Supplement

Tetradecyl Thioacetic Acid

Tetradecyl thioacetic acid is a modified fatty acid with a sulfur atom in its chain, which the body cannot burn for fuel like ordinary fats and which switches on fat-handling genes instead. In people with high cholesterol, small studies found apolipoprotein B improved and cell adhesion factors went down, though the evidence is limited. Those trials enrolled only 10 to 43 people, and blood glucose showed no clear difference in 18 people.

Updated 30 September 2026
How we grade
4 studies cited

Best evidence: Grade C
Conditions studied: 8
Outcomes: 97
Graded outcomes: 0054

Evidence by condition

Strong
Moderate
Limited
Very limited

8 conditions

High Cholesterol

High Cholesterol: outcomes studied for Tetradecyl Thioacetic Acid
Grade	Outcome	Effect	Size	Studies	People
	Apolipoprotein B Small Improvement	Improves (the measure goes down)	Small effect		10 people
	Cell Adhesion Factors Small Decrease	Improves (the measure goes down)	Small effect		43 people
	HbA1c	Improves (the measure goes down)		1 study	10 people
Studies that measured hba1c Lipid-lowering and anti-inflammatory effects of tetradecylthioacetic acid in HIV-infected patients on highly active antiretroviral therapyEur J Clin Invest · PMID 15473896
	Total cholesterol	Improves (the measure goes down)		1 study	53 people
Studies that measured total cholesterol Anti-inflammatory and hypolipidemic effects of the modified fatty acid tetradecylthioacetic acid in psoriasis--a pilot studyScand J Clin Lab Invest · PMID 21338276
	Weight	Improves (the measure goes down)		1 study	10 people
Studies that measured weight Tetradecylthioacetic acid attenuates dyslipidaemia in male patients with type 2 diabetes mellitus, possibly by dual PPAR-alpha/delta activation and increased mitochondrial fatty acid oxidationDiabetes Obes Metab · PMID 19267708
	Glycemic Control	Improves (the measure goes up)			10 people
	High-density lipoprotein (HDL)	Improves (the measure goes up)			10 people
	HIV Viral Load	Improves (the measure goes up)			10 people
	Kidney Function	Improves (the measure goes up)			10 people
	Liver Enzymes	Changes; see studies			10 people
	Low-density lipoprotein (LDL)	Improves (the measure goes down)			10 people
	TNF-Alpha	Improves (the measure goes down)			53 people
	Triglycerides	Improves (the measure goes down)			53 people

Psoriasis

Psoriasis: outcomes studied for Tetradecyl Thioacetic Acid
Grade	Outcome	Effect	Size	Studies	People
	Cell Adhesion Factors Small Decrease	Improves (the measure goes down)	Small effect		43 people
	Total cholesterol	Improves (the measure goes down)		1 study	43 people
Studies that measured total cholesterol Anti-inflammatory and hypolipidemic effects of the modified fatty acid tetradecylthioacetic acid in psoriasis--a pilot studyScand J Clin Lab Invest · PMID 21338276
	TNF-Alpha	Improves (the measure goes down)			43 people
	Triglycerides	Improves (the measure goes down)			43 people

Type 2 Diabetes

Blood Pressure: improves
HbA1c: improves
Weight: improves

Type 2 Diabetes: outcomes studied for Tetradecyl Thioacetic Acid
Grade	Outcome	Effect	Size	Studies	People
	Blood Pressure Small Improvement	Improves (the measure goes down)	Small effect		16 people
	HbA1c	Improves (the measure goes down)		1 study	16 people
Studies that measured hba1c Lipid-lowering and anti-inflammatory effects of tetradecylthioacetic acid in HIV-infected patients on highly active antiretroviral therapyEur J Clin Invest · PMID 15473896
	Weight	Improves (the measure goes down)		1 study	16 people
Studies that measured weight Tetradecylthioacetic acid attenuates dyslipidaemia in male patients with type 2 diabetes mellitus, possibly by dual PPAR-alpha/delta activation and increased mitochondrial fatty acid oxidationDiabetes Obes Metab · PMID 19267708
	C-Reactive Protein (CRP)	Improves (the measure goes down)			16 people
	High-density lipoprotein (HDL)	Improves (the measure goes up)			16 people
	Liver Enzymes	Changes; see studies			16 people
	Low-density lipoprotein (LDL)	Improves (the measure goes down)			16 people
	Uric Acid	Improves (the measure goes down)			16 people

Human Immunodeficiency Virus (HIV)

