Piperine is the pungent alkaloid from black pepper (Piper nigrum). Primary use is as a bioavailability enhancer - increases absorption of many supplements (curcumin by 2000%, CoQ10, resveratrol, etc.) by inhibiting drug-metabolizing enzymes and transporters. IMPORTANT: Same mechanism that increases supplement absorption also affects medications - significant drug interaction potential. As a standalone supplement, has mild thermogenic and metabolic effects. BioPerine is a standardized 95% piperine extract.
Piperine is the pungent alkaloid from black pepper (Piper nigrum). Primary use is as a bioavailability enhancer - increases absorption of many supplements (curcumin by 2000%, CoQ10, resveratrol, etc.) by inhibiting drug-metabolizing enzymes and transporters.
Best grade per condition (each condition may have multiple outcomes)
3 shared conditions · 12 outcomes
Terminalia chebula (Haritaki) is one of the three fruits in Triphala, an important Ayurvedic formula. Considered 'king of medicines' in Tibet. Contains tannins and antioxidants. Traditional uses include digestive issues, oral health, and as a general 'rejuvenative.' NO GRADED OUTCOMES - human research is very limited. Preclinical research shows antimicrobial, antioxidant, and anti-diabetic potential. Primarily available as part of Triphala rather than alone.
3 shared conditions · 11 outcomes
Salidroside is a glucoside compound and one of the main bioactive constituents of Rhodiola rosea. Often standardized in Rhodiola extracts (typically 1-3%). Has neuroprotective and adaptogenic properties. Research shows anti-fatigue, anti-stress, and potential anti-depressant effects. Mechanism involves HPA axis modulation, AMPK activation, and antioxidant effects. Most clinical evidence is for the whole Rhodiola rosea extract rather than isolated salidroside. May be more effective as part of whole plant extract than in isolation.
3 shared conditions · 6 outcomes
Sacred Lotus (Nelumbo nucifera) is an aquatic plant important in Asian cuisine and traditional medicine. All parts are used - seeds, leaves, rhizomes, flowers. Rich in polyphenols (catechins, procyanidins) and contains unique alkaloids like neferine. Preclinical research suggests anti-diabetic, anti-obesity, anti-depressant, and sedative effects. NO human clinical trials. Most interesting bioactive is neferine (unique to this plant) which shows various pharmacological effects in vitro. Remains underresearched in humans.
3 shared conditions · 8 outcomes
Piceatannol is a stilbene compound similar to resveratrol, found in passion fruit, grapes, and berries. Also a metabolite of resveratrol. May have superior bioavailability and bioactivity compared to resveratrol in some studies. Unique SIRT1 activation and AMPK effects. Preliminary human studies suggest benefits for insulin sensitivity. Less studied than resveratrol but potentially more promising. Contains extra hydroxyl group giving stronger antioxidant activity.
3 shared conditions · 8 outcomes
Mulberry fruit extract is derived from the fruit of Morus alba (white mulberry). Different from mulberry LEAF extract (which is used for blood sugar control), the FRUIT extract contains anthocyanins and has been researched for glycemic control and antioxidant effects. NO GRADED OUTCOMES - research is limited. Contains cyanidin-3-glucoside and other anthocyanins similar to other dark berries. May have benefits for blood sugar and oxidative stress. Safe as a food; the fruit has been consumed for millennia.
3 shared conditions · 7 outcomes
Eriobotrya japonica (Loquat) is a fruit-bearing tree whose leaves have been used in Traditional Chinese Medicine (TCM) for cough, sputum, and respiratory conditions. Rich in triterpenoids, particularly ursolic acid and related compounds. The fruit is consumed as food; the leaves and seeds are used medicinally. NO GRADED OUTCOMES - research is mostly preclinical. May have anti-inflammatory, antitussive (cough-suppressing), and glucose-regulating effects. The seeds have been added to alcoholic tonics for longevity. Safe as a fruit; medicinal leaf preparations have traditional use but limited modern research.
3 shared conditions · 8 outcomes
Haskap berries (blue honeysuckle) are antioxidant-rich berries native to northern regions, called 'fruit of longevity' in Japan. Rich in anthocyanins (particularly cyanidin-3-glucoside), vitamin C, and polyphenols. NO GRADED OUTCOMES - limited human research. Anthocyanin content exceeds blueberries. May have cardiovascular, anti-inflammatory, and cognitive benefits based on similar berry research, but haskap-specific studies are lacking. Safe as a food. Available fresh, frozen, or as supplements. Emerging berry gaining research interest due to high polyphenol content.
3 shared conditions · 10 outcomes
Cyanidin is a type of anthocyanin pigment found in dark berries, purple vegetables, and black rice. Cyanidin-3-glucoside (C3G) is the most studied form. Shows promise for blood glucose regulation, anti-inflammatory effects, and metabolic health. Notable for potentially improving glucose uptake without impairing muscle protein synthesis (unlike some AMPK activators). However, bioavailability is a major concern - most cyanidin is rapidly metabolized. Human evidence is limited despite promising in vitro data.