Dr. Grey AI

Inflammation

Research on inflammatory processes, cytokine modulation, and anti-inflammatory interventions.

Quick Answer

What it is

Research on inflammatory processes, cytokine modulation, and anti-inflammatory interventions.

Key findings

  • Grade B: Inflammatory Markers (CRP) (Black Seed Oil)
  • Grade B: C-Reactive Protein (Urolithin A)
  • Grade C: Anti-Inflammatory Activity (TB-500)

Safety

No specific caution or interaction language was detected in the current summary/outcome notes.

ℹ️ Quick Facts

Quick Facts: Inflammation

  • Supplements Studied:6
  • Top Supplement:Black Seed Oil (B)
6 supps · 6 outcomes

Detailed Outcomes

Grade:
Effect:
Size:
Sort:
|
B
Inflammatory Markers (CRP)
Meta-analysis: Significant reduction in CRP and MDA. Immunomodulatory effects on Th1/Th2 balance demonstrated.
10 studies
moderate↓Improves
B
C-Reactive Protein
Significantly lower CRP indicating reduced inflammation
3 studies
moderate↓Improves
C
Anti-Inflammatory Activity
Inhibits NF-κB signaling, reduces pro-inflammatory cytokines (TNF-α, IL-1β, IL-6). Demonstrated in multiple inflammation models.
5 studies
moderate↑Improves
C
Inflammatory Markers (IL-6, TNF-α)
Small decrease in inflammatory cytokines
4 studies
small↓Improves
C
Inflammatory Markers
Modest reduction in inflammatory markers; synergistic anti-inflammatory effect when combined with curcumin
4 studies
small↓Improves
C
Anti-inflammatory Effects
Preclinical and in vitro evidence: Inhibits NF-κB, NLRP3 inflammasome, and reduces pro-inflammatory cytokines. Shown to reduce neuroinflammation in sleep deprivation and chronic stress models. Clinical studies limited but mechanism well-established.
moderate↑Improves

Research Citations (100)

Thymosin beta 4 as an Alzheimer disease intervention target identified using human brain organoids
(2025)
PMID: 40816274
Thymosin Beta-4 Modulates Cardiac Remodeling by Regulating ROCK1 Expression in Adult Mammals
(2025)
PMID: 40362372
CCN5 suppresses injury-induced vascular restenosis by inhibiting smooth muscle cell proliferation and facilitating endothelial repair via thymosin β4 and Cd9 pathway.
(2025)
PMID: 39873228
Tβ4-exosome-loaded hemostatic and antibacterial hydrogel to improve vascular regeneration and modulate macrophage polarization for diabetic wound treatment.
(2025)
PMID: 40070869
Corrigendum to 'Tβ4-exosome-loaded hemostatic and antibacterial hydrogel to improve vascular regeneration and modulate macrophage polarization for diabetic wound treatment' [Mater. Today Bio,Volume 31, 2025, 101585].
(2025)
PMID: 40568017
Mechanistic study of the Tβ4/SLC7A11 signaling pathway regulating breast cancer evolution.
(2025)
PMID: 40912522
Identification of glutamine as a potential therapeutic target in dry eye disease.
(2025)
PMID: 39837870
Epimedin C promotes mitochondrial transfer and delays thymus atrophy in 4-VCD induced mimetic-menopausal mice.
(2025)
PMID: 39919331
Thymosin β4 Regulates Tissue Inflammatory Response in Mouse Nonalcoholic Fatty Liver Disease by Promoting Macrophage M2-Type Polarization.
(2025)
PMID: 40322536
Tβ4-Engineered ADSC Extracellular Vesicles Rescue Cell Senescence Through Separable Microneedle Patches for Diabetic Wound Healing.
(2025)
PMID: 40279568

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