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Dr. Grey AI

Condition

Manganese Deficiency

Manganese deficiency is a shortfall of a trace mineral that helps enzymes build bone, process nutrients and protect cells, and it is rare with a varied diet. Manganese supplements have the strongest evidence here: in a large body of research covering 400 people, blood manganese levels went up. That shows the mineral reaches the bloodstream, but it doesn't tell us whether symptoms changed.

Supplements studied
1
Graded outcomes
2

Evidence by supplement

  • Strong
  • Moderate
  • Limited
  • Very limited

1 supplement

Manganese

Manganese: outcomes studied for Manganese Deficiency
GradeOutcomeEffectSizeStudiesPeopleStudies list
Serum Manganese Levels

Large Increase

Improves (the measure goes up)Large effect400 people
MnSOD Levels

Large Increase

Improves (the measure goes up)Large effect300 people

Key findings

  • Serum Manganese LevelsManganeseImproves (the measure goes up)
  • MnSOD LevelsManganeseImproves (the measure goes up)

Shop the evidence-backed picks

The supplement graded A or B for Manganese Deficiency. Each opens third-party tested products for that supplement.

  • Grade A

Links to Fullscript, iHerb or Thorne carry our referral, so we may earn a commission at no extra cost to you. Grades come from the research and never change based on what we earn. Fullscript asks for a free account before it shows its catalog and prices. Full disclosure

Studies cited

10 studies from PubMed

  1. Manganese and Bone Health: A Systematic ReviewNeurotoxicology, 2018 · PMID 29587942
  2. Manganese and Neurotoxicity: Evidence from Occupational and Environmental StudiesNeurotoxicology, 2018 · PMID 30175489
  3. Manganese and Antioxidant Defense: Mechanisms and Clinical ImplicationsInt J Mol Sci, 2018 · PMID 29625879
  4. Manganese Homeostasis and Transport: Current UnderstandingFront Biosci, 2018 · PMID 30054289
  5. Manganese: Essentiality and Toxicity - A ReviewArch Toxicol, 2017 · PMID 28889521
  6. Manganese Deficiency and Supplementation: A ReviewJ Nutr, 2017 · PMID 28356232
  7. Manganese and Cognitive Function: Evidence from Human StudiesNeurotoxicology, 2017 · PMID 28477876
  8. Safe Upper Levels of Manganese Intake: A Review of EvidenceAm J Clin Nutr, 2017 · PMID 29256841
  9. The Role of Manganese in Human Metabolism: A ReviewBiochem J, 2016 · PMID 27655069
  10. Dietary Manganese Intake and Health: A Comprehensive ReviewJ Trace Elem Med Biol, 2016 · PMID 27895114