Dr. Grey AI

Mental Health

Research on anxiety, depression, mood disorders, and psychological well-being.

Quick Answer

What it is

Research on anxiety, depression, mood disorders, and psychological well-being.

Key findings

  • Grade B: Anxiety Symptoms (Selank)
  • Grade B: Mood and Stress Parameters (Magnolia Bark (Magnolia officinalis))
  • Grade B: Anxiety Reduction (Magnolia Bark (Magnolia officinalis))

Safety

No specific caution or interaction language was detected in the current summary/outcome notes.

ℹ️ Quick Facts

Quick Facts: Mental Health

  • Supplements Studied:5
  • Top Supplement:Magnolia Bark (Magnolia officinalis) (B)
5 supps · 6 outcomes

Detailed Outcomes

|
B
Anxiety Symptoms
Moderate Decrease
5 studies
moderate↓Improves
B
Mood and Stress Parameters
RCT (n=56, 4 weeks): Relora significantly improved mood state parameters vs placebo: Overall Stress (-11%), Tension (-13%), Depression (-20%), Anger (-42%), Fatigue (-31%), Confusion (-27%), Global Mood State (+11%), and Vigor (+18%).
moderate↑Improves
B
Anxiety Reduction
Pilot RCT (n=40 women, 6 weeks): Relora reduced temporary, transitory anxiety on Spielberger STATE anxiety questionnaire vs placebo. Animal studies: Honokiol (0.2 mg/kg) showed anxiolytic effects comparable to diazepam 1 mg/kg without motor dysfunction or sedation.
moderate↑Improves
B
General Well-Being
Quality of life parameters showed significant improvement in general well-being (P < 0.05) and libido (P < 0.01) in elderly men following 4 months of treatment.
moderate↑Improves
C
Anxiety Symptoms
Small Decrease
2 studies
small↓Improves
C
Anxiolytic and Antidepressant Effects
Preclinical studies: Luteolin (10-20 mg/kg) reduced anxiety and depression-like behaviors in sleep deprivation, PTSD, and chronic stress animal models. Effects comparable to paroxetine. Mechanisms include NF-κB/NLRP3 pathway modulation. Human clinical trials needed.
moderate↑Improves

Research Citations (100)

Hepatoprotective Effects of Thymogen Analogues in Hydrazine Hepatopathy in Rats.
(2025)
PMID: 40442470
Genes That Associated with Action of ACTH-like Peptides with Neuroprotective Potential in Rat Brain Regions with Different Degrees of Ischemic Damage.
(2025)
PMID: 40650034
The Potential of the Peptide Drug Semax and Its Derivative for Correcting Pathological Impairments in the Animal Model of Alzheimer's Disease.
(2025)
PMID: 41479572
Semax, a Copper Chelator Peptide, Decreases the Cu(II)-Catalyzed ROS Production and Cytotoxicity of aβ by Metal Ion Stripping and Redox Silencing.
(2025)
PMID: 40496623
Growth Hormone-Releasing Hormone Antagonists Increase Radiosensitivity in Non-Small Cell Lung Cancer Cells.
(2025)
PMID: 40244089
Luteolin Is More Potent than Cromolyn in Their Ability to Inhibit Mediator Release from Cultured Human Mast Cells
(2024)
PMID: 38588651
Luteolin: A promising multifunctional natural flavonoid for human diseases
(2024)
PMID: 38666435
Luteolin for neurodegenerative diseases: a review
(2024)
PMID: 38904713
Antidepressant-like and antistress effects of the ACTH(4-10) synthetic analogs Semax and Melanotan II on male rats in a model of chronic unpredictable stress.
(2024)
PMID: 39442746
Potential anxiolytic and antidepressant-like effects of luteolin in a chronic constriction injury rat model of neuropathic pain: Role of oxidative stress, neurotrophins, and inflammatory factors
(2023)
PMID: 37478667

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