Boron

Boron is a trace mineral often marketed for testosterone enhancement, but this claim lacks strong support. B-GRADE for C-reactive protein reduction (3 studies, 178 participants, moderate decrease). C-GRADE for estrogen effects (mixed), dysmenorrhea symptoms (moderate improvement), CRP in arthritis contexts, and knee pain. D-GRADE for blood glucose, body fat, and serum calcium (no effect). Anti-inflammatory effects are the most consistent finding. Testosterone claims are based on weak evidence from very small studies.

Quick Answer

What it is

Boron is a trace mineral often marketed for testosterone enhancement, but this claim lacks strong support. B-GRADE for C-reactive protein reduction (3 studies, 178 participants, moderate decrease).

Key findings

  • Grade B: C-Reactive Protein (CRP) (Immune Health)
  • Grade C: Estrogen (Menopause)
  • Grade C: Dysmenorrhea Symptoms (Primary Dysmenorrhea (Menstrual Cramps))

Safety

No specific caution or interaction language was detected in the current summary/outcome notes.

ℹ️ Quick Facts: Boron

Quick Facts: Boron

  • Best Evidence:Grade B
  • Conditions Studied:15
  • Research Outcomes:80
  • Grade B Findings:1
  • Key Effect:Immune Health
Outcomes by grade:
A0
B1
C10
D7
15 conditions Β· 80 outcomes

Detailed Outcomes

Grade:
Effect:
Size:
Sort:
|
B
C-Reactive Protein (CRP)
Moderate Decrease
moderate↓Improves
D
Blood glucose
No effect
1 study
none
?
Interleukin 6
2 studies
↑Worsens
?
Cortisol
1 study
↑Worsens
?
DHT
1 study
↑Improves
?
Erythrocyte Sedimentation Rate
1 study
↑Worsens
?
Estrogen
↑Worsens
?
Free Testosterone
1 study
↑Improves
?
High-density lipoprotein (HDL)
1 study
↑Improves
?
Inflammation
1 study
↑Worsens
?
Interleukin 1-alpha
1 study
↑Improves
?
Interleukin 1-beta
1 study
↑Worsens
?
Low-density lipoprotein (LDL)
1 study
↑Worsens
?
Monocyte Chemoattractant Protein-1
1 study
↑Improves
?
Rheumatoid Arthritis Symptoms
1 study
↑Worsens
?
Testosterone
↑Improves
?
TNF-Alpha
1 study
↑Worsens
?
Triglycerides
↑Worsens
C
Estrogen
Mixed effect
?
Follicle-Stimulating Hormone
1 study
↑Improves
?
Liver Enzymes
1 study
↑Worsens
?
Serum T3
1 study
↑Improves
?
Serum T4
1 study
↑Improves
?
Testosterone
↑Improves
?
Thyroid-Stimulating Hormone
1 study
↑Improves
?
White Blood Cell Count
1 study
↑Improves
C
Estrogen
Mixed effect
?
Testosterone
↑Improves
C
Dysmenorrhea Symptoms
Moderate Improvement
moderate↓Improves
?
PMS Symptoms
1 study
↑Worsens
C
C-Reactive Protein (CRP)
Moderate Decrease
moderate↓Improves
?
Erythrocyte Sedimentation Rate
1 study
↑Worsens
?
Fibrinogen
1 study
↑Improves
?
High-density lipoprotein (HDL)
1 study
↑Improves
?
Low-density lipoprotein (LDL)
1 study
↑Worsens
?
Total cholesterol
↑Worsens
C
C-Reactive Protein (CRP)
Moderate Decrease
moderate↓Improves
?
Erythrocyte Sedimentation Rate
1 study
↑Worsens
?
Interleukin 1-alpha
1 study
↑Improves
?
Interleukin 6
1 study
↑Worsens
?
Rheumatoid Arthritis Symptoms
1 study
↑Worsens
?
TNF-Alpha
1 study
↑Worsens
C
C-Reactive Protein (CRP)
Moderate Decrease
moderate↓Improves
?
High-density lipoprotein (HDL)
1 study
↑Improves
?
Low-density lipoprotein (LDL)
1 study
↑Worsens
?
N-terminal Prohormone of Brain Natriuretic Peptide
1 study
↑Improves
?
Total cholesterol
↑Worsens
?
Triglycerides
↑Worsens
C
C-Reactive Protein (CRP)
Moderate Decrease
moderate↓Improves
C
Pain
Moderate Improvement
moderate↓Improves
C
Range of Motion
Moderate Increase
1 study
moderate↑Improves
C
Kidney Stone Symptoms
Small Improvement
small↓Improves
D
Body Fat
No effect
1 study
none
?
Free Testosterone
1 study
↑Improves
?
Muscle Mass
1 study
↑Improves
?
Strength
1 study
↑Improves
?
Testosterone
↑Improves
D
Serum Calcium
No effect
1 study
none
?
Serum Magnesium
↑Improves
D
Blood glucose
No effect
1 study
none
?
C-Reactive Protein (CRP)
↑Worsens
?
High-density lipoprotein (HDL)
1 study
↑Improves
?
Homocysteine
1 study
↑Worsens
?
Interleukin 1-beta
1 study
↑Worsens
?
Interleukin 6
1 study
↑Worsens
?
Low-density lipoprotein (LDL)
1 study
↑Worsens
?
Monocyte Chemoattractant Protein-1
1 study
↑Improves
?
Total cholesterol
↑Worsens
?
Triglycerides
↑Worsens
D
Body Fat
No effect
1 study
none
D
Body Fat
No effect
1 study
none
?
Free Testosterone
1 study
↑Improves
?
Muscle Mass
1 study
↑Improves
?
Strength
1 study
↑Improves
?
Testosterone
↑Improves
D
Body Fat
No effect
1 study
none
?
Free Testosterone
1 study
↑Improves
?
Muscle Mass
1 study
↑Improves
?
Strength
1 study
↑Improves
?
Testosterone
↑Improves

