| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Adipogenesis and Fat Accumulation In vitro studies show piceatannol inhibits adipocyte differentiation by modulating mitotic clonal expansion and insulin receptor-dependent signaling during early-phase adipogenesis (PMID:22298784). Animal studies support anti-obesity effects through inhibition of lipid accumulation. | Improves (the measure goes down) | Small effect | 1 study | |||
Studies that measured adipogenesis and fat accumulation | ||||||
Supplement
Piceatannol is a polyphenol found in passion fruit seeds and grapes, closely related to resveratrol, that mops up free radicals in lab tests. People mostly look at it for insulin sensitivity, and small human studies of passion fruit seed extract found it improved in overweight people, while diabetic mice had lower blood glucose. Still, the evidence is limited, with one small study of about 50 people and mostly animal or lab work.
Sources: PMID 22579688
- Updated
- How we grade
- 23 studies cited
- Best evidence
- Grade C
- Conditions studied
- 3
- Outcomes
- 8
- Graded outcomes
- 0017
Evidence by condition
- Strong
- Moderate
- Limited
- Very limited
General
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Insulin Sensitivity Small human studies using passion fruit seed extract (a piceatannol source) reported improved insulin sensitivity in overweight individuals. In db/db diabetic mice, piceatannol promoted glucose uptake via GLUT4 translocation to plasma membrane and suppressed blood glucose levels (PMID:22579688). | Improves (the measure goes up) | Small effect | 1 study | 50 people | ||
| Cancer Cell Proliferation In vitro studies show piceatannol induces apoptosis in melanoma (PMID:15309446), inhibits proliferation and invasion in hepatoma cells (PMID:22496613), suppresses metastatic potential in breast epithelial cells (PMID:23877152), and enhances cisplatin sensitivity in ovarian cancer cells (PMID:23833193). Resveratrol is converted to piceatannol by CYP1B1, an enzyme overexpressed in tumors (PMID:11875742). All evidence is preclinical. | Changes; see studies | Moderate effect | 7 studies | |||
Studies that measured cancer cell proliferation
| ||||||
| Inflammatory Response In vitro evidence shows piceatannol inhibits mast cell-mediated allergic inflammation (PMID:23426871) and suppresses effector T cell functions by inhibiting TcR signaling (PMID:25676533). Also induces SIRT1 expression in human monocytic cells, a pathway linked to anti-inflammatory regulation (PMID:25360511). | Changes; see studies | Small effect | 3 studies | |||
| Neuronal Oxidative Damage In vitro studies show piceatannol protects HT22 neuronal cells against glutamate-mediated oxidative injury via heme oxygenase-1 induction (PMID:23712764) and exhibits neuroprotective activity in rat primary cortex neurons through the PI3K/Akt signalling pathway (PMID:30213108). | Improves (the measure goes down) | Small effect | 2 studies | |||
Studies that measured neuronal oxidative damage
| ||||||
| Liver Fibrosis In a mouse model, piceatannol attenuated carbon tetrachloride-induced liver fibrosis (PMID:34676843). Additionally, piceatannol reduced renal fibrosis in a unilateral ureteral obstruction model via downregulation of HDAC4/5 and p38-MAPK signaling (PMID:27902771), suggesting broad anti-fibrotic potential. | Improves (the measure goes down) | Small effect | 2 studies | |||
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Cardiovascular Function Preclinical studies show piceatannol promotes nitric oxide release via eNOS phosphorylation in human endothelial cells (PMID:26367737), inhibits PDGF-BB-induced smooth muscle cell proliferation via PI3K inhibition (PMID:19887493), and demonstrates antiarrhythmic effects in a whole-heart long QT syndrome model (PMID:28606656). A pharmacological review supports multiple cardiovascular-protective mechanisms (PMID:24919577). | Improves (the measure goes up) | Small effect | 4 studies | |||
Studies that measured cardiovascular function
| ||||||
Antioxidant Status
- Antioxidant Activity: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Antioxidant Activity Multiple in vitro studies demonstrate piceatannol has superior radical scavenging activity compared to resveratrol due to its additional hydroxyl group. Effectively scavenges hydroxyl and peroxyl radicals (PMID:18959413) and shows greater antioxidant potency than resveratrol in structure-activity comparisons (PMID:15748702). | Improves (the measure goes up) | Moderate effect | 3 studies | |||
Studies that measured antioxidant activity
| ||||||
Body Composition
- Adipogenesis and Fat Accumulation: improves
Key findings
- Insulin SensitivityImproves (the measure goes up)
- Cancer Cell ProliferationChanges; see studies
- Cardiovascular FunctionImproves (the measure goes up)
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- Grade C
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Studies cited
23 studies from PubMed
- Resveratrol, Piceatannol, Curcumin, and Quercetin as Therapeutic Targets in Gastric Cancer-Mechanisms and Clinical Implications for Natural Products.
