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Dr. Grey AI

Supplement

Hesperidin

Hesperidin is a flavonoid found in citrus fruit, especially oranges, that works as an antioxidant and may influence how blood vessels behave. In a small trial, apolipoprotein B, a cholesterol-carrying protein, improved, with moderate evidence, and blood flow went up in a study of nine people. Blood glucose showed no clear difference, and most findings come from small studies.

Sources: PMID 22307524

Best evidence
Grade B
Conditions studied
9
Outcomes
99
Graded outcomes
0118

Evidence by condition

  • Strong
  • Moderate
  • Limited
  • Very limited

9 conditions

High Cholesterol

High Cholesterol: outcomes studied for Hesperidin
GradeOutcomeEffectSizeStudiesPeopleStudies list
Apolipoprotein B

Small Improvement

Improves (the measure goes down)Small effect65 people
Blood glucose

No effect

NoneNo effect2 studies705 people

Studies that measured blood glucose

Low-density lipoprotein (LDL)Improves (the measure goes down)4 studies525 people

Studies that measured low-density lipoprotein (ldl)

Total cholesterolImproves (the measure goes down)2 studies525 people

Studies that measured total cholesterol

Blood PressureImproves (the measure goes down)338 people
High-density lipoprotein (HDL)Improves (the measure goes up)569 people
InsulinChanges; see studies302 people
LDL OxidationImproves (the measure goes down)25 people
Liver EnzymesChanges; see studies25 people
TNF-AlphaImproves (the measure goes down)241 people
TriglyceridesImproves (the measure goes down)569 people
Waist circumferenceImproves (the measure goes down)116 people
WeightImproves (the measure goes down)457 people

High Blood Pressure

High Blood Pressure: outcomes studied for Hesperidin
GradeOutcomeEffectSizeStudiesPeopleStudies list
Blood Flow

Moderate Increase

Improves (the measure goes up)Moderate effect1 study9 people

Studies that measured blood flow

Low-density lipoprotein (LDL)Improves (the measure goes down)4 studies24 people

Studies that measured low-density lipoprotein (ldl)

Blood glucoseImproves (the measure goes down)2 studies24 people

Studies that measured blood glucose

Total cholesterolImproves (the measure goes down)2 studies24 people

Studies that measured total cholesterol

C-Reactive Protein (CRP)Improves (the measure goes down)1 study24 people

Studies that measured c-reactive protein (crp)

Blood PressureImproves (the measure goes down)24 people
Cell Adhesion FactorsImproves (the measure goes down)24 people
High-density lipoprotein (HDL)Improves (the measure goes up)24 people
InsulinChanges; see studies24 people
Interleukin 6Improves (the measure goes down)24 people
MicrocirculationImproves (the measure goes up)24 people
Nitric OxideImproves (the measure goes up)24 people
Oxidative Stress BiomarkersImproves (the measure goes down)24 people
TriglyceridesImproves (the measure goes down)24 people

Metabolic Health

  • Blood glucose
  • Low-density lipoprotein (LDL): improves
  • Total cholesterol: improves
Metabolic Health: outcomes studied for Hesperidin
GradeOutcomeEffectSizeStudiesPeopleStudies list
Blood glucose

No effect

NoneNo effect2 studies1,023 people

Studies that measured blood glucose

Low-density lipoprotein (LDL)Improves (the measure goes down)4 studies525 people

Studies that measured low-density lipoprotein (ldl)

Total cholesterolImproves (the measure goes down)2 studies525 people

Studies that measured total cholesterol

C-Reactive Protein (CRP)Improves (the measure goes down)1 study296 people

Studies that measured c-reactive protein (crp)

Blood PressureImproves (the measure goes down)338 people
HbA1cImproves (the measure goes down)318 people
High-density lipoprotein (HDL)Improves (the measure goes up)569 people
InsulinChanges; see studies318 people
Insulin ResistanceImproves (the measure goes down)318 people
Intercellular Adhesion Molecule 1Changes; see studies296 people
Interleukin 6Improves (the measure goes down)296 people
sE-SelectinImproves (the measure goes up)296 people
TNF-AlphaImproves (the measure goes down)241 people
TriglyceridesImproves (the measure goes down)569 people
Vascular Adhesion Protein-1Improves (the measure goes up)296 people
Waist circumferenceImproves (the measure goes down)116 people
WeightImproves (the measure goes down)457 people

