Urolithin A

Urolithin A is a gut-microbiome-derived metabolite from pomegranate and berries that activates mitophagy (removal of damaged mitochondria). RCTs show ~12% improvement in muscle strength and significant endurance gains in older adults. Also reduces inflammation (CRP) and improves mitochondrial efficiency. One of the more promising healthy aging supplements with solid human evidence. Only ~40% of people produce UA naturally - supplements bypass this variability.

Quick Answer

What it is

Urolithin A is a gut-microbiome-derived metabolite from pomegranate and berries that activates mitophagy (removal of damaged mitochondria). RCTs show ~12% improvement in muscle strength and significant endurance gains in older adults.

Key findings

  • Grade B: Mitochondrial Efficiency
  • Grade B: Muscle Strength
  • Grade B: C-Reactive Protein (Inflammation)

Safety

No specific caution or interaction language was detected in the current summary/outcome notes.

ℹ️ Quick Facts: Urolithin A

Quick Facts: Urolithin A

  • Best Evidence:Grade B
  • Conditions Studied:2
  • Research Outcomes:7
  • Grade B Findings:4
  • Key Effect:Inflammation
Outcomes by grade:
A0
B4
C3
D0
2 conditions · 7 outcomes

Detailed Outcomes

|
B
Mitochondrial Efficiency
Lower plasma acylcarnitines indicating higher mitochondrial efficiency
4 studies
moderateImproves
B
Muscle Strength
~12% improvement in muscle strength (ATLAS trial)
3 studies
moderateImproves
B
Muscle Endurance
Significant improvement in muscle contractions until fatigue
2 studies
moderateImproves
B
C-Reactive Protein
Significantly lower CRP indicating reduced inflammation
3 studies
moderateImproves
C
6-Minute Walk Distance
Clinically meaningful but not statistically significant improvement
2 studies
smallImproves
C
Peak VO2
Clinically meaningful improvement in aerobic endurance
1 study
smallImproves
C
T Cell Function
Expanded naive-like CD8+ cells and increased fatty acid oxidation capacity
1 study
moderateImproves

Evidence by Condition

Best grade per condition (each condition may have multiple outcomes)

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