Supplement
Salidroside is a compound from the Rhodiola rosea plant that appears to influence the body's stress-response system. People mostly look at it for fatigue and stress resilience, and the evidence is limited: human trials found anti-fatigue effects from Rhodiola extracts rich in salidroside. Those trials tested the whole extract, not salidroside alone, and most other research has been in animals or cells.
Sources: PMID 25101546; PMID 34092295
- Updated
- How we grade
- 23 studies cited
- Best evidence
- Grade C
- Conditions studied
- 8
- Outcomes
- 11
- Graded outcomes
- 00110
Evidence by condition
- Strong
- Moderate
- Limited
- Very limited
General
Antioxidant Status
- Oxidative Stress: improves
Cardiovascular Health
- Cardiovascular Protection: improves
Age-Associated Memory Impairment and Cognitive Decline (AAMCD)
- Cognitive Function: improves
Arthritis (Multiple Kinds)
- Joint and Cartilage Degeneration: improves
Asthma
- Airway Inflammation: improves
Bladder Cancer
- Bladder Cancer Cell Growth: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Bladder Cancer Cell Growth In vitro, Rhodiola rosea extracts and salidroside decreased bladder cancer cell line growth via inhibition of the mTOR pathway and induction of autophagy. This is limited to a single cell-line study with no animal or human confirmation. | Improves (the measure goes down) | Small effect | 5 studies | |||
Studies that measured bladder cancer cell growth
| ||||||
Acute Mountain Sickness
- Hypoxia Tolerance: improves
Key findings
- Fatigue and Stress ResilienceChanges; see studies
- NeuroprotectionImproves (the measure goes up)
- Oxidative StressImproves (the measure goes down)
Safety notes in the studies
- Multiple preclinical studies demonstrate salidroside protects neurons against ischemia, polyglutamine toxicity, and oxidative damage in cell and animal models.
Shop Salidrosides
Third-party tested Salidrosides products. The evidence above is limited, so read it before you buy.
- Grade C
Links to Fullscript, iHerb or Thorne carry our referral, so we may earn a commission at no extra cost to you. Grades come from the research and never change based on what we earn. Fullscript asks for a free account before it shows its catalog and prices. Full disclosure
Studies cited
23 studies from PubMed
- Salidroside directly activates HSC70, revealing a new role for HSC70 in BDNF signalling and neurogenesis after cerebral ischemia.
- Salidroside pretreatment alleviates PM2.5 caused lung injury via inhibition of apoptosis and pyroptosis through regulating NLRP3 Inflammasome.
- Network pharmacology analysis combined with experimental validation to explore the therapeutic mechanism of salidroside on intestine ischemia reperfusion.
- Salidroside Attenuates Airway Inflammation and Remodeling via the miR-323-3p/SOCS5 Axis in Asthmatic Mice.
- Salidroside Exerts Beneficial Effect on Testicular Ischemia-Reperfusion Injury in Rats.
- Safety of a Sustainably Produced, Bioengineered, Nature-Identical Salidroside Compound.
- Salidroside in the Treatment of NAFLD/NASH.
- Salidroside protects endothelial cells against LPS-induced inflammatory injury by inhibiting NLRP3 and enhancing autophagy.
- The bioinformatics and metabolomics research on anti-hypoxic molecular mechanisms of Salidroside via regulating the PTEN mediated PI3K/Akt/NF-κB signaling pathway.
- Contribution of salidroside to the relieve of symptom and sign in the early acute stage of osteoarthritis in rat model.
- Salidroside Alleviates Cartilage Degeneration Through NF-κB Pathway in Osteoarthritis Rats.
- Salidroside inhibits platelet function and thrombus formation through AKT/GSK3β signaling pathway.
- Salidroside as a potential neuroprotective agent for ischemic stroke: a review of sources, pharmacokinetics, mechanism and safety.
- Salidroside Inhibits Lipopolysaccharide-ethanol-induced Activation of Proinflammatory Macrophages via Notch Signaling Pathway.
- Salidroside inhibits inflammatory factor release in BV-2 cells through p38 and JNK pathways.
- Salidroside protects against kainic acid-induced status epilepticus via suppressing oxidative stress.
- Salidroside, a Bioactive Compound of Rhodiola Rosea, Ameliorates Memory and Emotional Behavior in Adult Mice.
- Salidroside exhibits anti-dengue virus activity by upregulating host innate immune factors.
- Salidroside protects Caenorhabditis elegans neurons from polyglutamine-mediated toxicity by reducing oxidative stress.
- Antidepressant-like effects of salidroside on olfactory bulbectomy-induced pro-inflammatory cytokine production and hyperactivity of HPA axis in rats.
- Salidroside attenuates LPS-stimulated activation of THP-1 cell-derived macrophages through down-regulation of MAPK/NF-kB signaling pathways.
- Rhodiola rosea extracts and salidroside decrease the growth of bladder cancer cell lines via inhibition of the mTOR pathway and induction of autophagy.
- Salidroside and tyrosol from Rhodiola protect H9c2 cells from ischemia/reperfusion-induced apoptosis.