| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Body Composition In high-fat diet mouse models, haskap berry extract reduced body weight, adipocyte size, and abdominal/subcutaneous fat mass while increasing muscle mass by regulating SIRT1 and PGC1-alpha. A separate study confirmed decreased serum cholesterol and triacylglycerol through AMPK activation with prevention of fatty liver. | Improves (the measure goes up) | Small effect | 3 studies | |||
Studies that measured body composition
| ||||||
Supplement
Haskap berry is the tart blue fruit of the honeysuckle plant Lonicera caerulea, rich in anthocyanin pigments that work as antioxidants. People mostly look at it for endurance, and in a small trial of 30 male runners, 5 km times were about 21 seconds faster and time to exhaustion was 20 seconds longer. The evidence is limited, though, and most other research has been in animals or lab dishes.
Sources: PMID 35215430
- Updated
- How we grade
- 17 studies cited
- Best evidence
- Grade C
- Conditions studied
- 5
- Outcomes
- 8
- Graded outcomes
- 0026
Evidence by condition
- Strong
- Moderate
- Limited
- Very limited
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Episodic Memory A small pilot crossover RCT in 20 older adults (aged 62-81) found that haskap berry extract at 200 mg and 400 mg anthocyanin doses significantly improved word recall and word recognition scores at 1.5 hours post-consumption compared to placebo. | Improves (the measure goes up) | Small effect | 2 studies | 20 people | ||
Studies that measured episodic memory | ||||||
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Endurance Exercise Performance A double-blind placebo-controlled RCT in 30 male recreational runners found haskap berry supplementation improved 5 km time trial performance by ~21 seconds (>2% improvement) and increased time to exhaustion by 20 seconds during a VO2peak test. Proposed mechanism involves improved vascular function and exercise-induced oxidative stress management. | Improves (the measure goes up) | Small effect | 2 studies | 30 people | ||
General
- Inflammation: improves
- Liver Health: improves
Cardiovascular Health
- Cholesterol: improves
- Blood Pressure: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Cholesterol In rodent models, haskap berry polyphenols decreased plasma LDL and total cholesterol in obese Zucker rats, normalized serum lipid levels in hypercholesterolemic rats, and activated SIRT1 to promote cholesterol efflux and inhibit macrophage foam cell formation in vitro. No human lipid data available. | Improves (the measure goes down) | Moderate effect | 5 studies | |||
Studies that measured cholesterol
| ||||||
| Blood Pressure In a small pilot crossover RCT in 20 older adults, a single 400 mg anthocyanin dose of haskap berry extract produced a significant acute reduction in diastolic blood pressure and heart rate at 1.5 hours post-consumption. No chronic supplementation data available. | Improves (the measure goes down) | Small effect | 2 studies | 20 people | ||
Studies that measured blood pressure | ||||||
Antioxidant Status
- Antioxidant Status: improves
Body Composition
- Body Composition: improves
Key findings
- Episodic MemoryImproves (the measure goes up)
- Endurance Exercise PerformanceImproves (the measure goes up)
- InflammationImproves (the measure goes down)
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- Grade C
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Studies cited
17 studies from PubMed
- A Systematic Review of Cardio-Metabolic Properties of Lonicera caerulea L.
- Improved Endurance Running Performance Following Haskap Berry (Lonicera caerulea L.) Ingestion
- Antioxidant Effect of Lonicera caerulea L. in the Cardiovascular System of Obese Zucker Rats
- Anti-Sarcopenic Obesity Effects of Lonicera caerulea Extract in High-Fat Diet-Fed Mice
- Haskap Berry Phenolic Subclasses Differentially Impact Cellular Stress Sensing in Primary and Immortalized Dermal Fibroblasts
- Lonicera caerulea L. Polyphenols Alleviate Oxidative Stress-Induced Intestinal Environment Imbalance and Lipopolysaccharide-Induced Liver Injury in HFD-Fed Rats by Regulating the Nrf2/HO-1/NQO1 and MAPK Pathways
- Anthocyanin-rich haskap (Lonicera caerulea L.) berry extracts reduce nitrosamine-induced DNA damage in human normal lung epithelial cells in vitro
- Cyanidin-3-O-Glucoside-Rich Haskap Berry Administration Suppresses Carcinogen-Induced Lung Tumorigenesis in A/JCr Mice
- A pilot dose-response study of the acute effects of haskap berry extract (Lonicera caerulea L.) on cognition, mood, and blood pressure in older adults
- Lonicera caerulea Berry Polyphenols Activate SIRT1, Enhancing Inhibition of Raw264.7 Macrophage Foam Cell Formation and Promoting Cholesterol Efflux
- Lonicera caerulea Extract Attenuates Non-Alcoholic Fatty Liver Disease in Free Fatty Acid-Induced HepG2 Hepatocytes and in High Fat Diet-Fed Mice
- Wild Lonicera caerulea berry polyphenol extract reduces cholesterol accumulation and enhances antioxidant capacity in vitro and in vivo
- Anti-obesity and fatty liver-preventing activities of Lonicera caerulea in high-fat diet-fed mice
- Modulation of Gut Microbiota by Lonicera caerulea L. Berry Polyphenols in a Mouse Model of Fatty Liver Induced by High Fat Diet
- Polyphenols from Lonicera caerulea L. Berry Inhibit LPS-Induced Inflammation through Dual Modulation of Inflammatory and Antioxidant Mediators
- Polyphenols from Lonicera caerulea L. berry attenuate experimental nonalcoholic steatohepatitis by inhibiting proinflammatory cytokines productions and lipid peroxidation
- Anti-Inflammatory Activity of Haskap Cultivars is Polyphenols-Dependent