Quercetin

Quercetin is a widely consumed flavonoid found in onions, apples, berries, and tea. Despite significant hype, human evidence is mostly D-grade - it has NOT lived up to its preclinical promise. Low bioavailability is a major limitation (~2%). May reduce CRP inflammation in younger adults (<45). Popular during COVID-19 due to in vitro studies but NO proven clinical benefit. Used as zinc ionophore in some protocols. Better absorbed as isoquercetin or with bromelain/fat. Most clinical trials show no effect.

Quick Answer

What it is

Quercetin is a widely consumed flavonoid found in onions, apples, berries, and tea. Despite significant hype, human evidence is mostly D-grade - it has NOT lived up to its preclinical promise.

Key findings

  • Grade C: Anxiety Symptoms (Type 2 Diabetes)
  • Grade C: High-density lipoprotein (HDL) (High Cholesterol)
  • Grade D: Blood Pressure (High Blood Pressure)

Safety

No specific caution or interaction language was detected in the current summary/outcome notes.

ℹ️ Quick Facts: Quercetin

Quick Facts: Quercetin

  • Best Evidence:Grade C
  • Conditions Studied:11
  • Research Outcomes:52
  • Key Effect:Sarcoidosis
Outcomes by grade:
A0
B0
C2
D11
11 conditions Β· 52 outcomes

Detailed Outcomes

Grade:
Effect:
Size:
Sort:
|
C
Anxiety Symptoms
Small Improvement
1 study
small↓Improves
?
HbA1c
↓Improves
?
Quality of Life
↑Improves
C
High-density lipoprotein (HDL)
Small Improvement
small↑Improves
?
Low-density lipoprotein (LDL)
1 study
↓Improves
?
Total cholesterol
1 study
↓Improves
D
Blood Pressure
No effect
none
D
Blood glucose
No effect
1 study
none
?
Fat Oxidation
1 study
↑Improves
?
Heart Rate
1 study
↓Improves
?
High-density lipoprotein (HDL)
↑Improves
?
Low-density lipoprotein (LDL)
1 study
↓Improves
?
Metabolic Rate
1 study
↑Improves
?
Oxidative Stress Biomarkers
↓Improves
?
vLDL-C
1 study
↓Improves
?
Weight
1 study
↓Improves
D
Interleukin 6
No effect
1 study
none
?
Intestinal Permeability
1 study
↑Improves
?
Uric Acid
1 study
↓Improves
D
Anaerobic Capacity
No effect
none
?
Exercise-induced Stress Response
↓Improves
?
Interleukin 6
1 study
↓Improves
?
Intestinal Permeability
1 study
↑Improves
?
Rating of Perceived Exertion
↑Improves
?
Uric Acid
1 study
↓Improves
D
Anaerobic Capacity
No effect
none
?
Exercise-induced Stress Response
↓Improves
?
Hydration (Total Body Water)
1 study
↑Improves
?
Intestinal Permeability
1 study
↑Improves
?
Rating of Perceived Exertion
↑Improves
?
Training Volume
1 study
↑Improves
D
Anaerobic Capacity
No effect
none
?
Interleukin 6
1 study
↓Improves
?
Rating of Perceived Exertion
↑Improves
?
Uric Acid
1 study
↓Improves
D
Inflammation
No effect
1 study
none
?
Oxidative Stress Biomarkers
↓Improves
D
Fatigue Symptoms
No effect
1 study
none
?
Sleep Quality
↑Improves
D
Blood Pressure
No effect
none
?
Fat Oxidation
1 study
↑Improves
?
Metabolic Rate
1 study
↑Improves
D
Anaerobic Capacity
No effect
none
?
Interleukin 6
1 study
↓Improves
?
Rating of Perceived Exertion
↑Improves
?
Uric Acid
1 study
↓Improves
D
Anaerobic Capacity
No effect
none
?
Exercise-induced Stress Response
↑Worsens
?
Hydration (Total Body Water)
1 study
↑Improves
?
Intestinal Permeability
1 study
↑Improves
?
Rating of Perceived Exertion
↑Improves
?
Training Volume
1 study
↑Improves

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