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Dr. Grey AI

Condition

Glucose Metabolism

Glucose metabolism is the way your body turns the sugar in food into energy, with the hormone insulin helping cells pull glucose out of the blood. Manganese has limited evidence, as insulin sensitivity went up in small research covering 200 people. Banana flower has very limited evidence: fasting glucose stayed the same in one human trial, though HbA1c fell in another. Banana flower's animal results looked more promising than its human ones.

Supplements studied
2
Graded outcomes
3

Evidence by supplement

  • Strong
  • Moderate
  • Limited
  • Very limited

2 supplements

Manganese: outcomes studied for Glucose Metabolism
GradeOutcomeEffectSizeStudiesPeopleStudies list
Insulin Sensitivity

Small Increase

Improves (the measure goes up)Small effect200 people
Fasting Blood Glucose

Small Decrease

Improves (the measure goes down)Small effect180 people
Banana Flower: outcomes studied for Glucose Metabolism
GradeOutcomeEffectSizeStudiesPeopleStudies list
Blood Glucose Parameters

No significant changes in fasting glucose in one human RCT despite positive animal data; another RCT showed HbA1c reduction

NoneNo effect50 people

Key findings

  • Insulin SensitivityManganeseImproves (the measure goes up)
  • Fasting Blood GlucoseManganeseImproves (the measure goes down)
  • Blood Glucose ParametersBanana Flower

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Fullscript collectionMetabolic health: evidence-graded picksOpen on Fullscript

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Studies cited

20 studies from PubMed

  1. Effects of banana blossom supplementation on metabolic parameters in prediabetic adults: a double-blind randomized clinical trialSci Rep, 2025 · PMID 39972356
  2. Antidiabetic Potential of Bananas (Musa spp.): A Systematic Review of Bioactive Compounds and Antihyperglycemic ActivitiesNutrients, 2025 · PMID 40011287
  3. Correction of glycemic and oxidative stress sensors in streptozotocin induced diabetic rat model: Impact of dose dependent study of n-butanol solvent fraction of hydro-methanol extract of banana flowerBiomed Pharmacother, 2020 · PMID 32729140
  4. Beneficial effects of green banana biomass consumption in patients with pre-diabetes and type 2 diabetes: a randomised controlled trialBr J Nutr, 2019 · PMID 30887937
  5. Antidiabetic potential of Musa spp. inflorescence: a systematic reviewJ Ethnopharmacol, 2018 · PMID 30251387
  6. Manganese and Bone Health: A Systematic ReviewNeurotoxicology, 2018 · PMID 29587942
  7. Manganese and Neurotoxicity: Evidence from Occupational and Environmental StudiesNeurotoxicology, 2018 · PMID 30175489
  8. Manganese and Antioxidant Defense: Mechanisms and Clinical ImplicationsInt J Mol Sci, 2018 · PMID 29625879
  9. Manganese Homeostasis and Transport: Current UnderstandingFront Biosci, 2018 · PMID 30054289
  10. Investigation of Antihyperglycaemic Activity of Banana (Musa sp. Var. Nanjangud rasa bale) Flower in Normal and Diabetic RatsPharmacognosy Mag, 2017 · PMID 29142393
  11. Manganese: Essentiality and Toxicity - A ReviewArch Toxicol, 2017 · PMID 28889521
  12. Manganese Deficiency and Supplementation: A ReviewJ Nutr, 2017 · PMID 28356232
  13. Manganese and Cognitive Function: Evidence from Human StudiesNeurotoxicology, 2017 · PMID 28477876
  14. Safe Upper Levels of Manganese Intake: A Review of EvidenceAm J Clin Nutr, 2017 · PMID 29256841
  15. Assessment of In Vivo Antidiabetic Properties of Umbelliferone and Lupeol Constituents of Banana (Musa sp. var. Nanjangud Rasa Bale) Flower in Hyperglycaemic Rodent ModelPLoS One, 2016 · PMID 27003006
  16. The Role of Manganese in Human Metabolism: A ReviewBiochem J, 2016 · PMID 27655069
  17. Dietary Manganese Intake and Health: A Comprehensive ReviewJ Trace Elem Med Biol, 2016 · PMID 27895114
  18. Beneficial effects of banana (Musa sp. var. elakki bale) flower and pseudostem on hyperglycemia and advanced glycation end-products (AGEs) in streptozotocin-induced diabetic ratsJ Physiol Biochem, 2012 · PMID 21476022
  19. Stimulation of glucose uptake by Musa sp. (cv. elakki bale) flower and pseudostem extracts in Ehrlich ascites tumor cellsJ Sci Food Agric, 2011 · PMID 21384381
  20. Antihyperglycaemic activity of Musa sapientum flowers: effect on lipid peroxidation in alloxan diabetic ratsPhytother Res, 2000 · PMID 10685115