Dr. Grey AI

Selank

Peptide

Selank is a synthetic heptapeptide derived from tuftsin, an immunomodulatory peptide. It has been approved in Russia as a treatment for anxiety and neurasthenic conditions. Research indicates it may have anxiolytic, nootropic, and immunomodulatory properties without sedative effects. Like Semax, most clinical research has been conducted in Russia.

Quick Answer

What it is

Selank is a synthetic heptapeptide derived from tuftsin, an immunomodulatory peptide. It has been approved in Russia as a treatment for anxiety and neurasthenic conditions.

Key findings

  • Grade B: Anxiety Symptoms (Mental Health)
  • Grade C: Anti-Inflammatory Activity
  • Grade C: Memory Performance (Cognitive Function)

Safety

No specific caution or interaction language was detected in the current summary/outcome notes.

⚠️ Research Notice

This peptide information is for educational and research purposes only. Peptides may not be FDA-approved for human use and may only be legally available for research purposes. Consult qualified healthcare professionals before considering any peptide compounds.

ℹ️ Quick Facts: Selank

Quick Facts: Selank

  • Best Evidence:Grade B
  • Conditions Studied:3
  • Research Outcomes:9
  • Grade B Findings:1
  • Key Effect:Mental Health
A0
B1
C5
D3
3 conditions · 9 outcomes

Detailed Outcomes

|
B
Anxiety Symptoms
Moderate Decrease
moderate↓Improves
C
Anti-Inflammatory Activity
4 preclinical studies support this finding. Primarily preclinical evidence.
small↑Improves
C
Neuroprotection
3 preclinical studies support this finding. Primarily preclinical evidence.
small↑Improves
C
Liver Protection
3 preclinical studies support this finding. Primarily preclinical evidence.
small↑Improves
D
Cognitive Function
2 preclinical studies support this finding. Primarily preclinical evidence.
small↑Improves
D
Antimicrobial Activity
2 preclinical studies support this finding. Primarily preclinical evidence.
small↑Improves
C
Memory Performance
Small Increase
small↑Improves

Research Citations (24)

Hepatoprotective Effects of Thymogen Analogues in Hydrazine Hepatopathy in Rats.
(2025)
PMID: 40442470
Increase in False-Positive Fourth-Generation Human Immunodeficiency Virus Tests in Patients With Coronavirus Disease 2019.
(2023)
PMID: 37158382
Long-term Survival of Adhesively Luted Post-endodontic Restorations.
(2022)
PMID: 35183596
RISK OF HOSPITAL MORTALITY IN CRITICALLY ILL PATIENTS WITH TRANSIENT AND PERSISTENT THROMBOCYTOPENIA: A RETROSPECTIVE STUDY.
(2022)
PMID: 36516455
The Influence of Selank on the Level of Cytokines Under the Conditions of "Social" Stress.
(2021)
PMID: 32621722
Functional Connectomic Approach to Studying Selank and Semax Effects
(2020)
PMID: 32342318
The occurrence of putative cognitive enhancing research peptides in seized pharmaceutical preparations: An incentive for controlling agencies to prepare for future encounters of the kind.
(2020)
PMID: 31667971
Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in Rats
(2019)
PMID: 31625062
Effect of Selank on Morphological Parameters of Rat Liver in Chronic Foot-Shock Stress.
(2019)
PMID: 31243679
Peptide-based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological Activity
(2018)
PMID: 30255741

Related Peptides

Sermorelin

Peptide

2 shared conditions · 18 outcomes

Sermorelin (GHRH 1-29) is a 29-amino-acid synthetic analog of growth hormone-releasing hormone (GHRH) that retains full biological activity. It was FDA-approved in 1990 for diagnostic use and in 1997 for treating childhood growth hormone deficiency. Sermorelin stimulates natural GH release from the pituitary gland through the hypothalamic-pituitary axis, producing physiological GH patterns with built-in safety through somatostatin feedback regulation.

Semax

Peptide

2 shared conditions · 14 outcomes

Semax is a synthetic heptapeptide derived from ACTH (adrenocorticotropic hormone). It has been approved as a prescription medication in Russia and Ukraine for treating stroke, cognitive disorders, and peptic ulcers. Research suggests it may enhance BDNF expression and exhibit nootropic and neuroprotective effects. Most clinical research has been conducted in Russia, with limited Western clinical trials.

Tesamorelin

Peptide

1 shared condition · 15 outcomes

Tesamorelin is a 44-amino-acid synthetic analog of growth hormone-releasing hormone (GHRH) that is FDA-approved (2010) for reducing excess abdominal fat in HIV-infected patients with lipodystrophy. It stimulates endogenous pulsatile GH secretion from the pituitary gland. Tesamorelin has demonstrated efficacy in reducing visceral adipose tissue, liver fat (NAFLD), and improving cognitive function in clinical trials.

Pinealon

Peptide

1 shared condition · 4 outcomes

Pinealon is a synthetic tripeptide (Glu-Asp-Arg) developed by Russian researchers as part of the Khavinson peptide bioregulators. It is designed to target brain tissue and has been studied for potential neuroprotective and cognitive-enhancing effects. Research suggests it may help regulate circadian rhythms and support cognitive function in aging, though human clinical data is limited.