Reishi

Ganoderma lucidum is a potent immune system regulator, promising anti-cancer agent, and stress reducer. This mushroom is frequently used in traditional Chinese medicine.

Quick Answer

What it is

Ganoderma lucidum is a potent immune system regulator, promising anti-cancer agent, and stress reducer. This mushroom is frequently used in traditional Chinese medicine.

Key findings

  • Grade C: CD3 Lymphocytes (Immune Health)
  • Grade C: CD4 Lymphocytes (Immune Health)
  • Grade C: Anxiety Symptoms (Breast Cancer)

Safety

No specific caution or interaction language was detected in the current summary/outcome notes.

ℹ️ Quick Facts: Reishi

Quick Facts: Reishi

  • Best Evidence:Grade C
  • Conditions Studied:9
  • Research Outcomes:53
  • Key Effect:Immune Health
Outcomes by grade:
A0
B0
C5
D5
9 conditions Β· 53 outcomes

Detailed Outcomes

Grade:
Effect:
Size:
Sort:
|
C
CD3 Lymphocytes
Small Increase
small↑Improves
C
CD4 Lymphocytes
Small Increase
1 study
small↑Improves
?
Immunity
↑Improves
?
Natural Killer Cell Activity
1 study
↑Improves
?
Proteinuria
↑Improves
?
TNF-Alpha
1 study
↓Improves
C
Anxiety Symptoms
Small Improvement
small↓Improves
?
Depression Symptoms
1 study
↓Improves
?
Fatigue Symptoms
1 study
↓Improves
?
Subjective Well-Being
1 study
↑Improves
?
TNF-Alpha
1 study
↓Improves
C
Immunity
Small Improvement
small↑Improves
?
Natural Killer Cell Activity
1 study
↑Improves
?
TNF-Alpha
1 study
↓Improves
C
Fatigue Symptoms
Small Improvement
1 study
small↓Improves
?
Neurasthenia Symptoms
↓Improves
?
Subjective Well-Being
1 study
↑Improves
D
Benign Prostatic Hyperplasia Symptoms
No effect
none
?
Lower Urinary Tract Symptoms
2 studies
↓Improves
?
Prostate-Specific Antigen
2 studies
↑Improves
?
Subjective Well-Being
1 study
↑Improves
?
Testosterone
1 study
↑Improves
D
Blood Flow
No effect
none
?
Proteinuria
↑Improves
D
Adrenaline
No effect
none
?
Anti-Oxidant Enzyme Profile
1 study
↑Improves
?
Blood Pressure
1 study
↓Improves
?
Dopamine
1 study
↑Improves
?
High-density lipoprotein (HDL)
1 study
↑Improves
?
Oxidative Stress Biomarkers
1 study
↓Improves
?
Triglycerides
1 study
↓Improves
?
Weight
1 study
↓Improves
D
Adrenaline
No effect
none
?
Anti-Oxidant Enzyme Profile
1 study
↑Improves
?
Blood Pressure
1 study
↓Improves
?
Dopamine
1 study
↑Improves
?
High-density lipoprotein (HDL)
1 study
↑Improves
?
Oxidative Stress Biomarkers
1 study
↓Improves
?
Triglycerides
1 study
↓Improves
?
Weight
1 study
↓Improves
D
Anti-Oxidant Enzyme Profile
No effect
1 study
none
?
C-Reactive Protein (CRP)
1 study
↓Improves
?
DNA Damage
1 study
↑Worsens
?
High-density lipoprotein (HDL)
1 study
↑Improves
?
Immunity
↑Improves
?
Liver Enzymes
1 study
↑Worsens
?
Low-density lipoprotein (LDL)
1 study
↓Improves
?
Oxidative Stress Biomarkers
1 study
↓Improves
?
Total cholesterol
↓Improves
?
Triglycerides
1 study
↓Improves
?
Uric Acid
1 study
↓Improves
?
Colorectal Cancer Risk
↓Improves
?
Proteinuria
↑Improves

Research Citations (13)

Randomized clinical trial of an ethanol extract of Ganoderma lucidum in men with lower urinary tract symptoms
PMID: 18097505
Effect of an extract of Ganoderma lucidum in men with lower urinary tract symptoms: a double-blind, placebo-controlled randomized and dose-ranging study
PMID: 18097503
A randomized, double-blind and placebo-controlled study of a Ganoderma lucidum polysaccharide extract in neurasthenia
PMID: 15857210
Study of potential cardioprotective effects of Ganoderma lucidum (Lingzhi): results of a controlled human intervention trial
PMID: 21801467
Ganoderma lucidum ("Lingzhi"), a Chinese medicinal mushroom: biomarker responses in a controlled human supplementation study
PMID: 14756912
Monitoring of immune responses to a herbal immuno-modulator in patients with advanced colorectal cancer
PMID: 16428086
Safety and tolerability of Ganoderma lucidum in healthy subjects: a double-blind randomized placebo-controlled trial
PMID: 17597499
Effects of ganopoly (a Ganoderma lucidum polysaccharide extract) on the immune functions in advanced-stage cancer patients
PMID: 12916709
Ganoderma lucidum suppresses endothelial cell cytotoxicity and proteinuria in persistent proteinuric focal segmental glomerulosclerosis (FSGS) nephrosis
PMID: 15567896
Effect of Ganoderma lucidum capsules on T lymphocyte subsets in football players on "living high-training low"
PMID: 18048435

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