Peptide
Selank
Selank is a synthetic heptapeptide derived from tuftsin, an immunomodulatory peptide. It has been approved in Russia as a treatment for anxiety and neurasthenic conditions. Research indicates it may have anxiolytic, nootropic, and immunomodulatory properties without sedative effects. Like Semax, most clinical research has been conducted in Russia.
- Updated
- How we grade
- 24 studies cited
Research notice. This page is for education and research. Peptides may not be FDA-approved for human use and may only be legally available for research. Talk to a qualified clinician before considering any peptide.
- Best evidence
- Grade B
- Conditions studied
- 2
- Outcomes
- 7
- Graded outcomes
- 0142
Evidence by condition
- Strong
- Moderate
- Limited
- Very limited
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Anxiety Symptoms Moderate Decrease | Improves (the measure goes down) | Moderate effect | 6 studies | 240 people | ||
Studies that measured anxiety symptoms
| ||||||
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Memory Performance Small Increase | Improves (the measure goes up) | Small effect | 6 studies | 110 people | ||
Studies that measured memory performance
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General
Key findings
- Anxiety SymptomsImproves (the measure goes down)
- Memory PerformanceImproves (the measure goes up)
- Anti-Inflammatory ActivityImproves (the measure goes up)
Studies cited
24 studies from PubMed
- Hepatoprotective Effects of Thymogen Analogues in Hydrazine Hepatopathy in Rats.
- Increase in False-Positive Fourth-Generation Human Immunodeficiency Virus Tests in Patients With Coronavirus Disease 2019.
- Long-term Survival of Adhesively Luted Post-endodontic Restorations.
- RISK OF HOSPITAL MORTALITY IN CRITICALLY ILL PATIENTS WITH TRANSIENT AND PERSISTENT THROMBOCYTOPENIA: A RETROSPECTIVE STUDY.
- The Influence of Selank on the Level of Cytokines Under the Conditions of "Social" Stress.
- Functional Connectomic Approach to Studying Selank and Semax Effects
- The occurrence of putative cognitive enhancing research peptides in seized pharmaceutical preparations: An incentive for controlling agencies to prepare for future encounters of the kind.
- Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in Rats
- Effect of Selank on Morphological Parameters of Rat Liver in Chronic Foot-Shock Stress.
- Peptide-based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological Activity
- Peptides semax and selank affect the behavior of rats with 6-OHDA induced PD-like parkinsonism.
- Effect of Selank on Functional State of Rat Hepatocytes under Conditions of Restraint Stress.
- Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission
- A comparison of the anxiolytic effect and tolerability of selank and phenazepam in the treatment of anxiety disorders
- The temporary dynamics of inflammation-related genes expression under tuftsin analog Selank action.
- Expression of inflammation-related genes in mouse spleen under tuftsin analog Selank.
- [Changes in expression of the genes for chemokines, cytokines, and their receptors in response to selank and its fragments].
- Experimental optimization of learning and memory processes by selank
- Antiviral properties of structural fragments of the peptide Selank.
- [Antiviral activity of immunomodulator Selank in experimental influenza infection].
- Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia
- Effects of heptapeptide selank on genetically-based and situation-provoked symptoms of depression in behavior in WAG/Rij and Wistar rats, and in BALB/c mice
- [Immunomodulatory effects of selank in patients with anxiety-asthenic disorders].
- Effect of selank on cognitive processes after damage inflicted to the cerebral catecholamine system during early ontogeny.