Rhodiola Rosea

Rhodiola rosea, often called “rhodiola” for short, is a plant in the genus Rhodiola that’s used as an herbal supplement with adaptogenic properties that help to provide general resistance to stress. Although its mechanisms of action are not completely understood, it is clear that rhodiola increases resilience to stress at both the cellular and systemic levels.

Quick Answer

What it is

Rhodiola rosea, often called “rhodiola” for short, is a plant in the genus Rhodiola that’s used as an herbal supplement with adaptogenic properties that help to provide general resistance to stress. Although its mechanisms of action are not completely understood, it is clear that rhodiola increases resilience to stress at both the cellular and systemic levels.

Key findings

  • Grade B: Aerobic Exercise Metrics (Aerobic Exercise Performance)
  • Grade B: Depression Symptoms (Depression)
  • Grade B: Attention (Fatigue)

Safety

No specific caution or interaction language was detected in the current summary/outcome notes.

ℹ️ Quick Facts: Rhodiola Rosea

Quick Facts: Rhodiola Rosea

  • Best Evidence:Grade B
  • Conditions Studied:16
  • Research Outcomes:159
  • Grade B Findings:6
  • Key Effect:Aerobic Exercise Performance
Outcomes by grade:
A0
B6
C9
D3
16 conditions · 159 outcomes

Detailed Outcomes

Grade:
Effect:
Size:
Sort:
|
B
Aerobic Exercise Metrics
Small Improvement
11 studies
smallImproves
?
Creatine Kinase
8 studies
Worsens
?
Blood Lactate (Exercise)
7 studies
Worsens
?
Superoxide Dismutase Activity
6 studies
Improves
?
Total Antioxidant Capacity (TAC)
Improves
?
Oxidative Stress Biomarkers
5 studies
Improves
?
C-Reactive Protein (CRP)
Improves
?
Interleukin 6
3 studies
Improves
?
Cortisol
Improves
?
Fatigue Symptoms
2 studies
Improves
?
Heart Rate
2 studies
Improves
?
Power Output
2 studies
Improves
?
Reaction Time
2 studies
Improves
?
Alertness
1 study
Improves
?
Anti-Oxidant Enzyme Profile
1 study
Improves
?
Depression Symptoms
Improves
?
Growth Hormone
1 study
Improves
?
Rating of Perceived Exertion
1 study
Improves
?
Testosterone
1 study
Improves
?
Vigor/Activity
1 study
Improves
?
Weight
Improves
B
Depression Symptoms
Small Improvement
smallImproves
?
Insomnia Signs and Symptoms
Improves
?
Subjective Well-Being
1 study
Improves
B
Attention
Small Improvement
2 studies
smallImproves
?
Fatigue Symptoms
3 studies
Improves
?
Depression Symptoms
Improves
?
Stress Signs and Symptoms
Improves
?
Cortisol
Improves
?
Pain
1 study
Improves
?
Social Functioning
Improves
?
Subjective Well-Being
1 study
Improves
B
Anxiety Symptoms
Small Improvement
2 studies
smallImproves
?
Depression Symptoms
Improves
?
Fatigue Symptoms
3 studies
Improves
?
Stress Signs and Symptoms
Improves
?
Attention
2 studies
Improves
?
Cortisol
Improves
?
Libido
1 study
Improves
?
Reaction Time
1 study
Improves
?
Sexual Function
1 study
Improves
?
Sleep Deprivation Symptoms
1 study
Improves
?
Sleep Quality
1 study
Improves
?
Social Functioning
Improves
?
Subjective Well-Being
1 study
Improves
?
Vigor/Activity
1 study
Improves
B
C-Reactive Protein (CRP)
Small Decrease
smallImproves
?
Creatine Kinase
2 studies
Worsens
?
Interleukin 6
2 studies
Improves
?
Muscle Damage
2 studies
Worsens
?
Granulocyte-colony stimulating factor
1 study
Improves
?
Interleukin 10
1 study
Improves
?
Interleukin 8
1 study
Worsens
?
Lymphocyte Count
1 study
Improves
?
Monocyte Chemoattractant Protein-1
Improves
?
Monocyte Count
1 study
Improves
?
Muscle Soreness
1 study
Improves
?
Neutrophil Count
1 study
Improves
?
TNF-Alpha
1 study
Improves
B
C-Reactive Protein (CRP)
Small Decrease
smallImproves
?
Lung Function
Improves
?
Glutathione (GSH)
2 studies
Improves
?
N-terminal Prohormone of Brain Natriuretic Peptide
2 studies
Improves
?
Oxidative Stress Biomarkers
2 studies
Improves
?
Superoxide Dismutase Activity
2 studies
Improves
?
Total Antioxidant Capacity (TAC)
Improves
C
Alertness
Small Improvement
1 study
smallImproves
C
Attention
Small Improvement
1 study
smallImproves
?
Fatigue Symptoms
4 studies
Improves
?
Cognition
Improves
?
Cortisol
Improves
?
Subjective Well-Being
2 studies
Improves
?
Creatine Kinase
1 study
Worsens
?
Depression Symptoms
Improves
?
Growth Hormone
1 study
Improves
?
Heart Rate
1 study
Improves
?
Oxidative Stress Biomarkers
1 study
Improves
?
Processing Accuracy
1 study
Improves
?
Reaction Time
1 study
Improves
?
Stress Signs and Symptoms
Improves
?
Testosterone
1 study
Improves
C
Alertness
Small Improvement
1 study
smallImproves
?
Cognition
Improves
?
Fatigue Symptoms
3 studies
Improves
?
Subjective Well-Being
2 studies
Improves
?
Anti-Oxidant Enzyme Profile
1 study
Improves
?
Cortisol
Improves
?
Creatine Kinase
1 study
Worsens
?
Growth Hormone
1 study
Improves
?
Oxidative Stress Biomarkers
1 study
Improves
?
Processing Accuracy
1 study
Improves
?
Reaction Time
1 study
Improves
?
Testosterone
1 study
Improves
C
Aerobic Exercise Metrics
Small Improvement
1 study
smallImproves
?
Fatigue Symptoms
2 studies
Improves
?
Power Output
2 studies
Improves
?
Reaction Time
2 studies
Improves
?
Alertness
1 study
Improves
?
Anti-Oxidant Enzyme Profile
1 study
Improves
?
Attention
1 study
Improves
?
Blood Lactate (Exercise)
1 study
Worsens
?
Cognition
Improves
?
Cortisol
Improves
?
Creatine Kinase
1 study
Worsens
?
Growth Hormone
1 study
Improves
?
Heart Rate
1 study
Improves
?
Oxidative Stress Biomarkers
1 study
Improves
?
Subjective Well-Being
1 study
Improves
?
Testosterone
1 study
Improves
?
Total Antioxidant Capacity (TAC)
Improves
?
Weight
Improves
C
Aerobic Exercise Metrics
Small Improvement
1 study
smallImproves
?
Rating of Perceived Exertion
2 studies
Improves
?
Blood Lactate (Exercise)
1 study
Worsens
?
Carbohydrate Oxidation
Improves
?
Cortisol
Improves
?
Fat Oxidation
1 study
Improves
?
Fatigue Symptoms
1 study
Improves
?
Heart Rate
1 study
Improves
?
Metabolic Rate
1 study
Improves
?
Vigor/Activity
1 study
Improves
C
Fatigue Symptoms
Moderate Improvement
1 study
moderateImproves
?
Social Functioning
Improves
?
Stress Signs and Symptoms
Improves
C
Attention
Small Improvement
1 study
smallImproves
?
Fatigue Symptoms
1 study
Improves
?
Reaction Time
1 study
Improves
C
Blood Lactate (Exercise)
Small Decrease
1 study
smallImproves
?
Heart Rate
1 study
Improves
?
Muscle Damage
1 study
Worsens
?
Oxidative Stress Biomarkers
1 study
Improves
?
Oxygen Uptake
Improves
?
Rating of Perceived Exertion
1 study
Improves
C
C-Reactive Protein (CRP)
Small Decrease
smallImproves
?
Creatine Kinase
1 study
Worsens
?
Granulocyte-colony stimulating factor
1 study
Improves
?
Interleukin 10
1 study
Improves
?
Interleukin 6
1 study
Improves
?
Interleukin 8
1 study
Worsens
?
Lymphocyte Count
1 study
Improves
?
Monocyte Chemoattractant Protein-1
Improves
?
Monocyte Count
1 study
Improves
?
Muscle Soreness
1 study
Improves
?
Neutrophil Count
1 study
Improves
D
Blood Pressure
No effect
none
?
Creatine Kinase
1 study
Worsens
?
Heart Rate
1 study
Improves
?
Interleukin 6
1 study
Improves
?
Muscle Damage
1 study
Worsens
?
Muscle Oxygenation
1 study
Improves
?
Oxidative Stress Biomarkers
1 study
Improves
?
TNF-Alpha
1 study
Improves
D
Blood Pressure
No effect
none
?
Heart Rate
1 study
Improves
?
Muscle Oxygenation
1 study
Improves
?
Oxidative Stress Biomarkers
1 study
Improves
D
Metabolic Rate
No effect
1 study
none
?
Rating of Perceived Exertion
1 study
Improves
?
Subjective Well-Being
1 study
Improves