General Cardiovascular Health

  • Blood glucose
  • Low-density lipoprotein (LDL): improves
  • Total cholesterol: improves
General Cardiovascular Health: outcomes studied for Hesperidin
GradeOutcomeEffectSizeStudiesPeopleStudies list
Blood glucose

No effect

NoneNo effect2 studies705 people

Studies that measured blood glucose

Low-density lipoprotein (LDL)Improves (the measure goes down)4 studies476 people

Studies that measured low-density lipoprotein (ldl)

Total cholesterolImproves (the measure goes down)2 studies476 people

Studies that measured total cholesterol

Blood PressureImproves (the measure goes down)392 people
High-density lipoprotein (HDL)Improves (the measure goes up)476 people
InsulinChanges; see studies302 people
TNF-AlphaImproves (the measure goes down)241 people
TriglyceridesImproves (the measure goes down)476 people
Waist circumferenceImproves (the measure goes down)116 people
WeightImproves (the measure goes down)457 people

Type 2 Diabetes

  • Blood glucose
  • HbA1c: improves
  • Insulin: changes; see studies
Type 2 Diabetes: outcomes studied for Hesperidin
GradeOutcomeEffectSizeStudiesPeopleStudies list
Blood glucose

No effect

NoneNo effect2 studies318 people

Studies that measured blood glucose

HbA1cImproves (the measure goes down)318 people
InsulinChanges; see studies318 people
Insulin ResistanceImproves (the measure goes down)318 people

Cardiovascular Disease

  • Blood glucose
  • Low-density lipoprotein (LDL): improves
  • Total cholesterol: improves
Cardiovascular Disease: outcomes studied for Hesperidin
GradeOutcomeEffectSizeStudiesPeopleStudies list
Blood glucose

No effect

NoneNo effect2 studies705 people

Studies that measured blood glucose

Low-density lipoprotein (LDL)Improves (the measure goes down)4 studies525 people

Studies that measured low-density lipoprotein (ldl)

Total cholesterolImproves (the measure goes down)2 studies525 people

Studies that measured total cholesterol

Blood PressureImproves (the measure goes down)338 people
High-density lipoprotein (HDL)Improves (the measure goes up)569 people
InsulinChanges; see studies302 people
TNF-AlphaImproves (the measure goes down)241 people
TriglyceridesImproves (the measure goes down)569 people
Waist circumferenceImproves (the measure goes down)116 people
WeightImproves (the measure goes down)457 people

Rheumatoid Arthritis (RA)

  • C-Reactive Protein (CRP)
  • Rheumatoid Arthritis Symptoms: improves
Rheumatoid Arthritis (RA): outcomes studied for Hesperidin
GradeOutcomeEffectSizeStudiesPeopleStudies list
C-Reactive Protein (CRP)

No effect

NoneNo effect1 study19 people

Studies that measured c-reactive protein (crp)

Rheumatoid Arthritis SymptomsImproves (the measure goes down)1 study19 people

Studies that measured rheumatoid arthritis symptoms

Immune Health

  • B Cell Count
  • C-Reactive Protein (CRP): improves
  • Neutrophil Count: improves
Immune Health: outcomes studied for Hesperidin
GradeOutcomeEffectSizeStudiesPeopleStudies list
B Cell Count

No effect

NoneNo effect24 people
C-Reactive Protein (CRP)Improves (the measure goes down)1 study296 people

Studies that measured c-reactive protein (crp)

Neutrophil CountImproves (the measure goes up)1 study24 people

Studies that measured neutrophil count

Intercellular Adhesion Molecule 1Changes; see studies296 people
Interleukin 6Improves (the measure goes down)296 people
Natural Killer Cell ActivityImproves (the measure goes up)24 people
Natural Killer Cell ContentImproves (the measure goes up)24 people
Neutrophil ActivityImproves (the measure goes up)24 people
sE-SelectinImproves (the measure goes up)296 people
T Cell CountImproves (the measure goes up)24 people
Vascular Adhesion Protein-1Improves (the measure goes up)296 people
White Blood Cell CountImproves (the measure goes up)24 people