Apolipoprotein B: improves
HbA1c: improves
Total cholesterol: improves

Human Immunodeficiency Virus (HIV): outcomes studied for Tetradecyl Thioacetic Acid
Grade	Outcome	Effect	Size	Studies	People
	Apolipoprotein B Small Improvement	Improves (the measure goes down)	Small effect		10 people
	HbA1c	Improves (the measure goes down)		1 study	10 people
Studies that measured hba1c Lipid-lowering and anti-inflammatory effects of tetradecylthioacetic acid in HIV-infected patients on highly active antiretroviral therapyEur J Clin Invest · PMID 15473896
	Total cholesterol	Improves (the measure goes down)		1 study	10 people
Studies that measured total cholesterol Anti-inflammatory and hypolipidemic effects of the modified fatty acid tetradecylthioacetic acid in psoriasis--a pilot studyScand J Clin Lab Invest · PMID 21338276
	Weight	Improves (the measure goes down)		1 study	10 people
Studies that measured weight Tetradecylthioacetic acid attenuates dyslipidaemia in male patients with type 2 diabetes mellitus, possibly by dual PPAR-alpha/delta activation and increased mitochondrial fatty acid oxidationDiabetes Obes Metab · PMID 19267708
	Glycemic Control	Improves (the measure goes up)			10 people
	High-density lipoprotein (HDL)	Improves (the measure goes up)			10 people
	HIV Viral Load	Improves (the measure goes up)			10 people
	Kidney Function	Improves (the measure goes up)			10 people
	Liver Enzymes	Changes; see studies			10 people
	Low-density lipoprotein (LDL)	Improves (the measure goes down)			10 people
	TNF-Alpha	Improves (the measure goes down)			10 people
	Triglycerides	Improves (the measure goes down)			10 people

General Cardiovascular Health

Blood glucose
HbA1c: improves
Heart Rate: improves

General Cardiovascular Health: outcomes studied for Tetradecyl Thioacetic Acid
Grade	Outcome	Effect	Size	Studies	People
	Blood glucose No effect		NoneNo effect		18 people
	HbA1c	Improves (the measure goes down)		1 study	16 people
Studies that measured hba1c Lipid-lowering and anti-inflammatory effects of tetradecylthioacetic acid in HIV-infected patients on highly active antiretroviral therapyEur J Clin Invest · PMID 15473896
	Heart Rate	Improves (the measure goes down)		1 study	18 people
Studies that measured heart rate Pharmacology and safety of tetradecylthioacetic acid (TTA): phase-1 studyJ Cardiovasc Pharmacol · PMID 18427285
	Total cholesterol	Improves (the measure goes down)		1 study	18 people
Studies that measured total cholesterol Anti-inflammatory and hypolipidemic effects of the modified fatty acid tetradecylthioacetic acid in psoriasis--a pilot studyScand J Clin Lab Invest · PMID 21338276
	Weight	Improves (the measure goes down)		1 study	16 people
Studies that measured weight Tetradecylthioacetic acid attenuates dyslipidaemia in male patients with type 2 diabetes mellitus, possibly by dual PPAR-alpha/delta activation and increased mitochondrial fatty acid oxidationDiabetes Obes Metab · PMID 19267708
	Blood Pressure	Improves (the measure goes down)			34 people
	C-Reactive Protein (CRP)	Improves (the measure goes down)			34 people
	High-density lipoprotein (HDL)	Improves (the measure goes up)			34 people
	Liver Enzymes	Changes; see studies			34 people
	Low-density lipoprotein (LDL)	Improves (the measure goes down)			34 people
	Red Blood Cell Count	Improves (the measure goes up)			18 people
	Serum T4	Improves (the measure goes up)			18 people
	Thyroid-Stimulating Hormone	Improves (the measure goes up)			18 people
	Triglycerides	Improves (the measure goes down)			18 people
	Uric Acid	Improves (the measure goes down)			34 people
	White Blood Cell Count	Improves (the measure goes up)			18 people

Immune Health

Blood glucose
HbA1c: improves
Heart Rate: improves

Immune Health: outcomes studied for Tetradecyl Thioacetic Acid
Grade	Outcome	Effect	Size	Studies	People
	Blood glucose No effect		NoneNo effect		18 people
	HbA1c	Improves (the measure goes down)		1 study	10 people
Studies that measured hba1c Lipid-lowering and anti-inflammatory effects of tetradecylthioacetic acid in HIV-infected patients on highly active antiretroviral therapyEur J Clin Invest · PMID 15473896
	Heart Rate	Improves (the measure goes down)		1 study	18 people
Studies that measured heart rate Pharmacology and safety of tetradecylthioacetic acid (TTA): phase-1 studyJ Cardiovasc Pharmacol · PMID 18427285
	C-Reactive Protein (CRP)	Improves (the measure goes down)			18 people
	Glycemic Control	Improves (the measure goes up)			10 people
	High-density lipoprotein (HDL)	Improves (the measure goes up)			28 people
	HIV Viral Load	Improves (the measure goes up)			10 people
	Liver Enzymes	Changes; see studies			28 people
	Low-density lipoprotein (LDL)	Improves (the measure goes down)			28 people
	Red Blood Cell Count	Improves (the measure goes up)			18 people
	Serum T4	Improves (the measure goes up)			18 people
	Thyroid-Stimulating Hormone	Improves (the measure goes up)			18 people
	TNF-Alpha	Improves (the measure goes down)			10 people
	Triglycerides	Improves (the measure goes down)			28 people
	Uric Acid	Improves (the measure goes down)			18 people
	White Blood Cell Count	Improves (the measure goes up)			18 people

