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Sleep Quality

Research on sleep architecture, sleep disorders, and interventions that improve sleep quality.

Quick Answer

What it is

Research on sleep architecture, sleep disorders, and interventions that improve sleep quality.

Key findings

  • Grade B: Sleep Latency (Tryptophan)
  • Grade B: Subjective Sleepiness (Tryptophan)
  • Grade C: Total Sleep Time (DSIP (Delta Sleep-Inducing Peptide))

Safety

No specific caution or interaction language was detected in the current summary/outcome notes.

ℹ️ Quick Facts

Quick Facts: Sleep Quality

  • Supplements Studied:7
  • Top Supplement:Tryptophan (B)
7 supps · 13 outcomes

Detailed Outcomes

Grade:
Effect:
Size:
Sort:
|
B
Sleep Latency
Doses ≥1g decrease sleep latency; best results in mild insomnia
40 studies
moderate↓Improves
B
Subjective Sleepiness
Increased rated subjective sleepiness at doses ≥1g
20 studies
moderate↑Improves
C
Total Sleep Time
Moderate Increase
5 studies
moderate↑Improves
C
Sleep Onset Latency
Moderate Decrease
4 studies
moderate↓Improves
C
Delta Wave Activity
Moderate Increase
3 studies
moderate↑Improves
C
Sleep Latency
Moderate Decrease - 100mg GABA reduced time to fall asleep
4 studies
moderate↓Improves
C
Non-REM Sleep Duration
Small Increase in non-REM sleep duration
2 studies
small↑Improves
C
Melatonin Production
Moderate increase in nocturnal melatonin
3 studies
moderate↑Improves
D
Sleep Architecture
Small improvement in sleep quality
2 studies
small↑Improves
C
Slow-Wave Sleep Duration
Enhanced deep sleep duration (GHRH analog data)
2 studies
moderate↑Improves
C
Sleep Quality
Small Improvement (chamomile extract studies)
2 studies
small↑Improves
D
Daytime Functioning
Trend toward improvement, not statistically significant
1 study
small↑Improves
C
Sleep Quality
Preclinical: Honokiol (10-20 mg/kg) shortened sleep latency to NREM sleep and increased NREM sleep amount by modulating GABAA benzodiazepine site. Clinical evidence limited but mechanism supports sleep promotion without next-day sedation.
moderate↑Improves

Research Citations (100)

Analysis of growth hormone releasing hormone and its analogs in urine using nano liquid chromatography coupled with quadrupole/orbitrap mass spectrometry.
(2026)
PMID: 41138283
Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties
(2025)
PMID: 40141333
The Antioxidant Tetrapeptide Epitalon Enhances Delayed Wound Healing in an in Vitro Model of Diabetic Retinopathy.
(2025)
PMID: 40493162
Neuropharmacological potential of honokiol and its derivatives from Chinese herb Magnolia species: understandings from therapeutic viewpoint
(2023)
PMID: 37940681
Honokiol-Rich Magnolia officinalis Bark Extract Attenuates Trauma-Induced Neuropathic Pain
(2023)
PMID: 37629145
Early detection of cannabinoids in biological samples based on their affinity interaction with the growth hormone secretagogue receptor.
(2022)
PMID: 34736642
An antibody-free, ultrafiltration-based assay for the detection of growth hormone-releasing hormones in urine at low pg/mL concentrations using nanoLC-HRMS/MS.
(2022)
PMID: 35298973
Peptides Regulating Proliferative Activity and Inflammatory Pathways in the Monocyte/Macrophage THP-1 Cell Line.
(2022)
PMID: 35408963
Epitalon protects against post-ovulatory aging-related damage of mouse oocytes in vitro.
(2022)
PMID: 35413689
Dietary gamma-aminobutyric acid (GABA) induces satiation by enhancing the postprandial activation of vagal afferent nerves
(2022)
PMID: 35705389

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