Theanine

Theanine, also commonly referred to as L-theanine, is a naturally occurring amino acid found in tea. Supplementation with L-theanine may help reduce stress and anxiety and might improve sleep quality and some aspects of cognitive function.

Quick Answer

What it is

Theanine, also commonly referred to as L-theanine, is a naturally occurring amino acid found in tea. Supplementation with L-theanine may help reduce stress and anxiety and might improve sleep quality and some aspects of cognitive function.

Key findings

  • Grade B: Anxiety Symptoms (Stress)
  • Grade D: Alertness (Cognitive Improvement)
  • Grade D: Aerobic Exercise Metrics (Aerobic Exercise Performance)

Safety

No specific caution or interaction language was detected in the current summary/outcome notes.

ℹ️ Quick Facts: Theanine

Quick Facts: Theanine

  • Best Evidence:Grade B
  • Conditions Studied:15
  • Research Outcomes:155
  • Grade B Findings:1
  • Key Effect:Focus & Attention
Outcomes by grade:
A0
B1
C10
D5
15 conditions · 155 outcomes

Detailed Outcomes

Grade:
Effect:
Size:
Sort:
|
B
Anxiety Symptoms
Small Improvement
smallImproves
?
Stress Signs and Symptoms
Improves
?
Attention
Improves
?
Cognition
1 study
Improves
?
Cortisol
Improves
?
Depression Symptoms
1 study
Improves
?
Executive Function
Improves
?
Heart Rate
Improves
?
Mood
1 study
Improves
?
Motor Speed
1 study
Improves
?
Salivary Alpha-Amylase
Improves
?
Sleep Disturbance Signs and Symptoms
1 study
Improves
?
Sleep Duration
1 study
Improves
?
Sleep Latency
1 study
Improves
?
Sleep Quality
Improves
?
Verbal Fluency
1 study
Improves
?
Verbal Memory
1 study
Improves
?
Working Memory
1 study
Improves
C
Anxiety Symptoms
Small Improvement
smallImproves
D
Alertness
No effect
3 studies
none
?
Attention
Improves
?
Reaction Time
Improves
?
Executive Function
Improves
?
Processing Accuracy
3 studies
Improves
?
Working Memory
3 studies
Improves
?
Blood Pressure
2 studies
Improves
?
Subjective Well-Being
Improves
?
Cortisol
Improves
?
Depression Symptoms
1 study
Improves
?
Fatigue Symptoms
1 study
Improves
?
Headaches
1 study
Improves
?
Motor Speed
1 study
Improves
?
Numerical Memory
1 study
Improves
?
Prepulse Inhibition
Improves
?
Processing Speed
1 study
Improves
?
Sedation
1 study
Improves
?
Sleep Disturbance Signs and Symptoms
1 study
Improves
?
Sleep Latency
1 study
Improves
?
Sleep Quality
Improves
?
Verbal Fluency
1 study
Improves
?
Verbal Memory
1 study
Improves
C
Anxiety Symptoms
Small Improvement
smallImproves
?
Attention
Improves
?
Reaction Time
Improves
?
Executive Function
Improves
?
Heart Rate
Improves
?
Processing Accuracy
1 study
Improves
?
Sedation
1 study
Improves
?
Working Memory
1 study
Improves
C
Anxiety Symptoms
Small Improvement
smallImproves
?
Sleep Quality
Improves
?
Sleep Latency
10 studies
Improves
?
Day-Time Dysfunction
9 studies
Improves
?
Attention
Improves
?
Depression Symptoms
1 study
Improves
?
Executive Function
Improves
?
Insomnia Signs and Symptoms
Improves
?
Motor Speed
1 study
Improves
?
Sleep Disturbance Signs and Symptoms
1 study
Improves
?
Verbal Fluency
1 study
Improves
?
Verbal Memory
1 study
Improves
?
Working Memory
1 study
Improves
C
Anxiety Symptoms
Small Improvement
smallImproves
?
Blood Pressure
3 studies
Improves
?
Heart Rate
Improves
?
Reaction Time
Improves
?
Vigor/Activity
1 study
Improves
C
Anxiety Symptoms
Small Improvement
smallImproves
?
Granulocyte Count
1 study
Improves
?
Heart Rate
Improves
?
Interferon Gamma
1 study
Improves
?
Interleukin 10
1 study
Improves
?
Interleukin 2
1 study
Improves
?
Interleukin 4
Improves
?
Lymphocyte Count
1 study
Improves
?
Natural Killer Cell Content
1 study
Improves
?
Stress Signs and Symptoms
Improves
?
Total Antioxidant Capacity (TAC)
1 study
Improves
?
Treg Cells
1 study
Improves
?
White Blood Cell Count
1 study
Improves
C
Anxiety Symptoms
Small Improvement
smallImproves
?
Cortisol
Improves
?
DHEAS
1 study
Improves
?
Insulin
1 study
Worsens
?
Schizophrenia symptoms
1 study
Improves
?
Serum BDNF
1 study
Improves
?
Serum DHEA
1 study
Improves
?
Subjective Well-Being
Improves
?
Total cholesterol
1 study
Improves
C
Anxiety Symptoms
Small Improvement
smallImproves
?
Attention
Improves
?
Depression Symptoms
1 study
Improves
?
Executive Function
Improves
?
Motor Speed
1 study
Improves
?
Sleep Quality
Improves
?
Verbal Fluency
1 study
Improves
?
Verbal Memory
1 study
Improves
?
Working Memory
1 study
Improves
C
Anxiety Symptoms
Small Improvement
smallImproves
?
Depression Symptoms
1 study
Improves
?
Insomnia Signs and Symptoms
Improves
C
Anxiety Symptoms
Small Improvement
smallImproves
?
Heart Rate
Improves
?
Stress Signs and Symptoms
Improves
C
Anxiety Symptoms
Small Improvement
smallImproves
?
Schizophrenia symptoms
1 study
Improves
?
Subjective Well-Being
Improves
D
Alertness
No effect
3 studies
none
?
Subjective Well-Being
Improves
?
Attention
Improves
?
Anxiety Symptoms
Improves
?
Cortisol
Improves
?
Executive Function
Improves
?
Fatigue Symptoms
1 study
Improves
?
Headaches
1 study
Improves
?
Heart Rate
Improves
?
Numerical Memory
1 study
Improves
?
Processing Accuracy
1 study
Improves
?
Processing Speed
1 study
Improves
?
Reaction Time
Improves
?
Vigor/Activity
1 study
Improves
?
Working Memory
1 study
Improves
D
Alertness
No effect
1 study
none
?
Anxiety Symptoms
Improves
?
Subjective Well-Being
Improves
?
Cortisol
Improves
?
Executive Function
Improves
?
Stress Signs and Symptoms
Improves
?
Vigor/Activity
1 study
Improves
D
Aerobic Exercise Metrics
No effect
1 study
none
?
Blood Lactate (Exercise)
1 study
Worsens
?
Interferon Gamma
1 study
Improves
?
Interleukin 10
1 study
Improves
?
Interleukin 2
1 study
Improves
?
Interleukin 4
Improves
?
Lymphocyte Count
1 study
Improves
?
Natural Killer Cell Content
1 study
Improves
?
Power Output
1 study
Improves
?
Total Antioxidant Capacity (TAC)
1 study
Improves
?
Treg Cells
1 study
Improves
?
White Blood Cell Count
1 study
Improves
D
Aerobic Exercise Metrics
No effect
1 study
none
?
Blood Lactate (Exercise)
1 study
Worsens
?
Granulocyte Count
1 study
Improves
?
Interferon Gamma
1 study
Improves
?
Interleukin 10
1 study
Improves
?
Interleukin 2
1 study
Improves
?
Interleukin 4
Improves
?
Lymphocyte Count
1 study
Improves
?
Natural Killer Cell Content
1 study
Improves
?
Power Output
1 study
Improves
?
Total Antioxidant Capacity (TAC)
1 study
Improves
?
Treg Cells
1 study
Improves
?
White Blood Cell Count
1 study
Improves
?
Sleep Quality
Improves