Metabolic Syndrome

  • Apolipoprotein A
  • Low-density lipoprotein (LDL): improves
  • Blood glucose: improves
Metabolic Syndrome: outcomes studied for Hesperidin
GradeOutcomeEffectSizeStudiesPeopleStudies list
Apolipoprotein A

No effect

NoneNo effect24 people
Low-density lipoprotein (LDL)Improves (the measure goes down)4 studies24 people

Studies that measured low-density lipoprotein (ldl)

Blood glucoseImproves (the measure goes down)2 studies24 people

Studies that measured blood glucose

Total cholesterolImproves (the measure goes down)2 studies24 people

Studies that measured total cholesterol

Blood FlowImproves (the measure goes up)1 study24 people

Studies that measured blood flow

C-Reactive Protein (CRP)Improves (the measure goes down)1 study24 people
Apolipoprotein BImproves (the measure goes down)24 people
Blood PressureImproves (the measure goes down)24 people
Cell Adhesion FactorsImproves (the measure goes down)24 people
FibrinogenImproves (the measure goes up)24 people
Glycemic ControlImproves (the measure goes up)24 people
HbA1cImproves (the measure goes down)24 people
High-density lipoprotein (HDL)Improves (the measure goes up)24 people
HomocysteineImproves (the measure goes down)24 people
InsulinChanges; see studies24 people
TriglyceridesImproves (the measure goes down)24 people
WeightImproves (the measure goes down)24 people

Key findings

  • Apolipoprotein BHigh CholesterolImproves (the measure goes down)
  • Blood FlowHigh Blood PressureImproves (the measure goes up)
  • Blood glucoseHigh Cholesterol

Shop the evidence-backed picks

Third-party tested Hesperidin products, in the forms the graded studies used where we can match them.

  • Grade B

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Studies cited

12 studies from PubMed

  1. Bioavailability of orally administered water-dispersible hesperetin and its effect on peripheral vasodilatation in human subjects: implication of endothelial functions of plasma conjugated metabolitesFood Funct · PMID 22307524
  2. Hesperidin contributes to the vascular protective effects of orange juice: a randomized crossover study in healthy volunteersAm J Clin Nutr · PMID 21068346
  3. The effects of hesperidin supplementation on cardiovascular risk factors in adults: a systematic review and dose-response meta-analysis.Front Nutr · PMID 37502716
  4. Glucosyl hesperidin lowers serum triglyceride level in hypertriglyceridemic subjects through the improvement of very low-density lipoprotein metabolic abnormalityJ Nutr Sci Vitaminol · PMID 16521708
  5. Effects of glucosyl hesperidin on serum lipids in hyperlipidemic subjects: preferential reduction in elevated serum triglyceride levelJ Nutr Sci Vitaminol · PMID 15386934
  6. The citrus flavonoids hesperidin and naringin do not affect serum cholesterol in moderately hypercholesterolemic men and womenJ Nutr · PMID 20660284
  7. Citrus polyphenol hesperidin stimulates production of nitric oxide in endothelial cells while improving endothelial function and reducing inflammatory markers in patients with metabolic syndromeJ Clin Endocrinol Metab · PMID 21346065
  8. Hesperidin, a major flavonoid in orange juice, might not affect lipid profile and blood pressure: A systematic review and meta-analysis of randomized controlled clinical trialsPhytother Res · PMID 30632207
  9. Effects of alpha-glucosylhesperidin, a bioactive food material, on collagen-induced arthritis in mice and rheumatoid arthritis in humansImmunopharmacol Immunotoxicol · PMID 18306109
  10. Orange juice and its major polyphenol hesperidin consumption do not induce immunomodulation in healthy well-nourished humansClin Nutr · PMID 23602614
  11. The effect of hesperidin supplementation on inflammatory markers in human adults: A systematic review and meta-analysis of randomized controlled clinical trials.Chem Biol Interact · PMID 30991044
  12. Hesperidin supplementation has no effect on blood glucose control: A systematic review and meta-analysis of randomized controlled clinical trials.Br J Clin Pharmacol · PMID 31489695