Dr. Grey AI

Luteolin

Luteolin is a flavone found in celery, parsley, broccoli, chamomile, and peppers. It exhibits potent anti-inflammatory, neuroprotective, and mast cell-stabilizing properties. Open-label pilot study (n=50, 26 weeks): Luteolin formulation significantly improved adaptive functioning in children with ASD (P<0.005) with 26.6-34.8% reduction in Aberrant Behavior Checklist scores. Meta-analysis (n=441): PEA+luteolin combination improved post-COVID olfactory dysfunction. More potent than cromolyn at inhibiting mast cell mediator release (histamine, tryptase, IL-6, TNF). Preclinical evidence supports neuroprotective effects in AD, PD, and TBI models via NF-κB inhibition and Nrf2 activation.

Quick Answer

What it is

Luteolin is a flavone found in celery, parsley, broccoli, chamomile, and peppers. It exhibits potent anti-inflammatory, neuroprotective, and mast cell-stabilizing properties.

Key findings

  • Grade B: Autism Spectrum Disorder Symptoms (Neurological Health)
  • Grade B: Mast Cell Inhibition (Immune Health)
  • Grade B: Post-COVID Olfactory Recovery (Respiratory Health)

Safety

  • No major adverse effects (NCT01847521).
ℹ️ Quick Facts: Luteolin

Quick Facts: Luteolin

  • Best Evidence:Grade B
  • Conditions Studied:5
  • Research Outcomes:6
  • Grade B Findings:3
  • Key Effect:Neurological Health
Outcomes by grade:
A0
B3
C3
D0
5 conditions · 6 outcomes

Detailed Outcomes

|
B
Autism Spectrum Disorder Symptoms
Open-label pilot study (n=50, 26 weeks): Luteolin formulation (100mg luteolin + 70mg quercetin + 30mg rutin) significantly improved VABS scores: communication (+8.43 months), daily living skills (+7.17 months), social domain (+8 months). 26.6-34.8% reduction in Aberrant Behavior Checklist subscales. No major adverse effects (NCT01847521).
moderate↓Improves
C
Neuroprotection (Preclinical)
Multiple preclinical studies demonstrate neuroprotective effects in models of Alzheimer's disease, Parkinson's disease, traumatic brain injury, and stroke. Mechanisms include reduced Aβ plaque formation, microglial suppression, and enhanced neuronal survival. Clinical translation pending.
moderate↑Improves
B
Mast Cell Inhibition
In vitro studies: Luteolin significantly more potent than cromolyn (standard mast cell stabilizer) at inhibiting release of histamine, tryptase, MMP-9, VEGF, IL-1β, IL-6, IL-8, and TNF from human mast cells. Effective at concentrations achievable with oral supplementation.
large↑Improves
B
Post-COVID Olfactory Recovery
Systematic review and meta-analysis (5 studies, n=441): PEA+luteolin (CoUltraPEALut) combined with olfactory training showed superior olfactory recovery compared to olfactory training alone in patients with post-COVID olfactory dysfunction.
moderate↑Improves
C
Anti-inflammatory Effects
Preclinical and in vitro evidence: Inhibits NF-κB, NLRP3 inflammasome, and reduces pro-inflammatory cytokines. Shown to reduce neuroinflammation in sleep deprivation and chronic stress models. Clinical studies limited but mechanism well-established.
moderate↑Improves
C
Anxiolytic and Antidepressant Effects
Preclinical studies: Luteolin (10-20 mg/kg) reduced anxiety and depression-like behaviors in sleep deprivation, PTSD, and chronic stress animal models. Effects comparable to paroxetine. Mechanisms include NF-κB/NLRP3 pathway modulation. Human clinical trials needed.
moderate↑Improves

Related Supplements

Vitamin D

2 shared conditions · 308 outcomes

Vitamin D is a fat-soluble vitamin that our skin synthesizes when exposed to the sun. It benefits us in many ways, from bone health to mood.

Vitamin C

2 shared conditions · 262 outcomes

Vitamin C, or ascorbic acid, is an essential vitamin and a very popular supplement due to its antioxidant properties, safety profile, and low price. Many people supplement with vitamin C because it is believed to reduce symptoms of the common cold.

Magnolia Bark (Magnolia officinalis)

2 shared conditions · 6 outcomes

Magnolia bark extract contains the bioactive lignans honokiol and magnolol, used in traditional Chinese medicine for anxiety and stress. RCT (n=56, 4 weeks): Relora (magnolia+phellodendron) reduced salivary cortisol by 18% and improved mood parameters including stress (-11%), tension (-13%), depression (-20%), anger (-42%), and fatigue (-31%) vs placebo. Pilot RCT in women: Reduced transitory anxiety on Spielberger STATE questionnaire. Honokiol and magnolol are positive allosteric modulators of GABAA receptors, enhancing both synaptic and extra-synaptic inhibitory transmission. Anxiolytic effects comparable to diazepam without sedation, motor dysfunction, or amnesia in animal models.

Cannabis

2 shared conditions · 194 outcomes

Cannabis is the common name and genus for a few plants used around the world due to their psychoactive properties. Its major component, known as THC, possesses acute benefits but is subject to rapid tolerance. Additionally, nonpsychoactive components like CBD may have chronic benefits. While therapeutic, particularly for pain relief, the plant is not a panacea.

Zinc

1 shared condition · 148 outcomes

Zinc is an essential mineral that is critical for the function of hundreds of enzymes. Consequently, it plays many roles, including in antioxidant enzymes, brain function, and the immune system. Zinc is most commonly taken to reduce the duration of respiratory infections and the common cold.

Wild Yam

1 shared condition · 29 outcomes

Wild yam describes any uncultivated members of the Dioscorea genus, some of which are known specifically for their medicinal properties. Depending on the species, wild yams have been touted for improvements in menopausal symptoms, inflammation, healthy aging, and reproductive function.

Vitamin E

1 shared condition · 274 outcomes

Vitamin E is a fat-soluble antioxidant that protects cells from oxidative damage and is found in several common foods. Supplementing with extra vitamin E does not have broad health benefits, except in people with vitamin E deficiency, and long-term high-dose supplementation may cause harm.