Supplement
Fisetin is a plant pigment found in strawberries, apples, and onions, with antioxidant and anti-inflammatory properties. Small trials found that blood markers of inflammation, IL-6 and TNF-α, went down, as did markers of senescent (aging) cells, though the evidence is limited. The studies were small, with 95 people at most, and early hints of less joint pain or lower blood glucose are very limited.
- Updated
- How we grade
- 10 studies cited
- Best evidence
- Grade C
- Conditions studied
- 5
- Outcomes
- 7
- Graded outcomes
- 0052
Evidence by condition
- Strong
- Moderate
- Limited
- Very limited
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Senescent Cell Markers Moderate reduction in senescence markers | Improves (the measure goes down) | Moderate effect | 75 people | |||
| Physical Function in Elderly Small improvement in frailty measures | Improves (the measure goes up) | Small effect | 40 people |
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Inflammatory Markers (IL-6, TNF-α) Small decrease in inflammatory cytokines | Improves (the measure goes down) | Small effect | 95 people |
Cognitive Function
- Neuroprotective Markers: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Neuroprotective Markers Small neuroprotective effect observed | Improves (the measure goes up) | Small effect | 65 people |
Metabolic Health
- Oxidative Stress Markers: improves
- Fasting Blood Glucose: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Oxidative Stress Markers Small reduction in oxidative stress | Improves (the measure goes down) | Small effect | 72 people | |||
| Fasting Blood Glucose Minor reduction in glucose levels | Improves (the measure goes down) | Small effect | 48 people |
Osteoarthritis (OA)
- Joint Pain: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Joint Pain Preliminary pain reduction observed | Improves (the measure goes down) | Small effect | 30 people |
Key findings
- Senescent Cell MarkersImproves (the measure goes down)
- Physical Function in ElderlyImproves (the measure goes up)
- Inflammatory Markers (IL-6, TNF-α)Improves (the measure goes down)
Shop Fisetin
Third-party tested Fisetin products. The evidence above is limited, so read it before you buy.
- Grade C
Links to Fullscript, iHerb or Thorne carry our referral, so we may earn a commission at no extra cost to you. Grades come from the research and never change based on what we earn. Fullscript asks for a free account before it shows its catalog and prices. Full disclosure
Studies cited
10 studies from PubMed
- The Effects of Fisetin on Reducing Biological Aging: A Pilot Study
- Senolytics To slOw Progression of Sepsis (STOP-Sepsis) in elderly patients: Study protocol for a multicenter, randomized, adaptive allocation clinical trial
- The neuroprotective effects of fisetin, a natural flavonoid in neurodegenerative diseases: Focus on the role of oxidative stress
- Fisetin as a Senotherapeutic Agent: Biopharmaceutical Properties and Crosstalk between Cell Senescence and Neuroprotection
- Fisetin for COVID-19 in skilled nursing facilities: Senolytic trials in the COVID era
- Neuroprotective Effect of Fisetin Against the Cerebral Ischemia-Reperfusion Damage via Suppression of Oxidative Stress and Inflammatory Parameters
- Senolytic drugs: from discovery to translation
- Fisetin is a senotherapeutic that extends health and lifespan
- Fisetin as a caloric restriction mimetic protects rat brain against aging induced oxidative stress, apoptosis and neurodegeneration
- Fisetin Exerts Antioxidant and Neuroprotective Effects in Multiple Mutant hSOD1 Models of Amyotrophic Lateral Sclerosis by Activating ERK