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Fisetin

Fisetin is a flavonoid found in fruits and vegetables, particularly strawberries, with potent senolytic properties that selectively clear senescent (damaged, aging) cells. It works by inhibiting pro-survival pathways in senescent cells while sparing healthy cells. Mayo Clinic and other institutions are conducting clinical trials investigating its effects on aging, frailty, and age-related conditions.

Quick Answer

What it is

Fisetin is a flavonoid found in fruits and vegetables, particularly strawberries, with potent senolytic properties that selectively clear senescent (damaged, aging) cells. It works by inhibiting pro-survival pathways in senescent cells while sparing healthy cells.

Key findings

  • Grade C: Inflammatory Markers (IL-6, TNF-α) (Inflammation)
  • Grade C: Senescent Cell Markers (Aging & Longevity)
  • Grade C: Neuroprotective Markers (Cognitive Function)

Safety

No specific caution or interaction language was detected in the current summary/outcome notes.

ℹ️ Quick Facts: Fisetin

Quick Facts: Fisetin

  • Best Evidence:Grade C
  • Conditions Studied:5
  • Research Outcomes:7
  • Key Effect:Metabolic Health
Outcomes by grade:
A0
B0
C5
D2
5 conditions · 7 outcomes

Detailed Outcomes

|
C
Inflammatory Markers (IL-6, TNF-α)
Small decrease in inflammatory cytokines
4 studies
small↓Improves
C
Senescent Cell Markers
Moderate reduction in senescence markers
3 studies
moderate↓Improves
C
Physical Function in Elderly
Small improvement in frailty measures
2 studies
small↑Improves
C
Neuroprotective Markers
Small neuroprotective effect observed
3 studies
small↑Improves
C
Oxidative Stress Markers
Small reduction in oxidative stress
3 studies
small↓Improves
D
Fasting Blood Glucose
Minor reduction in glucose levels
2 studies
small↓Improves
D
Joint Pain
Preliminary pain reduction observed
1 study
small↓Improves

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