Evidence by Condition

Best grade per condition (each condition may have multiple outcomes)

BImmune Health
1
↓C-Reactive Protein (CRP)ImprovesBlood glucose↑Interleukin 6Worsens
CMenopause
1
Estrogen↑Follicle-Stimulating HormoneImproves↑Liver EnzymesWorsens
CLow Testosterone
1
Estrogen↑TestosteroneImproves
CPrimary Dysmenorrhea (Menstrual Cramps)
1
↓Dysmenorrhea SymptomsImproves↑PMS SymptomsWorsens
COsteoarthritis (OA)
1
↓C-Reactive Protein (CRP)Improves↑Erythrocyte Sedimentation RateWorsens↑FibrinogenImproves
CRheumatoid Arthritis (RA)
1
↓C-Reactive Protein (CRP)Improves↑Erythrocyte Sedimentation RateWorsens↑Interleukin 1-alphaImproves
CCardiovascular Disease
1
↓C-Reactive Protein (CRP)Improves↑High-density lipoprotein (HDL)Improves↑Low-density lipoprotein (LDL)Worsens
CMetabolic Health
1
↓C-Reactive Protein (CRP)Improves
CAcute Nonspecific Knee Pain
1
↓PainImproves↑Range of MotionImproves
CKidney Stones
1
↓Kidney Stone SymptomsImproves
DBody Composition
1
Body Fat↑Free TestosteroneImproves↑Muscle MassImproves
DBone Health
1
Serum Calcium↑Serum MagnesiumImproves
DDyslipidemia
1
Blood glucose↑C-Reactive Protein (CRP)Worsens↑High-density lipoprotein (HDL)Improves
DGeneral Athletic Performance
1
Body Fat↑Free TestosteroneImproves↑Muscle MassImproves
DMuscle Size & Strength
1
Body Fat↑Free TestosteroneImproves↑Muscle MassImproves

Research Citations (11)

The adjuvant use of calcium fructoborate and borax with etanercept in patients with rheumatoid arthritis: Pilot study
PMID: 28163961
Effects of Calcium Fructoborate on Levels of C-Reactive Protein, Total Cholesterol, Low-Density Lipoprotein, Triglycerides, IL-1Ξ², IL-6, and MCP-1: a Double-blind, Placebo-controlled Clinical Study
PMID: 25433580
Comparative effects of daily and weekly boron supplementation on plasma steroid hormones and proinflammatory cytokines
PMID: 21129941
Effects of boron supplementation on the severity and duration of pain in primary dysmenorrhea
PMID: 25906949
Plasma boron and the effects of boron supplementation in males
PMID: 7889885
Effect of dietary boron on mineral, estrogen, and testosterone metabolism in postmenopausal women
PMID: 3678698
Preliminary evidence hints at a protective role for boron in urolithiasis
PMID: 22385047
A double-blind, placebo-controlled pilot study to evaluate the effect of calcium fructoborate on systemic inflammation and dyslipidemia markers for middle-aged people with primary osteoarthritis
PMID: 21607703
Effect of boron supplementation on blood and urinary calcium, magnesium, and phosphorus, and urinary boron in athletic and sedentary women
PMID: 7840072
Oral resveratrol and calcium fructoborate supplementation in subjects with stable angina pectoris: effects on lipid profiles, inflammation markers, and quality of life
PMID: 23153742

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