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Dr. Grey AI

Supplement

Prebiotics

Prebiotics are plant fibers that the body can't digest but that feed the beneficial bacteria living in your gut. People mostly look at them around Clostridioides difficile infection, a gut infection that can follow antibiotics, and the evidence there is moderate, covering about 600 people. Elsewhere it is thinner: very limited studies found no clear difference in irritable bowel pain or bloating, or in body mass index in fatty liver disease.

Best evidence
Grade D
Conditions studied
4
Outcomes
13
Graded outcomes
0003

Evidence by condition

  • Strong
  • Moderate
  • Limited
  • Very limited

4 conditions

Irritable Bowel Syndrome (IBS): outcomes studied for Prebiotics
GradeOutcomeEffectSizeStudiesPeopleStudies list
Abdominal Pain

No effect

NoneNo effect8,315 people
Bloating

No effect

NoneNo effect8,315 people
Irritable Bowel Syndrome SymptomsImproves (the measure goes down)8,315 people
Quality of LifeImproves (the measure goes up)8,315 people
Nonalcoholic Fatty Liver Disease (NAFLD): outcomes studied for Prebiotics
GradeOutcomeEffectSizeStudiesPeopleStudies list
Body Mass Index (BMI)

No effect

NoneNo effect1,921 people
High-density lipoprotein (HDL)Improves (the measure goes up)1,921 people
Insulin ResistanceImproves (the measure goes down)1,921 people
Liver EnzymesChanges; see studies1,921 people
Low-density lipoprotein (LDL)Improves (the measure goes down)1,921 people
Total cholesterolImproves (the measure goes down)1,921 people
TriglyceridesImproves (the measure goes down)1,921 people

Prediabetes

  • Glycemic Control: improves
Prediabetes: outcomes studied for Prebiotics
GradeOutcomeEffectSizeStudiesPeopleStudies list
Glycemic ControlImproves (the measure goes up)1 study546 people

Malnutrition

  • Weight: changes; see studies
Malnutrition: outcomes studied for Prebiotics
GradeOutcomeEffectSizeStudiesPeopleStudies list
WeightChanges; see studies1 study213 people

Key findings

  • Abdominal PainIrritable Bowel Syndrome (IBS)
  • BloatingIrritable Bowel Syndrome (IBS)
  • Body Mass Index (BMI)Nonalcoholic Fatty Liver Disease (NAFLD)

Shop Prebiotics

Third-party tested Prebiotics products. The evidence above is limited, so read it before you buy.

  • Grade D

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Studies cited

1 study from PubMed

  1. Effect of Prebiotic Supplementation on Health Status in Adults with Prediabetes: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.J Nutr · PMID 39800313