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Condition

Pain

Pain is the nervous system's alarm, with nerves sending signals that the brain and spinal cord weigh and amplify, and chronic pain is when that alarm keeps sounding long after an injury should have settled. Among supplements, the one with findings so far is DSIP, a small peptide, and studies found chronic pain intensity went down. That rests on just four small studies with 35 people in total, so the evidence is limited.

Sources: PMID 6548970

Supplements studied
0
Medicines and peptides
1
Graded outcomes
1
No supplement studies yetWe haven’t found supplement studies for Pain. The medicines and peptides studied for it are listed below.

Prescription medicines and peptides studied, for context

These are not supplements. Most need a prescription, and some are research compounds with no approved use.

1 medicine or peptide

DSIP (Delta Sleep-Inducing Peptide)

DSIP (Delta Sleep-Inducing Peptide): outcomes studied for Pain
GradeOutcomeEffectSizeStudiesPeopleStudies list
Chronic Pain Intensity

Moderate Reduction

Improves (the measure goes down)Moderate effect4 studies35 people

Studies that measured chronic pain intensity

and 1 more on the DSIP (Delta Sleep-Inducing Peptide) page

What the published studies found

1 automated reading

Automated reading of the published studies (Decosa evidence engine), for outcomes Dr. Grey has not graded yet. It is not a Dr. Grey grade and does not change one. How it is read

Key findings

  • Chronic Pain IntensityDSIP (Delta Sleep-Inducing Peptide)Improves (the measure goes down)

