NAD+ is a critical coenzyme involved in cellular energy metabolism, DNA repair, and aging-related pathways. NAD+ levels decline with age, driving interest in supplementation for anti-aging. However, oral NAD+ itself has very poor bioavailability - PRECURSORS like NR (nicotinamide riboside) and NMN (nicotinamide mononucleotide) are generally preferred. NO GRADED OUTCOMES for direct NAD+ supplementation. Most NAD+ research actually uses precursors. Research on aging benefits is ongoing but preliminary.
NAD+ is a critical coenzyme involved in cellular energy metabolism, DNA repair, and aging-related pathways. NAD+ levels decline with age, driving interest in supplementation for anti-aging.
Best grade per condition (each condition may have multiple outcomes)
3 shared conditions · 8 outcomes
Mulberry fruit extract is derived from the fruit of Morus alba (white mulberry). Different from mulberry LEAF extract (which is used for blood sugar control), the FRUIT extract contains anthocyanins and has been researched for glycemic control and antioxidant effects. NO GRADED OUTCOMES - research is limited. Contains cyanidin-3-glucoside and other anthocyanins similar to other dark berries. May have benefits for blood sugar and oxidative stress. Safe as a food; the fruit has been consumed for millennia.
2 shared conditions · 6 outcomes
White Kidney Bean extract (Phase 2) is an alpha-amylase inhibitor that blocks starch digestion. It DOES work but potency is variable and modest - blocks ~25-65% of starch calories in acute studies. Meta-analyses show ~2kg weight loss over 4-12 weeks. Must be taken with starchy meals. Undigested starch goes to colon bacteria (gas, bloating). Better for preventing weight gain than losing existing weight. Works best with high-starch meals.
2 shared conditions · 7 outcomes
Valine is one of three branched-chain amino acids (BCAAs), along with leucine and isoleucine. It's essential (must come from diet). NO GRADED OUTCOMES for isolated valine. Least studied and likely least important of the BCAAs for muscle building. Generally supplemented as part of BCAA mixture rather than alone. No unique proven benefits compared to other BCAAs. Safe as an amino acid. Adequate protein intake typically provides sufficient valine.
2 shared conditions · 8 outcomes
Spikenard (Jatamansi) is an Ayurvedic herb traditionally used for calming, cognitive enhancement, and neuroprotection. Similar traditional uses to Bacopa but with less research. Contains sesquiterpenes and volatile oils. NO GRADED OUTCOMES - human research is very limited. Preclinical studies show neuroprotective potential. Traditionally used for epilepsy, anxiety, and memory. The plant is endangered due to overharvesting; sustainable sourcing is a concern.
2 shared conditions · 11 outcomes
Salidroside is a glucoside compound and one of the main bioactive constituents of Rhodiola rosea. Often standardized in Rhodiola extracts (typically 1-3%). Has neuroprotective and adaptogenic properties. Research shows anti-fatigue, anti-stress, and potential anti-depressant effects. Mechanism involves HPA axis modulation, AMPK activation, and antioxidant effects. Most clinical evidence is for the whole Rhodiola rosea extract rather than isolated salidroside. May be more effective as part of whole plant extract than in isolation.
2 shared conditions · 6 outcomes
Sacred Lotus (Nelumbo nucifera) is an aquatic plant important in Asian cuisine and traditional medicine. All parts are used - seeds, leaves, rhizomes, flowers. Rich in polyphenols (catechins, procyanidins) and contains unique alkaloids like neferine. Preclinical research suggests anti-diabetic, anti-obesity, anti-depressant, and sedative effects. NO human clinical trials. Most interesting bioactive is neferine (unique to this plant) which shows various pharmacological effects in vitro. Remains underresearched in humans.
2 shared conditions · 318 outcomes
Resveratrol is a bioactive molecule found in plant sources such as grapes, peanuts, blueberries, and, famously, red wine. Resveratrol has anti-inflammatory and antioxidant properties that benefit cardiovascular function, glycemic control, and lipid metabolism. Although it’s promoted for lifespan extension, there’s no evidence for this in humans and limited evidence in animals.
2 shared conditions · 2 outcomes
Rauwolscine is a diastereoisomer (stereoisomer) of yohimbine with similar alpha-2 adrenergic antagonist activity. May be more potent than yohimbine at the same receptor. Used in fat burner supplements for 'stubborn fat' areas. Like yohimbine, works by blocking alpha-2 receptors that inhibit fat release. VERY LIMITED human research - potency and safety extrapolated from yohimbine data. Likely shares yohimbine's stimulant side effects (anxiety, elevated heart rate).