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Myricetin

Myricetin is a flavonoid found in berries, vegetables, and wine, structurally related to quercetin and kaempferol. Among flavonoids, myricetin has been particularly associated with bone health and anti-osteoporotic effects in preclinical research. Also has antioxidant and potential anti-diabetic properties. NO GRADED OUTCOMES - human research is limited. Found in foods like berries, onions, and red wine. Not widely available as an isolated supplement. Low bioavailability may limit therapeutic use.

Quick Answer

What it is

Myricetin is a flavonoid found in berries, vegetables, and wine, structurally related to quercetin and kaempferol. Among flavonoids, myricetin has been particularly associated with bone health and anti-osteoporotic effects in preclinical research.

Key findings

  • Grade D: Cancer Cell Proliferation
  • Grade D: Bone Health
  • Grade D: Neuroprotection

Safety

No specific caution or interaction language was detected in the current summary/outcome notes.

ℹ️ Quick Facts: Myricetin

Quick Facts: Myricetin

  • Best Evidence:Grade D
  • Conditions Studied:4
  • Research Outcomes:8
  • Key Effect:Alzheimer’s Disease
Outcomes by grade:
A0
B0
C0
D8
4 conditions · 8 outcomes

Detailed Outcomes

|
D
Cancer Cell Proliferation
Multiple in vitro studies demonstrate myricetin inhibits neoplastic cell transformation via MEK1 and JAK1 targeting, induces apoptosis in colon cancer cells through PI3K/Akt/mTOR inhibition, triggers apoptosis in MCF-7 breast cancer cells via BRCA1-GADD45, and inhibits breast and lung cancer proliferation via MARK4. All evidence is preclinical with no human trials.
moderate↓Worsens
D
Inflammation
In vitro studies show myricetin inhibits TNF-alpha-induced inflammation in A549 cells via the SIRT1/NF-kappaB pathway. Additional preclinical evidence supports broad anti-inflammatory activity. No human trials have confirmed these effects.
moderate↓Improves
D
Gut Microbiota Composition
A single animal study found that myricetin and its lactose sodium salt (M10) modified gut microbiota composition in a mouse model of ulcerative colitis. No human studies have evaluated these effects.
small↑Improves
D
5-Alpha Reductase Activity
An in vitro study evaluating polyphenol structure-activity relationships found myricetin inhibits human 5-alpha reductases. Clinical relevance for conditions like benign prostatic hyperplasia or androgenic alopecia remains unstudied in humans.
small↓Worsens
D
Bone Health
In vitro and animal studies show myricetin induces osteoblast differentiation through the BMP-2/p38 MAPK pathway and may inhibit osteoclast-mediated bone resorption. Preclinical models suggest anti-osteoporotic effects, but no human clinical trials have been conducted.
moderate↑Improves
D
Neuroprotection
In vitro and animal studies suggest myricetin may protect against neurodegeneration by modifying amyloid-beta conformation, interfering with secretase activity, and reducing post-ischemic brain damage. Identified as a candidate molecule for Alzheimer's disease research, but no human data exist.
small↑Improves
D
Cardiovascular Protection
Preclinical studies show myricetin protects cardiomyocytes from LPS-induced injury in cell models. Review articles summarize protective effects against cardiovascular disease markers in animal and in vitro systems. No human clinical trials have evaluated cardiovascular endpoints.
small↑Improves
D
Antioxidant Status
In vitro studies demonstrate myricetin has antioxidant properties, though it can switch to prooxidant behavior in the presence of copper(II) ions. Its antioxidant capacity is well-characterized biochemically but unvalidated in human studies.
small↑Improves

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