Evidence by Condition

Best grade per condition (each condition may have multiple outcomes)

BFocus & Attention
2
Anxiety SymptomsImprovesAttentionImprovesReaction TimeImproves
BStress
1
Anxiety SymptomsImprovesStress Signs and SymptomsImprovesAttentionImproves
CCognitive Improvement
2
Anxiety SymptomsImprovesAlertnessAttentionImproves
CSleep Health
1
Anxiety SymptomsImprovesSleep QualityImprovesSleep LatencyImproves
CImmune Health
1
Anxiety SymptomsImprovesGranulocyte CountImprovesHeart RateImproves
CSchizophrenia
1
Anxiety SymptomsImprovesCortisolImprovesDHEASImproves
CDepression
1
Anxiety SymptomsImprovesAttentionImprovesDepression SymptomsImproves
CGeneralized Anxiety Disorder (GAD)
1
Anxiety SymptomsImprovesDepression SymptomsImprovesInsomnia Signs and SymptomsImproves
CMetabolic Health
1
Anxiety SymptomsImprovesHeart RateImprovesStress Signs and SymptomsImproves
CSchizoaffective Disorder
1
Anxiety SymptomsImprovesSchizophrenia symptomsImprovesSubjective Well-BeingImproves
DMental Resilience
1
AlertnessAnxiety SymptomsImprovesSubjective Well-BeingImproves
DMood Improvement
1
AlertnessSubjective Well-BeingImprovesAttentionImproves
DAerobic Exercise Performance
1
Aerobic Exercise MetricsBlood Lactate (Exercise)WorsensInterferon GammaImproves
DGeneral Athletic Performance
1
Aerobic Exercise MetricsBlood Lactate (Exercise)WorsensGranulocyte CountImproves

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