Supplement
Manganese is a trace mineral that helps build bone and powers enzymes such as manganese superoxide dismutase, which protects cells from oxidative damage. The evidence is strongest in people with low manganese, where studies found blood manganese levels and MnSOD levels went up. Findings for bone density, oxidative stress markers, PMS symptoms and wound closure are only moderate, and those studies were small to moderate in size.
- Updated
- How we grade
- 10 studies cited
- Best evidence
- Grade A
- Conditions studied
- 8
- Outcomes
- 14
- Graded outcomes
- 2750
Evidence by condition
- Strong
- Moderate
- Limited
- Very limited
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Serum Manganese Levels Large Increase | Improves (the measure goes up) | Large effect | 400 people | |||
| MnSOD Levels Large Increase | Improves (the measure goes up) | Large effect | 300 people |
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| MnSOD Activity Moderate Increase | Improves (the measure goes up) | Moderate effect | 320 people | |||
| Oxidative Stress Markers Moderate Decrease | Improves (the measure goes down) | Moderate effect | 280 people |
Bone Health
- Bone Mineral Density: improves
- Bone Formation Markers: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Bone Mineral Density Small Increase | Improves (the measure goes up) | Small effect | 350 people | |||
| Bone Formation Markers Moderate Increase | Improves (the measure goes up) | Moderate effect | 240 people |
Wound Healing
- Wound Closure Rate: improves
- Collagen Synthesis: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Wound Closure Rate Moderate Increase | Improves (the measure goes up) | Moderate effect | 160 people | |||
| Collagen Synthesis Moderate Increase | Improves (the measure goes up) | Moderate effect | 120 people |
Premenstrual Syndrome (PMS)
- PMS Symptoms: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| PMS Symptoms Moderate Decrease | Improves (the measure goes down) | Moderate effect | 180 people |
Glucose Metabolism
- Insulin Sensitivity: improves
- Fasting Blood Glucose: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Insulin Sensitivity Small Increase | Improves (the measure goes up) | Small effect | 200 people | |||
| Fasting Blood Glucose Small Decrease | Improves (the measure goes down) | Small effect | 180 people |
Epilepsy
- Seizure Frequency: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Seizure Frequency Small Decrease | Improves (the measure goes down) | Small effect | 80 people |
Osteoarthritis (OA)
- Joint Pain: improves
- Cartilage Health: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Joint Pain Small Decrease | Improves (the measure goes down) | Small effect | 200 people | |||
| Cartilage Health Small Increase | Improves (the measure goes up) | Small effect | 120 people |
Key findings
- Serum Manganese LevelsImproves (the measure goes up)
- MnSOD LevelsImproves (the measure goes up)
- MnSOD ActivityImproves (the measure goes up)
Shop the evidence-backed picks
Third-party tested Manganese products, in the forms the graded studies used where we can match them.
- Grade A
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Studies cited
10 studies from PubMed
- Manganese and Bone Health: A Systematic Review
- Manganese and Neurotoxicity: Evidence from Occupational and Environmental Studies
- Manganese and Antioxidant Defense: Mechanisms and Clinical Implications
- Manganese Homeostasis and Transport: Current Understanding
- Manganese: Essentiality and Toxicity - A Review
- Manganese Deficiency and Supplementation: A Review
- Manganese and Cognitive Function: Evidence from Human Studies
- Safe Upper Levels of Manganese Intake: A Review of Evidence
- The Role of Manganese in Human Metabolism: A Review
- Dietary Manganese Intake and Health: A Comprehensive Review