S-adenosylmethionine
S-adenosylmethionine (SAMe) is a metabolite in the body that helps maintain several important biological reactions. Low levels of SAMe in the body are associated with several conditions, including liver conditions, chronic kidney disease (CKD), coronary artery disease (CAD), depression, and neurodegenerative conditions like dementia and Alzheimer’s disease. Supplementation with SAMe might improve liver health and depression, but further high-quality clinical trials are needed to confirm those benefits.
Quick Answer
What it is
S-adenosylmethionine (SAMe) is a metabolite in the body that helps maintain several important biological reactions. Low levels of SAMe in the body are associated with several conditions, including liver conditions, chronic kidney disease (CKD), coronary artery disease (CAD), depression, and neurodegenerative conditions like dementia and Alzheimer’s disease.
Key findings
- Grade B: Depression Symptoms (Depression)
- Grade D: Bilirubin (Osteoarthritis (OA))
- Grade D: Attention (Depression)
Safety
No specific caution or interaction language was detected in the current summary/outcome notes.
ℹ️ Quick Facts: S-adenosylmethionine
Quick Facts: S-adenosylmethionine
- Best Evidence:Grade B
- Conditions Studied:11
- Research Outcomes:30
- Grade B Findings:1
- Key Effect:Depression
Detailed Outcomes
Evidence by Condition
Best grade per condition (each condition may have multiple outcomes)
Research Citations (23)
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