Dr. Grey AI

DSIP (Delta Sleep-Inducing Peptide)

Peptide

DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) first isolated from rabbit brain in 1977. It has been studied for sleep regulation, stress protection, pain modulation, and substance withdrawal. While demonstrating promise in various clinical applications including opioid and alcohol withdrawal, its mechanisms remain incompletely understood, and human clinical data shows mixed results for sleep induction.

Quick Answer

What it is

DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) first isolated from rabbit brain in 1977. It has been studied for sleep regulation, stress protection, pain modulation, and substance withdrawal.

Key findings

  • Grade C: Seizure Activity
  • Grade C: Total Sleep Time (Sleep Quality)
  • Grade C: Sleep Onset Latency (Sleep Quality)

Safety

No specific caution or interaction language was detected in the current summary/outcome notes.

⚠️ Research Notice

This peptide information is for educational and research purposes only. Peptides may not be FDA-approved for human use and may only be legally available for research purposes. Consult qualified healthcare professionals before considering any peptide compounds.

ℹ️ Quick Facts: DSIP (Delta Sleep-Inducing Peptide)

Quick Facts: DSIP (Delta Sleep-Inducing Peptide)

  • Best Evidence:Grade B
  • Conditions Studied:4
  • Research Outcomes:15
  • Key Effect:Symptoms of Withdrawal
A0
B0
C12
D3
4 conditions · 15 outcomes

Detailed Outcomes

|
C
Seizure Activity
7 preclinical studies support this finding. Primarily preclinical evidence.
small↓Improves
C
Hormone Levels
3 preclinical studies support this finding. Primarily preclinical evidence.
small↑Improves
D
GI Protection
2 preclinical studies support this finding. Primarily preclinical evidence.
small↑Improves
D
Anti-Aging
2 preclinical studies support this finding. Primarily preclinical evidence.
small↑Improves
C
Total Sleep Time
Moderate Increase
moderate↑Improves
C
Sleep Onset Latency
Moderate Decrease
moderate↓Improves
C
Delta Wave Activity
Moderate Increase
moderate↑Improves
C
Stress Tolerance
Moderate Improvement
moderate↓Improves
D
Cortisol Modulation
Small Effect
small↓Improves
C
Opioid Withdrawal Severity
Moderate Reduction
moderate↓Improves
C
Alcohol Withdrawal Severity
Moderate Reduction
moderate↓Improves
C
Chronic Pain Intensity
Moderate Reduction
moderate↓Improves

Research Citations (43)

Effect of delta sleep-inducing peptide on the expression of antioxidant enzyme genes in the brain and blood of rats during physiological aging.
(2014)
PMID: 25257425
Effect of delta sleep-inducing peptide on oxidative modification of proteins in rat tissues and blood during physiological aging.
(2012)
PMID: 22866315
[Endogenous anticonvulsants: neuropeptide Y and delta sleep inducing peptide].
(2008)
PMID: 19102071
Interaction of Delta sleep-inducing peptide and valproate on metaphit audiogenic seizure model in rats.
(2007)
PMID: 17957464
Delta sleep-inducing peptide (DSIP): a still unresolved riddle
(2006)
PMID: 16539679
Delta-sleep-inducing peptide potentiates anticonvulsive activity of valproate against metaphit-provoked audiogenic seizure in rats.
(2006)
PMID: 16645330
Antiepileptic activity of delta sleep-inducing peptide and its analogue in metaphit-provoked seizures in rats.
(2005)
PMID: 15911358
Delta sleep-inducing peptide and its tetrapeptide analogue alleviate severity of metaphit seizures.
(2004)
PMID: 14751449
[Behavioral and electroencephalographic effects of delta sleep inducing peptide and its analogue on metaphit-induced audiogenic seizures in rats].
(2004)
PMID: 15938222
Delta sleep inducing peptide (DSIP): effect on respiration activity in rat brain mitochondria and stress protective potency under experimental hypoxia
(2003)
PMID: 12668217