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Dr. Grey AI

Supplement

Glutathione

Glutathione is an antioxidant your cells build from three amino acids, helping neutralize damaging molecules and supporting immune cells. Research on immune health is limited: in one trial of 52 people, antioxidant enzyme levels went up, and so did natural killer cell activity, a measure of immune defense. Beyond that, a separate study of 39 people found no clear difference in DNA damage.

Sources: PMID 24791752

Best evidence
Grade C
Conditions studied
2
Outcomes
4
Graded outcomes
0021

Evidence by condition

  • Strong
  • Moderate
  • Limited
  • Very limited

2 conditions

Immune Health: outcomes studied for Glutathione
GradeOutcomeEffectSizeStudiesPeopleStudies list
Anti-Oxidant Enzyme Profile

Moderate Increase

Improves (the measure goes up)Moderate effect1 study52 people

Studies that measured anti-oxidant enzyme profile

Natural Killer Cell Activity

Small Increase

Improves (the measure goes up)Small effect52 people
Metabolic Health: outcomes studied for Glutathione
GradeOutcomeEffectSizeStudiesPeopleStudies list
DNA Damage

No effect

NoneNo effect39 people
Oxidative Stress BiomarkersImproves (the measure goes down)1 study39 people

Studies that measured oxidative stress biomarkers

Key findings

  • Anti-Oxidant Enzyme ProfileImmune HealthImproves (the measure goes up)
  • Natural Killer Cell ActivityImmune HealthImproves (the measure goes up)
  • DNA DamageMetabolic Health

Shop Glutathione

Third-party tested Glutathione products. The evidence above is limited, so read it before you buy.

  • Grade C

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Studies cited

2 studies from PubMed

  1. Effects of oral glutathione supplementation on systemic oxidative stress biomarkers in human volunteersJ Altern Complement Med · PMID 21875351
  2. Randomized controlled trial of oral glutathione supplementation on body stores of glutathioneEur J Nutr · PMID 24791752