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Peptide

Pinealon

Pinealon is a synthetic tripeptide (Glu-Asp-Arg) developed by Russian researchers as part of the Khavinson peptide bioregulators. It is designed to target brain tissue and has been studied for potential neuroprotective and cognitive-enhancing effects. Research suggests it may help regulate circadian rhythms and support cognitive function in aging, though human clinical data is limited.

Research notice. This page is for education and research. Peptides may not be FDA-approved for human use and may only be legally available for research. Talk to a qualified clinician before considering any peptide.

Best evidence
Grade C
Conditions studied
3
Outcomes
4
Graded outcomes
0022

Evidence by condition

  • Strong
  • Moderate
  • Limited
  • Very limited

3 conditions, plus general outcomes

Cognitive Function

Cognitive Function: outcomes studied for Pinealon
GradeOutcomeEffectSizeStudiesPeopleStudies list
Cognitive Performance

Small Increase

Improves (the measure goes up)Small effect48 studies85 people

Studies that measured cognitive performance

and 38 more in the citations list

Sleep

Sleep: outcomes studied for Pinealon
GradeOutcomeEffectSizeStudiesPeopleStudies list
Sleep Quality

Small Increase

Improves (the measure goes up)Small effect45 studies60 people

Studies that measured sleep quality

and 35 more in the citations list

Neurological Health

  • Neuroprotection: improves
Neurological Health: outcomes studied for Pinealon
GradeOutcomeEffectSizeStudiesPeopleStudies list
Neuroprotection

Minor Effect

Improves (the measure goes up)Small effect47 studies40 people

Studies that measured neuroprotection

and 37 more in the citations list

General

  • Oxidative Stress: improves
General: outcomes studied for Pinealon
GradeOutcomeEffectSizeStudiesPeopleStudies list
Oxidative Stress

2 preclinical studies support this finding. Primarily preclinical evidence.

Improves (the measure goes down)Small effect2 studies

Studies that measured oxidative stress

Key findings

  • Cognitive PerformanceCognitive FunctionImproves (the measure goes up)
  • Sleep QualityImproves (the measure goes up)
  • NeuroprotectionNeurological HealthImproves (the measure goes up)

Studies cited

8 studies from PubMed

  1. Neuroprotective Effects of Tripeptides-Epigenetic Regulators in Mouse Model of Alzheimer's DiseasePharmaceuticals, 2021 · PMID 34070466
  2. Optimization of Jiuzao protein hydrolysis conditions and antioxidant activity in vivo of Jiuzao tetrapeptide Asp-Arg-Glu-Leu by elevating the Nrf2/Keap1-p38/PI3K-MafK signaling pathway.Food & function, 2021 · PMID 33876788
  3. EDR Peptide: Possible Mechanism of Gene Expression and Protein Synthesis Regulation Involved in the Pathogenesis of Alzheimer's DiseaseMolecules, 2020 · PMID 33396470
  4. Short Peptides Stimulate Hepatocyte Proliferation In VitroBull Exp Biol Med, 2016 · PMID 27215831
  5. Effect of Synthetic Peptides on Aging of Patients with Chronic Polymorbidity and Organic Brain Syndrome of the Central Nervous System in RemissionAdv Gerontol, 2015 · PMID 26390612
  6. Pinealon peptide protects the rat offspring from prenatal hyperhomocysteinemiaInt J Clin Exp Med, 2012 · PMID 22765281
  7. Pinealon increases cell viability by suppression of free radical levels and activating proliferative processesRejuvenation Res, 2011 · PMID 22582135
  8. Pinealon increases cell viability by suppression of free radical levels and activating proliferative processes.Rejuvenation research, 2011 · PMID 21978084