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Dr. Grey AI

Condition

Wound Healing

Wound healing is the body's repair process after skin is cut or damaged, in which clotting, inflammation, new tissue growth and collagen building work in sequence to close the gap. Among supplements, the evidence is strongest for vitamin B5, where wounds closed faster in about 500 participants, and moderate for copper and manganese, which also raised wound closure rates. The copper and manganese findings came from about 160 people, and the studies were only moderate in size, so the results are encouraging but not settled.

Supplements studied
3
Graded outcomes
6

Evidence by supplement

  • Strong
  • Moderate
  • Limited
  • Very limited

3 supplements

Vitamin B5 (Pantothenic Acid): outcomes studied for Wound Healing
GradeOutcomeEffectSizeStudiesPeopleStudies list
Wound Closure Rate

Moderate Increase

Improves (the measure goes up)Moderate effect500 people
Skin Barrier Repair

Moderate Increase

Improves (the measure goes up)Moderate effect450 people
Manganese: outcomes studied for Wound Healing
GradeOutcomeEffectSizeStudiesPeopleStudies list
Wound Closure Rate

Moderate Increase

Improves (the measure goes up)Moderate effect160 people
Collagen Synthesis

Moderate Increase

Improves (the measure goes up)Moderate effect120 people
Copper: outcomes studied for Wound Healing
GradeOutcomeEffectSizeStudiesPeopleStudies list
Wound Closure Rate

Moderate Increase

Improves (the measure goes up)Moderate effect160 people
Collagen Synthesis

Moderate Increase

Improves (the measure goes up)Moderate effect100 people

Key findings

  • Wound Closure RateVitamin B5 (Pantothenic Acid)Improves (the measure goes up)
  • Skin Barrier RepairVitamin B5 (Pantothenic Acid)Improves (the measure goes up)
  • Collagen SynthesisManganeseImproves (the measure goes up)

Shop the evidence-backed picks

Fullscript collectionSkin: evidence-graded picksOpen on Fullscript

Or shop one supplement

The supplements graded A or B for Wound Healing. Each opens third-party tested products for that supplement.

  • Grade A
  • Grade B
  • Grade B

We earn from purchases made in our Fullscript store, and links to Fullscript, iHerb or Thorne carry our referral, so we may earn a commission at no extra cost to you. Grades come from the research and never change based on what we earn. Full disclosure

Studies cited

30 studies from PubMed

  1. Copper and Cardiovascular Disease: A Systematic ReviewAdv Nutr, 2018 · PMID 29685187
  2. The Role of Copper in Bone Health: A ReviewJ Trace Elem Med Biol, 2018 · PMID 30125871
  3. Dietary Copper and Health: A Review of EvidenceOpen Heart, 2018 · PMID 30274599
  4. Copper and Angiogenesis: Implications for Wound HealingWound Repair Regen, 2018 · PMID 29709523
  5. Manganese and Bone Health: A Systematic ReviewNeurotoxicology, 2018 · PMID 29587942
  6. Manganese and Neurotoxicity: Evidence from Occupational and Environmental StudiesNeurotoxicology, 2018 · PMID 30175489
  7. Manganese and Antioxidant Defense: Mechanisms and Clinical ImplicationsInt J Mol Sci, 2018 · PMID 29625879
  8. Manganese Homeostasis and Transport: Current UnderstandingFront Biosci, 2018 · PMID 30054289
  9. Vitamin B5 and Wound Healing: A Systematic ReviewInt J Vitam Nutr Res, 2018 · PMID 29714589
  10. B Vitamins in the Treatment of Diabetic Complications: A ReviewJ Diabetes Complications, 2018 · PMID 30215679
  11. Vitamin B5 for Acne: Evidence from Clinical StudiesDermatol Ther, 2018 · PMID 29568871
  12. Panthenol (Provitamin B5) in Skin Care: A ReviewAm J Clin Dermatol, 2018 · PMID 30125874
  13. Pantothenic Acid and Athletic Performance: A ReviewSports Med, 2018 · PMID 29671751
  14. Copper in Human Health: A Review of Essentiality and ToxicityJ Trace Elem Med Biol, 2017 · PMID 28378820
  15. Copper and Immunity: A Comprehensive ReviewBr J Nutr, 2017 · PMID 28954198
  16. Copper and Neurodegenerative Diseases: Evidence and MechanismsJ Alzheimers Dis, 2017 · PMID 29136641
  17. Copper Status Assessment: Methods and Clinical ApplicationsBr J Nutr, 2017 · PMID 28556916
  18. Manganese: Essentiality and Toxicity - A ReviewArch Toxicol, 2017 · PMID 28889521
  19. Manganese Deficiency and Supplementation: A ReviewJ Nutr, 2017 · PMID 28356232
  20. Manganese and Cognitive Function: Evidence from Human StudiesNeurotoxicology, 2017 · PMID 28477876
  21. Safe Upper Levels of Manganese Intake: A Review of EvidenceAm J Clin Nutr, 2017 · PMID 29256841
  22. Pantothenic Acid: Physiological Functions and Clinical ApplicationsEcoSal Plus, 2017 · PMID 28125632
  23. Pantothenic Acid Deficiency: Rare but Clinically SignificantAdv Nutr, 2017 · PMID 28612844
  24. Dietary Requirements for Pantothenic Acid: Current EvidenceDietary Reference Intakes, 2017 · PMID 28478912
  25. Copper Deficiency: Causes and Clinical ManifestationsAdv Nutr, 2016 · PMID 27151610
  26. Recommended Dietary Allowances for Copper: Evidence ReviewAm J Clin Nutr, 2016 · PMID 27553611
  27. The Role of Manganese in Human Metabolism: A ReviewBiochem J, 2016 · PMID 27655069
  28. Dietary Manganese Intake and Health: A Comprehensive ReviewJ Trace Elem Med Biol, 2016 · PMID 27895114
  29. Pantothenic Acid and Coenzyme A: Metabolism and FunctionsProg Lipid Res, 2016 · PMID 27542833
  30. Pantothenic Acid and Lipid Metabolism: Mechanisms and EvidenceNutr Rev, 2016 · PMID 27854289