Mulberry fruit extract is derived from the fruit of Morus alba (white mulberry). Different from mulberry LEAF extract (which is used for blood sugar control), the FRUIT extract contains anthocyanins and has been researched for glycemic control and antioxidant effects. NO GRADED OUTCOMES - research is limited. Contains cyanidin-3-glucoside and other anthocyanins similar to other dark berries. May have benefits for blood sugar and oxidative stress. Safe as a food; the fruit has been consumed for millennia.
Mulberry fruit extract is derived from the fruit of Morus alba (white mulberry). Different from mulberry LEAF extract (which is used for blood sugar control), the FRUIT extract contains anthocyanins and has been researched for glycemic control and antioxidant effects.
No specific caution or interaction language was detected in the current summary/outcome notes.
Best grade per condition (each condition may have multiple outcomes)
3 shared conditions · 11 outcomes
Salidroside is a glucoside compound and one of the main bioactive constituents of Rhodiola rosea. Often standardized in Rhodiola extracts (typically 1-3%). Has neuroprotective and adaptogenic properties. Research shows anti-fatigue, anti-stress, and potential anti-depressant effects. Mechanism involves HPA axis modulation, AMPK activation, and antioxidant effects. Most clinical evidence is for the whole Rhodiola rosea extract rather than isolated salidroside. May be more effective as part of whole plant extract than in isolation.
3 shared conditions · 6 outcomes
Sacred Lotus (Nelumbo nucifera) is an aquatic plant important in Asian cuisine and traditional medicine. All parts are used - seeds, leaves, rhizomes, flowers. Rich in polyphenols (catechins, procyanidins) and contains unique alkaloids like neferine. Preclinical research suggests anti-diabetic, anti-obesity, anti-depressant, and sedative effects. NO human clinical trials. Most interesting bioactive is neferine (unique to this plant) which shows various pharmacological effects in vitro. Remains underresearched in humans.
3 shared conditions · 9 outcomes
Piperine is the pungent alkaloid from black pepper (Piper nigrum). Primary use is as a bioavailability enhancer - increases absorption of many supplements (curcumin by 2000%, CoQ10, resveratrol, etc.) by inhibiting drug-metabolizing enzymes and transporters. IMPORTANT: Same mechanism that increases supplement absorption also affects medications - significant drug interaction potential. As a standalone supplement, has mild thermogenic and metabolic effects. BioPerine is a standardized 95% piperine extract.
3 shared conditions · 8 outcomes
Piceatannol is a stilbene compound similar to resveratrol, found in passion fruit, grapes, and berries. Also a metabolite of resveratrol. May have superior bioavailability and bioactivity compared to resveratrol in some studies. Unique SIRT1 activation and AMPK effects. Preliminary human studies suggest benefits for insulin sensitivity. Less studied than resveratrol but potentially more promising. Contains extra hydroxyl group giving stronger antioxidant activity.
3 shared conditions · 7 outcomes
Orange peel is rich in hesperidin (citrus flavonoid), polymethoxyflavones (PMFs), vitamin C, and fiber. Hesperidin has B-grade evidence for blood pressure reduction and vascular function. PMFs (tangeretin, nobiletin) have unique metabolic and neuroprotective effects in preclinical studies. Orange peel extracts used for cardiovascular health and chronic venous insufficiency. Essential oil (d-limonene) used topically and for aromatherapy. Standardized extracts dosed by hesperidin content.
3 shared conditions · 10 outcomes
NAD+ is a critical coenzyme involved in cellular energy metabolism, DNA repair, and aging-related pathways. NAD+ levels decline with age, driving interest in supplementation for anti-aging. However, oral NAD+ itself has very poor bioavailability - PRECURSORS like NR (nicotinamide riboside) and NMN (nicotinamide mononucleotide) are generally preferred. NO GRADED OUTCOMES for direct NAD+ supplementation. Most NAD+ research actually uses precursors. Research on aging benefits is ongoing but preliminary.
3 shared conditions · 8 outcomes
Myricetin is a flavonoid found in berries, vegetables, and wine, structurally related to quercetin and kaempferol. Among flavonoids, myricetin has been particularly associated with bone health and anti-osteoporotic effects in preclinical research. Also has antioxidant and potential anti-diabetic properties. NO GRADED OUTCOMES - human research is limited. Found in foods like berries, onions, and red wine. Not widely available as an isolated supplement. Low bioavailability may limit therapeutic use.
3 shared conditions · 8 outcomes
Haskap berries (blue honeysuckle) are antioxidant-rich berries native to northern regions, called 'fruit of longevity' in Japan. Rich in anthocyanins (particularly cyanidin-3-glucoside), vitamin C, and polyphenols. NO GRADED OUTCOMES - limited human research. Anthocyanin content exceeds blueberries. May have cardiovascular, anti-inflammatory, and cognitive benefits based on similar berry research, but haskap-specific studies are lacking. Safe as a food. Available fresh, frozen, or as supplements. Emerging berry gaining research interest due to high polyphenol content.