Hesperidin

Hesperidin, found abundantly in orange peels and various citrus fruits, exhibits promising potential in reducing risk factors associated with cardiovascular disease, such as triglycerides and total cholesterol. Additionally, it appears to some have anti-inflammatory properties. While other potential benefits of hesperidin exist, further clinical studies are required to fully understand its range of effects.

Quick Answer

What it is

Hesperidin, found abundantly in orange peels and various citrus fruits, exhibits promising potential in reducing risk factors associated with cardiovascular disease, such as triglycerides and total cholesterol. Additionally, it appears to some have anti-inflammatory properties.

Key findings

  • Grade B: Apolipoprotein B (High Cholesterol)
  • Grade C: Blood Flow (High Blood Pressure)
  • Grade D: Blood glucose (Metabolic Health)

Safety

  • Hesperidin, found abundantly in orange peels and various citrus fruits, exhibits promising potential in reducing risk factors associated with cardiovascular disease, such as triglycerides and total cholesterol.
ℹ️ Quick Facts: Hesperidin

Quick Facts: Hesperidin

  • Best Evidence:Grade B
  • Conditions Studied:8
  • Research Outcomes:99
  • Grade B Findings:1
  • Key Effect:High Cholesterol
Outcomes by grade:
A0
B1
C1
D8
8 conditions Β· 99 outcomes

Detailed Outcomes

Grade:
Effect:
Size:
Sort:
|
B
Apolipoprotein B
Small Improvement
2 studies
small↓Improves
D
Blood glucose
No effect
none
?
High-density lipoprotein (HDL)
10 studies
↑Improves
?
Triglycerides
10 studies
↓Improves
?
Low-density lipoprotein (LDL)
↓Improves
?
Total cholesterol
↓Improves
?
Blood Pressure
7 studies
↓Improves
?
Insulin
7 studies
↑Worsens
?
Weight
7 studies
↓Improves
?
TNF-Alpha
5 studies
↓Improves
?
Waist circumference
3 studies
↓Improves
?
LDL Oxidation
1 study
↓Improves
?
Liver Enzymes
1 study
↑Worsens
C
Blood Flow
Moderate Increase
moderate↑Improves
?
Blood glucose
↓Improves
?
Blood Pressure
1 study
↓Improves
?
C-Reactive Protein (CRP)
↓Improves
?
Cell Adhesion Factors
1 study
↓Improves
?
High-density lipoprotein (HDL)
1 study
↑Improves
?
Insulin
1 study
↑Worsens
?
Interleukin 6
1 study
↓Improves
?
Low-density lipoprotein (LDL)
↓Improves
?
Microcirculation
1 study
↑Improves
?
Nitric Oxide
1 study
↑Improves
?
Oxidative Stress Biomarkers
1 study
↓Improves
?
Total cholesterol
↓Improves
?
Triglycerides
1 study
↓Improves
D
Blood glucose
No effect
none
?
High-density lipoprotein (HDL)
10 studies
↑Improves
?
Triglycerides
10 studies
↓Improves
?
Low-density lipoprotein (LDL)
↓Improves
?
Total cholesterol
↓Improves
?
Blood Pressure
7 studies
↓Improves
?
Weight
7 studies
↓Improves
?
C-Reactive Protein (CRP)
↓Improves
?
Insulin
5 studies
↑Worsens
?
TNF-Alpha
5 studies
↓Improves
?
Interleukin 6
4 studies
↓Improves
?
Intercellular Adhesion Molecule 1
3 studies
↑Worsens
?
sE-Selectin
3 studies
↑Improves
?
Vascular Adhesion Protein-1
3 studies
↑Improves
?
Waist circumference
3 studies
↓Improves
?
HbA1c
2 studies
↓Improves
?
Insulin Resistance
1 study
↓Improves
D
Blood glucose
No effect
none
?
Blood Pressure
8 studies
↓Improves
?
High-density lipoprotein (HDL)
8 studies
↑Improves
?
Low-density lipoprotein (LDL)
↓Improves
?
Total cholesterol
↓Improves
?
Triglycerides
8 studies
↓Improves
?
Insulin
7 studies
↑Worsens
?
Weight
7 studies
↓Improves
?
TNF-Alpha
5 studies
↓Improves
?
Waist circumference
3 studies
↓Improves
D
B Cell Count
No effect
1 study
none
?
C-Reactive Protein (CRP)
↓Improves
?
Interleukin 6
4 studies
↓Improves
?
Intercellular Adhesion Molecule 1
3 studies
↑Worsens
?
sE-Selectin
3 studies
↑Improves
?
Vascular Adhesion Protein-1
3 studies
↑Improves
?
Natural Killer Cell Activity
1 study
↑Improves
?
Natural Killer Cell Content
1 study
↑Improves
?
Neutrophil Activity
1 study
↑Improves
?
Neutrophil Count
↑Improves
?
T Cell Count
1 study
↑Improves
?
White Blood Cell Count
1 study
↑Improves
D
C-Reactive Protein (CRP)
No effect
none
?
Rheumatoid Arthritis Symptoms
↓Improves
D
Blood glucose
No effect
none
?
Insulin
5 studies
↑Worsens
?
HbA1c
2 studies
↓Improves
?
Insulin Resistance
1 study
↓Improves
D
Blood glucose
No effect
none
?
High-density lipoprotein (HDL)
10 studies
↑Improves
?
Triglycerides
10 studies
↓Improves
?
Low-density lipoprotein (LDL)
↓Improves
?
Total cholesterol
↓Improves
?
Blood Pressure
7 studies
↓Improves
?
Insulin
7 studies
↑Worsens
?
Weight
7 studies
↓Improves
?
TNF-Alpha
5 studies
↓Improves
?
Waist circumference
3 studies
↓Improves
D
Apolipoprotein A
No effect
1 study
none
?
Apolipoprotein B
1 study
↓Improves
?
Blood Flow
↑Improves
?
Blood glucose
↓Improves
?
Blood Pressure
1 study
↓Improves
?
C-Reactive Protein (CRP)
↓Improves
?
Cell Adhesion Factors
1 study
↓Improves
?
Fibrinogen
1 study
↑Improves
?
Glycemic Control
1 study
↑Improves
?
HbA1c
1 study
↓Improves
?
High-density lipoprotein (HDL)
1 study
↑Improves
?
Homocysteine
1 study
↓Improves
?
Insulin
1 study
↑Worsens
?
Low-density lipoprotein (LDL)
↓Improves
?
Total cholesterol
↓Improves
?
Triglycerides
1 study
↓Improves
?
Weight
1 study
↓Improves

