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Condition

Colorectal Polyps

Colorectal polyps are small growths on the inner lining of the colon or rectum, and while most are harmless, some types called adenomas can slowly turn into colorectal cancer over time. Calcium and vitamin D have the most support as supplements people look at for polyps, with the evidence rated moderate for each, though little trial research on them has been reviewed here so far. Fiber and omega-3s also have moderate evidence, while the rest, such as folate, probiotics and green tea extract, rest on limited data.

Supplements studied
1
Graded outcomes
0
People studied
1,076

Evidence by supplement

  • Strong
  • Moderate
  • Limited
  • Very limited

1 supplement

Berberine: outcomes studied for Colorectal Polyps
GradeOutcomeEffectSizeStudiesPeopleStudies list
Colorectal Polyp IncidenceChanges; see studies1 study1,076 people

Studies that measured colorectal polyp incidence

The Colorectal Polyp Prevention Support protocol

2 primary supplements · 7 supporting supplements

  • Calcium1,000–1,200 mg daily with food
  • Vitamin D2,000–4,000 IU daily (maintain levels 40–60 ng/mL)

See the full protocol

Shop the evidence-backed picks

Support alongside medical care. These supplements are not a treatment for Colorectal Polyps. If you are being treated for it, talk to your clinician before adding one: supplements can interact with medicines.

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Studies cited

28 studies from PubMed

  1. Efficacy and Safety of Berberine Alone for Several Metabolic Disorders: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.Front Pharmacol, 2021 · PMID 33981233
  2. Berberine Ameliorates Metabolic Dysfunction in Obesity: A ReviewObes Rev, 2019 · PMID 31085515
  3. Berberine for NAFLD: A Systematic Review and Meta-AnalysisPhytomedicine, 2019 · PMID 30415781
  4. Berberine: Botanical Occurrence, Traditional Uses, Extraction Methods, and Relevance in HealthFront Pharmacol, 2018 · PMID 28220549
  5. Berberine: A Plant-Derived Alkaloid with Therapeutic ApplicationsOxid Med Cell Longev, 2018 · PMID 29404391
  6. Berberine and Gut Microbiota: Clinical Evidence and MechanismsPharmacol Res, 2018 · PMID 30076524
  7. Berberine Improves Glucogenesis and Lipid Metabolism in Diabetes: A Systematic ReviewBiomed Pharmacother, 2018 · PMID 29712638
  8. Safety and Tolerability of Berberine: A Systematic Review of Clinical StudiesComplement Ther Med, 2018 · PMID 29789093
  9. Effects of Berberine on Insulin Resistance: A Comprehensive ReviewPharmacol Res, 2017 · PMID 28853734
  10. The Role of Berberine in the Control of Metabolism: A ReviewEndocrinology, 2016 · PMID 27003073
  11. Molecular Targets of Berberine and Its Derivatives: Focus on Cardiovascular ProtectionExpert Opin Ther Targets, 2016 · PMID 27392742
  12. Effects of berberine on lipid profile in subjects with low cardiovascular riskExpert Opin Biol Ther, 2013 · PMID 23441841
  13. A network meta-analysis on the comparative effect of nutraceuticals on lipid profile in adults.Pharmacol Res · PMID 35988871
  14. The effects of berberine supplementation on cardiovascular risk factors in adults: A systematic review and dose-response meta-analysis.Front Nutr · PMID 36313096
  15. The Effect of Berberine on Metabolic Profiles in Type 2 Diabetic Patients: A Systematic Review and Meta-Analysis of Randomized Controlled TrialsOxid Med Cell Longev · PMID 34956436
  16. Berberine in the treatment of type 2 diabetes mellitus: a systemic review and meta-analysisEvid Based Complement Alternat Med · PMID 23118793
  17. Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberineJ Clin Endocrinol Metab · PMID 18397984
  18. Glucose-lowering effect of berberine on type 2 diabetes: A systematic review and meta-analysis.Front Pharmacol · PMID 36467075
  19. Effects of administering berberine alone or in combination on type 2 diabetes mellitus: a systematic review and meta-analysis.Front Pharmacol · PMID 39640489
  20. Overall and Sex-Specific Effect of Berberine for the Treatment of Dyslipidemia in Adults: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials.Drugs · PMID 36941490
  21. Efficacy of Berberine in Patients with Non-Alcoholic Fatty Liver DiseasePLoS One · PMID 26252777
  22. Effect of berberine administration on metabolic syndrome, insulin sensitivity, and insulin secretionMetab Syndr Relat Disord · PMID 23808999
  23. Efficacy and safety of berberine for congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathyAm J Cardiol · PMID 12860219
  24. Effects of berberine gelatin on recurrent aphthous stomatitis: a randomized, placebo-controlled, double-blind trial in a Chinese cohortOral Surg Oral Med Oral Pathol Oral Radiol · PMID 23246229
  25. Efficacy and safety of berberine for several cardiovascular diseases: A systematic review and meta-analysis of randomized controlled trials.Phytomedicine · PMID 36805484
  26. Efficacy and safety of berberine in preventing recurrence of colorectal adenomas: A systematic review and meta-analysis.J Ethnopharmacol · PMID 34509605
  27. Effects of berberine and barberry on anthropometric measures: A systematic review and meta-analysis of randomized controlled trialsComplement Ther Med · PMID 32147051
  28. The Effect of Berberine on Reproduction and Metabolism in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Randomized Control Trials.Evid Based Complement Alternat Med · PMID 31915452