Evidence by Condition

Best grade per condition (each condition may have multiple outcomes)

BAerobic Exercise Performance
1
Aerobic Exercise MetricsImprovesCreatine KinaseWorsensBlood Lactate (Exercise)Worsens
BFatigue
1
AttentionImprovesFatigue SymptomsImprovesDepression SymptomsImproves
BStress
1
Anxiety SymptomsImprovesDepression SymptomsImprovesFatigue SymptomsImproves
BDepression
1
Depression SymptomsImprovesInsomnia Signs and SymptomsImprovesSubjective Well-BeingImproves
BMuscle Recovery
1
C-Reactive Protein (CRP)ImprovesCreatine KinaseWorsensInterleukin 6Improves
BChronic Obstructive Pulmonary Disease (COPD)
1
C-Reactive Protein (CRP)ImprovesLung FunctionImprovesGlutathione (GSH)Improves
CMental Resilience
1
AlertnessImprovesAttentionImprovesFatigue SymptomsImproves
CCognitive Improvement
1
AlertnessImprovesCognitionImprovesFatigue SymptomsImproves
CGeneral Athletic Performance
1
Aerobic Exercise MetricsImprovesFatigue SymptomsImprovesPower OutputImproves
CCycling Performance
1
Aerobic Exercise MetricsImprovesRating of Perceived ExertionImprovesBlood Lactate (Exercise)Worsens
CMyalgic Encephalomyelitis (Chronic Fatigue Syndrome)
1
Fatigue SymptomsImprovesSocial FunctioningImprovesStress Signs and SymptomsImproves
CFocus & Attention
1
AttentionImprovesFatigue SymptomsImprovesReaction TimeImproves
CRowing Performance
1
Blood Lactate (Exercise)ImprovesHeart RateImprovesMuscle DamageWorsens
CRunners' Health
1
C-Reactive Protein (CRP)ImprovesCreatine KinaseWorsensGranulocyte-colony stimulating factorImproves
DMetabolic Health
1
Blood PressureCreatine KinaseWorsensHeart RateImproves
DMood Improvement
1
Metabolic RateRating of Perceived ExertionImprovesSubjective Well-BeingImproves

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