Leucic acid (also known as α-hydroxyisocaproic acid or HICA) is a leucine metabolite touted to have anabolic properties. Although it appears to be effective following oral supplementation, comparisons to leucine or HMB do not exist.
Leucic acid (also known as α-hydroxyisocaproic acid or HICA) is a leucine metabolite touted to have anabolic properties. Although it appears to be effective following oral supplementation, comparisons to leucine or HMB do not exist.
No specific caution or interaction language was detected in the current summary/outcome notes.
Best grade per condition (each condition may have multiple outcomes)
5 shared conditions · 49 outcomes
Glutamine is an amino acid that may benefit the body when it is under a period of great physical stress, such as after surgery, burns, or radiation exposure.
5 shared conditions · 433 outcomes
Creatine is among the most well-studied and effective supplements for improving exercise performance. It does this mainly by increasing energy availability during high-intensity activity. Creatine may also provide cognitive and mental health benefits in some contexts.
5 shared conditions · 82 outcomes
Beta-alanine is a non-essential amino acid that increases muscle carnosine, buffering acid during high-intensity exercise. B-GRADE evidence for anaerobic capacity (18 RCTs, 331 participants, small improvement). Works best for exercise lasting 1-10 minutes. The 'tingles' (paresthesia) are harmless but annoying. One of the most evidence-backed sports supplements alongside creatine and caffeine. Does NOT improve aerobic exercise (D-grade).
4 shared conditions · 197 outcomes
Whey protein is one of the two high-quality proteins derived from cow’s milk (casein being the other). Its high digestibility, quick absorption, and well-researched benefits for muscle gain and cardiometabolic health make it a popular protein supplement among athletes and older adults.
4 shared conditions · 100 outcomes
Tribulus terrestris is a plant whose root and fruits are used in Ayurvedic medicine for male virility and general vitality, respectively. It is also used in Traditional Chinese Medicine. It appears to reduce symptoms of sexual dysfunction (but not improve testosterone levels) in men and women and might improve metabolic health as well.
4 shared conditions · 304 outcomes
Spirulina, commonly known as “blue-green algae”, is a nontoxic cyanobacterium that is rich in various nutrients and bioactive pigments and polyphenols. Spirulina contains many antioxidant compounds and could have beneficial cardiometabolic effects.
4 shared conditions · 228 outcomes
Panax ginseng is commonly referred to as “Korean ginseng”. It appears to be effective for mood, immunity, and cognition, but is subpar for erectile function, testosterone, and exercise performance.
4 shared conditions · 248 outcomes
Magnesium is an essential dietary mineral that is involved in energy production, nervous system function, blood pressure regulation, and blood glucose control. A lack of magnesium in the diet — which is common in modern societies — is associated with an increased risk of diabetes, cardiovascular disease, and other health conditions.