Condition
Psoriasis
Psoriasis is a chronic autoimmune condition in which the immune system pushes skin cells to build up too fast, causing red, scaly, inflamed patches. Omega-3 fatty acids and vitamin D have the strongest support among supplements, each with moderate evidence, though reviews of probiotics found mixed results on CRP, a blood marker of inflammation. Most other options rest on limited evidence, small studies, or mouse work, so conclusions stay tentative.
Sources: PMID 39798817; PMID 41156763
- Supplements studied
- 7
- Graded outcomes
- 5
- Trials
- 4
- People studied
- 1,037
Evidence by supplement
- Strong
- Moderate
- Limited
- Very limited
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| C-Reactive Protein (CRP) Mixed effect | 2 studies | 400 people | ||||
| Psoriasis Symptoms | Improves (the measure goes down) | 1 study | 400 people | |||
Studies that measured psoriasis symptoms | ||||||
| Interleukin 6 | Improves (the measure goes down) | 400 people | ||||
| Quality of Life | Improves (the measure goes up) | 400 people | ||||
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Cell Adhesion Factors Small Decrease | Improves (the measure goes down) | Small effect | 43 people | |||
| Total cholesterol | Improves (the measure goes down) | 1 study | 43 people | |||
Studies that measured total cholesterol | ||||||
| TNF-Alpha | Improves (the measure goes down) | 43 people | ||||
| Triglycerides | Improves (the measure goes down) | 43 people | ||||
Aloe Vera
- Psoriasis Symptoms
- Pain
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Psoriasis Symptoms No effect | NoneNo effect | 1 study | 120 people | |||
Studies that measured psoriasis symptoms | ||||||
| Pain No effect on psoriasis pain | NoneNo effect | 456 people | ||||
Bakuchi
- Antipsoriatic Activity: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Antipsoriatic Activity Mouse tail model: 75.87% antipsoriatic activity vs 87.94% for tazarot gel; preclinical only | Improves (the measure goes up) | Moderate effect |
Zinc
- Psoriasis Symptoms: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Psoriasis Symptoms | Improves (the measure goes down) | 1 study | 60 people | |||
Studies that measured psoriasis symptoms | ||||||
Phlebodium aureum
- Psoriasis Symptoms: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Psoriasis Symptoms | Improves (the measure goes down) | 1 study | 63 people | |||
Studies that measured psoriasis symptoms | ||||||
Inositol
- Psoriasis Symptoms: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Psoriasis Symptoms | Improves (the measure goes down) | 1 study | 15 people | |||
Studies that measured psoriasis symptoms | ||||||
What the published studies found
1 automated reading
Bromelain: psoriasis
The search of the published studies found none on Bromelain and psoriasis that could be read, so there is no finding to report either way.
Key findings
- C-Reactive Protein (CRP)
- Cell Adhesion FactorsImproves (the measure goes down)
- Psoriasis Symptoms
The Psoriasis Supportive Care protocol
2 primary supplements · 7 supporting supplements
- Omega-3 Fatty Acids3–4 g EPA+DHA daily
- Vitamin D2,000–4,000 IU daily (higher doses under medical supervision)
Shop the evidence-backed picks
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Or shop one supplement
The supplement graded A or B for Psoriasis. Each opens third-party tested products for that supplement.
- Grade B
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Studies cited
100 studies from PubMed
- The effects of probiotic supplementation on cardiometabolic health in patients with prediabetes: a systematic review, meta-analysis, and GRADE assessment.
- Lactococcus lactis strain Plasma activates plasmacytoid dendritic cells and mitigates common cold-like symptoms in healthy adults: a meta-analysis of individual participant data.
