Urolithin A
Urolithin A is a gut-microbiome-derived metabolite from pomegranate and berries that activates mitophagy (removal of damaged mitochondria). RCTs show ~12% improvement in muscle strength and significant endurance gains in older adults. Also reduces inflammation (CRP) and improves mitochondrial efficiency. One of the more promising healthy aging supplements with solid human evidence. Only ~40% of people produce UA naturally - supplements bypass this variability.
Quick Answer
What it is
Urolithin A is a gut-microbiome-derived metabolite from pomegranate and berries that activates mitophagy (removal of damaged mitochondria). RCTs show ~12% improvement in muscle strength and significant endurance gains in older adults.
Key findings
- Grade B: Mitochondrial Efficiency
- Grade B: Muscle Strength
- Grade B: C-Reactive Protein (Inflammation)
Safety
No specific caution or interaction language was detected in the current summary/outcome notes.
ℹ️ Quick Facts: Urolithin A
Quick Facts: Urolithin A
- Best Evidence:Grade B
- Conditions Studied:2
- Research Outcomes:7
- Grade B Findings:4
- Key Effect:Inflammation
Detailed Outcomes
Evidence by Condition
Best grade per condition (each condition may have multiple outcomes)
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