Supplement
Mulberry fruit extract is a concentrate of the dark berries of the mulberry tree, rich in anthocyanins and other plant pigments that act as antioxidants in the body. People mostly look at it for blood sugar control, and the evidence is limited: in diabetic mice and rats, the extract improved glucose control and insulin sensitivity. Nearly all of this work was in animals or cell studies, so it says little yet about how the extract affects people.
Sources: PMID 27441957; PMID 15630209
- Updated
- How we grade
- 25 studies cited
- Best evidence
- Grade C
- Conditions studied
- 4
- Outcomes
- 8
- Graded outcomes
- 0017
Evidence by condition
- Strong
- Moderate
- Limited
- Very limited
General
Alzheimer’s Disease
- Cognitive Function: improves
Body Composition
- Body Weight Management: improves
Cardiovascular Health
- Blood Pressure: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Blood Pressure In spontaneously hypertensive rats, an ethanolic extract of mulberry fruit reduced blood pressure and attenuated vascular remodeling (PMID:29771623). Only a single animal study is available. | Improves (the measure goes down) | Small effect | 5 studies | |||
Studies that measured blood pressure
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Key findings
- Blood Sugar ControlImproves (the measure goes down)
- Antioxidant StatusImproves (the measure goes up)
- Cognitive FunctionImproves (the measure goes up)
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Third-party tested Mulberry Fruit Extract products. The evidence above is limited, so read it before you buy.
- Grade C
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Studies cited
25 studies from PubMed
- Antioxidant and Anti-Inflammatory Effects of White Mulberry (Morus alba L.) Fruits on Lipopolysaccharide-Stimulated RAW 264.7 Macrophages.
- Bioactive Phytochemicals from Mulberry: Potential Anti-Inflammatory Effects in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages.
- Mulberry fruit extract alleviates the intracellular amyloid-β oligomer-induced cognitive disturbance and oxidative stress in Alzheimer's disease model mice.
- Pharmacological Activities for Morus alba L., Focusing on the Immunostimulatory Property from the Fruit Aqueous Extract.
- Polysaccharide from Mulberry Fruit (Morus alba L.) Protects against Palmitic-Acid-Induced Hepatocyte Lipotoxicity by Activating the Nrf2/ARE Signaling Pathway.
- Mulberry Fruit Extract Ameliorates Adipogenesis via Increasing AMPK Activity and Downregulating MicroRNA-21/143 in 3T3-L1 Adipocytes.
- Mulberry Fruit Extract Alleviates Cognitive Impairment by Promoting the Clearance of Amyloid-β and Inhibiting Neuroinflammation in Alzheimer's Disease Mice.
- Effects of an ethanolic extract of mulberry fruit on blood pressure and vascular remodeling in spontaneous hypertensive rats.
- Anti-Inflammatory Effects of High Hydrostatic Pressure Extract of Mulberry (Morus alba) Fruit on LPS-Stimulated RAW264.7 Cells.
- Nutraceutical and Medicinal Potential of the Morus Species in Metabolic Dysfunctions.
- Red mulberry fruit aqueous extract and silk proteins accelerate acute ethanol metabolism and promote the anti-oxidant enzyme systems in rats.
- Systematic fractionation and immunoenhancement of water-soluble polysaccharides isolated from fruit of Morus alba L.
- Antidiabetic effects of Morus alba fruit polysaccharides on high-fat diet- and streptozotocin-induced type 2 diabetes in rats.
- The Mulberry (Morus alba L.) Fruit-A Review of Characteristic Components and Health Benefits.
- Protective Effect of Mulberry (Morus alba L.) Extract against Benzo[a]pyrene Induced Skin Damage through Inhibition of Aryl Hydrocarbon Receptor Signaling.
- In vitro and In vivo Antioxidant Activity of Flavonoid Extracted from Mulberry Fruit (Morus alba L.).
- Structural analysis and anti-obesity effect of a pectic polysaccharide isolated from Korean mulberry fruit Oddi (Morus alba L.).
- Mulberry (Morus alba L.) Fruit Extract Containing Anthocyanins Improves Glycemic Control and Insulin Sensitivity via Activation of AMP-Activated Protein Kinase in Diabetic C57BL/Ksj-db/db Mice.
- Phytochemistry, pharmacology, and clinical trials of Morus alba.
- Memory-enhancing effect of Mori Fructus via induction of nerve growth factor.
- Antidiabetic and antioxidant effects and phytochemicals of mulberry fruit (Morus alba L.) polyphenol enhanced extract.
- Purification, characterization and immunomodulating activity of a pectic polysaccharide isolated from Korean mulberry fruit Oddi (Morus alba L.).
- Antioxidant activity of mulberry fruit extracts.
- HPLC-DAD-ESI-MS/MS analysis and antioxidant activities of nonanthocyanin phenolics in mulberry (Morus alba L.).
- Promoting effect and recovery activity from physical stress of the fruit of Morus alba.