Condition
Intrahepatic Cholestasis of Pregnancy (ICP)
Intrahepatic cholestasis of pregnancy is a liver condition of the third trimester in which bile acids build up in the blood, causing intense itching, especially on the palms and soles, and it clears up after delivery. Little research on supplements for it has been reviewed here so far, so there are no trial findings to report yet. Vitamins K, D and E are discussed because cholestasis can interfere with absorbing fat-soluble vitamins, but that is a rationale rather than a result.
- Supplements studied
- 1
- Graded outcomes
- 0
- Trials
- 1
- People studied
- 2,085
Evidence by supplement
- Strong
- Moderate
- Limited
- Very limited
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Cholestasis | Changes; see studies | 2 studies | 2,085 people | |||
The Intrahepatic Cholestasis of Pregnancy Supportive Care protocol
2 primary supplements · 4 supporting supplements
- S-Adenosylmethionine (SAMe)800–1,600 mg daily in divided doses
- Ursodeoxycholic Acid (UDCA)10–15 mg/kg/day (prescription medication)
Studies cited
23 studies from PubMed
- Influence of oral S-adenosylmethionine on plasma 5-methyltetrahydrofolate, S-adenosylhomocysteine, homocysteine and methionine in healthy humans
- Dietary supplement S-adenosyl-L-methionine (AdoMet) effects on plasma homocysteine levels in healthy human subjects: a double-blind, placebo-controlled, randomized clinical trial
- Bioavailability and lack of toxicity of S-adenosyl-L-methionine (SAMe) in humans
- S-Adenosyl-Methionine improves depression in patients with Parkinson's disease in an open-label clinical trial
- Safety and efficacy of S-adenosylmethionine (SAMe) for osteoarthritis
- Comparative clinical trial of S-adenosylmethionine versus nabumetone for the treatment of knee osteoarthritis: an 8-week, multicenter, randomized, double-blind, double-dummy, Phase IV study in Korean patients
- Italian double-blind multicenter study comparing S-adenosylmethionine, naproxen, and placebo in the treatment of degenerative joint disease
- S-adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: a double-blind cross-over trial. [ISRCTN36233495]
- S-adenosyl-L-methionine for treatment of depression, osteoarthritis, and liver disease.
- S-Adenosylmethionine for osteoarthritis of the knee or hip.
- Oral S-adenosylmethionine in primary fibromyalgia. Double-blind clinical evaluation
- S-adenosyl-L-methionine treatment for alcoholic liver disease: a double-blinded, randomized, placebo-controlled trial
- Randomized prospective comparative study of ursodeoxycholic acid and S-adenosyl-L-methionine in the treatment of intrahepatic cholestasis of pregnancy
- Pharmacological interventions for treating intrahepatic cholestasis of pregnancy.
- S-adenosyl methionine (SAMe) augmentation of serotonin reuptake inhibitors for antidepressant nonresponders with major depressive disorder: a double-blind, randomized clinical trial
- S-adenosyl methionine (SAMe) versus escitalopram and placebo in major depression RCT: efficacy and effects of histamine and carnitine as moderators of response
- S-adenosyl methionine (SAMe) for depression in adults
- S-Adenosylmethionine (SAMe) as an adjuvant therapy for patients with depression: An updated systematic review and meta-analysis.
- Efficacy and acceptability of S-adenosyl-L-methionine (SAMe) for depressed patients: A systematic review and meta- analysis.
- Effects of S-adenosylmethionine augmentation of serotonin-reuptake inhibitor antidepressants on cognitive symptoms of major depressive disorder
- S-adenosyl methionine improves early viral responses and interferon-stimulated gene induction in hepatitis C nonresponders
- S-adenosylmethionine (AdoMet) supplementation for treatment of chemotherapy-induced liver injury
- S-adenosyl-L-methionine for the treatment of chronic liver disease: a systematic review and meta-analysis