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Studies cited

43 studies from PubMed

  1. Effect of delta sleep-inducing peptide on the expression of antioxidant enzyme genes in the brain and blood of rats during physiological aging.Bulletin of experimental biology and medicine, 2014 · PMID 25257425
  2. Effect of delta sleep-inducing peptide on oxidative modification of proteins in rat tissues and blood during physiological aging.Bulletin of experimental biology and medicine, 2012 · PMID 22866315
  3. [Endogenous anticonvulsants: neuropeptide Y and delta sleep inducing peptide].Medicinski pregled, 2008 · PMID 19102071
  4. Interaction of Delta sleep-inducing peptide and valproate on metaphit audiogenic seizure model in rats.Cellular and molecular neurobiology, 2007 · PMID 17957464
  5. Delta sleep-inducing peptide (DSIP): a still unresolved riddleJ Neurochem, 2006 · PMID 16539679
  6. Delta-sleep-inducing peptide potentiates anticonvulsive activity of valproate against metaphit-provoked audiogenic seizure in rats.Pharmacology, 2006 · PMID 16645330
  7. Antiepileptic activity of delta sleep-inducing peptide and its analogue in metaphit-provoked seizures in rats.Seizure, 2005 · PMID 15911358
  8. Delta sleep-inducing peptide and its tetrapeptide analogue alleviate severity of metaphit seizures.Pharmacology, biochemistry, and behavior, 2004 · PMID 14751449
  9. [Behavioral and electroencephalographic effects of delta sleep inducing peptide and its analogue on metaphit-induced audiogenic seizures in rats].Srpski arhiv za celokupno lekarstvo, 2004 · PMID 15938222
  10. Delta sleep inducing peptide (DSIP): effect on respiration activity in rat brain mitochondria and stress protective potency under experimental hypoxiaPeptides, 2003 · PMID 12668217
  11. Opioid detoxification with delta sleep-inducing peptide: results of an open clinical trialJ Clin Psychopharmacol, 1998 · PMID 9617990
  12. Delta-sleep-inducing peptide sequels in the mechanisms of resistance to emotional stressAnn N Y Acad Sci, 1995 · PMID 8597403
  13. Delta sleep-inducing peptide administration does not influence growth hormone and prolactin secretion in normal women.Psychoneuroendocrinology, 1993 · PMID 8475226
  14. [The delta sleep-inducing peptide and its role in modulating epileptic activity].Fiziologicheskii zhurnal imeni I.M. Sechenova, 1993 · PMID 8330074
  15. Effects of delta sleep-inducing peptide on sleep of chronic insomniac patients. A double-blind studyNeuropsychobiology, 1992 · PMID 1299794
  16. Immunohistochemical localization of delta sleep-inducing peptide-like immunoreactivity in the central nervous system and pituitary of the frog Rana ridibunda.Neuroscience, 1992 · PMID 1315935
  17. Delta-sleep-inducing peptide stimulates melatonin, 5-methoxytryptophol and serotonin secretion from perifused rat pineal glands.Biological signals, 1992 · PMID 1339175
  18. Immunohistochemical localization of delta sleep-inducing peptide (DSIP) in the brain and pituitary of the cartilaginous fish Scyliorhinus canicula.Peptides, 1992 · PMID 1437707
  19. Delta sleep-inducing-peptide-like immunoreactivity (DSIP-LI) and delta sleep in schizophrenic volunteers.Sleep, 1992 · PMID 1475566
  20. Production and immunohistochemical application of monoclonal antibodies against delta sleep-inducing peptide.Journal of chemical neuroanatomy, 1992 · PMID 1476667
  21. Immunoreactive delta sleep-inducing peptide in the rat hypothalamus, pituitary and adrenal gland: effects of adrenalectomy.Hormone research, 1991 · PMID 1814802
  22. Phosphorylation of delta sleep-inducing peptide (DSIP) by casein kinase II in vitro.Peptides, 1991 · PMID 1815223
  23. Characterization of delta-sleep-inducing peptide-evoked release of Met-enkephalin from brain synaptosomes in rats.Journal of neurochemistry, 1991 · PMID 1861139
  24. Immunohistochemical mapping of delta sleep-inducing peptide in the cat brain and hypophysis. Relationships with the LHRH system and corticotropes.Journal of chemical neuroanatomy, 1990 · PMID 2222894
  25. Immunohistochemical distribution of delta sleep inducing peptide in the rabbit brain and hypophysis.Neuroendocrinology, 1989 · PMID 2657475
  26. Delta sleep-inducing peptide (DSIP)-like immunoreactivity in gut: coexistence with known peptide hormones.Peptides, 1989 · PMID 2664725
  27. Involvement of spinal noradrenergic system in the mechanism of an antinociceptive effect of delta-sleep-inducing peptide (DSIP).Brain research, 1989 · PMID 2713670
  28. Potent antinociceptive effect of centrally administered delta-sleep-inducing peptide (DSIP).European journal of pharmacology, 1988 · PMID 2853064
  29. Evidence for a role of delta sleep-inducing peptide in slow-wave sleep and sleep-related growth hormone release in the rat.Proceedings of the National Academy of Sciences of the United States of America, 1988 · PMID 3368469
  30. DSIP--a tool for investigating the sleep onset mechanism: a review.The International journal of neuroscience, 1988 · PMID 3286557
  31. Delta sleep-inducing peptide modulates the stimulation of rat pineal N-acetyltransferase activity by involving the alpha 1-adrenergic receptorJ Neurochem, 1987 · PMID 3029331
  32. Comparison of DSIP- (delta sleep-inducing peptide) and P-DSIP-like (phosphorylated) immunoreactivity in cerebrospinal fluid of patients with senile dementia of Alzheimer type, multi-infarct syndrome, communicating hydrocephalus and Parkinson's disease.Journal of neurology, 1987 · PMID 2448424
  33. The effects of DSIP on pain threshold during light and dark periods in rats are not naloxone-sensitive.The International journal of neuroscience, 1987 · PMID 3679693
  34. Delta sleep-inducing peptide (DSIP) stimulates growth hormone (GH) release in the rat by hypothalamic and pituitary actions.Peptides, 1987 · PMID 3575154
  35. Delta-sleep-inducing peptide (DSIP): a reviewNeurosci Biobehav Rev, 1984 · PMID 6145137
  36. DSIP in the treatment of withdrawal syndromes from alcohol and opiatesEur Neurol, 1984 · PMID 6548969
  37. A clinical trial with DSIPEur Neurol, 1984 · PMID 6391926
  38. Therapeutic effects of delta-sleep-inducing peptide (DSIP) in patients with chronic, pronounced pain episodes. A clinical pilot studyEur Neurol, 1984 · PMID 6548970
  39. Successful treatment of withdrawal symptoms with delta sleep-inducing peptide, a neuropeptide with potential agonistic activity on opiate receptorsNeuropsychobiology, 1983 · PMID 6328354
  40. Delta sleep-inducing peptide (DSIP)-like material is absorbed by the gastrointestinal tract of the neonatal rat.Life sciences, 1983 · PMID 6688848
  41. Acute and delayed effects of DSIP (delta sleep-inducing peptide) on human sleep behaviorInt J Clin Pharmacol Ther Toxicol, 1981 · PMID 6895513
  42. Radioimmunoassay of DSIP-like material in rat brain.Brain research bulletin, 1978 · PMID 318193
  43. Characterization of a delta-electroencephalogram (-sleep)-inducing peptide.Proceedings of the National Academy of Sciences of the United States of America, 1977 · PMID 265572