Research Citations (12)

Bioavailability of orally administered water-dispersible hesperetin and its effect on peripheral vasodilatation in human subjects: implication of endothelial functions of plasma conjugated metabolites
PMID: 22307524
Hesperidin contributes to the vascular protective effects of orange juice: a randomized crossover study in healthy volunteers
PMID: 21068346
The effects of hesperidin supplementation on cardiovascular risk factors in adults: a systematic review and dose-response meta-analysis.
PMID: 37502716
Glucosyl hesperidin lowers serum triglyceride level in hypertriglyceridemic subjects through the improvement of very low-density lipoprotein metabolic abnormality
PMID: 16521708
Effects of glucosyl hesperidin on serum lipids in hyperlipidemic subjects: preferential reduction in elevated serum triglyceride level
PMID: 15386934
The citrus flavonoids hesperidin and naringin do not affect serum cholesterol in moderately hypercholesterolemic men and women
PMID: 20660284
Citrus polyphenol hesperidin stimulates production of nitric oxide in endothelial cells while improving endothelial function and reducing inflammatory markers in patients with metabolic syndrome
PMID: 21346065
Hesperidin, a major flavonoid in orange juice, might not affect lipid profile and blood pressure: A systematic review and meta-analysis of randomized controlled clinical trials
PMID: 30632207
Effects of alpha-glucosylhesperidin, a bioactive food material, on collagen-induced arthritis in mice and rheumatoid arthritis in humans
PMID: 18306109
Orange juice and its major polyphenol hesperidin consumption do not induce immunomodulation in healthy well-nourished humans
PMID: 23602614

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