Apigenin
Apigenin is a bioflavonoid found in chamomile tea, celery, and parsley. Evidence from chamomile extract studies (~1.2% apigenin) shows benefits for anxiety and sleep quality (C-grade). Acts as a weak GABA-A receptor modulator and CD38 inhibitor (increases NAD+). BIOAVAILABILITY ISSUE: Isolated apigenin has poor stability and absorption - chamomile extract is better studied. Often discussed for longevity (CD38/NAD+ pathway) but this is largely theoretical. High doses may cause muscle relaxation and sedation.
Quick Answer
What it is
Apigenin is a bioflavonoid found in chamomile tea, celery, and parsley. Evidence from chamomile extract studies (~1.2% apigenin) shows benefits for anxiety and sleep quality (C-grade).
Key findings
- Grade C: Anxiety Symptoms (Generalized Anxiety Disorder (GAD))
- Grade C: Sleep Quality (Sleep Quality)
- Grade C: Depression Symptoms (Depression)
Safety
No specific caution or interaction language was detected in the current summary/outcome notes.
ℹ️ Quick Facts: Apigenin
Quick Facts: Apigenin
- Best Evidence:Grade C
- Conditions Studied:3
- Research Outcomes:4
- Key Effect:Generalized Anxiety Disorder (GAD)
Detailed Outcomes
Evidence by Condition
Best grade per condition (each condition may have multiple outcomes)
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