Dr. Grey AI

Manganese

Manganese is an essential trace mineral required for numerous enzymatic reactions in the body. It serves as a cofactor for manganese superoxide dismutase (MnSOD, the primary mitochondrial antioxidant), arginase (urea cycle), glutamine synthetase (ammonia detoxification), and pyruvate carboxylase (gluconeogenesis). Manganese is critical for bone formation, glucose metabolism, wound healing, and neurotransmitter synthesis. The Adequate Intake (AI) is 2.3mg/day for men and 1.8mg/day for women. Deficiency is rare due to widespread dietary availability but can cause impaired growth, skeletal abnormalities, and altered glucose tolerance. Toxicity from excessive intake (primarily occupational inhalation) can cause manganism, a Parkinson-like neurological syndrome.

Quick Answer

What it is

Manganese is an essential trace mineral required for numerous enzymatic reactions in the body. It serves as a cofactor for manganese superoxide dismutase (MnSOD, the primary mitochondrial antioxidant), arginase (urea cycle), glutamine synthetase (ammonia detoxification), and pyruvate carboxylase (gluconeogenesis).

Key findings

  • Grade A: Serum Manganese Levels (Manganese Deficiency)
  • Grade A: MnSOD Levels (Manganese Deficiency)
  • Grade B: MnSOD Activity (Antioxidant Status)

Safety

  • Toxicity from excessive intake (primarily occupational inhalation) can cause manganism, a Parkinson-like neurological syndrome.
ℹ️ Quick Facts: Manganese

Quick Facts: Manganese

  • Best Evidence:Grade A
  • Conditions Studied:8
  • Research Outcomes:14
  • Grade A Findings:2
  • Grade B Findings:7
  • Key Effect:Manganese Deficiency
Outcomes by grade:
A2
B7
C5
D0
8 conditions Β· 14 outcomes

Detailed Outcomes

Grade:
Effect:
Size:
Sort:
|
A
Serum Manganese Levels
Large Increase
8 studies
large↑Improves
A
MnSOD Levels
Large Increase
6 studies
large↑Improves
B
MnSOD Activity
Moderate Increase
6 studies
moderate↑Improves
B
Oxidative Stress Markers
Moderate Decrease
5 studies
moderate↓Improves
B
Bone Mineral Density
Small Increase
5 studies
small↑Improves
B
Bone Formation Markers
Moderate Increase
4 studies
moderate↑Improves
B
Wound Closure Rate
Moderate Increase
4 studies
moderate↑Improves
B
Collagen Synthesis
Moderate Increase
3 studies
moderate↑Improves
B
PMS Symptoms
Moderate Decrease
3 studies
moderate↓Improves
C
Insulin Sensitivity
Small Increase
4 studies
small↑Improves
C
Fasting Blood Glucose
Small Decrease
3 studies
small↓Improves
C
Joint Pain
Small Decrease
3 studies
small↓Improves
C
Cartilage Health
Small Increase
2 studies
small↑Improves
C
Seizure Frequency
Small Decrease
2 studies
small↓Improves

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