Black Pepper
Black pepper contains piperine (5-9% by weight), an alkaloid that potently inhibits drug-metabolizing enzymes and transporters. A landmark study (PMID: 9619120) showed piperine at 20mg increased curcumin bioavailability by 2000% in humans. Piperine inhibits UDP-glucuronosyltransferases, CYP3A4, P-glycoprotein efflux pump, and intestinal lipase, thereby enhancing absorption of numerous compounds including curcumin, CoQ10, resveratrol, beta-carotene, and selenium. Beyond bioenhancement, piperine activates TRPV1 receptors (thermogenesis), inhibits NF-κB (anti-inflammatory), and may improve glucose metabolism. Standard bioenhancer dose is 5-20mg piperine taken with supplements.
Quick Answer
What it is
Black pepper contains piperine (5-9% by weight), an alkaloid that potently inhibits drug-metabolizing enzymes and transporters. A landmark study (PMID: 9619120) showed piperine at 20mg increased curcumin bioavailability by 2000% in humans.
Key findings
- Grade B: Nutrient/Drug Absorption (Drug Metabolism)
- Grade B: Curcumin Bioavailability (Optimal Nutrient Levels)
- Grade C: Inflammatory Markers (Inflammation)
Safety
No specific caution or interaction language was detected in the current summary/outcome notes.
ℹ️ Quick Facts: Black Pepper
Quick Facts: Black Pepper
- Best Evidence:Grade B
- Conditions Studied:4
- Research Outcomes:4
- Grade B Findings:2
- Key Effect:Optimal Nutrient Levels
Detailed Outcomes
Evidence by Condition
Best grade per condition (each condition may have multiple outcomes)
Research Citations (7)
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