- Applications of bakuchiol in dermatology: Systematic review of the literature
- Multidirectional activity of bakuchiol against cellular mechanisms of facial ageing - Experimental evidence for a holistic treatment approach
- Probiotics and Immune Health: Current Knowledge and Future Perspectives
- Probiotics for Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis
- Probiotics for Prevention and Treatment of Diarrhea: A Systematic Review and Meta-Analysis
- Probiotics for the Prevention and Treatment of Depression: A Systematic Review and Meta-Analysis
- Effects of Probiotics on Metabolic Syndrome: A Systematic Review of Randomized Clinical Trials
- Probiotics and Weight Loss: A Systematic Review and Meta-Analysis
- The Gut Microbiome, Probiotics, and Their Impact on Skin Health: A Review
- Psoralea corylifolia L: Ethnobotanical, biological, and chemical aspects: A review
- Corylin, a flavonoid derived from Psoralea Fructus, induces osteoblastic differentiation via estrogen and Wnt/β-catenin signaling pathways
- Health Benefits of Probiotics: A Review
- Probiotics: Comprehensive Review of Growth Promotion Mechanisms and Action in Food Products
- Probiotics: Classification, Mode of Action and Role in Human Nutrition
- Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing
- Safety of Probiotics: A Comprehensive Review
- Probiotics, Prebiotics and Inflammation: A Review of the Science
- Probiotics and Healthy Ageing: A Systematic Review and Meta-Analysis
- Myo-Inositol in Patients with PCOS: A Systematic Review and Meta-Analysis
- Myo-Inositol and D-Chiro-Inositol in PCOS Treatment: A Meta-Analysis
- Inositol and Insulin Resistance: Mechanisms and Clinical Evidence
- Inositol and Depression: A Systematic Review
- Inositol and PCOS: A Comprehensive Review of Clinical Evidence
- Inositol in Anxiety Disorders: A Systematic Review
- Myo-Inositol in Gestational Diabetes: A Meta-Analysis
- Inositol and Fertility: A Comprehensive Review
- Safety and Efficacy of Inositol in Clinical Practice: A Review
- World Gastroenterology Organisation Global Guidelines: Probiotics and Prebiotics
- Probiotics for Human Use: Current Advances and Future Perspectives
- Inositol Effects on Metabolic Syndrome: A Systematic Review
- Bakuchiol: a retinol-like functional compound revealed by gene expression profiling and clinically proven to have anti-aging effects
- Osteoblasts proliferation and differentiation stimulating activities of the main components of Fructus Psoraleae corylifoliae
- Neobavaisoflavone stimulates osteogenesis via p38-mediated up-regulation of transcription factors and osteoid genes expression in MC3T3-E1 cells
- Psoralen stimulates osteoblast differentiation through activation of BMP signaling
- Phytoestrogens from Psoralea corylifolia reveal estrogen receptor-subtype selectivity
- Psoralen photochemotherapy (PUVA) is only moderately effective in widespread vitiligo: a 10-year retrospective study
- Treatment of vitiligo with UV-B radiation vs topical psoralen plus UV-A
- Evaluation of the therapeutic effects of Aloe vera gel on minor recurrent aphthous stomatitis
- Acemannan, a Polysaccharide Extracted from Aloe vera, Is Effective in the Treatment of Oral Aphthous Ulceration
- Effects of Aloe Vera in the Treatment of Oral Ulcers: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.
- Efficacy of Aloe Vera Supplementation on Prediabetes and Early Non-Treated Diabetic Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
- Effect of Aloe vera on glycaemic control in prediabetes and type 2 diabetes: a systematic review and meta-analysis
- Effects of Aloe vera in adults with mucocutaneous problems: A systematic review and meta-analysis.
- Natural and miscellaneous agents for the prevention of acute radiation dermatitis: a systematic review and meta-analysis.
- Is Effective and Safe in Short-term Treatment of Irritable Bowel Syndrome: A Systematic Review and Meta-analysis.
- The combined therapy with myo-inositol and D-chiro-inositol reduces the risk of metabolic disease in PCOS overweight patients compared to myo-inositol supplementation alone
- Effects of inositol on ovarian function and metabolic factors in women with PCOS: a randomized double blind placebo-controlled trial
- Differential insulin response to myo-inositol administration in obese polycystic ovary syndrome patients
- Inositol administration reduces oxidative stress in erythrocytes of patients with polycystic ovary syndrome
- Effects of d-chiro-inositol in lean women with the polycystic ovary syndrome
- Insulin sensitiser agents alone and in co-treatment with r-FSH for ovulation induction in PCOS women
- Efficacy of myo-inositol in the treatment of cutaneous disorders in young women with polycystic ovary syndrome
- Metabolic and hormonal effects of myo-inositol in women with polycystic ovary syndrome: a double-blind trial
- Myo-inositol administration positively affects hyperinsulinemia and hormonal parameters in overweight patients with polycystic ovary syndrome
- Pharmacological and Non-Pharmacological Interventions for Polycystic Ovary Syndrome (PCOS) in Indian Women: A Systematic Review and Meta-Analysis.