General Liver Health

Blood glucose
Heart Rate: improves
Total cholesterol: improves

General Liver Health: outcomes studied for Tetradecyl Thioacetic Acid
Grade	Outcome	Effect	Size	Studies	People
	Blood glucose No effect		NoneNo effect		18 people
	Heart Rate	Improves (the measure goes down)		1 study	18 people
Studies that measured heart rate Pharmacology and safety of tetradecylthioacetic acid (TTA): phase-1 studyJ Cardiovasc Pharmacol · PMID 18427285
	Total cholesterol	Improves (the measure goes down)		1 study	18 people
Studies that measured total cholesterol Anti-inflammatory and hypolipidemic effects of the modified fatty acid tetradecylthioacetic acid in psoriasis--a pilot studyScand J Clin Lab Invest · PMID 21338276
	C-Reactive Protein (CRP)	Improves (the measure goes down)			18 people
	High-density lipoprotein (HDL)	Improves (the measure goes up)			18 people
	Kidney Function	Improves (the measure goes up)			18 people
	Liver Enzymes	Changes; see studies			18 people
	Low-density lipoprotein (LDL)	Improves (the measure goes down)			18 people
	Red Blood Cell Count	Improves (the measure goes up)			18 people
	Serum T4	Improves (the measure goes up)			18 people
	Thyroid-Stimulating Hormone	Improves (the measure goes up)			18 people
	Triglycerides	Improves (the measure goes down)			18 people
	Uric Acid	Improves (the measure goes down)			18 people
	White Blood Cell Count	Improves (the measure goes up)			18 people

Metabolic Health

Blood glucose
Heart Rate: improves
Total cholesterol: improves

Metabolic Health: outcomes studied for Tetradecyl Thioacetic Acid
Grade	Outcome	Effect	Size	Studies	People
	Blood glucose No effect		NoneNo effect		18 people
	Heart Rate	Improves (the measure goes down)		1 study	18 people
Studies that measured heart rate Pharmacology and safety of tetradecylthioacetic acid (TTA): phase-1 studyJ Cardiovasc Pharmacol · PMID 18427285
	Total cholesterol	Improves (the measure goes down)		1 study	18 people
Studies that measured total cholesterol Anti-inflammatory and hypolipidemic effects of the modified fatty acid tetradecylthioacetic acid in psoriasis--a pilot studyScand J Clin Lab Invest · PMID 21338276
	Blood Pressure	Improves (the measure goes down)			18 people
	C-Reactive Protein (CRP)	Improves (the measure goes down)			18 people
	High-density lipoprotein (HDL)	Improves (the measure goes up)			18 people
	Kidney Function	Improves (the measure goes up)			18 people
	Liver Enzymes	Changes; see studies			18 people
	Low-density lipoprotein (LDL)	Improves (the measure goes down)			18 people
	Serum T4	Improves (the measure goes up)			18 people
	Thyroid-Stimulating Hormone	Improves (the measure goes up)			18 people
	Triglycerides	Improves (the measure goes down)			18 people
	Uric Acid	Improves (the measure goes down)			18 people
	White Blood Cell Count	Improves (the measure goes up)			18 people

Key findings

Apolipoprotein BHigh CholesterolImproves (the measure goes down)
Cell Adhesion FactorsHigh CholesterolImproves (the measure goes down)
Blood PressureType 2 DiabetesImproves (the measure goes down)

Shop Tetradecyl Thioacetic Acid

Third-party tested Tetradecyl Thioacetic Acid products. The evidence above is limited, so read it before you buy.

Grade C

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Studies cited

4 studies from PubMed

Pharmacology and safety of tetradecylthioacetic acid (TTA): phase-1 studyJ Cardiovasc Pharmacol · PMID 18427285
Tetradecylthioacetic acid attenuates dyslipidaemia in male patients with type 2 diabetes mellitus, possibly by dual PPAR-alpha/delta activation and increased mitochondrial fatty acid oxidationDiabetes Obes Metab · PMID 19267708
Lipid-lowering and anti-inflammatory effects of tetradecylthioacetic acid in HIV-infected patients on highly active antiretroviral therapyEur J Clin Invest · PMID 15473896
Anti-inflammatory and hypolipidemic effects of the modified fatty acid tetradecylthioacetic acid in psoriasis--a pilot studyScand J Clin Lab Invest · PMID 21338276