Peptide
DSIP (Delta Sleep-Inducing Peptide)
DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) first isolated from rabbit brain in 1977. It has been studied for sleep regulation, stress protection, pain modulation, and substance withdrawal. While demonstrating promise in various clinical applications including opioid and alcohol withdrawal, its mechanisms remain incompletely understood, and human clinical data shows mixed results for sleep induction.
- Updated
- How we grade
- 43 studies cited
Research notice. This page is for education and research. Peptides may not be FDA-approved for human use and may only be legally available for research. Talk to a qualified clinician before considering any peptide.
- Best evidence
- Grade C
- Conditions studied
- 4
- Outcomes
- 12
- Graded outcomes
- 0093
Evidence by condition
- Strong
- Moderate
- Limited
- Very limited
General
Symptoms of Withdrawal
- Opioid Withdrawal Severity: improves
- Alcohol Withdrawal Severity: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Opioid Withdrawal Severity Moderate Reduction | Improves (the measure goes down) | Moderate effect | 4 studies | 167 people | ||
Studies that measured opioid withdrawal severity
| ||||||
| Alcohol Withdrawal Severity Moderate Reduction | Improves (the measure goes down) | Moderate effect | 3 studies | 107 people | ||
Pain
- Chronic Pain Intensity: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Chronic Pain Intensity Moderate Reduction | Improves (the measure goes down) | Moderate effect | 4 studies | 35 people | ||
Studies that measured chronic pain intensity
| ||||||
Stress
- Stress Tolerance: improves
- Cortisol Modulation: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Stress Tolerance Moderate Improvement | Improves (the measure goes down) | Moderate effect | 3 studies | 78 people | ||
Studies that measured stress tolerance | ||||||
| Cortisol Modulation Small Effect | Improves (the measure goes down) | Small effect | 3 studies | 40 people | ||
Studies that measured cortisol modulation | ||||||
Key findings
- Sleep Onset LatencyImproves (the measure goes down)
- Total Sleep TimeImproves (the measure goes up)
- Seizure ActivityImproves (the measure goes down)
Studies cited
43 studies from PubMed
- Effect of delta sleep-inducing peptide on the expression of antioxidant enzyme genes in the brain and blood of rats during physiological aging.
- Effect of delta sleep-inducing peptide on oxidative modification of proteins in rat tissues and blood during physiological aging.
- [Endogenous anticonvulsants: neuropeptide Y and delta sleep inducing peptide].
- Interaction of Delta sleep-inducing peptide and valproate on metaphit audiogenic seizure model in rats.
- Delta sleep-inducing peptide (DSIP): a still unresolved riddle
- Delta-sleep-inducing peptide potentiates anticonvulsive activity of valproate against metaphit-provoked audiogenic seizure in rats.
- Antiepileptic activity of delta sleep-inducing peptide and its analogue in metaphit-provoked seizures in rats.
- Delta sleep-inducing peptide and its tetrapeptide analogue alleviate severity of metaphit seizures.
- [Behavioral and electroencephalographic effects of delta sleep inducing peptide and its analogue on metaphit-induced audiogenic seizures in rats].
- Delta sleep inducing peptide (DSIP): effect on respiration activity in rat brain mitochondria and stress protective potency under experimental hypoxia
- Opioid detoxification with delta sleep-inducing peptide: results of an open clinical trial
- Delta-sleep-inducing peptide sequels in the mechanisms of resistance to emotional stress
- Delta sleep-inducing peptide administration does not influence growth hormone and prolactin secretion in normal women.
- [The delta sleep-inducing peptide and its role in modulating epileptic activity].
- Effects of delta sleep-inducing peptide on sleep of chronic insomniac patients. A double-blind study
- Immunohistochemical localization of delta sleep-inducing peptide-like immunoreactivity in the central nervous system and pituitary of the frog Rana ridibunda.
- Delta-sleep-inducing peptide stimulates melatonin, 5-methoxytryptophol and serotonin secretion from perifused rat pineal glands.
- Immunohistochemical localization of delta sleep-inducing peptide (DSIP) in the brain and pituitary of the cartilaginous fish Scyliorhinus canicula.
- Delta sleep-inducing-peptide-like immunoreactivity (DSIP-LI) and delta sleep in schizophrenic volunteers.
- Production and immunohistochemical application of monoclonal antibodies against delta sleep-inducing peptide.
- Immunoreactive delta sleep-inducing peptide in the rat hypothalamus, pituitary and adrenal gland: effects of adrenalectomy.
- Phosphorylation of delta sleep-inducing peptide (DSIP) by casein kinase II in vitro.
- Characterization of delta-sleep-inducing peptide-evoked release of Met-enkephalin from brain synaptosomes in rats.
- Immunohistochemical mapping of delta sleep-inducing peptide in the cat brain and hypophysis. Relationships with the LHRH system and corticotropes.
- Immunohistochemical distribution of delta sleep inducing peptide in the rabbit brain and hypophysis.
- Delta sleep-inducing peptide (DSIP)-like immunoreactivity in gut: coexistence with known peptide hormones.
- Involvement of spinal noradrenergic system in the mechanism of an antinociceptive effect of delta-sleep-inducing peptide (DSIP).
- Potent antinociceptive effect of centrally administered delta-sleep-inducing peptide (DSIP).
- Evidence for a role of delta sleep-inducing peptide in slow-wave sleep and sleep-related growth hormone release in the rat.
- DSIP--a tool for investigating the sleep onset mechanism: a review.
- Delta sleep-inducing peptide modulates the stimulation of rat pineal N-acetyltransferase activity by involving the alpha 1-adrenergic receptor
- Comparison of DSIP- (delta sleep-inducing peptide) and P-DSIP-like (phosphorylated) immunoreactivity in cerebrospinal fluid of patients with senile dementia of Alzheimer type, multi-infarct syndrome, communicating hydrocephalus and Parkinson's disease.
- The effects of DSIP on pain threshold during light and dark periods in rats are not naloxone-sensitive.
- Delta sleep-inducing peptide (DSIP) stimulates growth hormone (GH) release in the rat by hypothalamic and pituitary actions.
- Delta-sleep-inducing peptide (DSIP): a review
- DSIP in the treatment of withdrawal syndromes from alcohol and opiates
- A clinical trial with DSIP
- Therapeutic effects of delta-sleep-inducing peptide (DSIP) in patients with chronic, pronounced pain episodes. A clinical pilot study
- Successful treatment of withdrawal symptoms with delta sleep-inducing peptide, a neuropeptide with potential agonistic activity on opiate receptors
- Delta sleep-inducing peptide (DSIP)-like material is absorbed by the gastrointestinal tract of the neonatal rat.
- Acute and delayed effects of DSIP (delta sleep-inducing peptide) on human sleep behavior
- Radioimmunoassay of DSIP-like material in rat brain.
- Characterization of a delta-electroencephalogram (-sleep)-inducing peptide.