- Inositol is an effective and safe treatment in polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials.
- Effects of myo-inositol supplementation on oocyte's quality in PCOS patients: a double blind trial
- Myo-inositol rather than D-chiro-inositol is able to improve oocyte quality in intracytoplasmic sperm injection cycles. A prospective, controlled, randomized trial
- Myo-inositol may prevent gestational diabetes in PCOS women
- Inositol for subfertile women with polycystic ovary syndrome.
- Myo-inositol treatment increases serum plasmalogens and decreases small dense LDL, particularly in hyperlipidemic subjects with metabolic syndrome
- One-year effects of myo-inositol supplementation in postmenopausal women with metabolic syndrome
- A phase I study of myo-inositol for lung cancer chemoprevention
- Treatment of hirsutism with myo-inositol: a prospective clinical study
- Inositol for depressive disorders.
- Double-blind, controlled trial of inositol treatment of depression
- Treatment-resistant bipolar depression: a STEP-BD equipoise randomized effectiveness trial of antidepressant augmentation with lamotrigine, inositol, or risperidone
- Inositol addition does not improve depression in SSRI treatment failures
- Effect of inositol on bulimia nervosa and binge eating
- Inositol Nutritional Supplementation for the Prevention of Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
- The effect of myoinositol supplementation on insulin resistance in patients with gestational diabetes
- Dietary supplementation with myo-inositol in women during pregnancy for treating gestational diabetes.
- A phase 2 randomized trial of ELND005, scyllo-inositol, in mild to moderate Alzheimer disease
- Inositol treatment of Alzheimer's disease: a double blind, cross-over placebo controlled trial
- Lack of effect of inositol treatment in chronic schizophrenia
- CSF inositol in schizophrenia and high-dose inositol treatment of schizophrenia
- Double-blind, controlled, crossover trial of inositol versus fluvoxamine for the treatment of panic disorder
- Double-blind, placebo-controlled, crossover trial of inositol treatment for panic disorder
- Acute inositol does not attenuate m-CPP-induced anxiety, mydriasis and endocrine effects in panic disorder
- Myo-inositol in the treatment of premenstrual dysphoric disorder
- Myo-inositol has no beneficial effect on premenstrual dysphoric disorder
- Inositol as an add-on treatment for bipolar depression
- Inositol treatment of autism
- Inositol treatment of obsessive-compulsive disorder
- Inositol treatment of post-traumatic stress disorder
- Lack of effect of 6 g inositol treatment of post-ECT cognitive function in humans
- The effect of inositol supplements on the psoriasis of patients taking lithium: a randomized, placebo-controlled trial
- Pretreatment with myo-inositol in non polycystic ovary syndrome patients undergoing multiple follicular stimulation for IVF: a pilot study
- The effects of inositol supplementation on lipid profiles among patients with metabolic diseases: a systematic review and meta-analysis of randomized controlled trials.
- The efficacy and safety of inositol supplementation in preterm infants to prevent retinopathy of prematurity: a systematic review and meta-analysis.
- Oral polypodium leucotomos extract photoprotective activity in 57 patients with idiopathic photodermatoses
- Double-blind, randomized, placebo-controlled pilot study with anapsos in senile dementia: effects on cognition, brain bioelectrical activity and cerebral hemodynamics
- Treatment of vitiligo vulgaris with narrow-band UVB and oral Polypodium leucotomos extract: a randomized double-blind placebo-controlled study
- Photoprotective activity of oral polypodium leucotomos extract in 25 patients with idiopathic photodermatoses
- Oral Polypodium leucotomos extract decreases ultraviolet-induced damage of human skin
- A new agent (hydrophilic fraction of polypodium leucotomos) for management of psoriasis
- Oral administration of a hydrophilic extract of Polypodium leucotomos for the prevention of polymorphic light eruption
- Probiotics for people with cystic fibrosis.