- Hepatoprotective effect of piceatannol against carbon tetrachloride-induced liver fibrosis in mice.
- Antioxidant Activity and Neuroprotective Activity of Stilbenoids in Rat Primary Cortex Neurons via the PI3K/Akt Signalling Pathway.
- Divergent antiarrhythmic effects of resveratrol and piceatannol in a whole-heart model of long QT syndrome.
- A Comprehensive Review on the Chemotherapeutic Potential of Piceatannol for Cancer Treatment, with Mechanistic Insights.
- Piceatannol Attenuates Renal Fibrosis Induced by Unilateral Ureteral Obstruction via Downregulation of Histone Deacetylase 4/5 or p38-MAPK Signaling.
- Piceatannol inhibits effector T cell functions by suppressing TcR signaling.
- Piceatannol, a natural hydroxylated analog of resveratrol, promotes nitric oxide release through phosphorylation of endothelial nitric oxide synthase in human endothelial cells.
- A review of the pharmacological effects of piceatannol on cardiovascular diseases.
- Piceatannol and its metabolite, isorhapontigenin, induce SIRT1 expression in THP-1 human monocytic cell line.
- Piceatannol inhibits mast cell-mediated allergic inflammation.
- Involvement of heme oxygenase-1 expression in neuroprotection by piceatannol, a natural analog and a metabolite of resveratrol, against glutamate-mediated oxidative injury in HT22 neuronal cells.
- Piceatannol enhances cisplatin sensitivity in ovarian cancer via modulation of p53, X-linked inhibitor of apoptosis protein (XIAP), and mitochondrial fission.
- Piceatannol suppresses the metastatic potential of MCF10A human breast epithelial cells harboring mutated H-ras by inhibiting MMP-2 expression.
- Piceatannol, natural polyphenolic stilbene, inhibits adipogenesis via modulation of mitotic clonal expansion and insulin receptor-dependent insulin signaling in early phase of differentiation.
- Antiproliferative and anti-invasive effect of piceatannol, a polyphenol present in grapes and wine, against hepatoma AH109A cells.
- Piceatannol, a resveratrol derivative, promotes glucose uptake through glucose transporter 4 translocation to plasma membrane in L6 myocytes and suppresses blood glucose levels in type 2 diabetic model db/db mice.
- Phosphoinositide 3-kinase is a novel target of piceatannol for inhibiting PDGF-BB-induced proliferation and migration in human aortic smooth muscle cells.
- Crystal and molecular structure of piceatannol; scavenging features of resveratrol and piceatannol on hydroxyl and peroxyl radicals and docking with transthyretin.
- Antioxidant activity of resveratrol, piceatannol and 3,3',4,4',5,5'-hexahydroxy-trans-stilbene in three leukemia cell lines.
- Antioxidant, prooxidant and cytotoxic activity of hydroxylated resveratrol analogues: structure-activity relationship.
- The grape and wine polyphenol piceatannol is a potent inducer of apoptosis in human SK-Mel-28 melanoma cells.
- The cancer preventative agent resveratrol is converted to the anticancer agent piceatannol by the cytochrome P450 enzyme CYP1B1.