Flow
1 study
↑Improves
?
Oxidative Stress Biomarkers
↑Worsens
?
Serum Platelets
1 study
↑Improves
?
Total cholesterol
↑Worsens
?
Triglycerides
↑Worsens
?
White Blood Cell Count
1 study
↑Improves
D
Exercise-Induced Oxidation
No effect
none
?
Muscle Damage
1 study
↑Worsens
?
Oxidative Stress Biomarkers
↑Worsens
?
Training Volume
1 study
↑Improves
D
Ejaculate Volume
No effect
1 study
none
?
Oocyte Quality
3 studies
↑Improves
?
Oocyte Quantity
↑Improves
?
Fertility
↑Improves
?
Follicle-Stimulating Hormone
1 study
↑Improves
?
Inhibin B
1 study
↑Improves
?
Oxidative Stress Biomarkers
↑Worsens
?
Seminal Motility
1 study
↑Improves
?
Sperm Count
1 study
↑Improves
?
Sperm Quality
1 study
↑Improves
?
Superoxide Dismutase Activity
1 study
↑Improves
?
Testosterone
1 study
↑Improves
?
Total Antioxidant Capacity (TAC)
1 study
↑Improves
?
Inflammation
↑Worsens

Evidence by Condition

Best grade per condition (each condition may have multiple outcomes)

BOverweight
1
↑Anti-Oxidant Enzyme ProfileImproves↑Oxidative Stress BiomarkersWorsens↑Apolipoprotein AImproves
CCarpal Tunnel Syndrome
2
↑High-density lipoprotein (HDL)ImprovesCarpal Tunnel Symptoms↑Low-density lipoprotein (LDL)Worsens
CMetabolic Health
1
↑Anti-Oxidant Enzyme ProfileImprovesArterial Stiffness
CImmune Health
1
↓B Cell CountWorsens↑Liver EnzymesWorsens↑C-Reactive Protein (CRP)Worsens
CType 2 Diabetes
1
↑AdiponectinImproves↑Blood glucoseWorsens↑Blood PressureWorsens
CHigh Blood Pressure
1
↑AdiponectinImproves↑Blood glucoseWorsens↑Blood PressureWorsens
CHigh Cholesterol
1
↑AdiponectinImproves↑Blood glucoseWorsens↑Blood PressureWorsens
CCycling Performance
1
↑Aerobic Exercise MetricsImproves↑Blood glucoseWorsens↑Blood Lactate (Exercise)Worsens
CGeneral Liver Health
1
↓DNA DamageImproves↑Gamma-GlutamyltransferaseImproves↑Liver EnzymesWorsens
CIndigestion
1
GERD Symptoms
CWeight Loss & Maintenance
1
↑AdiponectinImproves↑Blood glucoseWorsens↑Blood PressureWorsens
CSoccer Performance
1
↓Oxidative Stress BiomarkersImproves↑Total Antioxidant Capacity (TAC)Improves↑Uric AcidWorsens
CAerobic Exercise Performance
1
↑Aerobic Exercise MetricsImproves↑Blood Lactate (Exercise)Worsens↑Blood glucoseWorsens
DGastroesophageal Reflux Disease (GERD)
1
Inflammation
DCardiovascular Disease
1
Blood glucose↑High-density lipoprotein (HDL)Improves↑Low-density lipoprotein (LDL)Worsens
DSkin Health
1
Bilirubin↑Skin DrynessImproves↑Skin ElasticityImproves
DMetabolic Syndrome
1
Blood glucose↑High-density lipoprotein (HDL)Improves↑Low-density lipoprotein (LDL)Worsens
DFatigue
1
Fat Oxidation↑Processing AccuracyImproves↑Reaction TimeImproves
DMenopause
1
Blood Pressure↑DNA DamageWorsens↑EstrogenWorsens
DEye Health
1
Bilirubin↑Blood glucoseWorsens↑HbA1cWorsens

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