Magnolia bark extract contains the bioactive lignans honokiol and magnolol, used in traditional Chinese medicine for anxiety and stress. RCT (n=56, 4 weeks): Relora (magnolia+phellodendron) reduced salivary cortisol by 18% and improved mood parameters including stress (-11%), tension (-13%), depression (-20%), anger (-42%), and fatigue (-31%) vs placebo. Pilot RCT in women: Reduced transitory anxiety on Spielberger STATE questionnaire. Honokiol and magnolol are positive allosteric modulators of GABAA receptors, enhancing both synaptic and extra-synaptic inhibitory transmission. Anxiolytic effects comparable to diazepam without sedation, motor dysfunction, or amnesia in animal models.
Magnolia bark extract contains the bioactive lignans honokiol and magnolol, used in traditional Chinese medicine for anxiety and stress. RCT (n=56, 4 weeks): Relora (magnolia+phellodendron) reduced salivary cortisol by 18% and improved mood parameters including stress (-11%), tension (-13%), depression (-20%), anger (-42%), and fatigue (-31%) vs placebo.
No specific caution or interaction language was detected in the current summary/outcome notes.
Best grade per condition (each condition may have multiple outcomes)
2 shared conditions · 215 outcomes
Probiotics are microorganisms that can have a positive effect on health.
2 shared conditions · 141 outcomes
Melatonin is a hormone secreted in the brain that regulates sleep. It appears to be highly sensitive to light therapy and dark therapy. Oral ingestion of melatonin may be used as a sleep aid. It is non-addictive.
2 shared conditions · 248 outcomes
Magnesium is an essential dietary mineral that is involved in energy production, nervous system function, blood pressure regulation, and blood glucose control. A lack of magnesium in the diet — which is common in modern societies — is associated with an increased risk of diabetes, cardiovascular disease, and other health conditions.
2 shared conditions · 6 outcomes
Luteolin is a flavone found in celery, parsley, broccoli, chamomile, and peppers. It exhibits potent anti-inflammatory, neuroprotective, and mast cell-stabilizing properties. Open-label pilot study (n=50, 26 weeks): Luteolin formulation significantly improved adaptive functioning in children with ASD (P<0.005) with 26.6-34.8% reduction in Aberrant Behavior Checklist scores. Meta-analysis (n=441): PEA+luteolin combination improved post-COVID olfactory dysfunction. More potent than cromolyn at inhibiting mast cell mediator release (histamine, tryptase, IL-6, TNF). Preclinical evidence supports neuroprotective effects in AD, PD, and TBI models via NF-κB inhibition and Nrf2 activation.
2 shared conditions · 7 outcomes
GABA is the main inhibitory neurotransmitter in the brain. Oral GABA supplements show modest benefits for sleep onset and anxiety in small trials. CRITICAL ISSUE: Oral GABA probably does NOT cross the blood-brain barrier significantly - studies conflict but most suggest very poor BBB penetration. Effects may occur via gut-brain axis, enteric nervous system, or vagus nerve signaling rather than direct brain action. Safe even at high doses but mechanism of any CNS effects is unclear.